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Role of Bacterial Lectins in Urinary Tract Infections

Molecular Mechanisms for Diversification of Bacterial Surface Lectins

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Genes and Proteins Underlying Microbial Urinary Tract Virulence

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 485))

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References

  1. Ofek, I., Mirelman, D., and Sharon, N., 1977, Adherence of Escherichia coli to human mucosal cells mediated by mannose receptors. Nature 265: 623–625.

    Article  PubMed  CAS  Google Scholar 

  2. Ofek, I. and R. J. Doyle, 1994, Bacterial Adhesion to Cells and Tissues, Chapman & Hall, New York, NY.

    Google Scholar 

  3. Wentworth, J. S., F. E. Austin, N. Barger, N. Gilboa-Garber, C. A. Paterson, and R. J. Doyle, 1991, Cytoplasmic lectins contribute to the adhesion of Pseudomonas aeruginosa. Biofouling 4: 99–104.

    Article  CAS  Google Scholar 

  4. Yu, C., A. M. Lee, and S. Roseman, 1987, The sugar-specific adhesion/deadhesion apparatus of the marine bacterium Vibrio furnissi is a sensorium that continuously monitors nutriend levels in the environment. Biochem. Biophys. Res. Commun. 149: 86–92.

    Article  PubMed  CAS  Google Scholar 

  5. Rosenberg, E., Y. Ben-Haim, A. Toren, E. Banim, A. Kushmaro, M. Fine, and Y. Loya, 1999, Effects of temperature on bacterial bleaching of corals. In. Microbial Ecology and Infectious Diseases (E. Rosenberg, ed). ASM Press, Washington D.C. pp242–254.

    Google Scholar 

  6. Strömberg, N., P. G. Nyholm, I. Pascher, and S. Normark, 1991, Saccharide orientation at the cell surface affects glycolipid receptor function. Proc. Natl. Acad. Sci. USA 88: 9340–9344.

    PubMed  Google Scholar 

  7. Ofek, I. and N. Sharon, 1990, Adhesins as lectins: Specificity and role in infection. In Bacterial Capsules and Adhesins: Facts and Principles. Current Topics in Microbiology and Immunology. (K. Jann and B. Jann, eds.), Springer-Verlag, Berlin Heideberg, Vol. 151, 91–113.

    Google Scholar 

  8. Hasty, D.L. and E.V. Sokurenko, 2000, FimH, an adaptable adhesin. In Glycomicrobiology. (R. J. Doyle, ed.), Plenum Press, Inc. London. In press.

    Google Scholar 

  9. Hultgren, S. J., F. Lindberg, G. Magnusson, J. Kihlberg, J. M. Tennant and S. Normark, 1989, The PapG adhesin of uropathogenic Escherichia coli contains separate regions for receptor binding and for the incorporation into the pilus. Proc. Natl. Acad. Sci. USA 86: 4357–4361.

    PubMed  CAS  Google Scholar 

  10. Klemm, P., and Krogfeld, K.A., 1994, Type 1 fimbriae of Escherichia coli. In: Fimbriae, adhesion, genetics, biogenesis and vaccins.. P. Klemm, ed. pp. 9–26. CRC press, Boca Raton, Fla.

    Google Scholar 

  11. Choudhury, D., A. Thompson, V. Stojanoff, S. Langermann, J. Pinkner, S. J. Hultgren and S. D. Knight, 1999, X-ray structure of the FimC-FimH chaperone-adhesin complex from uropathogenic Escherichia coli. Science 285: 1061–1066.

    Article  PubMed  CAS  Google Scholar 

  12. Madison, B., I. Ofek, S. Clegg, and S. N. Abraham, 1994, The type 1 fimbrial shafts of Escherichia coli and Klebsiella pneumoniae influence the sugar specificity of their FimH adhesins. Infect. Immun. 62: 843–848.

    PubMed  CAS  Google Scholar 

  13. Thankavel, K., A. H. Shah, M. S. Cohen, T. Ikeda, R. G. Lorenz, R. Curtiss III, and S. N. Abraham, 1999, Molecular basis for the enterocyte tropism exhibited by Salmonella typhimurium type 1 fimbriae. J. Biol. Chem. 274: 5797–5809.

    Article  PubMed  CAS  Google Scholar 

  14. Sokurenko, E. V., V. Chesnokova, D. E. Dykhuizen, I. Ofek, X.-R. Wu, K. A. Krogfelt, C. Struve, M. A. Schembri and D. L. Hasty, 1998, Pathogenic adaptation of Escherichia coli by natural variation of the FimH adhesin. Proc. Natl. Acad. Sci. USA 95: 8922–8926.

