Conclusions
Trace element intakes and status are frequently marginal in elderly, resulting in nutrition-related diseases. Considering the essential protective roles of zinc and selenium against oxidative damage and decline of immune functions, or the beneficial effect of chromium on glucose tolerance, there is now increasing evidence that appropriate supplementations, restoring marginal trace element status, should reduce the risk of several common age-related degenerative diseases. Institutionalized people should also be monitored with respect to their antioxidant trace element status. Surprisingly, little information is available concerning the real mineral requirements of elderly people. Additional research also needs to be done to evaluate the efficiency of preventive supplementations associating several complementary micronutrients. In any case, many authors agree that more attention should be devoted to elderly people who represent the best target of preventive intervention, since the challenge is to maintain in a better state the growing older population.
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References
Anderson, R.A., Bryden, N.A., Polansky, M.M., and Reiser, S., 1990, Urinary chromium excretion and insulinogenic properties of carbohydrates, Am. J. Clin, Nutr., 51:864–868.
Anderson, R.A., 1994, Chromium nutrition in the elderly, Handbook of Nutrition in the Aged, R.R. Watson, Ed, CRC Press, Boca Raton, FL, 385–392.
Anderson, R.A., 1997a, Chromium as an essential nutrient for humans, Regul. Toxicol. Pharmacol, 26:S35–S41.
Anderson, R.A., 1997b, Nutritional factors influencing the glucose/insulin system: Chromium, J. Am. Coll. Nutr., 16:404–410.
Anderson, R.A., 1998, Chromium, glucose intolerance and diabetes, J. Am. Coll. Nutr., 17(6):548–555.
Ascherio, A., Willett, W.C., Rimm, E.B., Giovannucci, E.L., and Stampfer, M., 1994, Dietary iron intake and risk of coronary disease among men, Circulation, 89:969–974.
Beattie, J.H. and Peace, H.S., 1993, The influence of a low-boron diet and boron supplementation on bone, major mineral and sex metabolism in postmenopausal women, Br. J. Nutr., 69(3):871–884.
Berr, C., Richard, M.J., Roussel, A.M., and Bonithon-Kopp, C., 1998, Systemic oxidative stress and cognitive performance in the population-based EVA study, Free Radic. Biol. Med, 24(7/8):1202–1208.
Bogden, J.D., Bendich, A., Kemp, F.W., Bruening, K.S., Skumick, J.H., Denny, T., Baker, H., and Louria, D.B., 1994, Daily micronutriment supplements enhance delayed hypersensibility skin test responses in older people, Am. J. Clin. Nutr., 60:437–442.
Bortoli, A., Fazzin, G., Marchiori, M., Mello, F., Brugiolo, R., and Martelli, F, 1991, Selenium status and effect of selenium supplementation in a group of elderly women, J. Trace Elem. Electrolytes Health Dis. 5:19–21.
Boukaiba, N., Flament, C., Acher, S., et al., 1993, A physiological amount of zinc supplementation effects on nutritional, lipid, and thymic status in an elderly population, Am. J. Clin. Nutr., 57:566–572.
Bray, T.M. and Bettger W.J., 1990, The physiological role of zinc as an antioxidant, Free Rad. Biol. Med., 8:281–291.
Clark, L. and Combs, J., 1996, Effects of Selenium supplementation for cancer prevention in patients with carcinoma of the skin, JAMA, 25:1957–1963.
Congy, F, Bonnefont-Rousselot, D., Dever, S., Delattre, J., and Emerit, I., 1995, Oxidative stress in the elderly, Press. Med., 24:115–118.
Coudray, C., Roussel, A.M., Arnaud, J., and Favier, A., 1997, Selenium and antioxidant vitamin and lipoperoxidation levels in preaging French population. EVA Study group, Biol. Trace. Elem. Res., 57(2):183–190.
Davis, S., Mc Laren-Howard, J., Hunnisett, A., and Howard, M., 1997, Age-related decreases in chromium levels in 51,665 hair, sweat, and serum samples from 40,872 patients: implications for the prevention of cardiovascular disease and type II diabetes mellitus, Metabolism, 46:469–473.
