Conclusions
It is concluded that Zn absorption is enhanced by Zn deficiency and this is in part facilitated by MT. The effect of MT to limit Zn absorption in the Zn replete state but enhance absorption in Zn deficiency appears to result from MT sequestering Zn in the gut and pancreas as well as in the liver. The higher levels of induction of pancreatic and small intestinal MT found in Zn deficient mice may be important to sequestering Zn, limiting its secretion.
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References
Cousins, R.J., 1985, Absorption, transport and hepatic metabolism of copper and zinc: special reference to metallothionein and caeruloplasmin. Physiol. Rev. 65:238–309.
Coyle, P., Philcox, J.C., and Rofe, A.M., 1999, Metallothionein-null mice absorb less Zn from an egg-white diet, but a similar amount from solutions, although with altered intertissue Zn distribution. J. Nutr. 129:372–379.
Davis, S.R., McMahon, R.J., and Cousins, R.J., 1998, Metallothionein knockout and transgenic mice exhibit altered intestinal processing of zinc with uniform zinc-dependent zinc transporter-1 expression. J. Nutr. 128:825–831.
Eaton, D.L. and Toal, B.F., 1982, Evaluation of the Cd/hemoglobin assay for the rapid determination of metallothionein in biological tissues. Toxicol. Appl. Pharmacol. 66:134–142.
Hoadley, J.E., Leinart, A.S., and Cousins, R.J., 1987, Kinetic analysis of zinc uptake and serosal transfer by vascularly perfused rat intestine. Am. J. Physiol. 252:g825–g831.
Hoadley, J.E., Leinart, A.S., and Cousins, R.J., 1988, Relationship of 65Zn absorption kinetics to intestinal metallothionein in rats: Effects of zinc depletion and fasting. J. Nutr. 118:497–502.
Lönnerdal, B., 1989, Intestinal absorption of zinc, in: Zinc in human biology (C.F. Mills, ed.), pp. 33–55, Springer-Verlag, London.
Steel, L. and Cousins, R.J., 1985, Kinetics of zinc absorption by luminally and vascularly perfused rat intestine. Am. J. Physiol. 248:G46–G53.
Tran, C.D., Butler, R.N., Philcox, J.C., Rofe, A.M., Howarth G.S., and Coyle, P., 1998, Regional distribution of metallothionein and zinc in the mouse gut. Comparison with Metallothionein-null mice. Biol. Trace Elem. Res. 63:239–251.
Valee, B.L. and Falchuk, K.H., 1993, The biochemical basis of zinc physiology. Physiol. Rev. 73:79–118.
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Coyle, P., Philcox, J.C., Rofe, A.M. (2002). Metallothionein Faciltates Zinc Absorption in Zinc Deficient Mice but Limits Absorption in Zinc Replete Mice. In: Roussel, A.M., Anderson, R.A., Favier, A.E. (eds) Trace Elements in Man and Animals 10. Springer, New York, NY. https://doi.org/10.1007/0-306-47466-2_7
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DOI: https://doi.org/10.1007/0-306-47466-2_7
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