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Taurine 4 pp 321–324Cite as

Taurine Transport Mechanism Through the Bloos-Brain Barrier in Spontaneously Hypertensive Rats

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 483))

Abstract

Taurine levels in the brain decrease when an animal is subjected to pathological conditions, such as ischemia-anoxia and seizure, but they tend to increase in hypertension. The present study investigated the blood-brain barrier (BBB) transport of [3H]-labelled taurine in spontaneously hypertensive rats (SHR) using internal artery carotid perfusion (ICAP) at a rate of 4 ml/min for 10, 15 and 30 seconds. The volume of distribution in brain (VD) and the permeability surface area product (PS) of [3H]-taurine through the BBB in SHR were calculated. The PS value for taurine at 15 s was higher than at the longer perfusion times. This could result from taurine efflux back into blood occurring after 15 s. As in the case of normotensive rats, taurine was shown to enter the brain via the sodium and chloride ion dependent carrier system.

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Author information

Authors and Affiliations

  1. College of Pharmacy, Sookmyung Women’s University, Seoul, Korea

    Young-Sook Kang

Authors
  1. Young-Sook Kang
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Editors and Affiliations

  1. University of Florence, Florence, Italy

    Laura Della Corte

  2. University of Arizona College of Medicine, Tucson, Arizona

    Ryan J. Huxtable

  3. University of Siena, Siena, Italy

    Giampietro Sgaragli

  4. Trinity College, Dublin, Ireland

    Keith F. Tipton

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© 2002 Kluwer Academic Publishers

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Kang, YS. (2002). Taurine Transport Mechanism Through the Bloos-Brain Barrier in Spontaneously Hypertensive Rats. In: Della Corte, L., Huxtable, R.J., Sgaragli, G., Tipton, K.F. (eds) Taurine 4. Advances in Experimental Medicine and Biology, vol 483. Springer, Boston, MA. https://doi.org/10.1007/0-306-46838-7_36

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  • DOI: https://doi.org/10.1007/0-306-46838-7_36

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46447-8

  • Online ISBN: 978-0-306-46838-4

  • eBook Packages: Springer Book Archive

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