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Schistosomiasis and Reduced Risk of Atopic Diseases: New Insights and Possible Mechanisms

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The Geohelminths: Ascaris, Trichuris and Hookworm

Part of the book series: World Class Parasites ((WCPA,volume 2))

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References

  • AALBERSE, R.C., VAN DER GAAG, R., & VAN Leeuwen, J. (1983). Serologic aspects of IgG4 antibodies. I. Prolonged immunization results in an IgG4-restricted response. Journal of Immunology 130, 722–726.

    CAS  Google Scholar 

  • AKDIS, C.A., BLESKEN, T., AKDIS, M., WUTHRICH, B. & BLASER, K. (1998). Role of interleukin 10 in specific immunotherapy. Journal of Clinical Investigations 102, 98–106.

    CAS  Google Scholar 

  • ALLEN, J.E. & MAIZELS, R.M. (1996). Immunology of human helminth infection. International Archives of Allergy 109, 3–10.

    CAS  Google Scholar 

  • ARAUJO, M.I., DE JESUS, A.R., BACELLAR, O., SABIN, E., PEARCE, E. & CARVALHO, E.M. (1996). Evidence of a T helper type 2 activation in human schistosomiasis. European Journal of Immunology 26, 1399–1403.

    PubMed  CAS  Google Scholar 

  • ARAUJO, M.I., LOPES, A.A., MEDEIROS, M., CRUZ, A.A., SOUSA-ATTA, L., SOLE, D. & CARVALHO, E.M., (2000). Inverse association between skin response to aeroallergens and schistosoma mansoni infection. International archives of allergy and Immunology 123, 145–148.

    Article  PubMed  CAS  Google Scholar 

  • ARMITAGE, R.J., MACDUFF, B.M., SPRIGGS, M.K. & FANSLOW, W.C. (1993). Human B cell proliferation and Ig secretion induced by recombinant CD40 ligand are modulated by soluble cytokines. Journal of Immunology 150, 3671–3680.

    CAS  Google Scholar 

  • BICHLER, K.H., FEIL, G., ZUNBRAGEL, A., EIPPER, E. & DYBALLA, S. (2001). Schistosomiasis: a critical review. Current Opinions in Urology 11, 97–101.

    CAS  Google Scholar 

  • BOCTOR, F.N. & PETER, J,B,. (1990). IgG subclasses in human chronic schistosomiasis: over-production of schistosome-specificand non-specific IgG4. Clinical and Experimental Immunology 82, 574–578.

    PubMed  CAS  Google Scholar 

  • BRUNET, L.R., KOPF, M.A. & PEARCE, E.J. (1999). Schistosoma mansoni: IL-4 is necessary for concomitant immunity in mice. Journal of Parasitology 85, 734–736.

    PubMed  CAS  Google Scholar 

  • DE BOER, B.A., KRUIZE, Y.C., ROTMANS, P.J. & YAZDANBAKHSH, M. (1997) Interleukin-12 suppresses immunoglobulin E production but enhances immunoglobulin G4 production by human peripheral blood mononuclear cells. Infection and Immunity 65, 1122–1125.

    PubMed  Google Scholar 

  • DE JESUS, A.M., ALMEIDA, R.P., BACELLAR, O., ARAUJO, M.I., DEMEURE, C., BINA, J.C., DESSEIN, A.J. & CARVALHO, E.M. (1993). Correlation between cell-mediated immunity and degree of infection in subjects living in an endemic area of schistosomiasis. European Journal of Immunology 23, 152–158.

    PubMed  Google Scholar 

  • DE JONG, E.C., VIEIRA, P.L., KALINSKI, P., SCHUITEMAKER, J.H.N., TANAKA, Y., WIEREINGA, E.A., YAZDANBAKHSH, M. & KAPSENBERG, M. (2001). Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendretic cells through diverse Th cell-polarizing signals. Submitted.

    Google Scholar 

  • DEL PRETE, G., DE CARLI, M., ALMERIGOGNA, F., GIUDIZI, M.G., BIAGIOTTI, R. & ROMAGNANI, S. (1993). Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production, Journal of Immunology 150, 353–360.

    Google Scholar 

  • DEMEURE, C.E., RIHET, P., ABEL, L., OUATTARA, M., BOURGOIS, A. & DESSEIN, A.J. (1993). Resistance to Schistosoma mansoni in humans: influence of the IgE/IgG4 balance and IgG2 in immunity to reinfection after chemotherapy. Journal of Infectious Diseases 168, 1000–1008.

    PubMed  CAS  Google Scholar 

  • DESSEIN, A.J., HILLAIRE, D., ELWALI, N.E, MARQUET, S., MOHAMED-ALI, Q., MIRGHANI, A., HENRI, S., ABDELHAMEED, A.A., SAEED, O.K., MAGZOUB, M.M. & ABEL, L. (1999). Severe hepatic fibrosis in Schistosoma mansoni infection is controlled by a major locus that is closely linked to the interferon-gamma receptor gene. American Journal of Human Genetics 65, 709–721.

    PubMed  CAS  Google Scholar 

  • DUNNE, D.W., BUTTERWORTH, A.E., FULFORD, A.J., KARIUKI, H.C., LANGLEY, J.G., OUMA, J.H., CAPRON, A., PIERCE, R.J. & STURROCK, R.F. (1992). Immunity after treatment of human schistosomiasis: association between IgE antibodies to adult worm antigens and resistance to reinfection. European Journal of Immunology 22, 1483–1494.

    PubMed  CAS  Google Scholar 

  • DUNNE, D.W., HAGAN, P. & ABATH, F.G. (1995). Prospects for immunological control of schistosomiasis. Lancet 345, 1488–1491.

    PubMed  CAS  Google Scholar 

  • EL-KALOUBY, A.H., AMER, R., ABDEL-WAHAB, M.F. & EL-RAZIKY, E.H. (1979). Delayed hypersensitivity to specific antigen and hetrologous PPD antigen in patients infected with Schistosoma mansoni and/or Schistosoma haematobium. Egyptian Journal of Bilharzia 6, 43–49.

    CAS  Google Scholar 

  • FALCAO, P.L., MALAQUIAS, L.C., MARTINS-FILHO, O.A., SILVEIRA, A.M., PASSOS, V.M., PRATA, A., GAZZINELLI, G., COFFMAN, R.L. & CORREA-GUTIERREZ, Y. (2000). Diagnostic Pathology of Parasitic Infections with Clinical Correlation (2nd Edition), pp. 545–576. Oxford University Press, Oxford.

    Google Scholar 

  • GALLI, S.J. & COSTA, J.J. (1995). Mast-cell-leukocyte cytokine cascades in allergic inflammation. Allergy 50, 851–862.

    PubMed  CAS  Google Scholar 

  • GODFREY, R.C. (1975). Asthma and IgE levels in rural and urban communities of The Gambia. Clinical Allergy 5, 201–207.

    PubMed  CAS  Google Scholar 

  • GROGAN, J.L., KREMSNER, P.G., DEELDER, A..M. & YAZDANBAKHSH, M. (1998). The effect of anti-IL-10 on proliferation and cytokine production in human schistosomiasis: fresh versus cryopreserved cells. Parasite Immunology 20, 345–349.