Ducros, V., Faure, P., Ferry, M., Couzy, F., Biajoux I., and Favier, A., 1998, The sizes of the exchangeable pools of selenium in elderly women and their relation to institutionalization, Br. J. Nutr., 3:379–396.
Euronut Seneca Investigators, 1991a, Intake of vitamins and minerals, Eur. J. Clin. Nutr., 45(suppl.3):121–138.
Fairbanks V.F., 1994, Iron in Medicine and Nutrition, in “Modern nutrition in health and diseases,” vol. 1, 185–213, 8th Ed, Shils ME, Olson JA, Shike M, edts., Philadelphia: Lea and Febiger.
Fortes, C, Agabiti, N., Fano, V., Paciflci, R., Forastiere F., Virgili, F., Zuccaro, P., Perruci, C.A., and Ebrahim, S., 1997, Zinc supplementation and plasma lipid peroxides in an elderly population, Eur. J. Clin. Nutr., 51:97–101.
Fortes, C., Forastiere, F., Fano, V., Agabiti, N., Paciflci, R., Virgili, F., Piras, G., Bartoloni, C., Tricerri, A., Zuccaro, P., Ebrahim, S., and Perruci, C.A., 1998, The effect of Zinc and Vitamin A supplementation on immune response in an older population, JAGS, 46:19–26.
Galan, P., Preziosi, P., Monget, A.L., Richard, M.J., Arnaud J, Lesourd B, Girodon P, Bourgeois C.F., Keller H., Favier, A., and Hercberg S., 1997, Effects of trace element and/or vitamin supplementation on vitamin and mineral status, free radical metabolism and immunological markers in elderly long-term hospitalized subjects, Internat. J. Vit. Nutr. Res., 67:45–460.
Girodon, F., Blache, D., Monget, A.L., Lombard, M., Brunet, P., Arnaud, J., Richard, M.J., and Galan, P., 1997a, Effect of a two year supplementation with low doses of antioxidant vitamins and/or minerals in elderly subjects on levels of nutrients and antioxidant defense parameters, J. Am. Coll. Nutr., 16:357–365.
Girodon, F., Lombard, M., Galan, P., Brunet-Lecomte, P., Monget, A.L., Arnaud, J., Prezioci, P., and Hercberg, S., 1997b, Effect of micronutrient supplementation on infections in institutionalized elderly subjects: a controlled trial, Ann. Nutr. Met., 41:98–107.
Hercberg, S., Preziosi, P., Galan, P., Deheeger, M., Papoz, L., and Dupin, H., 1991, Apports nutritionnels’ un échantillon représentatif de la population du Val de Marne: III Les apports en minéraux et vitamines, Rev. Epid. Santé publique, 39:245–261.
Johnson, M.A., Fisher, J.G., Bowman, B.A., and Gunter, E.W., 1994, Iron nutriture in elderly individuals, FASEB J., 8:609–621.
Jones, A., DiSilvestro, R., Coleman, M., and Wagner, T., 1997, Copper supplementation of adult men: Effects on blood copper enzyme activities and indicators of cardiovascular disease risk, Metabolism, 12:1380–1383.
Knight, J.A., 1995, The process and theory of aging, Ann. Clin. Lab. Sci., 25:11–12.
Mac Kenzie, R., Rafferty, T., and Beckett, G., 1998, Selenium: An essential element for immune function, Immunology Today, 19:342–345.
Mertz, W., 1990, The role of trace elements in the aging process, Prog. Clin. Biol. Res., 326:229–240.
Monget, A.L., Galan, P., Preziosi, P., Keller, H., Bourgeois, C., Arnaud, J., Favier, A., and Hercberg, S., 1996, Micronutrient status in elderly people. Geriatrie / Min. VitAOX network, Int. J. Vitam. Nutr. Res., 66(l):71–76.
Neve, J., 1992, Prevention du vieillissement par les oligoéléments essentiels. De Natura Rera, 5:100–115.
Olivieri, O., Stanziali, A.M., and Girelli, D. et al., 1994, Selenium status, fatty acids, vitamin A and E, and aging: the Nove Study, Am. J. Clin Nutr., 1994, 60:510–517.
