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Molecular Design of Biodegradable Dextran Hydrogels for the Controlled Release of Proteins

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Biomedical Polymers and Polymer Therapeutics

Conclusion

A biodegradable and biocompatible dextran hydrogel system has been developed of which the degradation time can be tailored between 2 days and 3 months. This chapter shows that hydrogels based on crosslinked dextrans have unique properties as protein releasing matrices. Both the release pattern (first-order, zero-order or biphasic) as well as the duration of the release can be controlled by an appropriate selection of the characteristics and the geometry of the hydrogel.

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Author information

Authors and Affiliations

  1. Faculty of Pharmacy, Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), University of Utrecht, P.O. Box 80 082, 3508 TB, Utrecht, The Netherlands

    W.E. Hennink, J.A. Cadée, S.J. de Jong, O. Franssen, R.J.H. Stenekes, H. Talsma & W.N.E. van Dijk-Wolthuis

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  1. W.E. Hennink
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  2. J.A. Cadée
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  3. S.J. de Jong
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  4. O. Franssen
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  5. R.J.H. Stenekes
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  6. H. Talsma
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  7. W.N.E. van Dijk-Wolthuis
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Editor information

Editors and Affiliations

  1. University of Pisa, Pisa, Italy

    Emo Chiellini

  2. Niihama National College of Technology, Niihama, Japan

    Junzo Sunamoto

  3. University of Trento, Trento, Italy

    Claudio Migliaresi

  4. Virginia Commonwealth University, Richmond, Virginia

    Raphael M. Ottenbrite

  5. The Hebrew University of Jerusalem, Jerusalem, Israel

    Daniel Cohn

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© 2002 Kluwer Academic Publishers

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Hennink, W. et al. (2002). Molecular Design of Biodegradable Dextran Hydrogels for the Controlled Release of Proteins. In: Chiellini, E., Sunamoto, J., Migliaresi, C., Ottenbrite, R.M., Cohn, D. (eds) Biomedical Polymers and Polymer Therapeutics. Springer, Boston, MA. https://doi.org/10.1007/0-306-46842-5_1

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  • DOI: https://doi.org/10.1007/0-306-46842-5_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46472-0

  • Online ISBN: 978-0-306-46842-1

  • eBook Packages: Springer Book Archive

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