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Integration of Pharmaceutical Discovery and Development pp 81–112Cite as

Discovery and Development of an Endothelin a Receptor-Selective Antagonist PD 156707

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Part of the book series: Pharmaceutical Biotechnology ((PBIO,volume 11))

Summary

PD 156707 is a highly potent, selective antagonist of ET A the receptor that has demonstrated efficacy in a number of different disease models. The next few years will be exciting in the field of ET research as several compounds progress through clinical development. It is our hope that the efficacy data demonstrated to date with PD 156707 will some day be translated into real hope for the patients who are waiting beyond the confines of our research laboratories.

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Authors and Affiliations

  1. Department of Chemistry, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan, 48105

    Annette M. Doherty

  2. Department of Cardiac and Vascular Diseases, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan, 48105

    Andrew C. G. Uprichard

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  1. Annette M. Doherty
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  1. The University of Kansas, Lawrence, Kansas

    Ronald T. Borchardt

  2. Merck Research Laboratories, West Point, Pennsylvania

    Roger M. Freidinger

  3. ARIAD Pharmaceuticals, Inc., Cambridge, Massachusetts

    Tomi K. Sawyer

  4. Smith Kline Beecham, Collegeville, Pennsylvania

    Philip L. Smith

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Doherty, A.M., Uprichard, A.C.G. (2002). Discovery and Development of an Endothelin a Receptor-Selective Antagonist PD 156707. In: Borchardt, R.T., Freidinger, R.M., Sawyer, T.K., Smith, P.L. (eds) Integration of Pharmaceutical Discovery and Development. Pharmaceutical Biotechnology, vol 11. Springer, Boston, MA. https://doi.org/10.1007/0-306-47384-4_5

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