    Article  PubMed  CAS  Google Scholar 

  • GROGAN, J.L., KREMSNER, P.G., DEELDER, A.M.. & YAZDANBAKHSH, M. (1998). Antigen-specific proliferation and interferon-gamma and interleukin-5 production are down-regulated during Schistosoma haematobium infection. Journal of Infectious Diseases 177, 1433–1437.

    PubMed  CAS  Google Scholar 

  • GRUNIG, G., CORRY, D.B., LEACH, M.W., SEYMOUR, B.W., KURUP, V.P. & RENNICK, D.M. (1997). Interleukin-10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosis. Journal of Experimental Medicine 185, 1089–1099.

    Article  PubMed  CAS  Google Scholar 

  • GUTIERREZ, Y. (2000). Diagnostic Pathology of Parasitic Infections with Clinical Correlation (2nd Edition), pp. 545–576. Oxford University Press, Oxford.

    Google Scholar 

  • HAGAN, P., BLUMENTHAL, U.J., DUNN, D., SIMPSON, A.J. & WILKINS, H.A. (1991). Human IgE, IgG4 and resistance to reinfection with Schistosoma haematobium. Nature 17 (349), 243–245.

    Google Scholar 

  • HANSEN, G., BERRY, G., DeKRUYFF, R.H. & UMETSU, D.T. (1999). Allergen-specific Th1 cells fail to counter balance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. Journal of Clinical Investigation, 175–183.

    Google Scholar 

  • HOFFMANN, K.F., CHEEVER, A.W. & WYNN, T.A. (2000). IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis. Journal of Immunology 164, 6406–6416.

    CAS  Google Scholar 

  • HUSSAIN, R., HOFSTETTER, M., GOLDSTONE, A., KNIGHT, W.B. & OTTESEN, E.A. (1983). IgE responses in human schistosomiasis. I. Quantitation of specific IgE by radioimmunoassay and correlation of results with skin test and basophil histamine release. American Journal of Tropical Medicine and Hygiene 32, 1347–1355.

    PubMed  CAS  Google Scholar 

  • JARVIS, D., CHINN, S., LUCZYNSKA, C. & BURNEY, P. (1997). The association of family size with atopy and atopic disease. Clinical and Experimental Allergy 27, 240–245.

    PubMed  CAS  Google Scholar 

  • JEANNIN, P., LECOANET, S., DELNESTE, Y., GAUCHAT, J.F. & BONNEFOY, J.Y. (1998). IgE versus IgG4 production can be differentially regulated by IL-10. Journal of Immunology 160, 3555–3561.

    CAS  Google Scholar 

  • JONULEIT, H., SCHMITT, E., SCHULER, G., KNOP, J. & ENK, A.H. (2000). Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. Journal of Experimental Medicine 192, 1213–1222.

    Article  PubMed  CAS  Google Scholar 

  • JONULEIT, H., SCHMITT, E., STEINBRINK, K. & ENK, A.H. (2001). Dendritic cells as a tool to induce anergic and regulatory T cells. Trends in Immunology 22, 394–400.

    Article  PubMed  CAS  Google Scholar 

  • KALINSKI, P., HILKENS, C.M., WIERENGA, E.A. & KAPSENBERG, M.L. (1999). T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal. Immunology Today 20, 561–567.

    Article  PubMed  CAS  Google Scholar 

  • KAPLAN, M.H., WHITFIELD, J.R., BOROS, D.L. & GRUSBY, M.J. (1998). Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response. Journal of Immunology 160, 1850–1856.

    CAS  Google Scholar 

  • KAPSENBERG, M.L., HILKENS, C.M., WIERENGA, E.A. & KALINSKI, P. (1999). The paradigm of type 1 and type 2 antigen-presenting cells. Implications for atopic allergy. Clinical and Experimental Allergy 29 Suppl 2, 33–36.

    PubMed  Google Scholar 

  • KAPSENBERG, M.L., HILKENS, C.M., VAN DER POUW KRAAN, T.C., WIERENGA, E.A. & KALINSKI, P. (2000). Atopic allergy: a failure of antigen-presenting cells to properly polarize helper T cells? American Journal of Respiratory Critical Care and Medicine 162, S76–80.

    Google Scholar 

  • KEATINGS, V.M., O’CONNOR, B.J., WRIGHT, L.G., HUSTON, D.P., CORRIGAN, C.J. & BARNES, P.J. (1997). Late response to allergen is associated with increased concentrations of tumor necrosis factor-alpha and IL-5 in induced sputum. Journal of Allergy and Clinical Immunology 99, 693–698.

    Article  PubMed  CAS  Google Scholar 

  • KIM, T.S., DEKRUYFF, R.H., RUPPER, R., MAECKER, H.T., LEVY, S. & UMETSU, D.T. (1997). An ovalbumin-IL-12 fusion protein is more effective than ovalbumin plus free recombinant IL-12 in inducing a T helper cell type 1-dominated immune response and inhibiting antigen-specific IgE production. Journal of Immunology 158, 4137–4144.

    CAS  Google Scholar 

  • KING, C.L., MAHANTY, S., KUMARASWAMI, V., ABRAMS, J.S., REGUNATHAN, J., JAYARAMAN, K., OTTESEN, E.A. & NUTMAN, T.B. (1993). Cytokine control of parasite-specific anergy in human lymphatic filariasis. Preferential induction of a regulatory T helper type 2 lymphocyte subset. Journal of Clinical Investigations 92, 1667–7316.

    CAS  Google Scholar 

  • KING, C.L., MEDHAT, A., MALHOTRA, I., NAFEH, M., HELMY, A., KHAUDARY, J., IBRAHIM, S., EL-SHERBINY, M., ZAKY, S., STUPI, R.J., BRISTPSLO, K., SHEHATA, M. & SHATA, M.T. (1996). Cytokine control of parasite-specific anergy in human urinary schistosomiasis. IL-10 modulates lymphocyte reactivity. Journal of Immunology 156, 4715–4721.

    CAS  Google Scholar 

  • LARRICK, J.W., BUCKLEY, C.E. 3RD, MACHAMER, C.E., SCHLAGEL, G.D., YOST, J.A., BLESSING-MOORE, J. & LEVY, D. (1983). Does hyperimmunoglobulinemia-E protect tropical populations from allergic disease? Journal of Allergy and Clinical Immunology 71, 184–188.

    Article  PubMed  CAS  Google Scholar 

  • LUNDGREN, M., PERSSON, U., LARSSON, P., MAGNUSSON, C., SMITH, C.I., HAMMARSTROM, L. & SEVERINSON, E. (1989). Interleukin 4 induces synthesis of IgE and IgG4 in human B cells. European Journal of Immunology 19, 1311–1315.

    PubMed  CAS  Google Scholar 

  • LYNCH, N.R., HAGEL, I., PEREZ, M., DI PRISCO, M.C., LOPEZ, R. & ALVAREZ, N. (1993). Effect of anthelmintic treatment on the allergic reactivity of children in a tropical slum. Journal of Allergy and Clinical Immunology 92, 404–411.

