Abstract
Malondialdehyde (MDA) as an indicator of lipid peroxidation (LPO), content and composition of phospholipids (PL) were analyzed in synaptosomes of the rat brain hemispheres using immobilization stress without and with pretreatment with a new synthetic taurine derivative (STD). The stress was accompanied by a decrease MDA content, inversion of the initial asymmetry of total phospholipids (TPL) and modification PL composition in the brain hemispheres of rats. STD administration to the rats after stress antagonized the decrease of the MDA level, attenuates stress induced inversion TPL asymmetry and normalized PL composition in the brain hemispheres. Prevention or diminution of synaptosomal PL changes in the rat brain hemispheres are interpreted as one of the possible mechanisms of the neuroprotective effect of STD.
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References
Vartanian G.A., Klement'ev B.I., 1991, The Chemical Symmetry and Asymmetry of the Brain. “Nauka”, St.-Petersburg.
Bragina N.N., Dobrokhotova T.A., 1981, Functional asymmetry of the human brain, Moscow, “Medizine”.
Springer S.P., Deutsch G. 1983, Left Brain, Right Brain. University of New York.
Opitz B., Sarkisova K. Yu. 1996, Interhemisphere asymmetry of cerebral lipidperoxidation in rats with various types of behavior as a prognostic indicator of their resistance to cerebral ischemia and effectiveness of the anti-ischemic action of substance P. DAN. 346: 275–277.
Levshina I.P., Guliava N.V. 1991, Effects of acute stress on lateralitation of lipid peroxidation in the brain depend on the behavioral typology of rats. Biul-Eksp-Biol-Med. 111: 568–570.
Ginobili de Martinez M.S., Rodriguez de Turco E.B. and Barrantes F.J. 1986, Asymmetry of diacylglycerol metabolism in rat cerebral hemispheres. J. Neurochem. 46: 1382–1386
Folch J., Lees M., Sloane-Stanly G.H. 1957, A simple method for the isolation and purification of total lipids from animal tissues. J. Biol.Chem. 226: 497–509.
Lapetina E.G., Soto E.F., De Robertis E. 1967, Gangliosides and acetylcholinesterase iisolated membranes of the rat brain cortex. Biochem. Biophys. Acta. 135: 33–43.
Vaskovsky V.E., Kostetsky E.V., Vasendin I.M. 1972, A simplified technique for thin-layer microchromatography of lipids J. Chromatograph. 2,67: 376–378.
Rouser G., Siakotos A.N., Fleisher S. 1966, Quantitative analysis of phospholipids by thin-layer chromatography and phophorus analysis of spots. Lipids., 1: 85–86
Vaskovsky V.E., Kostetsky E.V., Vasendin I.M. 1975, Universal reagent for phospholipid analysis. J. Chromatograph. 1,114: 29–141.
Vladimirov Y.A. Archakov A.I. 1972, Lipid peroxidation in biological membranes. Moscow:241–43.
Markwell M.A., Suzanne M.H., Bieber L.L. et al. 1978, A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. J. Analyt. Biochem. 87: 206–21 1.
Guliava N.V., Luzina N.L., Levshina I.P. and Kryzhanovskii G. N. 1988, The inhibition stage of lipid peroxidation during stress. Biul-Eksp-Biol-Med. 106,12: 660–3
Novoselova N. Yu., Moskvin A.N., Torkounov P.A., Sapronov N.S. and Demchenko I.T. 1999, Effect of hyperbaric oxygen on lipid peroxidation and phospholipid content in rat brain. Biul-Eksp-Biol-Med. 128,9: 261–3.
Bruyer R 1980, Differential implication of cerebral hemispheres in emotional behavior. Acta Phychiatr. Belg., 3: 266–84.
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Novoselova, N.Y., Sapronov, N.S., Fedotova, Y.0., Torkounov, P.A. (2002). The Effect of Taurine Derivative on Lipid Peroxidation and InterHemispheric Asymmetry of Phospholipids from the Brain Synaptosomes in Rats after Immobilization Stress. In: Della Corte, L., Huxtable, R.J., Sgaragli, G., Tipton, K.F. (eds) Taurine 4. Advances in Experimental Medicine and Biology, vol 483. Springer, Boston, MA. https://doi.org/10.1007/0-306-46838-7_35
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DOI: https://doi.org/10.1007/0-306-46838-7_35
Publisher Name: Springer, Boston, MA
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