Skip to main content
SpringerLink
Log in

The Role of Calpain Proteolysis in Cerebral ischemia

  • Chapter
Role of Proteases in the Pathophysiology of Neurodegenerative Diseases

  • 128 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. R. Bonita, Epidemiology of stoke, Lancet 339:3420350 (1992).

    Article  Google Scholar 

  2. RD. Brown, J.P. Whisnant, J.D. Sicks, W.M. O′Fallon and D.O. Wiebers, Stroke incidence, prevalence, and survival.Secular trends in Rochester, Minnesota, through 1989. Stroke 27:373–380 (19%).

    Google Scholar 

  3. J. Astrup, B.K. Siesjo, and L. Symon, Thresholds in cerebral ischemia — The ischemic penumbra, Stroke 12:723–725 (1981).

    PubMed  CAS  Google Scholar 

  4. W.I. Rosenblum. Histopathological clues to the pathways of neuronal death following iscehmia/hypoxia, J. Neurotr 14:313–326 (1997).

    CAS  Google Scholar 

  5. W.-D. Heiss, M. Huber, G.R Fink. K. Herholz, U. Pietrzyk, R Wagner, and K. Wienhard, Progressive derangement of periinfarct viable tissue in ischemic stroke, J. Cereb. Blood Flow Metab., 12:193–200 (1992).

    PubMed  CAS  Google Scholar 

  6. B.K. Siesjo and F. Bengtsson, Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression: A unifying hypothesis, J. Cereb. Blood Flow Metab. 9:127 (1989).

    PubMed  CAS  Google Scholar 

  7. D.F. Emerich, and RT. Bartus, Intracellular events associated with cerebral ischemia, in: Stroke Therapy Basic, Preclinical and Clinical Directions, L.P. Miller, ed., Wiley-Liss, Inc., New York, NY (1999).

    Google Scholar 

  8. RT. Bartus, The calpain hypothesis of neurodegeneration: Evidence for a common cytotoxic pathway, Neuroscientist 3:3 14–327 (1997).

    Google Scholar 

  9. RT. Bartus, Calpain Inhibition:A common therapeutic rationale for treating multiple neurodegenerative conditions? Bar PR, Beal MF, eds. Neuroprotection: Fundamental and Clinical Aspects, Marcel Dekker, Inc., New York, NY pp71–86 (1997).

    Google Scholar 

  10. H. Sorimachi, T.C. Saido, and K. Suzuki, New era of calpain research. Discovery of tissue-specific calpains, FEBS Lotters 1994:343:1–5.

    CAS  Google Scholar 

  11. E. Melloni and S. Pontremoli, The calpains, TINS 12:438 (1989).

    PubMed  CAS  Google Scholar 

  12. P. Seubert and G Lynch, Plasticity to pathology: Brain calpains as modifiers of synaptic structure. In Intracellular Calcium Dependent proteolysis, RL. Mellgren and T. Murachi, eds., CRC Press, Boca Raton (1990).

    Google Scholar 

  13. K. Onizuka, M. Kunimatsu, Y. Ozaki, K. Muramatsu, M. Sasaki, and H. Nishino, Distribution of u-calpain proenzyme in the brain and other neural tissues in the rat, Brain Res. 697:179–186 (1995).

    Article  PubMed  CAS  Google Scholar 

  14. K Suzuki and S. Ohno, Calcium activated neutral protease structure-function relationship and functional implications, Cell Struct. Funct 156:1–6 (1990).

    Google Scholar 

  15. K. Suzuki, H. Sorimachi, T. Yoshizawa, K. Kinbara, and S. Ishiura. Calpain: novel family members, avtivationand physiological function, Biol. Chem Hoppe-Seyler 376 (1995).

    Google Scholar 

  16. T. Saido, H. Sorimachi. and K. Suzuki, Calpain: New perspectives in molecular diversity and phusiological-pathological involvement, FASEB J 8:814 (1994).

    PubMed  CAS  Google Scholar 

  17. A. Kishimoto, K. mikawa, K. Hashimoto, I. Yasuda, S. Tanaka, M. Tominaga, T. Kuroda, and Y. Nishizuka, Limited proteolysis of protein kinase C subspecies by calcium-dependent neutral protease (calpain), J. Biol. Chem. 264:4088–4092 (1989).

