Conclusion
Neurodegenerative diseases are characterized by a progressive loss of neurons but the underlying mechanisms are not well understood. Several lines of evidence indicate that neurons and microglial cells cooperate in the initiation and development of toxic signaling pathways. Both cell-surface interactions and released molecules seem to be involved in the process of neuronal degeneration. Our results indicate that CGA, which is up-regulated in many neuropathologies, represents an endogeneous inflammatory molecule responsible for the induction of signalling cascade leading to secretion of neurotoxic factors from microglia (Fig 2).
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Ciesielski-Treska, J., Aunis, D. (2002). Chromogranin A Induces a Neurotoxic Phenotype in Brain Microglial Cells. In: Helle, K.B., Aunis, D. (eds) Chromogranins. Advances in Experimental Medicine and Biology, vol 482. Springer, Boston, MA. https://doi.org/10.1007/0-306-46837-9_23
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