    Article  PubMed  CAS  Google Scholar 

  • LYNCH, N.R., LOPEZ, R., ISTURIZ, G. & TENIAS-SALAZAR, E. (1983). Allergic reactivity and helminthic infection in Amerindians of the Amazon Basin. International Archives of Allergy and Applied Immunology 72, 369–372.

    PubMed  CAS  Google Scholar 

  • MACAUBAS, C., SLY, P.D., BURTON, P., TILLER, K., YABUHARA, A., HOLT, B.J., SMALLACOMBE, T.B., KENDALL, G., JENMALM, M.C. & HOLT, P.G. (1999). Regulation of T-helper cell responses to inhalant allergen during early childhood. Clinical and Experimental Allergy 29, 1223–1231.

    PubMed  CAS  Google Scholar 

  • MALHOTRA, I., MUNGAI, P., WAMACHI, A., KIOKO, J., OUMA, J.H., KAZURA, J.W. & KING, C.L. (1999). Helminth-and Bacillus Calmette-Guerin-induced immunity in children sensitized in utero to filariasis and schistosomiasis. Journal of Immunology 162, 6843–6848.

    CAS  Google Scholar 

  • MATRICARDI, P.M., ROSMINI, F., FERRIGNO, L., NISINI, R., RAPICETTA, M., CHIONNE, P., STROFFOLINI, T., PASQUINI, P. & D’AMELIO, R. (1997). Cross sectional retrospective study of prevalence of atopy among Italian military students with antibodies against hepatitis A virus. British Medical Journal 314, 999–1003.

    PubMed  CAS  Google Scholar 

  • MEDHAT, A., SHEHATA, M., BUCCI, K., MOHAMED, S., DIEF, A.D., BADARY, S., GALAL, H., NAFEH, M. & KING, C.L. (1998). Increased interleukin-4 and interleukin-5 production in response to Schistosoma haematobium adult worm antigens correlates with lack of reinfection after treatment. Journal of Infectious Diseases 178, 512–519.

    PubMed  CAS  Google Scholar 

  • MOHAMED-ALI, Q., ELWALI, N.E., ABDELHAMEED, A.A., MERGANI, A., RAHOUD, S., ELAGIB, K.E., SAEED, O.K., ABEL, L., MAGZOUB, M.M. & DESSEIN, A.J. (1999). Susceptibility to periportal (Symmers) fibrosis in human Schistosoma mansoni infections: Evidence that intensity and duration of infection, gender, and inherited factors are critical in disease progression. Journal of Infectious Diseases 180, 1298–1306.

    Article  PubMed  CAS  Google Scholar 

  • MOLA, P.W., FARAH, I.O., KARIUKI, T.M., NYINDO, M., BLANTON, R.E. & KING, C.L. (1999). Cytokine control of the granulomatous response in Schistosoma mansoni-infected baboons: role of exposure and treatment. Infection and Immunity 67, 6565–6571.

    PubMed  CAS  Google Scholar 

  • MONTENEGRO, S.M., MIRANDA, P., MAHANTY, S., ABATH, F.G., TEIXEIRA, K.M., COUTINHO, E.M., BRINKMAN, J., GONCALVES, I., DOMINGUES, L.A., DOMINGUES, A.L., SHER A, & WYNN, T.A. (1999). Cytokine production in acute versus chronic human Schistosomiasis mansoni: the cross-regulatory role of interferon-gamma and interleukin-10 in the responses of peripheral blood mononuclear cells and splenocytes to parasite antigens. Journal of Infectious Diseases 179, 1502–1514.

    Article  PubMed  CAS  Google Scholar 

  • MWATHA, J.K., KIMANI, G., KAMAU, T., MBUGUA, G.G., OUMA, J.H., MUMO, J., FULFORD, A.J., JONES, F.M., BUTTERWORTH, A.E., ROBERTS, M.B. & DUNNE, D.W. (1998). High levels of TNF, soluble TNF receptors, soluble ICAM-1, and IFN-gamma, but low levels of IL-5, are associated with hepatosplenic disease in human Schistosomiasis mansoni. Journal of Immunology 160, 1992–1999.

    CAS  Google Scholar 

  • NAUS, C.W., KIMANI, G., OUMA, J.H., FULFORD, A.J., WEBSTER, M., VAN DAM, G.J., DEELDER, A.M., BUTTERWORTH. A.E. & DUNNE, D.W. (1999). Development of antibody isotype responses to Schistosoma mansoni in an immunologically naïve immigrant population: influence of infection duration, infection intensity, and host age. Infection and Immunity 67, 3444–3451.

    PubMed  CAS  Google Scholar 

  • NDHLOVU P., CADMAN, H., VENNERVALD, B.J., CHRISTENSEN, N.O., CHIDIMU, M. & CHANDIWANA, S.K. (1996). Age-related antibody profiles in Schistosoma haematobium infections in a rural community in Zimbabwe. Parasite Immunology 18, 181–191.

    Article  PubMed  CAS  Google Scholar 

  • OHKAWARA, Y., LIM, K.G., XING, Z., GLIBETIC, M., NAKANO, K., DOLOVICH, J., CROITORU, K., WELLER, P.F. & JORDANA, M. (1996). CD40 expression by human peripheral blood eosinophils. Journal of Clinical Investigations 97, 1761–1766.

    CAS  Google Scholar 

  • ONKAMO, P., VAANANEN, S., KARVONEN, M. & TUOMILEHTO, J. (1999). World wide increase in incidence of Type I diabetes. The analysis of the data on published incidence trends. Diabetologia 42, 1395–1403.

    Article  PubMed  CAS  Google Scholar 

  • OUMA, J.H., FULFORD, A.J., KARIUKI, H.C., KIMANI, G., STURROCK, R.F., MUCHEMI, G., BUTTERWORTH, A.E. & DUNNE, D.W. (1998). The development of Schistosomiasis mansoni in an immunologically naïve immigrant population in Masongaleni, Kenya. Parasitology 117, 123–132.

    Article  PubMed  Google Scholar 

  • PELLETIER, C., VARIN-BLANK, N., RIVERA, J., IANNASCOLI, B., MARCHAND, F., DAVID, B., WEYER, A. & BLANK, U. (1998). Fc epsilon RI-mediated induction of TNF-alpha gene expression in the RBL-2H3 mast cell line: regulation by a novel NF-kappa B-like nuclear binding complex. Journal of Immunology 161, 4768–4776.

    CAS  Google Scholar 

  • PLATTS-MILLS, T., VAUGHAN, J., SQUILLACE, S., WOODFOLK, J. & SPORIK, R. (2001). Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study. Lancet 357, 752–756.

    PubMed  CAS  Google Scholar 

  • RANDOLPH, D.A., CARRUTHERS, C.J., SZABO, S.J., MURPHY, K.M. & CHAPLIN, D.D. (1999). Modulation of airway inflammation by passive transfer of allergen-specific Th1 and Th2 cells in a mouse model of asthma. Journal of Immunology 162, 2375–2383.

