Conclusion
Secretion of PTH from parathyroid glands can be regulated by extracellular calcium concentrations, 1,25-dihydroxy vitamin D3, chromogranin peptides, and interleukin-8. More detailed studies of the mechanism of secretion and the pathways of signal transduction must be
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References
Aardal, S., and Helle, K.B., 1992, The vasoinhibitory activity of bovine chromogranin A fragment (vasostatin) and its independence of extracellular calcium in isolated segments ofhuman blood vessels. Reg. Peptides 41: 9–18
Angeletti, R.H., D’Amico, T., Ashok, S., and Russell, J., 1998, The chemokine interleukin-8 regulates parathyroid secretion. J. Bone Mineral Research 13: 1232–1237.
Angeletti, R.H., Mints, L., Aber, C., and Russell, J., 1996, Determination of residues in chromogranin A (1 6–40) required for inhibition of parathyroid hormone secretion. Endocrinology 137: 2918–2922.
Brown, E. M., Gamba, G, Riccardi, D., Lombardi, M, Butters, R., Kifor, O., Sun, A., Hediger, M.A., Lytton, J., and Hebert, S.C., 1993, Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid. Nature(London) 366: 575–580.
Cantley, L.K., Russell, J., Lettieri, D., and Sherwood, L.M., 1985, 1,25-Dihydroxyvitamin D3 suppresses parathyroid hormone secretion from bovine parathyroid cells in tissue culture. EndocrinoIogv 117: 2114–2119.
Cohn, D.V., Momssey, J.J., Hamilton, J.W., Shofstall, R.E., Smardo, F.L., and Chu, L.L.H., 1981, Isolation and partial characterization of secretory protein I from bovine parathyroid glands. Biochemistry 20: 4135–4140.
Drees, B.M., Rouse, J., Johnson, J., and Hamilton, J.W., 1991, Bovine parathyroid glands secrete a 26 kDa N-terminal fragment of chromogranin A which inhibits parathyroid cell secretion. Endocrinology 129: 3381–3387.
Fasciotto, B.H., Gorr, S.-U., Bourdeau, A.M., and Cohn, D.V., 1990, Autocrine regulation of parathyroid secretion: Inhibition of secretion by chromogranin-A (secretory protein-I) and potentiation of secretion by chromogranin-A and pancreastatin antibodies. Endocrinology 127: 1329–1335.
Fasciotto, B.H., Trauss, C.A., Greeley, G.H., and Cohn, D.V., 1993, Parastatin (porcine chromogranin A347-419), a novel chromogranin A-derived peptide, inhibits parathyroid cell secretion. Endocrinology 133: 461–466.
Helle, K.B., Marley, P.D., Angeletti, R.H., Aunis, D., Galindo, E., Small, D.H., and Livett, B.G., 1993, Chromogranin A: Secretion of processed products from the stimulated retrogradely perfused bovine adrenal gland. J. Neuroendocrinol. 5: 413–420.
Lazure, C., Seidah, N.G., Pelaprat, D., Chretien, M., 1983, Proteases and posttranslational processing ofprohormones: a review. Can. J. Biochem. Cell Biol. 61: 501–15.
Nemeth, E.F., Wallace, J., and Scarpa, A., 1986, Stimulus-secretion coupling in bovine parathyroid cells. Dissociation between secretion and net changes in cytosolic Ca2+. J. Biol. Chem. 261: 2668–2674.
Nemeth, E.F., and Scarpa, A., 1987, Cytosolic Ca2+ and the regulation of secretion in parathyroid cells. FEBS Lett. 203: 15–19.
Russell, J., Gee, P., Liu, S.M., and Angeletti, R.H., 1994, Stimulation of parathyroid hormone secretion by low calcium is inhibited by amino terminal chromogranin peptides. Endocrinology 135: 337–342.
Russell, J., Lettieri, D., Adler, J., and Sherwood, L.M., 1990, 1,25-Dihydroxyvitamin D3 has opposite effects on the expression of parathyroid secretory protein and parathyroid hormone genes. Mol. Endocrinol. 4: 505–509.
Russell, J., Zhao, W., Christ, G., Ashok, S., and Angeletti, R.H., 1999, Calcium induced increases in steady-state concentrations of intracellular calcium are not required for inhibition ofparathyroid hormone secretion. Mol. Cell Biol. Res. Comm. 1: 221–226.
Wohlfarter, T., Fischer-Colbrie, R., Angeletti, R.H., Eiden, L.E., and Winkler, H., 1988, Processing of chromogranin A within chromaffin granules starts at C-and N-terminal sites. FEBS Letters 231: 67–70.
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Angeletti, R.H., D’Amico, T., Russell, J. (2002). Regulation of Parathyroid Secretion. In: Helle, K.B., Aunis, D. (eds) Chromogranins. Advances in Experimental Medicine and Biology, vol 482. Springer, Boston, MA. https://doi.org/10.1007/0-306-46837-9_17
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DOI: https://doi.org/10.1007/0-306-46837-9_17
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