    PubMed  CAS  Google Scholar 

  18. T.B. Shea, C.M. Cressman, M.J. Spencer, M.L. Beermann, and RA. Nixon, Enhancement of neurite outgrowth following calpain inhibition is mediated by protein kinase C, J. Neurochem. 517–527 (1995).

    Google Scholar 

  19. G. Lynch, and M. Baudry, The biochemistry of memory: A new and specific hypothesis, Science 224: 1057–1063 (1984).

    PubMed  CAS  Google Scholar 

  20. RA. Nixon, Calcium-activated neutral proteinases as regulators of cellular function: Implications for Alzheimer’s disease pathogenesis, Ann. N. Y. Acad. Sci. 568: 198–206 (1989).

    PubMed  CAS  Google Scholar 

  21. S.R Goodman, and I.S. Zagon, The neural cell spectrin skeleton: a review, Invited Review, Ameri. Physiol. Soc. C347 (1986).

    Google Scholar 

  22. S.C. Hong, G. Lanzino, Y. Goto, S.K. Kang, F. Schottler, N.F. Kassell, and K.S. Lee, Calcium-activated proteolysis in rat neocortex induced by transient focal ischemia, Brain Res. 661:43 (1994).

    Article  PubMed  CAS  Google Scholar 

  23. RT. Bartus, RL. Dean, K. Cavanaugh, D. Eveleth, D. Carriero and G. Lynch, Time-related neuronal changes following middle cerebral artery occlusion: Implications for therapeutic intervention and the role of calpain, J. Cereb. Blood Flow Metab. 15:969 (1995).

    PubMed  CAS  Google Scholar 

  24. H. Yao, M.D. Ginsberg, D.D. Eveleth, J.C. LaManna, B.D. Watson, O.F. Alonso, J.Y. Loor, J.H. Foreman, and R Busto, Local cerebral glucose Utilization and cytoskeletal proteolysis as indices of evolving focal ischemic injury in core and penumbra, J. Cereb. Blood Flow Metab. 15:398 (1995).

    PubMed  CAS  Google Scholar 

  25. M. Liebetrau, B. Staufer, E.A. Auerswald, D. Geiger, H. Fritz, C. Zimmerman, T. Pfefferkorn, and G.F. Hamann, Increased intracellular calpain detection in experimental focal cerebral ischemia, NeuroReport 10:529–534 (1999).

    PubMed  CAS  Google Scholar 

  26. Z. Li, G.S. Patil, and Z.E. Golubski, Peptide alpha-ketoester, a-ketoamid, and alpha-ketoacid inhibotirs of calpain and other cysteine proteases. J. Med. Chem. 36:3472–3480 (1993).

    Article  PubMed  CAS  Google Scholar 

  27. S.-C. Hong, Y. Goto, G. Lanzino, B.A. Soleau, N.F. Kassell, and K.S. Lee, Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia, Stroke 25:3:663 (1994).

    PubMed  CAS  Google Scholar 

  28. RT. Bartus, N.J. Hayward, P.J. Elliott, S.D. Sawyer, K.L. Baker, RL. Dean, A. Akiyama, J.A. Straub, S.L. Harbeson, Z. Li, and J. Powers, Calpain inhibitor AK295 protects neurons from focal brain ischemia: Effects of postocclusion intra-arterial administration, Stroke 25:11:2265–2270 (1994).

    PubMed  CAS  Google Scholar 

  29. RT. Bartus, K.L. Baker, A.D. Heiser, S.D. Sawyer, RL. Dean, P.J. Elliott, and J.A. Straub, Postischemic administration of AK275, a calpain inhibitor, provides substantial protection against focal ischemic brain damage, J. Cereb. Blood Flow Metab. 14:537–544 (1994).

    PubMed  CAS  Google Scholar 

  30. RT. Bartus, E.-Y. Chen, G. Lynch, and J.H. Kordower, Cortical ablation induces a secondary calcium-dependant pathogensis which can bereduced by inhibiitng calpain, Exper. Neurol. 155:315–326 (1999).

