Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Referencess
De Abreu R. Nucleotides metabolism: mode of action of thiopurines in leukemia. In: Sahota A. and Taylor M. eds, Purine and pyrimidine metabolism in man VIII, Plenum press, 1995: 195–200.
Weinshilboum RM., Sladeck SL. Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocytes thiopurine methyl transferase activity. Am. J. Hum. Gen. 1980; 32: 651.
Anstey A., Lennard L., Mayou SC. Kirby JD. Pancytopenia related to azathioprine — an enzyme deficiency caused by a common genetic polymorphism: a review. J. Royal Soc. Med., 1992; 85: 752–7.
Schütz E., Gummert J., Mohr FM., Armstrong VW., Oellerich M.: Azathioprine pharmacogenetics: The relationship between 6-thioguanine nucleotides and thiopurine methyl transferase in patients after heat and kidney transplantation. Eur. J. Clin. Chem. Clin. Biochem., 1996; 34: 199–205.
Lilleyman JS., Lennard L. Mercaptopurine metabolism and risk of relapse in chilhood lymphoblastic leukemia. Lancet, 1994; 343: 188–190.
Chan G, Erdman G., Gruber S., Matas A., Canafax D. Azathioprine metabolism: Pharmacokinetics of 6-mercaptopurine, 6-thiouric acid and 6-thioguanine nucléotides in renal transplant patients. J. Clin. Pharmacol. 1990; 30: 358–363.
Boulieu R., Lenoir A., Mornex JF., Bertocchi M. Intracellular thiopurine nucleotides and azathioprine myelotoxicity in organ transplant patients. Br. J. Clin. Pharmacol., 1997; 43: 116–118.
Serre de Beauvais F., Bayle F., Bosson JL., Vialtel P., Bessard G.: Thiopurine methyltransferase activity: influence on azathioprine therapy in renal transplantation, Fund. Clin. Pharmacol., 1994; 10: 94.
Mircheva J., Legendre C., Soria Royer C., Thervet E., Beaune P., Kreis H. Monitoring of azathioprine-induced immunosuppression with thiopurine methyl transferase activity in kidney transplant recipients. Transplantation, 1995; 60: 639–642.
Chocair P., Duley J., Simmonds H., Cameron J. The importance of thiopurine methyltransferase activity for the use of azathioprine in transplant recipient. Transplantation, 1992; 53: 1051–1056
Dervieux T., Boulieu R. Stimultaneous determination of 6-thioguanine and methyl 6-mercaptopurine nucleotides of azathioprine in red blood cells by HPLC. Clin. Chem. 1998; 44: 551–555.
Dervieux T., Boulieu R. Identification of methyl 6-mercaptopurine derivative formed during acid hydrolysis of 6-thiopurine nucleotides using LC-MS, RMN and infrared spectrometry. Clin. Chem. in press.
Rowland K., Lennard L, Lilleyman JS. High performance liquid chromatographic assay of methylthioguanine nucleotide. J. Chromatogr., 1998; 705: 29–37.
Bergan S., Bentdal O;, Sodal G., Brun A., Rugstad H., Stokke O. Patterns of azathioprine metabolism in neutrophils, reticulocytes and erythrocytes: relevance to toxicity and monitoring in recipient of renal allograft. Ther. Drug Monit. 1997; 19: 502–503.
Lennard L., Welch JC, Lilleyman JF. Thiopurine drugs in the treatment of childhood leukemia: the influence of inherited thiopurine methyltransferase activity on drug metabolism and cytotoxicity. Br. J. Clin. Pharmacol., 1997; 44: 455–461.
Erb N., Harms H., Janka-Schaub G. Pharmacokinetics and metabolism of thiopurines in children with acute lymphoblastic leukemia receiving 6-thioguanine versus 6-mercaptopurine. Cancer Chemother. Pharmacol. 1998; 42: 266–272.
Brandt Andersen J., Szumlanski C., Weinshilboum RM, Schmiegelow K. Pharmacokinetics, dose adjustments and 6-mercaptopurine/methotrexate drug interactions in two patients with thiopurine methyltransferase deficiency. Acta Paediatr., 1998; 87: 108–111.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Kluwer Academic Publishers
About this chapter
Cite this chapter
Boulieu, R., Dervieux, T., Gallant, I., Sauviat, M., Bertochhi, M., Mornex, JF. (2002). Methylated and Non Methylated Thiopurine Nucleotide Ratio (ME6-MPN/6-TGN): Usefulness in the Monitoring of Azathioprine Therapy?. In: Zoref-Shani, E., Sperling, O. (eds) Purine and Pyrimidine Metabolism in Man X. Advances in Experimental Medicine and Biology, vol 486. Springer, Boston, MA. https://doi.org/10.1007/0-306-46843-3_69
Download citation
DOI: https://doi.org/10.1007/0-306-46843-3_69
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-306-46515-4
Online ISBN: 978-0-306-46843-8
eBook Packages: Springer Book Archive