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Interrelationship Between Virulence Properties of Uropathogenic E. coli and Blood Group Phenotype of Patients with Chronic Urinary Tract Infection

  • Chapter
Genes and Proteins Underlying Microbial Urinary Tract Virulence

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 485))

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Conclusion

The ABO-and Lewis-antigens located at the cells of the epithelial boundary layer of the human organism represent a natural protective mechanism against the invasive efforts of pathogens. However, antigen structures on the uroepithelial cells, such as the glycosphingo-lipids of the P- blood group system, serve as receptors for adhesion. In dependence on this situation, microorganisms are able to express virulence factors at different degrees.

In 53 patients, ABO-, P1-and Lewis-blood group phenotypes as well as the secretor status were investigated in terms of virulence properties of E. coli strains and the degree of bacterial adherence to uroepithelial cells. Pathogenicity was determined in 144 E. coli strains over three years. Patients with PI-antigens (n = 40/76%)had fewer microorganisms with the ability to produce hemolysin and mannose-resistant hemagglutination than persons without P-antigen. This difference was statistically significant (p = 0.05)and greater in patients with blood group B (n = 13/23%), especially in B- secretors (n =9/16%;p <0.0005). E coli strains with K 1-antigen were significantly more often found in patients with Lewis(a+).

The phenotypic expression of virulence properties of E. coli is very likely to be determined by host-specific factors, such as the antigens P1 and B as well as the Lewis-blood group phenotype.

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Authors and Affiliations

  1. Department of Internal Medicine IVFriedrich-Schiller, University of Jena, D-07740, Jena, Erlanger Allee 101, Germany

    Reinhard Fünfstück, Niels Jacobsohn & Günter Stein

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  1. University of Pécs, Pécs, Hungary

    Levente Emoődy  & Tibor Pál  & 

  2. University of Würzburg, Würzburg, Germany

    Jörg Hacker  & Gabriele Blum-Oehler  & 

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© 2002 Kluwer Academic Publishers

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Fünfstück, R., Jacobsohn, N., Stein, G. (2002). Interrelationship Between Virulence Properties of Uropathogenic E. coli and Blood Group Phenotype of Patients with Chronic Urinary Tract Infection. In: Emoődy, L., Pál, T., Hacker, J., Blum-Oehler, G. (eds) Genes and Proteins Underlying Microbial Urinary Tract Virulence. Advances in Experimental Medicine and Biology, vol 485. Springer, Boston, MA. https://doi.org/10.1007/0-306-46840-9_27

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  • DOI: https://doi.org/10.1007/0-306-46840-9_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46455-3

  • Online ISBN: 978-0-306-46840-7

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