Skip to main content

Synthetic Peptide and Their Polymers as Vaccomes

Synthetic Peptide Polymers as the Next Generation of Vaccines

  • Chapter
  • 272 Accesses

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ionescu-Matiu, I., Kennedy, R. C., Sparrow, J. T., et al., 1983, Epitopes associated with a synthetic hepatitis B surface antigen peptide. J Immunol 130: 1947–52.

    PubMed  CAS  Google Scholar 

  2. Relf, W. A., Cooper, J., Brandt, E. R., et al., 1996, Mapping a conserved conformational epitope from the M protein of group A streptococci. Pept Res 9: 12–20.

    PubMed  CAS  Google Scholar 

  3. Mutter, M., Tuchscherer, G. G., Miller, C., et al., 1992, Template-assembled synthetic proteins with four-helix-bundle topology. J. Am. Chem. Soc. 114: 1463–1470.

    Article  CAS  Google Scholar 

  4. Sutcliffe, J. G., Shinnick, T. M., Green, N., Liu, F. T., Niman, H. L., Lerner, R. A., 1980, Chemical synthesis of a polypeptide predicted from nucleotide sequence allows detection of a new retroviral gene product. Nature 287: 801–5.

    Article  PubMed  CAS  ISI  Google Scholar 

  5. Talwar, G. P., Sharma, N. C., Dubey, S. K.., et al., 1976, Isoimmunization against human chorionic gonadotropin with conjugates of processed beta-subunit of the hormone and tetanus toxoid. Proc Natl Acad Sci U S A 73: 218–22.

    PubMed  CAS  Google Scholar 

  6. Fraser, H. M., Gunn, A., Jeffcoate, S. L., Holland, D. T., 1974, Effect of active immunization to luteinizing hormone releasing hormone on serum and pituitary gonadotrophins, testes and accessory sex organs in the male rat. J Endocrinol 63: 399–406.

    Article  PubMed  CAS  Google Scholar 

  7. Briand, J. P., Muller, S., Van Regonmortel, M. H. V., 1985, Synthetic peptides as antigens: pitfalls of conjugation methods. J. Immunol. Meth 78: 59.

    Article  CAS  Google Scholar 

  8. Schutze, P. M., Leclerc, C., Jolivet, M., Audibert, F., Chedid, L., 1985, Carrier-induced epitopic suppression, a major issue for future synthetic vaccines. J Immunol 135: 2319–2322.

    PubMed  CAS  Google Scholar 

  9. Francis, M. J., Hastings, G. Z., Syred, A. D., McGinn, B., Brown, F., Rowlands, D. J., 1987, Non-responsiveness to a foot-and-mouth disease virus peptide overcome by addition of foreign helper T-cell determinants. Nature 330: 168–70.

    Article  PubMed  CAS  ISI  Google Scholar 

  10. Borras-Cuesta, F., Fedon, Y., Petit-Camurdan, A., 1988, Enhancement of peptide immunogenicity by linear polymerization. Eur J Immunol 18: 199–202.

    PubMed  CAS  Google Scholar 

  11. Dyrberg, T., Oldstone, M. B., 1986, Peptides as antigens. Importance of orientation. J Exp Med 164: 1344–9.

    Article  PubMed  CAS  Google Scholar 

  12. Etlinger, H. M., Knorr, R., 1991, Model using a peptide with carrier function for vaccination against different pathogens. Vaccine 9: 512–4.

    PubMed  CAS  ISI  Google Scholar 

  13. Ghosh, S., Jackson, D. C., 1999, Antigenic and immunogenic properties of totally synthetic peptide-based anti-fertility vaccines. Int Immunol 11: 1103–1110.

    Article  PubMed  CAS  Google Scholar 

  14. Fitzmaurice, C. J., Brown, L. E., McInerney, T. L., Jackson, D. C., 1996, The assembly and immunological properties of non-linear synthetic immunogens containing T-cell and B-cell determinants. Vaccine 14: 553–60.

    Article  PubMed  CAS  ISI  Google Scholar 

  15. Panina-Bordignon, P., Tan, A., Termijtelen, A., Demotz, S., Corradin, G., Lanzavecchia, A., 1989, Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells. Eur J Immunol 19: 2237–42.

    PubMed  CAS  Google Scholar 

  16. Sharma, P., Kumar, A., Batni, S., Chauhan, V. S., 1993, Co-dominant and reciprocal T-helper cell activity of epitopic sequences and formation of junctional B-cell determinants in synthetic T:B chimeric immunogens. Vaccine 11: 1321–6.

    Article  PubMed  CAS  ISI  Google Scholar 

  17. Tam, J. P., 1988, Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system. Proc Natl Acad Sci U S A 85: 5409–13.

    PubMed  CAS  Google Scholar 

  18. Hudecz, F., 1995, Design of synthetic branched-chain polypeptides as carriers for bioactive molecules. Anticancer Drugs 6: 171–93.

