Conclusion
The E. coli HPI consists of a well vonserved core part, encoding for the yersiniabactin siderophore system (irp/fyuA genes)and for the P4-like integrase (int gene). We could demonstrate that genes as fyuA or irpl and irp2 encoded by the HPI are expressed in E. coli. Moreover, HPI positive E. coli strains were shown to produce the siderophore yersinibactin, indicating the functional integrity of the HPI core in E. coli. Further studies are required to define the impact of the E. coli HPI on virulence and/or fitness.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Hacker, J., Blum Oehler, G., Muhldorfer, I., Tschape, H., 1997, Pathogenicity islands of virulent bacteria: structure, function and impact on microbial evolution. Mol. Microbiol. 23: 1089–1097.
Rakin, A., Noelting, C., Schubert, S., Heesemann, J., 1999, Common and specific characteristics of the high-pathogenicity island of Yersinia enterocolitica. Infect. Immun. 67: 5265–5274.
Schubert, S., Rakin, A., Karch, H., Carniel, E., Heesemann, J., 1998, Prevalence of the "high-pathogenicity island" of Yersinia species among Escherichia coli strains that are pathogenic to humans. Infect. Immun. 66: 480–485
Schubert, S., Rakin, A., Fischer, D., Sorsa, J., Heesemann, J., 1999, Characterization of the integration site of Yersinia high-pathogenicity island in Escherichia coli. FEMS Microbiol. Lett. 179: 409–414.
Pelludat, C., Rakin, A., Jacobi, C.A., Schubert, S., Heesemann, J., 1998, The yersiniabactin biosynthetic gene cluster of Yersinia enterocolitica: organization and siderophore-dependent regulation. J. Bacteriol. 180: 538–546.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Kluwer Academic Publishers
About this chapter
Cite this chapter
Schubert, S., Sorsa, J.L., Cuenca, S., Fischer, D., Jacobi, C.A., Heesemann, J. (2002). HPI of High-Virulent Yersinia is Found in E. coli Strains Causing Urinary Tract Infection. In: Emoődy, L., Pál, T., Hacker, J., Blum-Oehler, G. (eds) Genes and Proteins Underlying Microbial Urinary Tract Virulence. Advances in Experimental Medicine and Biology, vol 485. Springer, Boston, MA. https://doi.org/10.1007/0-306-46840-9_9
Download citation
DOI: https://doi.org/10.1007/0-306-46840-9_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-306-46455-3
Online ISBN: 978-0-306-46840-7
eBook Packages: Springer Book Archive