    CAS  Google Scholar 

  • RANDOLPH, D.A., STEPHENS, R., CARRUTHERS, C.J. & CHAPLIN, D.D. (1999). Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammation. Journal of Clinical Investigation 104, 1021–1029.

    Article  PubMed  CAS  Google Scholar 

  • ROBERTS, M., BUTTERWORTH, A.E., KIMANI, G., KAMAU, T., FULFORD, A.J., DUNNE, D.W., OUMA, J.H. & STURROCK, R.F. (1993). Immunity after treatment of human schistosomiasis: association between cellular responses and resistance to reinfection. Infection and Immunity 61, 4984–4993.

    PubMed  CAS  Google Scholar 

  • ROBINSON, D.S., HAMID, Q., YING, S., TSICOPOULOS, A., BARKAMS, J., BENTLEY, A.M., CORRIGAN, C., DURHAM, S.R. & KAY, A.B. (1992). Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. New England Journal of Medicine 326, 298–304.

    Article  PubMed  CAS  Google Scholar 

  • RONCAROLO, M.G., LEVINGS, M.K. & TRAVERSARI, C. (2001). Differentiation of T regulatory cells by immature dendritic cells. Journal of Experimental Medicine 193, F5–9.

    Article  PubMed  CAS  Google Scholar 

  • ROYER, B., VARADARADJALOU, S., SAAS, P., GUILLOSSON, J.J., KANTELIP, J.P. & AROCK, M. (2001). Inhibition of IgE-induced activation of human mast cells by IL-10. Clinical and Experimental Allergy 31, 694–704.

    PubMed  CAS  Google Scholar 

  • SABIN, E.A., ARAUJO, M.I., CARVALHO, E.M. & PEARCE, E.J. (1996), Impairment of tetanus toxoid-specific Th1-like immune responses in humans infected with Schistosoma mansoni. Journal of Infectious Diseases 173, 269–272.

    PubMed  CAS  Google Scholar 

  • SAINI, S.S., MACGLASHAN, D.W. JR, STERBINSKY, S.A., TOGIAS, A., ADELMAN, D.C., LICHTENSTEIN, L.M. & BOCHNER, B.S. (1999). Down-regulation of human basophil IgE and FC epsilon RI alpha surface densities and mediator release by anti-IgE-infusions is reversible in vitro and in vivo. Journal of Immunology 162, 5624–5630.

    CAS  Google Scholar 

  • SCHOTTELIUS, A.J., MAYO, M.W., SARTOR, R.B. & BALDWIN, A.S. JR. (1999). Interleukin-10 signaling blocks inhibitor of kappaB kinase activity and nuclear factor kappaB DNA binding. Journal of Biological Chemisry 274, 31868–31874.

    CAS  Google Scholar 

  • SHAHEEN, S.O., AABY, P., HALL, A.J., BARKER, D.J., HEYES, C.B., SHIELL, A.W. & GOUDIABY, A. (1996). Measles and atopy in Guinea-Bissau. Lancet 347, 1792–1796.

    Article  PubMed  CAS  Google Scholar 

  • SHER, A. & COFFMAN, R.L. (1992). Regulation of immunity to parasites by T cells and T cell-derived cytokines. Annual Reviews in Immunology 10, 385–409.

    CAS  Google Scholar 

  • SHER, A., FIORENTINO, D., CASPAR, P., PEARCE, E. & MOSMANN, T. (1991). Production of IL-10 by CD4+ T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth infection. Journal of Immunology 147, 2713–2716.

    CAS  Google Scholar 

  • SHER, A., GAZZINELLI, R.T., OSWALD, I.P., CLERICI, M., KULLBERG, M., PEARCE, E.J., BERZOFSKY, J.A., MOSMANN, T.R., JAMES, S.L., MORSE, H.C., III & SHEARER, G.M. (1992). Role of T-cell derived cytokines in the down regulation of immune responses in parasitic and retroviral infection. Immunological Reviews 127, 183–204.

    PubMed  CAS  Google Scholar 

  • SHIRAKAWA, T., ENOMOTO, T., SHIMAZU, S., HOPKIN, J.M. (1997). The inverse association between tuberculin responses and atopic disorder. Science 275, 77–79.

    Article  PubMed  CAS  Google Scholar 

  • STELMA, F.F., TALLA, I., POLMAN, K., NIANG, M., STURROCK, R.F., DEELDER, A.M. & GRYSEELS, B. (1993). Epidemiology of Schistosoma mansoni infection in a recently exposed community in northern Senegal. American Journal of Trpical Medicine and Hygiene 49, 701–706.

    CAS  Google Scholar 

  • STRACHAN, D.P.. (1989). Hay fever, hygiene, and household size. British Medical Journal 299, 1259–1260.

    PubMed  CAS  Google Scholar 

  • TAKANASHI, S., HASEGAWA, Y., KANEHIRA, Y., YAMAMOTO, K., FUJIMOTO, K., SATOH, K. & OKAMURA, K. (1999). Interleukin-10 level in sputum is reduced in bronchial asthma, COPD and in smokers. European Respiratory Journal 14, 309–314.

    PubMed  CAS  Google Scholar 

  • TAKANASKI, S., NONAKA, R., XING, Z., O’BYRNE, P., DOLOVICH, J. & JORDANA, M. (1994). Interleukin 10 inhibits lipopolysaccharide-induced survival and cytokine production by human peripheral blood eosinophils. Journal of Experimental Medicine 180, 711–715.

    Article  PubMed  CAS  Google Scholar 

  • TEDESCHI, A. & AIRAGHI, L. (2001). Common risk factors in type 1 diabetes and asthma. The Lancet 357, 1622.

    Article  CAS  Google Scholar 

  • TEN HACKEN, N.H., OOSTERHOFF, Y., KAUFFMAN, H.F., GUEVARRA, L., SATOH, T., TOLLERUD, D.J. & POSTMA, D.S. (1998). Elevated serum interferon-gamma in atopic asthma correlates with increased airways responsiveness and circadian peak expiratory flow variation. European Respiratory Journal 11, 312–316.

    PubMed  Google Scholar 

  • THE INTERNATIONAL STUDY OF ASTHMA AND ALLERGIES IN CHILDHOOD (ISAAC) STEERING COMMITTEE. (1998). Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. Lancet 351, 1225–1232.

    Google Scholar 

  • THOMAS, W.R.. & SMITH, W. (1999). Towards defining the full spectrum of important house dust mite allergens. Clinical and Experimental Allergy 29, 1583–1587.

    PubMed  CAS  Google Scholar 

  • TSURUTA, L., LEE, H.J., MASUDA, E.S., YOKOTA, T., ARAI, N. & ARAI, K. (1995). Regulation of expression of the IL-2 and IL-5 genes and the role of proteins related to nuclear factor of activated T cells. Journal of Allergy and Clinical Immunology 96, 1126–1135.

    Article  PubMed  CAS  Google Scholar 

  • UMETSU, D.T. & DeKRUYFF, R.H. (1997). TH1 and TH2 CD4+ cells in human allergic diseases. Journal of allergy and Clinical Immunology 100, 1–6.

