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IUTAM Symposium on Synthesis in Bio Solid Mechanics pp 11–20Cite as

Mechanical and Hormonal Mechanisms Influencing Skeletal Form

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Part of the book series: Solid Mechanics and its Applications ((SMIA,volume 69))

Conclusions

The rationale and methodology for an integrated computational/experimental study of the interaction of mechanical and hormonal influences on skeletal form has been described. An implementation of the ideas has been presented using a simple computational model of an idealized system. Realistic finite element models of rat tibiae under four point bending will be studied with the proposed adaptation models at a later date. By relating the results obtained from finite element analyses to specific experimental results for different treatment groups, we hope to generate statistically significant data concerning the interaction between osteogenic levels of mechanical loading and intermittent PTH treatment.

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References

  • Akhter, M. P., Raab, D. M., Turner, C. H., Kimmel, D. B., and Recker, R. R. (1992) Characterization of in vivo strain in the rat tibia during external application of a four-point bending load. Journal of Biomechanics 25(10), 1241–1246.

    Article  CAS  Google Scholar 

  • Beaupré, G. S., Orr, T. E., and Cater, D. R. (1990) An approach for time-dependent bone modeling and remodeling: Theoretical development. Journal of Orthopaedic Research(8), 651–661.

    Google Scholar 

  • Bober, M. B. (1996) The regulation of gene expression by mechanical stimulation and parathyroid hormone in bone in vivo. Ph.D. Dissertation, Tulane University, New Orleans, Louisiana.

    Google Scholar 

  • Capozza, R., Ma, Y. F., Ferretti, J. L., Meta, M., Alippi, R., Zanchetta, J., and Jee, W. S. S. (1995) Tomographic (pQCT) and biomechanical effects of hPTH(1–38) on chronically immobilized or overloaded rat femurs. Bone 17(4), 233S–239S.

    Article  CAS  Google Scholar 

  • Carter, D. R., Wong, M., and Orr, T. E. (1991) Musculoskeletal ontogeny, phylogeny, and functional adaptation. Journal of Biomechanics 24 (Supplement 1). 3–16.

    Article  Google Scholar 

  • Conroy, B. P., Raab, D. M., Kimmel, D. B., and Recker, R. R. (1993) Interaction of parathyroid hormone (PTH) treatment and in vivo mechanical loading. Journal of Bone and Mineral Research 8(Suppl 1), S 281.

    Google Scholar 

  • Cowin, S. C., and Firoozbakhsh, K. (1981) Bone remodeling of diaphyseal surfaces under constant load: theoretical predictions. Journal of Biomechanics 7, 471–484.

    Google Scholar 

  • Dempster, D., Cosman, F., Parisien, M., Shen, V., and Lindsay, R. (1993) Anabolic actions of parathyroid hormone on bone. Endocrine Reviews 14, 690–709.

    Article  CAS  Google Scholar 

  • Forwood, M. R. (1996) Inducible cyclo-oxygenase (COX-2) mediates the induction of bone formation by mechanical loading in vivo. Journal of Bone and Mineral Research 11(11), 1688–1693.

    CAS  Google Scholar 

  • Frost, H. M. (1987a) Bone “mass” and the “;mechanostat”: a proposal. Anatomical Record 219, 1–9.

    Article  CAS  Google Scholar 

  • Frost, H. M. (1987b) The mechanostat: a proposed pathogenic mechanism of osteoporoses and the bone mass effects of mechanical and nonmechanical agents. Bone and Mineral 2, 73–85.

    CAS  Google Scholar 

  • Gunness, M., and Hock, J. M. (1993) Anabolic effect of parathyroid hormone on cancellous and cortical bone histology. Bone 14, 277–281.

    Article  CAS  Google Scholar 

  • Hagino, H., Raab, D. M., Kimmel, D. B., Akhter, M. P., and Recker, R. R. (1993) Effect of ovariectomy on bone response to in vivo external loading tibia. Journal of Bone and Mineral Research 8(3), 347–357.

    CAS  Google Scholar 

  • Hart, R. T. (1983) Quantitative response of bone to mechanical stress. Ph.D. Dissertation, Case Western Reserve University, Cleveland, Ohio.

    Google Scholar 

  • Hart, R. T., Davy, D. T., and Heiple, K. G. (1984a) A computational method for stress analysis of adaptive elastic materials with a view toward applications in strain-induced bone remodeling. Journal of Biomechanical Engineering 106(November), 342–350

    CAS  Google Scholar 

  • Hart, R. T., Davy, D. T., and Heiple, K. G. (1984b) Mathematical modeling and numerical solutions of functionally dependent bone remodeling. Calcified Tissue International 36, S104–S109.

