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Mimetic peptides, demanding enzymes and drug discovery

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Peptides for the New Millennium

Part of the book series: American Peptide Symposia ((APSY,volume 6))

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References

  1. Merrifield, R.B., J. Am. Chem. Soc. 85 (1963) 2149.

    Article  CAS  Google Scholar 

  2. Elion, G.B., Science 244 (1989) 41.

    PubMed  CAS  Google Scholar 

  3. Hitchings, G.H., Jr., In Vitro Cell. Dev. Biol. 25 (1989) 303.

    PubMed  CAS  Google Scholar 

  4. Tipper, D.J. and Strominger, J.L., Proc. Natl. Acad. Sci. USA 54 (1965) 1133.

    PubMed  CAS  Google Scholar 

  5. Umezawa, H., Ann. Rev. Microbiol. 36 (1982) 75.

    Article  CAS  Google Scholar 

  6. Wolfenden, R., Ace. Chem. Res. 5 (1972) 10.

    Article  CAS  Google Scholar 

  7. Ondetti, M.A., Rubin, B., and Cushman, D.W., Science 196 (1977) 441.

    PubMed  CAS  Google Scholar 

  8. Aoyagi, T., Kunimoto, S., Morishima, H., Takeuchi, T., and Umezawa, H., J. Antibiot. 24 (1971) 687.

    PubMed  CAS  Google Scholar 

  9. Marks, N., Grynbaum, A., and Lajtha, A., Science 181 (1973) 949.

    PubMed  CAS  Google Scholar 

  10. Rich, D.H., Sun, E., and Singh, J., Biochem. Biophys. Res. Comm. 74 (1977) 762.

    Article  PubMed  CAS  Google Scholar 

  11. Rich, D.H., Sun, E.T., and Boparai, A.S., J. Org. Chem. 43 (1978) 3625.

    Google Scholar 

  12. Rich, E.H., Sun, E.T.O., and Ulm, E., J. Med. Chem. 23 (1980) 27.

    Article  PubMed  CAS  Google Scholar 

  13. Rich, D.H. and Sun, E.T.O., Biochem. Phys. 29 (1980) 2205.

    CAS  Google Scholar 

  14. Morrison, J., Biochim. Biophys. Acta 185 (1969) 269.

    PubMed  CAS  Google Scholar 

  15. Boger, J., Lohr, N.S., Ulm, E.H., Poe, M., Blaine, E.G., Fanelli, G.M., Lin, T.-Y., Payne, L.S., Schorn, T.W., Lamont, B.I., Vassil, T.C., Stabilito, I.I., Veber, D.F., Rich, D.H., and Boparai, A.S., Nature 303 (1983) 81.

    Article  PubMed  CAS  Google Scholar 

  16. Boger, J., Payne, L.S., Perlow, D.S., Lohr, N.S., Poe, M., Blaine, E.H., Ulm, E.H., Schorn, T.W., Lamont, T.I., Lin, T.-Y., Kawai, M., Rich, D.H., and Veber, D.F., J. Med. Chem. 28 (1985) 1779.

    Article  PubMed  CAS  Google Scholar 

  17. James, M.N.G., Sielecki, A., Salituro, F., Rich, D.H., and Hofmann, T., Proc. Natl. Acad. Sci. USA 79 (1982) 6137.

    PubMed  CAS  Google Scholar 

  18. Salituro, F.G., Agarwal, N., Hofmann, T., and Rich, D.H., J. Med. Chem. 30 (1987) 286.

    Article  PubMed  CAS  Google Scholar 

  19. Holladay, M.W. and Rich, D.H., Tetrahedron Lett. 24 (1983) 4401.

    Article  CAS  Google Scholar 

  20. Rich, D.H., Boparai, A.S., and Bernatowicz, M.S., Biochem. Biophys. Res. Comm. 104 (1982) 1127.

    Article  PubMed  CAS  Google Scholar 

  21. Rich, D.H., Bernatowicz, M.S., and Schmidt, P.G., J. Am. Chem. Soc. 104 (1982) 3535.

    Article  CAS  Google Scholar 

  22. Rich, D.H., J. Med. Chem. 28 (1985) 263.

    Article  PubMed  CAS  Google Scholar 

  23. Miller, M, Schneider, J., Sathyanarayana, B.K., Toth, M.V., Marshall, G.R., Clawson, L., Selk, L., Kent, S.B., and Wlodawer, A., Science 246 (1989) 1149.

    PubMed  CAS  Google Scholar 

  24. Rich, D.H., Green, J., Toth, M.V., Marshall, G.R., and Kent, S.B.H., J. Med. Chem. 33 (1990) 1285.

    Article  PubMed  CAS  Google Scholar 

  25. Swain, A.L., Miller, M.M., Green, J., Rich, D.H., Schneider, J., Kent, S.B.H., and Wlodawer, A., Proc. Natl. Acad. Sci. USA 87 (1990) 8805.

    PubMed  CAS  Google Scholar 

  26. Rich, D.H., Sun, C.-Q., Vara Prasad, J.V.N., Pathiasseril, A., Toth, M.V., Marshall, G.R., Clare, M., Mueller, R.A., and Houseman, K., J. Med. Chem. 34 (1991) 1222.

    Article  PubMed  CAS  Google Scholar 

  27. Rich, D.H., Moon, B.J., and Harbeson, S., J. Med. Chem. 27 (1984) 417.

    Article  PubMed  CAS  Google Scholar 

  28. Ocain, T.D. and Rich, D.H., J. Med. Chem. 31 (1988) 2193.

    Article  PubMed  CAS  Google Scholar 

  29. Lim, S. and Rich, D.H., In Hodges, R.S. and Smith, J.A. (Eds.) Peptides: Chemistry and Biology, Escom, Leiden, The Netherlands, 1994, p. 625.

    Google Scholar 

  30. Lowther, W.T., Orville, A.M., Madden, D.T., Lim, S.J., Rich, D.H., and Matthews, B.W., Biochemistry 38 (1999) 7678.

    Article  PubMed  CAS  Google Scholar 

  31. Keding, S.J., Dales, N.A., Beaulieu, D., and Rich, D.H., Syn. Comm. 28 (1998) 4463.

    CAS  Google Scholar 

  32. Shute, R.E., Kawai, M., and Rich, D.H., Tetrahedron 44 (1988) 685.

    Article  CAS  Google Scholar 

  33. Rich, D.H. and Mathiaparanam, P., Tetrahedron Lett. 4037 (1974).

    Google Scholar 

  34. Steele, J.A., Uchytil, T.F., Durbin, R.D., Bhatnagar, P., and Rich, D.H., Proc. Natl. Acad. Sci. USA 73 (1976) 2245.

    PubMed  CAS  Google Scholar 

  35. Steele, J.A., Durbin, R.D., Uchytil, T.F., and Rich, D.H., Biochem. Biophys. Acta 501 (1978) 72.

    Article  PubMed  CAS  Google Scholar 

  36. Steele, J.A., Uchytil, T.F., Durbin, R.D., Bhatnagar, P.K., and Rich, D.H., Biochem. Biophys. Res. Comm. 84 (1978) 215.

    Article  PubMed  CAS  Google Scholar 

  37. Rich, D.H., Dhaon, M.K., Dunlap, B., and Miller, S.P.F., J. Med. Chem. 29 (1986) 978.

    Article  PubMed  CAS  Google Scholar 

  38. Tung, R.D., Dhaon, M.K., and Rich, D.H., J. Org. Chem. 51 (1986) 3350.

    Article  CAS  Google Scholar 

  39. Aebi, J.D., Deyo, D.T., Guillaume, D., and Rich, D.H., J. Med. Chem. 33 (1990) 999.

    Article  PubMed  CAS  Google Scholar 

  40. Angell, Y.M., Thomas, T.L., Flentke, G.R., and Rich, D.H., J. Am. Chem. Soc. 117 (1995) 7279.

    Article  CAS  Google Scholar 

  41. Raman, P., Stokes, S.S., Angell, Y.M., Flentke, G.R., and Rich, D.H., J. Org. Chem. (1998) 5734.

    Google Scholar 

  42. Rich, D.H., Sun, C.-Q., Plzak, K.J., Aebi, J.D., Dunlap, B.E., Dumont, P.L., and Staruch, M.J., In Rivier, J.E. and Marshall, G.R. (Eds.) Peptides: Chemistry, Structure and Biology, Escom, Leiden, 1990, p. 49.

    Google Scholar 

  43. Sigal, N.H., Durette, P.L., Siekierka, J.J., Peterson, L., Rich, D.H., Dunlap, B.E., Staruch, M.J., Melino, M.R., Koprak, S.L., Williams, D., Witzel, B., Pisano, J., and Dumont, F., J. Exp. Med. 173 (1991) 619.

    Article  PubMed  CAS  Google Scholar 

  44. Bartz, S.R., Hohenwalter, E., Hu, M.-K., Rich, D.H., and Malkovsky, M., Proc. Natl. Acad. Sci. USA 92 (1995) 5381.

    PubMed  CAS  Google Scholar 

  45. Sherry, B., Zybarth, G., Alfano, M., Dubrovsky, L., Mitchell, R., Rich, D.H., Ulrich, P., Bucala, R., Cerami, A., and Bukrinsky, M. Proc. Natl. Acad. Sci. USA 95 (1998) 1758.

