Abstract
The application of recombinant DNA technologies for molecular genetic approaches promises to bring about new strategies for control of vector-borne-diseases. These approaches can also enhance the existing tools. Here, one application of this technology is presented where parasite refractory insects are engineered that can then be spread to replace their susceptible counterparts in the field to reduce disease transmission. The approach presented here utilizes the symbiotic bacteria that are naturally harbored in tsetse to express foreign genes. As these naturally harbored organisms reside in the same tissues as trypanosomes, the expression of anti-trypanosoma1 products in these bacterial symbionts can adversely effect parasite biology. The use of Wolbachia symbionts, which are known to induce phenomena such as cytoplasmic incompatibility, is discussed as a potential gene driving system.
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Aksoy, S. (2002). Tsetse Vector Based Strategies for Control of African Try Panosomiasis. In: The African Trypanosomes. World Class Parasites, vol 1. Springer, Boston, MA. https://doi.org/10.1007/0-306-46894-8_4
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DOI: https://doi.org/10.1007/0-306-46894-8_4
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