    Article  PubMed  CAS  Google Scholar 

  • UMETSU, D.T. & DeKRUYFF, R.H. (1999). Interleukin-10: The missing link in asthma regulation? American Journal of Respiratory Cell and Molecular Biology 21, 562–563.

    PubMed  CAS  Google Scholar 

  • VAN DAM, G.J., STELMA, F.F., GRYSEELS, B., FALCAO FERREIRA, S.T., TALLA, I., NIANG, M., ROTMANS, J.P. & DEELDER, A.M. (1996). Antibody response patterns against Schistosoma mansoni in a recently exposed community in Senegal. Journal of Infectious Diseases 173, 1232–1241.

    PubMed  Google Scholar 

  • VAN Den BIGGELAAR, A.H.J., LOPUHAA, C., VAN REE, R., VAN DERZEE, J.S., JANS, J.., HOEK, A., MIGOMBET, B., LUCKNER, C., KREMSNER, P.G. & YAZDANBAKHSH, M. (2001). The prevalence of parasite infestation and house dust mite sensitization in Gabonese schoolchildren. International Archives of Allergy and Immunology, In press.

    Google Scholar 

  • VAN DEN BIGGELAAR, A.H.J., VAN REE, R., RODRIGUES, L.C., LELL, B., DEELDER, A.M., KREMSNER, P.G. & YAZDANBAKHSH, M. (2000). Decreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin-10. Lancet 356, 1723–1727.

    PubMed  Google Scholar 

  • VIANA, I.R., SHER, A., CARVALHO, O.S., MASSARA, C.L., ELOI-SANTOS, S.M., PEARCE, E.J., COLLEY, D.G., GAZZINELLI, G. & CORREA-OLIVEIRA, R. (1994). Interferon-gamma production by peripheral blood mononuclear cells from residents of an area endemic for Schistosoma mansoni. Transactions of the Royal Socieety of Tropical Medicine and Hygiene 88, 466–470.

    CAS  Google Scholar 

  • VLAHOPOULOS, S., BOLDOGH, I., CASOLA, A. & BRASIER, A.R. (1999). Nuclear factor-kappaB-dependent induction of interleukin-8 gene expression by tumor necrosis factor alpha: evidence for an antioxidant sensitive activating pathway distinct from nuclear translocation. Blood 94, 1878–1889.

    PubMed  CAS  Google Scholar 

  • WHELAN, M., HARNETT, M.M., HOUSTON, K.M., PATEL, V., HARNETT, W. & RIGLEY, K.P. (2000). A filarial nematode-secreted product signals dendritic cells to acquire a phenotype that drives development of Th2 cells. Journal of Immunology 164, 6453–6460.

    CAS  Google Scholar 

  • WHO REPORT OF THE WHO INFORMAL CONSULTATION ON SCHISTOSOMIASIS CONTROL. (1999). World Health Organization, Geneva.

    Google Scholar 

  • WILLIAMS, M.E., MONTENEGRO, S., DOMINGUES, A.L., WYNN, T.A., TEIXEIRA, K., MAHANTY, S., COUTINHO, A. & SHER, A. (1994). Leukocytes of patients with Schistosoma mansoni respond with a Th2 pattern of cytokine production to mitogen or egg antigens but with a Th0 pattern to worm antigens. Journal of Infectious Diseases 170, 946–954.

    PubMed  CAS  Google Scholar 

  • WILSON, R.A., COULSON, P.S., BETTS, C., DOWLING, M.A. & SMYTHIES, L.E. (1996). Impaired immunity and altered pulmonary responses in mice with a disrupted interferon-gamma receptor gene exposed to the irradiated Schistosoma mansoni vaccine. Immunology 87, 275–282.

    Article  PubMed  CAS  Google Scholar 

  • WYNN, T.A., CHEEVER, A.W., JANKOVIC, D., POINDEXTER, R.W., CASPAR, P., LEWIS, F.A. & SHER, A. (1995). An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection. Nature 376 (6541), 594–596.

    Article  PubMed  CAS  Google Scholar 

  • WYNN, T.A., CHEEVER, A.W., WILLIAMS, M.E., HIENY, S., CASPAR, P., KUHN, R., MULLER, W. & SHER, A. (1998). IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immunedown-modulation of chronic disease. Journal of Immunology 160, 4473–4480.

    CAS  Google Scholar 

  • YAZDANBAKHSH, M., PAXTON, W.A., KRUIZE, Y.C., SARTONO, E., KURNIAWAN, A., VAN HET WOUT, A., SELKIRK, M.E., PARTONO, F. & MAIZELS, R.M. (1993). T cell responsiveness correlates differentially with antibody isotype levels in clinical and asymptomatic filariasis. Journal of Infectious Diseases 167, 925–931.

    PubMed  CAS  Google Scholar 

  • YEMANEBERHAN, H., BEKELE, Z., VENN, A., LEWIS, S., PARRY, E. & BRITTON, J. (1997). Prevalence of wheeze and asthma and relation to atopy in urban and rural Ethiopia. Lancet 350, 85–90.

    Article  PubMed  CAS  Google Scholar 

References for Table

  1. BODNER C, GODDEN D, LITTLE J. et al. (1999). Antioxidant intake and adult-onset wheeze: a case control study. Aberdeen WHEASE Study Group. The European Respiratory Journal 13, 22–30.

    PubMed  CAS  Google Scholar 

  2. HIJAZI, N., ABALKHAIL, B. & SEATON, A. (2000). Diet and childhood asthma in a society in transition: a study in urban and rural Saudi Arabia. Thorax 55, 775–779.

    Article  PubMed  CAS  Google Scholar 

  3. HODGE, L., SALOME, C.M., HUGHES, J.M., LIU-BRENNAN, D., RIMMER, J., ALLMAN, M., PANG, D., ARMOUR, C. & WOOLCOCK, A.J. (1998). Effect of dietary intake of omega-3 and omega-6 fatty acids on severity of asthma in children. The European Respiratory Journal 11, 361–365.

    PubMed  CAS  Google Scholar 

  4. HODGE, L., SALOME, C.M., PEAT, J.K., HABY, M.M., XUAN, W. & WOOLCOCK, A.J. (1996). Consumption of oily fish and childhood asthma risk. The Medical Journal of Australia 164, 137–140.

    PubMed  CAS  Google Scholar 

  5. WEILAND, S.K., VON MUTIUS, E., HUSING, A. & ASHER, M.I. (1999). Intake of trans fatty acids and prevalence of childhood asthma and allergies in Europe. ISAAC Steering Committee. Lancet 353 (9169), 2040–2041

    Article  PubMed  CAS  Google Scholar 

  6. DEMISSIE, K., ERNST, P., GRAY,, DONALD K. & JOSEPH, L. (1996). Usual dietary salt intake and asthma in children: a case-control study. Thorax 51, 59–63.

    PubMed  CAS  Google Scholar 

  7. CAREY, O.J., LOCKE, C. & COOKSON, J.B. (1993). Effect of alterations of dietary sodium on the severity of asthma in men. Thorax 48, 714–718.

    PubMed  CAS  Google Scholar 

  8. VON MUTIUS, E., MARTINEZ, F.D., FRITZSCH, C., NICOLAI, T., ROELL, G. & THIEMANN, H.H. (1994). Prevalence of asthma and atopy in two areas of West and East Germany. American Journal of Respiratory Critical Care and Medicine 149, 358–364

    Google Scholar 

  9. WONG, G.W., KO, F.W, LAU, T.S., LI, ST., HUI, D., PANG, S..W., LEUNG, R., FOK, T.F. & Lai, C.K. (2001). Temporal relationship between air pollution and hospital admissions for asthmatic children in Hong Kong. Clinical and Experimental Allergy 31, 565–569.

    PubMed  CAS  Google Scholar 

  10. ANDERSON, H..R., PONCE DE LEON, A., BLAND, J.M., BOWER, J.S., EMBERLIN, J. & STRACHAN, D.P. (1998). Air pollution, pollens, and daily admissions for asthma in London 1987–92. Thorax 53, 842–848.

    PubMed  CAS  Google Scholar 

  11. GARTY, B.Z., KOSMAN, E., GANOR, E., BERGER, V., GARTY, L., WIETZEN, T., WAISMAN, Y., MIMOUNI, M, & WAISEL, Y. (1998). Emergency room visits of asthmatic children, relation to air pollution, weather, and airborne allergens. Annals of Allergy, Asthma and Immunology 81, 563–570.

    Article  CAS  Google Scholar 

  12. HAJNAL, B.L., BRAUN-FAHRLANDER, C., GRIZE, L., GASSNER, M., VARONIER, H.S., VUILLER J.C., WUTHRICH, B, & SENNHAUSER. F.H. (1999). Effect of environmental tobacco smoke exposure on respiratory symptoms in children. SCARPOL Team. Swiss Study on Childhood Allergy and Respiratory Symptoms with Respect to Air Pollution, Climate and Pollen. Schweizerische medizinische Wochenschrift 129, 723–730.

    PubMed  CAS  Google Scholar 

  13. ODHIAMBO, J.A., NG’ANG’A, L.W., MUNGAI, M.W., GICHEHA, C.M., NYAMWAYA, J.K., KARIMI, F., MACKLEM, P.T, & BECKLAKE, M.R. (1998). Urban-rural differences in questionnaire-derived markers of asthma in Kenyan school children. The European Respiratory Journal 12, 1105–12.

    PubMed  CAS  Google Scholar 

  14. ZOCK, J.P., SUNYER, J., KOGEVINAS, M., KROMHOUT, H., BURNEY, P, & ANTO, J.M. (2001) Occupation, Chronic Bronchitis, and Lung Function in Young Adults. An international study. American Journal of Respiratory Critical Care and Medicine l63, 1572–1577.

    Google Scholar 

  15. WYLER, C., BRAUN-FAHRLANDER, C., KUNZLI, N., SCHINDLER, C., ACKERMANN-LIEBRICH, U., PERRUCHOUD, A.P., LEUENBERGER, P. & WUTHRICH B. (2000). Exposure to motor vehicle traffic and allergic sensitization. The Swiss Study on Air Pollution and Lung Diseases in Adults (SAPALDIA) Team. Epidemiology 11, 450–456.

    Article  PubMed  CAS  Google Scholar 

  16. BRAUN-FAHRLANDER, C., VUILLER J.C., SENNHAUSER, F.H., NEU, U., KUNZLE, T., GRIZE, L., GASSNER, M., MINDER, C., SCHINDLER, C., VARONIER, H.S. & WUTHRICH, B. (2000), Respiratory health and long-term exposure to air pollutants in Swiss schoolchildren. SCARPOL Team. Swiss Study on Childhood Allergy and Respiratory Symptoms with Respect to Air Pollution, Climate and Pollen. American Journal of Respiratory Critical Care and Medicine 155, 1042–1049.

    Google Scholar 

  17. DIAZ-SANCHEZ, D., JYRALA, M., NG,, D., NEL, A, & SAXON, A. (2000). In vivo nasal challenge with diesel exhaust particles enhances expression of the CC chemokines rantes, MIP-1alpha, and MCP-3 in humans Clinical Immunology 97, 140–145.

    Article  PubMed  CAS  Google Scholar 

  18. HUANG, S.L., SHIAO, G, & CHOU, P. (1999). Association between body mass index and allergy in teenage girls in Taiwan. Clinical and Expimental Allergy 29, 323–329

    CAS  Google Scholar 

  19. STENIUS-AARNALIA, B., POUSSA, T., KVARNSTROM, J., GRONLUND, E.L., YLIKAHRI, M, & MUSTAJOKI, P. (2000). Immediate and long term effects of weight reduction in obese people with asthma: randomised controlled study. British Medical Journal 320, 827–832

    Google Scholar 

  20. SHAHEEN, S.O., STERNE, J.A., MONTGOMERY, S.M, & AZIMA, H. (1999). Birth weight, body mass index and asthma in young adults. Thorax 54, 396–402.

    PubMed  CAS  Google Scholar 

  21. FIGUEROA-MUNOZ, J.I., CHINN, S, & RONA, R.J. (2001). Association between obesity and asthma in 4–11 year old children in the UK. Thorax 56, 133–137.

    Article  PubMed  CAS  Google Scholar 

  22. LUDER, E., MELNIK, T.A, & DIMAIO, M. (1998). Association of being overweight with greater asthma symptoms in inner city black and Hispanic children. Journal of Pediatrics 132, 699–703.

    PubMed  CAS  Google Scholar 

  23. CHEN, Y., DALES, R., KREWSKI, D, & BREITHAUPT, K. (1999). Increased effects of smoking and obesity on asthma among female Canadians: the National Population Health Survey, 1994’1995. American Journal of Epidemiology 150, 255–262

    PubMed  CAS  Google Scholar 

  24. CAMARGO, C.A., WEISS, S.T., ZHANG, S., WILLETT, W.C, & SPEIZER, F.E. (1999). Prospective study of body mass index, weight change, and risk of adult-onset asthma in women. Archives of Internal Medicine 159, 2582–2588.

    Article  PubMed  Google Scholar 

  25. CASTRO-RODRIGUEZ, J..A., HOLBERG, C..J., MORGAN, W..J., WRIGHT, A.L. & MARTINEZ, F.D. (2001). Increased Incidence of Asthmalike Symptoms in Girls Who Become Overweight or Obese during the School Years. American Journal of Respiratory Critical Care and Medicine 163, 1344–1349.

    CAS  Google Scholar 

  26. VAN DEN BIGGELAAR, A.H.J., VAN REE. R., RODRIGUES, L.C., LELL, B., DEELDER, A.M., KREMSNER, P.G, & YAZDANBAKHSH, M. (2000). Decreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin-10. Lancet 356(9243), 1723–1727.

    PubMed  Google Scholar 

  27. ARAUJO, M.I., LOPES, A.A., MEDEIROS, M., CRUZ, A.A., SOUSA-ATTA, L., SOLE, D, & CARVALHO, E.M. (2000). Inverse association between skin response to aeroallergens and Schistosoma mansoni infection. International Archives of Allergy and Immunology 123, 145–148.