Parat, M.O., Richard, M.J., Pollet, S., Hadjur, C., Favier, A., and Beani, J.C., 1997, Zinc and DNA fragmentation in keratinocyte apoptosis: its inhibitory effect in UVB irradiated cells, Photochem. Photobiol, 37:101–106.
Penland, J.G., 1998, The importance of Boron nutrition for brain and psychological function, Biol. Trace Elem. Res., 66(l-3):299–317.
Peretz, A., Neve, J., Desmedt, J., Duchateau, J., Dramaix, M., and Famaey, J.P. 1991a, Lymphocyte response is enhanced by supplementation of elderly subjects with selenium enriched yeast, Am. J. Clin. Nutr., 53:1323–1328.
Peretz, A., Neve, J., Duchateau, J., Siderova, V., Huygen, K.M., Famaey, J.P., and Carpentier, Y.A., 1991b, Effects of selenium supplementation on immune parameters in gut failure patients on total parenteral nutrition, Nutrition, 7:215–221.
Perry, D., Smyth, M.J., Stennicke, H.R., Salvesen, G.S., Durier, P., Poirier, G., and Hannun, Y., 1997, Zinc is a potent inhibitor of the apoptotic protease, caspase-3: a novel target for zinc in the inhibition of apoptosis, J. Biol. Chem., 271:18530–18533.
Piperakis, S.M., Visvardis, E.E., Sagnou, M., and Tassiou A.M., 1998, Effects of smoking and aging on oxidative DNA drainage of human lymphocytes, Carcinogenesis, 19:695–698.
Prasad, A., Fitzgerald, J.T., Hess, J.W., Kaplan, J., Pelen, F., and Dardenne, M., 1993, Zinc deficiency in elderly patients, Nutrition, 9:218–224.
Preziosi, P., Galan, P., Herberth, B., Valeix, P., Roussel, A.M., Malvy, D., Paul-Dauphin, A., Arnaud, J., Richard, M.J., Briancon, S., Favier, A., and Hercberg, S., 1998, Effects of supplementation with a combination of antioxidant vitamins and trace elements at nutritional doses, on biochemical indicators and markers of the antioxidant system in adult subjects, J. Am. Coll. Nutr., 17(3):244–249.
Saltman, P.D. and Strause, L.G., 1993, The role of trace minerals in osteoporosis, J. Am. Coll. Nutr., 12(4):384–389.
Samiec, P.S., Drews-Botsch, C, Flagg, E.W., Kurtz, J.C., Sternberg, P., Reed, R.L., and Jones, D.P., 1998, Glutathione in human plasma: decline in association with aging, age-related macular degeneration and diabetes, Free Radic. Biol. Med., 24(5):699–704.
Schmuck, A., Roussel, A.M., Arnaud, J., Ducros, V., Favier, A., and Franco, A., 1996, Analyzed dietary intakes, plasma concentrations of zinc, copper, and selenium and related metalloenzyme activities in hospitalized elderly women, J. Am. Coll. Nutr., 15:462–470.
Smith, M., Harris, P., Sayre, L., and Perry, G., 1997, Iron accumulation in Alzeihmer disease is a source of redox-generated free radicals, Proc. Natl. Acad. Sci. USA, 94:9866–9868.
Strain, J.J., 1988, A reassessment of diet and osteoporosis-possible role for copper, Med. Hypothesis, 27(4):333–338.
Toussaint, O., Raes, M., Michiels, C., and Remacle, J., 1998, The response of cells to stress: relationship to the aging process and the pathology, Med. Science, 14:622–635.
Verhaegh, G., Parta, M.O., Richard, M.J., and Hainaut, P., 1998, Modulation of p53 protein conformation and DNA-binding activity by intracellular chelation of zinc, Mol. Carcin., 21:205–214.
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Roussel, AM. (2002). Trace Element Deficiencies and Supplementations in the Elderly. In: Roussel, A.M., Anderson, R.A., Favier, A.E. (eds) Trace Elements in Man and Animals 10. Springer, New York, NY. https://doi.org/10.1007/0-306-47466-2_129
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