Mitochondrial Dysfunction in the Pathogenesis of Acute Neural Cell Death

  • Gary Fiskum


Now that the involvement of mitochondrial dysfunction in both necrotic and apoptotic neuronal cell death is firmly established, the molecular mechanisms by which acute stress alters mitochondrial activities and induces cell death must be elucidated. Although a greater understanding of mitochondrial ROS production and apoptogenic protein release is essential, we should also continue to study the ways in which oxidative phosphorylation and cerebral energy metabolism are impaired. Clarification of mitochondrial dysfunction mechanisms will likely require a combination of approaches using measurements performed with living cells, as well as isolated mitochondria and permeabilized cells. The knowledge thus obtained should lead to development of novel modes of protection against neural cell death. The relevance of such results will need verification with animal models of acute neurodegeneration, including models of ischemia and traumatic brain injury.


Cerebral Ischemia Mitochondrial Dysfunction Mitochondrial Permeability Transition Permeability Transition Pore Adenine Nucleotide Translocase 
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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Gary Fiskum
    • 1
  1. 1.Department of Anesthesiology, School of MedicineUniversity of MarylandBaltimore

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