    Article  CAS  Google Scholar 

  31. C. Markgraf, N.L. Velayo, M.P. Johnson, D.R McCarty, S. Medhi, J.R. Koehl, P.A. Chmielewski, and M.D. Linnik, Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats, Stroke 29:152–158 (1998).

    PubMed  CAS  Google Scholar 

  32. P. Seubert, K. Lee, and G. Lynch, Ishemia triggers NMDA receptor-linked cytoskeletal proteolysis in hippocampus, Brain Res. 429:366–370 (1989).

    Google Scholar 

  33. T.C. Saido, M. Yokota, S. Nagao, I. Yamaura, E. Tani, T. Tsuchiya, K. Suzuki, and S. Kawashima, Spatial resolution of fodrin proteolysis in postischemic brain, J. Biol. Chem. 268:33:25239 (1993).

    PubMed  CAS  Google Scholar 

  34. J.M. Roberts-Lewis, M.J. Savage, V.R Marcy, L.R Pinsker, and R. Siman, Immunolocalization of Calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain, J. Neurosci. 14:6:3934 (1994).

    PubMed  CAS  Google Scholar 

  35. RT. Bartus, R Dean, S. Mennerick, D. Eveleth, and G. Lynch, Temporal ordering of pathogenic events following transient global ischemia, Brain Res. 790:1–13 (1998).

    Article  PubMed  CAS  Google Scholar 

  36. T. Yamashima, T.C. Saido, M. Takita, J. Miyazawa, A. Miyakawa, H. Nishijyo, J. Yamashita, S. Kawashima, T. Ono and T. Yoshioka, Transient brain ischemia provokes Calcium, PIP2 and calpain responses prior to delayed neuronal death in monkeys, Eur. J. Neurosci. 8:1932–1944 (19%).

    Google Scholar 

  37. A. Rami and J. Krieglstein, Protective effects of calpain inhibitors against neuronal damage caused by cytotoxic hypoxia in vitro and ischemia in vivo, Brain Res. 609:67–70 (1993).

    Article  PubMed  CAS  Google Scholar 

  38. RT. Bartus, P.J. Elliott, N.J. Hayward, R.L. Dean, S. Harbeson, J.A. Straub, Z. Li, and J.C. Powers, Calpain as a novel target for treating acute neurodegenerative disorders, Neurological Res. 17:249–258 (1995).

    CAS  Google Scholar 

  39. P. Li, W. Howlett, Q.P. He, H. Miyashita, M. Siddiqui, and A. Shuaib, Postischemic treatment with calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia, Neurosci. Lett. 247: 17–20 (1998).

    Article  PubMed  CAS  Google Scholar 

  40. M. Yokata, E. Tani, S. Tsubuki, I Yamura, I. Nakagaki, S. Hori, and T.C. Saido, Calpain inhibitor entrapped in liposome rescues ischemic neuronal damage, Brain Res. 819:8–14 (1999).

    Google Scholar 

  41. M.D. Ginsberg, Neuroprotection in brain ischemia: An update (Part1), Neuroscientist 1:95–103 (1995).

    Google Scholar 

  42. M.D. Ginsberg, Neuroprotection in brain ischemia: An update (Part II), Neuroscientist 1:l64–175 (1995).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Alkermes, Inc, Cambridge, MA, 02139

    Dwaine F. Emerich & Raymond T. Bartus

Authors
  1. Dwaine F. Emerich
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Raymond T. Bartus
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York

    Abel Lajtha

  2. Medical University of South Carolina, Charleston, South Carolina

    Naren L. Banik

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Kluwer Academic Publishers

About this chapter

Cite this chapter

Emerich, D.F., Bartus, R.T. (2002). The Role of Calpain Proteolysis in Cerebral ischemia. In: Lajtha, A., Banik, N.L. (eds) Role of Proteases in the Pathophysiology of Neurodegenerative Diseases. Springer, Boston, MA. https://doi.org/10.1007/0-306-46847-6_6

Download citation

  • DOI: https://doi.org/10.1007/0-306-46847-6_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46579-6

  • Online ISBN: 978-0-306-46847-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation