Conclusions
The common occurrence of ECM-binding proteins in enteric bacteria supports the notion that ECM-adherence has an ecological and/or pathogenetic role in the life style of enteric pathogens. Indeed, we have few cases where the ECM-adherence has been shown to take place in vivo and on the other hand to potentiate bacterial virulence and spread within the host. Enterobacterial adhesion to ECM also is involved in bacterial invasion into epithelial cells, and it is likely that new functions will be detected as the ECM-binding proteins are better characterized. It is notable that enterobacterial adhesins appear to be multifunctional:they express multiple adhesive characteristics or have nonadhesive functions as well, such as proteolytic activity. An intriguing possibility is the role of ECM-adherence in bacterial metastasis across BMs. Many of the enterobacterial ECM- binding proteins also function as plasminogen receptors (fimbriae)or plasminogen activators (Pla)and enhance conversion of plasminogen into active plasmin that can be targeted at BM through bacterial adherence. This has been demonstrated in vitro to potentiate bacterial penetration through reconstituted BM14,25, but the in vivo evidence is lacking. These findings, however, give evidence for a multifunctional nature of enterobacterial adhesion proteins.
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Korhonen, T.K. (2002). Adherence of Enteric Bacteria Onto the Mammalian Extracellular Matrix. In: Emoődy, L., Pál, T., Hacker, J., Blum-Oehler, G. (eds) Genes and Proteins Underlying Microbial Urinary Tract Virulence. Advances in Experimental Medicine and Biology, vol 485. Springer, Boston, MA. https://doi.org/10.1007/0-306-46840-9_26
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