Conclusion
This study described the potential of a new class of ATP analogues as NTPDase inhibitors. From previous studies, 8-BuS-ATP appears to be a specific and efficient NTPDase inhibitor.10–11 This novel inhibitor is a new tool to regulate NTPDase activity and thereby influencing purine signalling in mammalian.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Beaudoin, A.R., Sévigny, J. and Picher, M. In: Biomembrane, vol. 5; Lee A.G. Ed., Greenwich, CT: JAI, pp. 369–401, 1996.
Beaudoin, A.R. et al. Proceeding of the 2nd International Workshop on ecto-ATPase and related nucleotidases. Diepenbeek, Belgium, 14–18 June 1999. Vanduffel L., and Lemmens R., Eds. Shaker Publishing B.V., The Netherlands; pp. 125–135
Zimmermann, H. et al. Proceeding of the 2nd International Workshop on ecto-ATPase and related nucleotidases. Diepenbeek, Belgium, 14–18 June 1999. Vanduffel L., and Lemmens R., Eds. Shaker Publishing B.V., The Netherlands; pp. 1–8
Vlajkovic, S.M. et al. Neuroreport 9: 1559–1565, 1998.
Vlajkovic, S.M. et al. Mol. Brain Res. 73: 85–92, 1999.
Ziganshin, A.U.; Hoyle, C.H.V.; Burnstock, G. Drug. Dev. Res. 32: 134–146, 1994.
Picher, M. et al. Biochem. Pharmacol. 51: 1453–1460, 1996.
Bültmann, R. et al. Naunyn-Schmiedeberg’s Arch. Pharmacol. 354: 498–504, 1996.
Crack, B.E. et al. Br. J. Pharmacol. 273: 24814–24821, 1994.
Gendron et al. J. Med. Chem. 43: 2239–2247, 2000
Halbfinger, E. et al. J. Med. Chem. 42: 5325–5337, 1999.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Kluwer Academic Publishers
About this chapter
Cite this chapter
Gendron, F., Halbfinger, E., Fischer, B., Beaudoin, A. (2002). Inhibitors of NTPDase: Key Players in the Metabolism of Extracellular Purines. In: Zoref-Shani, E., Sperling, O. (eds) Purine and Pyrimidine Metabolism in Man X. Advances in Experimental Medicine and Biology, vol 486. Springer, Boston, MA. https://doi.org/10.1007/0-306-46843-3_24
Download citation
DOI: https://doi.org/10.1007/0-306-46843-3_24
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-306-46515-4
Online ISBN: 978-0-306-46843-8
eBook Packages: Springer Book Archive