    Article  PubMed  CAS  Google Scholar 

  15. Sokurenko, E. V., D. L. Hasty and D. E. Dykhuizen, 1999, Pathoadaptive mutations: gene loss and variation in bacterial pathogens. Trends Microbiol. 7: 191–195.

    PubMed  CAS  Google Scholar 

  16. Firon, N., I. Ofek and N. Sharon, 1983, Carbohydrate specificity ofthe surface lectins of Escherichia coli, Klebsiella pneumoniae, and Salmonella typhimurium. Carbohydr. Res. 120: 235–249.

    Article  PubMed  CAS  Google Scholar 

  17. Sokurenko, E.V., H.S. Courtney, D. E. Ohman, P. Klemm, and D. L. Hasty, 1994, FimH family of type 1 fimbrial adhesins: Functional heterogeneity due to minor sequence variations among fimH genes. J. Bact. 176: 748–755.

    PubMed  CAS  Google Scholar 

  18. Sokurenko, E.V., H. S. Courtney, J. Maslow, A. Siitonen, and D. L. Hasty, 1995, Quantitative differences in adhesiveness of type 1 fimbriated Escherichia coli due to structural differences in fimH genes. J. Bact. 177: 3680–3686.

    PubMed  CAS  Google Scholar 

  19. Sokurenko, E. V., V. Chesnokova, R. J. Doyle and D. L. Hasty, 1997, Diversity of the Escherichia coli type 1 fimbrial lectin. Differential binding to mannosides and uroepithelial cells. J. Biol. Chem. 272: 17880–17886.

    Article  PubMed  CAS  Google Scholar 

  20. Duguid, J.P., and Old, D.C., 1980, Adhesive properties of Enterobacteriaceae In Bacterial adherence (Receptors and recogition). (E.H. Beachey, ed.). Chapman and Hall, London, pp. 187–217

    Google Scholar 

  21. Ofek I., J. Goldhar, Y. Eshdat, and N. Sharon, 1982, The importance of mannose specific adhesins (lectins) in infections caused by Escherichia coli Scand. J. Infect. Dis. Suppl. 33: 61–67.

    PubMed  CAS  Google Scholar 

  22. Strömberg, N., B.-I. Marklund, B. Lund, D. Ilver, A. Hamers, W. Gaastra, K.-A. Karlsson, and S. Normark, 1990, Host-specificity of uropathogenic Escherichia coli depends on differences in binding specificity to Gal_1-4Gal-containing isoreceptors, EMBO J. 9: 2001–2010

    PubMed  Google Scholar 

  23. Sokurenko, E. V., H. S. Courtney, S. N. Abraham, P. Klemm, and D. L. Hasty, 1992, Functional heterogeneity of type 1 fimbriae of Escherichia coli, Infect. Immun. 60: 4709–4719.

    PubMed  CAS  Google Scholar 

  24. Pouttu, R., T. Puustinen, R. Virkola, J. Hacker, P. Klemm, and T. K. Korhonen, 1999, Amino acid residue Ala-62 in the FimH fimbrial adhesin is critical for the adhesiveness of meningitis-associated Escherichia coli to collagens. Mol. Microbial. 31: 1747–1757.

    Article  CAS  Google Scholar 

  25. Barondes, S. H., 1988, Bifunctional properties of lectins: lectins redefined, Trends Biochem. Sci. 13: 480–482.

    Article  PubMed  CAS  Google Scholar 

  26. Kaur KJ, Khurana S, Salunke DM. 1997. Topological analysis of the functional mimicry between a peptide and a carbohydrate moiety. J. Biol. Chem. 272: 5539–5543

    PubMed  CAS  Google Scholar 

  27. Varki, A., 1993, Biological roles of oligosaccharides: all of the theories are correct. Glycobiology 3: 97–130.

    PubMed  CAS  Google Scholar 

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Ofek, I., Hasty, D.L., Abraham, S.N., Sharon, N. (2002). Role of Bacterial Lectins in Urinary Tract Infections. In: Emoődy, L., Pál, T., Hacker, J., Blum-Oehler, G. (eds) Genes and Proteins Underlying Microbial Urinary Tract Virulence. Advances in Experimental Medicine and Biology, vol 485. Springer, Boston, MA. https://doi.org/10.1007/0-306-46840-9_25

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  • DOI: https://doi.org/10.1007/0-306-46840-9_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46455-3

  • Online ISBN: 978-0-306-46840-7

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