    Article  PubMed  CAS  Google Scholar 

  28. LYNCH, N.R., HAGEL, I., PEREZ, M., DI PRISCO, M.C., LOPEZ, R, & ALVAREZ, N. (1993) Effect of anthelmintic treatment on the allergic reactivity of children ina tropical slum. The Journal of Allergy and Clinical Immunology 92, 404–411

    PubMed  CAS  Google Scholar 

  29. SHIELD, J.M., SCRIMGEOUR, E.M, & VATERLAWS, A.L. (1980). Intestinal helminths in an adult hospital population in the Eastern Highlands of Papua New Guinea: relationship with anaemia, eosinophilia and asthma. Papua New Guinea Medical Journal 23, 157–164.

    CAS  PubMed  Google Scholar 

  30. SHAHEEN, S.O., AABY, P., HALL, A..J., BARKER, D.J., HEYES, C.B., SHIELL, A.W. & GOUDIABY, A. (1996). Measles and atopy in Guinea-Bissau. Lancet 347(9018), 1792–1796

    Article  PubMed  CAS  Google Scholar 

  31. LEWIS, S.A, & BRITTON, J.R. (1998). Measles infection, measles vaccination and the effect of birth order in the aetiology of hay fever. Clinical and Experimental Allergy 28, 1493–1500.

    PubMed  CAS  Google Scholar 

  32. PAUNIO, M., HEINONEN, O.P., VIRTANEN, M., LEINIKKI, P., PATJA, A. & PELTOLA, H. (2000). Measles history and atopic diseases: apopulation-basedcross-sectional study. The Journal of the American Microbiological Association 283, 343–346.

    CAS  Google Scholar 

  33. WICKENS, K.L., CRANE, J., KEMP, T.J., LEWIS, S.J., D’SOUZA, W.J., SAWYER, G.M., STONE, M.L., TOHILL, S.J., KENNEDY, J.C., SLATER, T.M, & PEARCE, N.E. (1999). Family size, infections, and asthma prevalence in New Zealand children. Epidemiology 10, 699–705.

    PubMed  CAS  Google Scholar 

  34. DOLD, S., HEINRICH, J., WICHMANN, H.E, & WJST, M. (1998). Ascaris-specific IgE and allergic sensitization in a cohort of schoolchildren in the former East Germany. The Journal of Allergy and Clinical Immunology 102, 414–420

    PubMed  CAS  Google Scholar 

  35. SELASSIE, F.G., STEVENS, R.H., CULLINAN, P., PRITCHARD, D., JONES, M., HARRIS, J., AYRES, J.G, & NEWMAN TAYLOR, A.J. (2000). Total and specific IgE (house dust mite and intestinal helminths) in asthmatics and controls from Gondar, Ethiopia. Clinical and Experimental Allergy 30, 356–358

    PubMed  CAS  Google Scholar 

  36. BUIJS, J., BORSBOOM, G., RENTING, M., HILGERSOM, W..J., VAN WIERINGEN, J.C., JANSEN, G, & NEIJENS, J. (1997). Relationship between allergic manifestations and Toxocara seropositivity: a cross-sectional study among elementary school children. The European Respiratory Journal 10, 1467–1475

    Article  PubMed  CAS  Google Scholar 

  37. HAKIM, S..L., THADASAVANTH, M., SHAMILAH, R.H, & YOGESWARI, S. (1997). Prevalence of Toxocara canis anti body among children with bronchial asthma in Klang Hospital, Malaysia. Transactions of the Royal Society of Tropical Medicineand Hygiene 91, 528.

    CAS  Google Scholar 

  38. OTEIFA, N..M., MOUSTAFA, M.A, & ELGOZAMY, B.M. (1998). Toxocariasis as a possibl ecause of allergic diseases in children. Journal of the Egyptian Society of Parasitology 28, 365–372.

    PubMed  CAS  Google Scholar 

  39. SHIRAKAWA, T., ENOMOTO, T., SHIMAZU, S, & HOPKIN, J.M. (1997). The inverse association between tuberculin responses and atopic disorder. Science 275, 77–79.

    Article  PubMed  CAS  Google Scholar 

  40. VON HERTZEN, L., KLAUKKA, T., MATTILA, H, & HAAHTELA, T. (1999). Mycobacterium tuberculosis infection and the subsequent development of asthma and allergic conditions. The Journal of Allergy and Clinical Immunology 104, 1211–1214.

    Google Scholar 

  41. VON MUTIUS, E., PEARCE, N., BEASLEY, R., CHENG, S., VON EHRENSTEIN, O., BJORKSTEN, B, & WEILAND, S. (2000). International patterns of tuberculosis and the prevalence of symptoms of asthma, rhinitis, and eczema. Thorax 55, 449–453.

    Google Scholar 

  42. AABY, P., SHAHEEN, S.O., HEYES, C.B., GOUDIABY, A., HALL, A.J., SHIELL, A.W., JENSEN, H, & MARCHANT, A. (2000). Early BCG vaccination and reduction in atopy in Guinea-Bissau. Clinical and Experimental Allergy 30, 644–650.

    PubMed  CAS  Google Scholar 

  43. ALM, J.S., LILJA, G., PERSHAGEN, G, & SCHEYNIUS, A. (1997). Early BCG vaccination and development of atopy. Lancet 350(9075), 400–403.

    Article  PubMed  CAS  Google Scholar 

  44. OMENAAS, E., JENTOFT, H.F., VOLLMER, W..M., BUIST, A.S, & GULSVIK, A. (2000). Absence of relationship between tubeculin reactivity and atopy in BCG vaccinated young adults. Thorax 55, 454–458.

    Article  PubMed  CAS  Google Scholar 

  45. MATRICARDI, P.M., ROSMINI, F., FERRIGNO, L., NISINI, R., RAPICETTA, M., CHIONNE, P., STROFFOLINI, T., PASQUINI, P, & D’AMELIO, R. (1997). Cross sectional retrospective study of prevalence of atopy among Italian military students with antibodies against hepatitis A virus. British Medical Journal 314, 999–1003.

    PubMed  CAS  Google Scholar 

  46. MATRICARDI, P.M., ROSMINI, F., RIONDINO, S., FORTINI, M., FERRIGNO, L., RAPICETTA, M, & BONINI, S. (2000). Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: epidemiological study. British Medical Journal 320, 412–417.

    PubMed  CAS  Google Scholar 

  47. BODNER, C., ANDERSON, W.J., REID, T.S, & GODDEN, D.J. (2000). Childhood exposure to infection and risk of adult onset wheeze and atopy. Thorax 55, 383–387.

    Article  PubMed  CAS  Google Scholar 

  48. ILLI, S., VON MUTIUS, E., LAU, S., BERGMANN, R., NIGGEMANN, B., SOMMERFELD, C, & WAHN, U. (2001). Early childhood infectious diseases and the development of asthma up to school age: a birth cohort study. British Medical Journal 322, 390–395.

    PubMed  CAS  Google Scholar 

  49. MATRICARDI, P.M., FRANZINELLI, F., FRANCO, A., CAPRIO, G., MURRU, F., CIOFFI, D., FERRIGNO, L., PALERMO, A., CICCARELLI, N, & ROSMINI, F. (1998). Sibship size, birth order, and atopy in 11,371 Italian young men. The Journal of Allergy and Clinical Immunology 101, 439–444.

