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Thiopurine Methyl Transferase: Activity and Genotyping in Patients with Acute Lymphoblastic Leukemia

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Purine and Pyrimidine Metabolism in Man X

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 486))

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References

  1. M.H. Vogt, E.H. Stet, R.A. De Abreu, J.P. Bokkerink, L.H. Lambooy, and F.J. Trijbels, The importance of methylthio-IMP for methylmercaptopurine ribonucleoside (Me-MPR) cytotoxicity in Molt F4 human malignant T-lymphoblasts, Biochim. Biophys. Acta 1181:189–194 (1993).

    CAS  PubMed  Google Scholar 

  2. R.M. Weinshilboum and S.L. Sladek, Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity, Am. J. Hum. Genet. 32:651–662 (1980).

    CAS  PubMed  Google Scholar 

  3. H.L. McLeod, J.S. Lin, E.P. Scott, C H. Pui, and W.E. Evans, Thiopurine methyltransferase activity in American white subjects and black subjects, Clin Pharmacol Ther. 55:15–20 (1994).

    CAS  PubMed  Google Scholar 

  4. Otterness, C. Szumlanski, L. Lennard, B. Klemetsdal, J. Aarbakke, J.O. Park-Hah, H. Iven, K. Schmiegelow, E. Branum, J. O’Brien, and R. Weinshilboum, Human thiopurine methyltransferase pharmacogenetics: gene sequence polymorphisms, Clin Pharmacol Ther. 62:60–73 (1997).

    Article  CAS  PubMed  Google Scholar 

  5. H.L. McLeod, S. Coulthard, A.E. Thomas, S.C. Pritchard, D.J. King, S.M. Richards, O.B. Eden, A.G. Hall, and B.E. Gibson, Analysis of thiopurine methyltransferase variant alleles in childhood acute lymphoblastic leukaemia, Br. J Haematol. 105:696–700 (1999).

    Article  CAS  PubMed  Google Scholar 

  6. L. Lennard, J.A. Van Loon, and R.M. Weinshilboum, Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphism, Clin Pharmacol Ther. 46: 149–154 (1989).

    CAS  PubMed  Google Scholar 

  7. H.L. McLeod, M.V. Relling, Q. Liu, C.H. Pui, and W.E. Evans, Polymorphic thiopurine methyltransferase in erythrocytes is indicative of activity in leukemic blasts from children with acute lymphoblastic leukemia, Blood 85: 1897–1902 (1995).

    CAS  PubMed  Google Scholar 

  8. C. W. Keuzenkamp-Jansen, P.A. Leegwater, R.A. De Abreu, M.A. Lambooy, J.P. Bokkerink, and J.M. Trijbels, Thiopurine methyltransferase: a review and a clinical pilot study, J. Chromatogr. B. Biomed. Appl. 678: 15–22 (1996).

    CAS  PubMed  Google Scholar 

  9. C.R. Yates, E.Y. Krynetski, T. Loennechen, M.Y. Fessing, H.L. Tai, C.H. Pui, M.V. Relling, and W.E. Evans, Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance [see comments], Ann Intern. Med 126:608–614 (1997).

    CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Center for Pediatric Oncology S.E. Netherlands, University Medical Center St Radboud, Department of Pediatrics, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands

    C. Brouwer, J. J. Keizer-Garritsen, K. Ament, P. G. J. H. Ter Riet, R. A. De Abreu, J. P. M. Bökkerink & J. P. M. F. Trijbels

  2. Dutch Childhood Leukemia Study Group, P.O.Box 43515, 2504 AM, Den Haag, The Netherlands

    J. P. M. Bökkerink, E. R. Van Wering, A. Van Der Does-Van Den Berg & A. J. P. Veerman

Authors
  1. C. Brouwer
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  2. J. J. Keizer-Garritsen
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  3. L. H. J. Lambooy
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  4. K. Ament
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  5. P. G. J. H. Ter Riet
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  6. R. A. De Abreu
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  7. J. P. M. Bökkerink
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  8. E. R. Van Wering
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  9. A. Van Der Does-Van Den Berg
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  10. A. J. P. Veerman
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  11. J. P. M. F. Trijbels
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Editor information

Editors and Affiliations

  1. Tel-Aviv University, Tel-Aviv, Israel

    Esther Zoref-Shani  & Oded Sperling  & 

  2. Rabin Medical Center, Petah-Tikva, Israel

    Oded Sperling

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© 2002 Kluwer Academic Publishers

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Brouwer, C. et al. (2002). Thiopurine Methyl Transferase: Activity and Genotyping in Patients with Acute Lymphoblastic Leukemia. In: Zoref-Shani, E., Sperling, O. (eds) Purine and Pyrimidine Metabolism in Man X. Advances in Experimental Medicine and Biology, vol 486. Springer, Boston, MA. https://doi.org/10.1007/0-306-46843-3_63

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  • DOI: https://doi.org/10.1007/0-306-46843-3_63

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46515-4

  • Online ISBN: 978-0-306-46843-8

  • eBook Packages: Springer Book Archive

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