Conclusion
We have provided novel evidence that CGA-LI is stored in the cells of granular convoluted tubule, and is secreted into saliva by stimulation with NAd in the isolated and perfused rat submandibular gland. The cells are also known to secrete various growth factors, which are released into blood stream. The cells may release CGA-LI into blood stream (endocrine secretion) in addition to salivary release (exocrine secretion). The endocrine- exocrine secretion of the cells resembles the secretion of renin in the cells of juxtaglomerular apparatus and coagulating gland.
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Kanno, T., Asada, N., Yanase, H., Iwanaga, T., Yanaihara, N. (2002). Salivary Secretion of Chromogranin A Control by Autonomic Nervous System . In: Helle, K.B., Aunis, D. (eds) Chromogranins. Advances in Experimental Medicine and Biology, vol 482. Springer, Boston, MA. https://doi.org/10.1007/0-306-46837-9_11
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