    PubMed  CAS  Google Scholar 

  19. Butz, S., Rawer, S., Rapp, W., Birsner, U., 1994, Immunization and affinity purification of antibodies using resin-immobilized lysine-branched synthetic peptides. Pept Res 7: 20–3.

    PubMed  CAS  Google Scholar 

  20. Jackson, D. C., Fitzmaurice, C. J., Sheppard, R. C., McMurray, J., Brown, L. E., 1995, The antigenic and immunogenic properties of synthetic peptide-based T-cell determinant polymers. Biomed Pep Prot and Nucl Acids 1: 171–176.

    CAS  Google Scholar 

  21. Brandt, E. R., Hayman, W. A., Currie, B., et al., 1996, Opsonic human antibodies from an endemic population specific for a conserved epitope on the M protein of group A streptococci. Immunology 89: 331–7.

    Article  PubMed  CAS  ISI  Google Scholar 

  22. Rose, K., 1994, Facile synthesis of homogeneous artificial proteins. J. Am. Chem. Soc. 116:30–33.

    Article  CAS  Google Scholar 

  23. Zeng, W., Rose, K.. and Jackson, D.C. Polyoximes: a flexible approach for producing homogeneous artificial proteins (1995). In: “Peptides 1994”, Proceedings of the Twenty-Third Peptide Symposium (September 4–10, 1994, Braga, Portugal). L.S. Maia, Ed. ESCOM, Leiden, The Netherlands 1995, pp 855–856.

    Google Scholar 

  24. Rose, K., Zeng, W., Brown, L. E., Jackson, D. C., 1995, A synthetic peptide-based polyoxime vaccine construct of high purity and activity. Mol Immunol 32: 1031–7.

    Article  PubMed  CAS  Google Scholar 

  25. Wilce, J. A., Zeng, W., Rose, K., Craik, D. J., Jackson, D. C., 1996, 1H NMR structural study of free and template-linked antigenic peptide representing the C-terminal region of the heavy chain of influenza virus hemagglutinin. Biomed Pept Proteins Nucleic Acids 2: 51–8.

    PubMed  CAS  Google Scholar 

  26. O’Brien-Simpson, N. M., Ede, N. J., Brown, L. E., Swan, J., Jackson, D. C., 1997, Polymerisation of unprotected synthetic peptides: a view towards synthetic peptide vaccines. J. Am. Chem. Soc. 119: 1183–1188.

    CAS  Google Scholar 

  27. Jackson, D. C., O’Brien-Simpson, N., Ede, N. J., Brown, L. E., 1997, Free radical induced polymerization of synthetic peptides into polymeric immunogens. Vaccine 15: 1697–705.

    Article  PubMed  CAS  ISI  Google Scholar 

  28. Wiesmuller, K. H., Bessler, W., Jung, G., 1983, Synthesis of themitogenic S-[2,3-bis(palmitoyloxy)propyl]-N-palmitoylpentapeptide from Escherichia coli lipoprotein. Hoppe Seylers Z Physiol Chem 364: 593–606.

    PubMed  CAS  Google Scholar 

  29. Zeng, W., Jackson, D.C., Murray, J., Rose, K., and Brown, L.E. 1999, Totally synthetic lipid containing polyoxime peptide constructs are potent immunogens Vaccine in press.

    Google Scholar 

  30. Nardelli, B., Haser, P. B., Tam, J. P., 1994, Oral administration of an antigenic synthetic lipopeptide (MAP-P3C) evokes salivary antibodies and systemic humoral and cellular responses. Vaccine 12: 1335–9.

    PubMed  CAS  ISI  Google Scholar 

  31. Deres, K., Schild, H., Wiesmuller, K. H., Jung, G., Rammensee, H. G., 1989, In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine. Nature 342: 561–4.

    Article  PubMed  CAS  ISI  Google Scholar 

  32. Melief, C. J., Offringa, R., Toes, R. E., and Kast, W. M. 1996, Peptide-based cancer vaccines. Curr Opin Immunol 8: 651–657.

    Article  PubMed  CAS  Google Scholar 

  33. Minev, B. R., Chavez, F. L., and Mitchell, M. S. 1998, New trends in the development of cancer vaccines. In Vivo 12: 629–638

    PubMed  CAS  ISI  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Kluwer Academic Publishers

About this chapter

Cite this chapter

Jackson, D. et al. (2002). Synthetic Peptide and Their Polymers as Vaccomes. In: Chiellini, E., Sunamoto, J., Migliaresi, C., Ottenbrite, R.M., Cohn, D. (eds) Biomedical Polymers and Polymer Therapeutics. Springer, Boston, MA. https://doi.org/10.1007/0-306-46842-5_23

Download citation

  • DOI: https://doi.org/10.1007/0-306-46842-5_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46472-0

  • Online ISBN: 978-0-306-46842-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics