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HPLC/ESI Tandem-MS of Liquid Urine or Urine Soaked Filter-Paper Strips for the Detection of Thymine-Uraciluria and Dihydropyrimidinuria

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Purine and Pyrimidine Metabolism in Man X

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 486))

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References

  1. Lu, Z., Zhang, R., Diasio, R.B., 1993, Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy. Cancer Res. 55:5433–5438

    Google Scholar 

  2. Wei, X., McLeod, H.L., McMurrough, J., Gonzalez, F.J., Fernandez-Salguero, P., 1996, Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity. J. Clin. Invest. 98:610–615.

    CAS  PubMed  Google Scholar 

  3. Van Kuilenburg, A.B.P., Vreken, P., Beex, L.V.A.M., Meinsma, J.R., Van Lenthe, H., De Abreu, R.A., Van Gennip, A H., 1997, Heterozygosity for a point mutation in an invariant splice donor site of dihydropyrimidine dehydrogenase and severe 5-fluorouracil related toxicity. Eur. J. Cancer 13:2258–2264.

    Google Scholar 

  4. Sumi, S., Imaeda, M., Kidouchi, K., Ohba, S., Hamajima, N., Kodama, K., Togari, H., Wada, Y., 1998, Population and family studies of dihydropyrimidinuria — prevalence, inheritance mode, and risk of fluorouracil toxicity. Am. J. Med. Gen. 78(4):336–340.

    Article  CAS  Google Scholar 

  5. Van Gennip, A.H., Busch, S., Elzinga, L., Stroomer, A.E.M., Van Cruchten, A.C., Scholten, E.G., Abeling, N.G.G.M., 1993, Application of simple chromatographic methods for the diagnosis of defects in pyrimidine degradation. Clin. Chem. 39:380–385.

    PubMed  Google Scholar 

  6. Van Gennip, A.H., 1990, Screening for inborn errors of purine and pyrimidine metabolism by bi-dimensional TLC and HPLC. In: CRC handbook of chromatography, (Zweig, G., Sherma, J., eds), Molume I: Part A, Nucleic acids and related compounds, Boca Ration: CRC press, pp.22l–245.

    Google Scholar 

  7. Simmonds, H.A., Duley, J.A., Davies, P.M., 1991, Analysis of purines and pyrimidines in blood, urine, and other physiological fluids. In: Techniques in diagnostic human biochemical genetics: A 1aboratorty manual (Hommes, F.A., ed). New York: Wiley-Liss, pp.397–424.

    Google Scholar 

  8. Duran, M., Dorland, L., Meulemann, E.E.E., Allers, P., Berger, R., 1997, Inherited defects of purine and pyrimidine metabolism: Laboratory methods for diagnosis. J. Inher. Metab. Dis. 20:227–236.

    CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Emma Children’s Hospital and Department of Clinical Chemistry, Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam, P. O. Box 22700, 1100 DE, Amsterdam, The Netherlands

    Albert H Van Gennip, Henk Van Lenthe, Albert H. Bootsma, Arno C. Van Cruchten & Andre B.P. Van Kuilenburg

  2. Department of Pediatrics, Nagoya City University Medical School, Nagoya, 467-8601, Japan

    Tetsuya Ito & Yoshiro Wada

Authors
  1. Albert H Van Gennip
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  2. Henk Van Lenthe
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  3. Tetsuya Ito
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  4. Albert H. Bootsma
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  5. Arno C. Van Cruchten
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  6. Yoshiro Wada
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  7. Andre B.P. Van Kuilenburg
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Editor information

Editors and Affiliations

  1. Tel-Aviv University, Tel-Aviv, Israel

    Esther Zoref-Shani  & Oded Sperling  & 

  2. Rabin Medical Center, Petah-Tikva, Israel

    Oded Sperling

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© 2002 Kluwer Academic Publishers

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Van Gennip, A.H. et al. (2002). HPLC/ESI Tandem-MS of Liquid Urine or Urine Soaked Filter-Paper Strips for the Detection of Thymine-Uraciluria and Dihydropyrimidinuria. In: Zoref-Shani, E., Sperling, O. (eds) Purine and Pyrimidine Metabolism in Man X. Advances in Experimental Medicine and Biology, vol 486. Springer, Boston, MA. https://doi.org/10.1007/0-306-46843-3_72

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  • DOI: https://doi.org/10.1007/0-306-46843-3_72

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46515-4

  • Online ISBN: 978-0-306-46843-8

  • eBook Packages: Springer Book Archive

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