    Article  PubMed  CAS  Google Scholar 

  46. Sigal, N.H., Durette, P.L., Siekierka, J.J., Peterson, L., Rich, D.H., Dunlap, B.E., Staruch, M.J., Melino, M.R., Koprak, S.L., Williams, D., Witzel, B., Pisano, J., and Dumont, F., J. Exp. Med. 173 (1991) 619.

    Article  PubMed  CAS  Google Scholar 

  47. Pearson, A.J. and Park, J.G., J. Org. Chem. 57 (1992) 1744.

    Article  CAS  Google Scholar 

  48. Pearson, A.J. and Lee, K.J., Org. Chem. 59 (1994) 2304.

    Article  CAS  Google Scholar 

  49. Pearson, A.J and Lee, K., J. Org. Chem. 60 (1995) 7153.

    Article  CAS  Google Scholar 

  50. Janetka, J.W. and Rich, D.H., J. Am. Chem. Soc. 117 (1995) 10585.

    Article  CAS  Google Scholar 

  51. Janetka, J.W. and Rich, D.H., J. Am. Chem. Soc. 119 (1997) 6488.

    Article  CAS  Google Scholar 

  52. Janetka, J.W., Raman, P., Satyshur, K., Flentke, G.R., and Rich, D.H., J. Am. Chem. Soc. 119 (1997) 441.

    Article  CAS  Google Scholar 

  53. Elder, A.M. and Rich, D.H., Org. Lett. 1 (1999) 1443.

    Article  PubMed  CAS  Google Scholar 

  54. Bohacek, R.S. and McMartin, C., J. Am. Chem. Soc. 116 (1994) 5560.

    Article  CAS  Google Scholar 

  55. Bohacek, R.S., McMartin, C., and Guida, W.C., Med. Res. Rev. 16 (1996) 3.

    Article  PubMed  CAS  Google Scholar 

  56. Chen, L., Erickson, J.W., Rydel, T.J., Park, C.H., Neidhart, D., Luly, J., and Abad-Zapatero, C., Acta Cryst. B48 (1992) 476.

    CAS  Google Scholar 

  57. Rich, D.H., Bohacek, R.S., Dales, N.A., Glunz, P., and Ripka, A.S., In Actualités de Chimie Thérapeutique-22e Série, Elsevier, 1996, p. 101.

    Google Scholar 

  58. Rich, D.H., Boheck, R.S., Dales, N.A., Glunz, P., and Ripka, A.S., Chimia, 51 (1997) 45.

    CAS  Google Scholar 

  59. Szewczuk, Z., Rebholz, K., and Rich, D.H., Int. J. Peptide Protein Res. 40 (1992) 233.

    Article  CAS  Google Scholar 

  60. Dales, N.A., Bohacek, R.S., Satyshur, K.A., and Rich, D.H., submitted.

    Google Scholar 

  61. Oefner, C., Binggeli, A., Breu, V., Bur, D., Clozel, J.P., Díarcy, A., Dorn, A., Fischli, W., Gruninger, F., Guller, R., Hirth, G., Marki, H., Mathews, S., Miller, M., Ridley, R.G., Stadler, H., Viera, E., Wilhelm, M., Winkler, F., and Wostl, W., Chem. Biol. 6 (1999) 127.

    Article  PubMed  CAS  Google Scholar 

  62. Viera, E., Binggeli, A., Breu, V., Bur, D., Fischli, W., Gller, R., Hirth, G., Märki, H.P., Müller, M., Oefner, C., Scalone, M., Stadler, H., Wilhelm, M., and Wostl, W., Bioorg. Med. Chem. Lett. 9 (1999) 1397.

    Article  Google Scholar 

  63. Güller, R., Binggeli, A., Breu, V., Bur, D., Fischli, W., Hirth, G., Jenny, C., Kansy, M., Montavon, F., Müller, M., Oefner, C., Stadler, H., Vieira, E., Wilhelm, M., Wostl, W., and Märki, P., Bioorg. Med. Chem. Lett. 9 (1999) 1403.

    Article  PubMed  Google Scholar 

  64. West, C. and Bursavich, M., unpublished data.

    Google Scholar 

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Rich, D.H. (2002). Mimetic peptides, demanding enzymes and drug discovery. In: Fields, G.B., Tam, J.P., Barany, G. (eds) Peptides for the New Millennium. American Peptide Symposia, vol 6. Springer, Dordrecht. https://doi.org/10.1007/0-306-46881-6_1

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  • DOI: https://doi.org/10.1007/0-306-46881-6_1

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-0-7923-6445-0

  • Online ISBN: 978-0-306-46881-0

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