Conclusion
Collectively, these studies provide an insight into some of the dynamic factors that modulate the CGA expression, posttranslational processing and secretion during ontogeny and in the mature neuroendocrine cell population of the GEP system. The dynamic changes probably reflect the differential expression of proteolytic enzymes that take part in the processing of CGA. Understanding the mechanisms that control the expression and processing of CGA-derived peptides will help us elucidate their functional significance.
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Curry, W.J., Norlén, P., Barkatullah, S.C., Johnston, C.F., Håkanson, R., Hutton, J.C. (2002). Chromogranin A and Its Derived Peptides in the Rat and Procine Gastro-Entero-Pancreatic System. In: Helle, K.B., Aunis, D. (eds) Chromogranins. Advances in Experimental Medicine and Biology, vol 482. Springer, Boston, MA. https://doi.org/10.1007/0-306-46837-9_16
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