    PubMed  CAS  Google Scholar 

  50. FORASTIERE, F., AGABITI, N., CORBO, G.M., DELL’ORCO, V., PORTA, D., PISTELLI, R., LEVENSTEIN, S. & PERUCCI, C.A. (1997). Socioeconomic status, number of siblings, and respiratory infections in early life as determinants of atopy in children. Epidemiology 8 , 566–570.

    PubMed  CAS  Google Scholar 

  51. STRACHAN, D.P. (1989). Hay fever, hygiene, and household size. British Medical Journal 299, 1259–1260.

    PubMed  CAS  Google Scholar 

  52. JARVIS, D., CHINN, S., LUCZYNSKA, C. & BURNEY, P. (1997). The association of family size with atopy and atopic disease. Clinical and Experimental Allergy 27, 240–245.

    Article  PubMed  CAS  Google Scholar 

  53. BODNER, C., GODDEN, D. & SEATON, A. (1998). Family size, childhood infections and atopic diseases. The Aberdeen WHEASE Group. Thorax 53, 28–32.

    Article  PubMed  CAS  Google Scholar 

  54. BALL, T.M., CASTRO-RODRIGUEZ, J.A., GRIFFITH, K.A., HOLBERG, C.J., MARTINEZ, F.D. & WRIGHT, A.L. (2000). Siblings, day-care attendance, and the risk of asthma and wheezing during childhood. The New England Journal of Medicine 343. 538–543.

    Article  PubMed  CAS  Google Scholar 

  55. KRAMER, U., HEINRICH, J., WJST, M. & WICHMANN, H.E. (1999). Age of entry to day nursery and allergy in later childhood. Lancet 353, 450–454.

    PubMed  CAS  Google Scholar 

  56. ALM, J.S., SWARTZ, J., LILJA, G., SCHEYNIUS, A. & PERSHAGEN, G. (1999). Atopy in children of families with an anthroposophic lifestyle. Lancet 353, 1485–1488.

    Article  PubMed  CAS  Google Scholar 

  57. YEMANEBERHAN, H., BEKELE, Z., VENN, A., LEWIS, S., PARRY, E. & BRITTON, J. (1997). Prevalence of wheeze and asthma and relation to atopy in urban and rural Ethiopia. Lancet 350, 85–90.

    Article  PubMed  CAS  Google Scholar 

  58. SUNYER, J., TORREGROSA, J., ANTO, J.M., MENENDEZ, C., ACOSTA, C., SCHELLENBERG, D., ALONSO, P.L. & KAHIGWA, E. (2000). The association between atopy and asthma in a semirural area of Tanzania (East Africa). Allergy 55, 762–766.

    Article  PubMed  CAS  Google Scholar 

  59. FANIRAN, A.O., PEAT, J.K. & WOOLCOCK, A.J. (1999). Prevalence of atopy, asthma symptoms and diagnosis, and the management of asthma: comparison of an affluent and a non-affluent country. Thorax 54, 606–610.

    PubMed  CAS  Google Scholar 

  60. LEUNG, R., HO, P., LAM, C.W. & LAI, C.K. (1997). Sensitization to inhaled allergens as a risk factor for asthma and allergic diseases in Chinese population. The Journal of Allergy and Clinical Immunology 99, 594–599.

    PubMed  CAS  Google Scholar 

  61. KILPELAINEN, M., TERHO, E.O., HELENIUS, H. & KOSKENVUO, M. (2000). Farm environment in childhood prevents the development of allergies. Clinical and Experimental Allergy 30, 201–208.

    Article  PubMed  CAS  Google Scholar 

  62. VON EHRENSTEIN, O.S, VON MUTIUS, E., ILLI, S., BAUMANN, L., BOHM, O. & VON KRIES, R. (2000). Reduced risk of hay fever and asthma among children of farmers. Clinical and Experimental Allergy 30, 187–193.

    Google Scholar 

  63. RIEDLER, J., EDER, W., OBERFELD, G. & SCHREUER, M. (2000). Austrian children living on a farm have less hay fever, asthma and allergic sensitization. Clinical and Experimental Allergy 30, 194–200.

    PubMed  CAS  Google Scholar 

  64. BRAUN-FAHRLANDER, C., GASSNER, M., GRIZE, L., NEU, U., SENNHAUSER, F.H., VARONIER, H.S., VUILLE, J.C. & WUTHRICH, B. (1999). Prevalence of hay fever and allergic sensitization in farmer’s children and their peers living in the same rural community. SCARPOL team. Swiss Study on Childhood Allergy and Respiratory Symptoms with Respect to Air Pollution. Clinical and Experimental Allergy 29, 28–34.

    PubMed  CAS  Google Scholar 

  65. WICKENS, K., PEARCE, N., CRANE, J. & BEASLEY, R. (1999). Antibiotic use in early childhood and the development of asthma. Clinical and Experimental Allergy 29, 766–771.

    PubMed  CAS  Google Scholar 

  66. GEREDA, J.E., LEUNG, D.Y., THATAYATIKOM, A., STREIB, J.E., PRICE, M.R., KLINNERT, M.D. & LIU, A.H. (2000). Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma. Lancet 355, 1680–1683.

    Article  PubMed  CAS  Google Scholar 

  67. BOTTCHER, M.F., NORDIN, E.K., SANDIN. A., MIDTVEDT. T. & BJORKSTEN, B. (2000). Microflora-associated characteristics in faeces from allergic and nonallergic infants. Clinical and Experimental Allergy 30, 1590–1596.

    PubMed  CAS  Google Scholar 

  68. KALLIOMAKI, M., SALMINEN, S., ARVILOMMI, H., KERO, P., KOSKINEN, P. & ISOLAURI, E. (2001). Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet 357, 1076–1079.

    Article  PubMed  CAS  Google Scholar 

  69. RENZI, P.M., TURGEON, J.P., MARCOTTE, J.E., DRBLIK, S.P., BERUBE, D., GAGNON, M.F. & SPIER, S. (1999). Reduced interferon-gamma production in infants with bronchiolitis and asthma. American Journal of Respiratory Critical Care and Medicine 159, 1417–1422.

    CAS  Google Scholar 

  70. SIGURS, N., BJARNASON, R., SIGURBERGSSON, F. & KJELLMAN, B. (2000). Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7. American Journal of Respiratory Critical Care and Medicine 161, 1501–1507.

    CAS  Google Scholar 

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van den Biggelaar, A.H., Yazdanbakhsh, M. (2002). Schistosomiasis and Reduced Risk of Atopic Diseases: New Insights and Possible Mechanisms. In: Holland, C.V., Kennedy, M.W. (eds) The Geohelminths: Ascaris, Trichuris and Hookworm. World Class Parasites, vol 2. Springer, Boston, MA. https://doi.org/10.1007/0-306-47383-6_15

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  • DOI: https://doi.org/10.1007/0-306-47383-6_15

  • Publisher Name: Springer, Boston, MA

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