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Scale up aspects of sparged insect-cell bioreactors

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Insect Cell Culture: Fundamental and Applied Aspects

Part of the book series: Current Applications of Cell Culture Engineering ((CACC,volume 2))

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Conclusion

In this chapter we have attempted to evaluate the most important parameters which can be useful for the purpose of design and scale up. Insect cells and animal cells in general can be grown well in large vessels. However, none of the theories and parameters discussed in this chapter have been validated on a larger scale than laboratory and small pilot reactors. Selection of the most suitable design and scale-up method therefore needs in particular studies in larger vessels. The Kolmogorov theory and the killing-volume model are in this respect the most promising approaches for the optimal design of large-scale animal-cell bioreactors.

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Author information

Authors and Affiliations

  1. Food and Bioprocess Engineering Group, Wageningen Agricultural University, P.O. Box 8129, 6700 EV, Wageningen, The Netherlands

    J. Tramper & C.D. de Gooijer

  2. Department of Virology, Wageningen Agricultural University, P.O. Box 8129, 6700 EV, Wageningen, The Netherlands

    J.M. Vlak

Authors
  1. J. Tramper
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  2. J.M. Vlak
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  3. C.D. de Gooijer
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Editor information

Editors and Affiliations

  1. Dept. of Virology, Wageningen Agricultural University, The Netherlands

    J.M. Vlak

  2. Dept. of Food Science, Wageningen Agricultural University, The Netherlands

    C.D. de Gooijer  & J. Tramper  & 

  3. Dept. of Zoology, Technical University, Darmstadt, Germany

    H.G. Miltenburger

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© 1996 Kluwer Academic Publishers

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Tramper, J., Vlak, J., de Gooijer, C. (1996). Scale up aspects of sparged insect-cell bioreactors. In: Vlak, J., de Gooijer, C., Tramper, J., Miltenburger, H. (eds) Insect Cell Culture: Fundamental and Applied Aspects. Current Applications of Cell Culture Engineering, vol 2. Springer, Dordrecht. https://doi.org/10.1007/0-306-46850-6_19

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  • DOI: https://doi.org/10.1007/0-306-46850-6_19

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-0-7923-3403-3

  • Online ISBN: 978-0-306-46850-6

  • eBook Packages: Springer Book Archive

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