    Google Scholar 

  • Huiskes, R., Weinans, H., Grootenboer, H. J., Dalstra, M., Fudala, B., and Slooff, T. J. (1987) Adaptive bone-remodeling theory applied to prosthetic-design analysis. Journal of Biomechanics 20(11/12), 1135–1150.

    CAS  Google Scholar 

  • Knothe-Tate, M. L., Steck, R., Niederer, P., and Forwood, M. R. (1998) In vivo load-induced fluid flow data corroborate theoretical predictions of fliud displacements in rat tibiae subjected to bending loads. Transactions of the 44th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, 134.

    Google Scholar 

  • Lanyon, L. E., Rubin, C. T., and Baust, G. (1986) Modulation of Bone Loss During Calcium Insufficiency by Controlled Dynamic Loading. Calcified Tissue International 38, 209–216.

    CAS  Google Scholar 

  • Mosekilde, L., Danielson, C. C., Sogaard, H. H., McOsker, J. E., and Wronski, T. J. (1995) The anabolic effects of parathyroid hormone (hPTH) on cortical bone mass, dimension, and strength-assessed in a sexually mature, ovariectomized rat model. Bone 16(2), 223–230.

    Article  CAS  Google Scholar 

  • Oxlund, H., Ejersted, C., Andreassen, T. T., Torring, O., and Nilsson, M. H. L. (1993) Parathyroid hormone (1-34) and (1-84) stimulate cortical bone formation both from periosteum and endosteum. Calcified Tissue Internnational 53, 394–399.

    CAS  Google Scholar 

  • Raab-Cullen, D. M., Akhter, M. P., Kimmel, D. B., and Recker, R. R. (1994) Bone response to alternate-day mechanical loading of the rat tibia. Journal of Bone and Mineral Research 9(2), 203–211.

    CAS  Google Scholar 

  • Riond, J.-L. (1993) Modulation of the anabolic effect of synthetic human parathyroid hormone fragment-(1-34) in the bone of growing rats by variations in the dosage regimen. Clinical Science 85, 223–228.

    CAS  Google Scholar 

  • Skerry, T. M., and Lanyon, L. E. (1993) Immobilisation induced bone loss in the sheep is not modulated by calcitonin treatment. Bone 14, 511–516.

    Article  CAS  Google Scholar 

  • Tang, L. Y., Cullen, D. M., Yee, J. A., Jee, W. S., and Kimmel, D. B. (1997) Prostaglandin E2 increases the skeletal response to mechanical loading. Journal of Bone and Mineral Research 12(2), 276–282.

    CAS  Google Scholar 

  • Turner, C. H. (1991) Homeostatic control of bone structure: an application of feedback theory. Bone 12, 203–217.

    CAS  Google Scholar 

  • Turner, C. H., Akhter, D. M., Kimmel, D. B., and Recker, R. R. (1991) A noninvasive, in vivo model for studying strain adaptive bone modeling. Bone 12, 73–79.

    CAS  Google Scholar 

  • Turner, C. H., Forwood, M. R., Rho, J.-Y., and Yoshikawa, T. (1994) Mechanical loading thresholds for lamellar and woven bone formation. Journal of Bone and Mineral Research 9(1), 87–97.

    Article  CAS  Google Scholar 

  • Turner, C. H., Takano, Y., Owan, I., and Murrell, G. A. C. (1996) Nitric oxide inhibitor L-NAME suppresses mechanically induced bone formation in rats. American Journal of Physiology 270(Endocrinol. Metab. 33). E634–E639.

    CAS  Google Scholar 

  • Wronski, T. J., and Yen, C.-F. (1994) Anabolic effects of parathyroid hormone on cortical bone in ovariectomized rats. Bone 15(1), 51–58.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Biomedical Engineering, Tulane University, New Orleans, LA, 70118, USA

    M. D. Roberts & R. T. Hart

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  1. M. D. Roberts
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  2. R. T. Hart
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Editor information

Editors and Affiliations

  1. Department of Solid Mechanics, Technical University of Denmark, Lyngby, Denmark

    Pauli Pedersen

  2. Department of Mathematics, Technical University of Denmark, Lyngby, Denmark

    Martin P. Bendsøe

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© 1999 Kluwer Academic Publishers

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Roberts, M.D., Hart, R.T. (1999). Mechanical and Hormonal Mechanisms Influencing Skeletal Form. In: Pedersen, P., Bendsøe, M.P. (eds) IUTAM Symposium on Synthesis in Bio Solid Mechanics. Solid Mechanics and its Applications, vol 69. Springer, Dordrecht. https://doi.org/10.1007/0-306-46939-1_2

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  • DOI: https://doi.org/10.1007/0-306-46939-1_2

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-0-7923-5615-8

  • Online ISBN: 978-0-306-46939-8

  • eBook Packages: Springer Book Archive

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