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Serotonin in Early-Onset Alcoholism

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Recent Developments in Alcoholism

Part of the book series: Recent Development in Alcoholism ((RDIA,volume 13))

Abstract

This chapter examines current common schemes to subgroup alcoholics to arrive at relatively homogeneous groups of patients to facilitate psychobiological and molecular genetic studies. Early-onset, male-limited alcoholism is commonly associated with antisocial personality disorder or antisocial behavioral traits. It is often preceded by early-onset aggressiveness, which is followed by conduct disorder. Early-onset alcoholism among men is associated with low central serotonin turnover rate. The data concerning platelet MAO activity and serotonin uptake to platelets among early-onset alcoholics are conflicting. Recent molecular genetic and brain imaging studies on early-onset alcoholics are preliminary but appear very promising.

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  1. Department of Psychiatry, Helsinki University Central Hospital, Helsinki, 00180, Finland

    Matti Virkkunen

  2. Laboratory of Clinical Studies, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, 20892-1256

    Markku Linnoila

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  1. New York University School of Medicine, New York, New York

    Marc Galanter

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Virkkunen, M., Linnoila, M. (2002). Serotonin in Early-Onset Alcoholism. In: Galanter, M., et al. Recent Developments in Alcoholism. Recent Development in Alcoholism, vol 13. Springer, Boston, MA. https://doi.org/10.1007/0-306-47141-8_10

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  • DOI: https://doi.org/10.1007/0-306-47141-8_10

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