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Taurine 4 pp 431–440Cite as

Regulation of High Affinity Taurine Transport in Goldfish and Rat Retinal Cells

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 483))

Abstract

Adaptive regulation and modulation by phosphorylation are mechanisms by which some cells control taurine transport. Goldfish and rat retinal cells were incubated with the activator of protein kinase C, phorbol 12,13-dibutyrate (PDBu), or the inhibitor of protein phosphatases, okadaic acid (OKA). OKA, 1 nM, inhibited the uptake of taurine at short period of incubation in goldfish retinal cells, and at low concentrations in rat retinal cells incubated with the inhibitor for 1 h. PDBu treatment did not produce significant effects. Isolated Muller cells from the goldfish retina presented a clear adaptive regulation and a decrease of taurine uptake by increasing phosphorylation either by the stimulation of PKC with PDBu or the inhibition of phosphatases with OKA.

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Author information

Authors and Affiliations

  1. Laboratorio de Neuroquimica, Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones Cientificas (IVIC), Apdo. 21827, Caracas, 1020-A, Venezuela

    L. Lima, S. Cubillos & A. Guerra

Authors
  1. L. Lima
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  2. S. Cubillos
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  3. A. Guerra
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Editor information

Editors and Affiliations

  1. University of Florence, Florence, Italy

    Laura Della Corte

  2. University of Arizona College of Medicine, Tucson, Arizona

    Ryan J. Huxtable

  3. University of Siena, Siena, Italy

    Giampietro Sgaragli

  4. Trinity College, Dublin, Ireland

    Keith F. Tipton

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© 2002 Kluwer Academic Publishers

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Lima, L., Cubillos, S., Guerra, A. (2002). Regulation of High Affinity Taurine Transport in Goldfish and Rat Retinal Cells. In: Della Corte, L., Huxtable, R.J., Sgaragli, G., Tipton, K.F. (eds) Taurine 4. Advances in Experimental Medicine and Biology, vol 483. Springer, Boston, MA. https://doi.org/10.1007/0-306-46838-7_48

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  • DOI: https://doi.org/10.1007/0-306-46838-7_48

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46447-8

  • Online ISBN: 978-0-306-46838-4

  • eBook Packages: Springer Book Archive

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