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Legionnaires’ Disease

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Community-Acquired Pneumonia
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References

  • Bahl, S. Wali, J. P., Handa, R., Rattan. A, Aggarwal, P., & Kindo, A. J. (1997) Legionella as a lower respiratory pathogen in north India. Indian J. Chest Dis. Allied Sci.. 39, 81–86.

    PubMed  CAS  Google Scholar 

  • Baty, V., Hoen, B., Schuhmacher, H., Amiel, C., Reyrolle, M., Garin, H., & Canton, P. (1997). Legionella jordanis pneumonia unresponsive to fluoroquinolones in a non-immuno-compromised host. Scand. J. Infect. Dis., 29, 319–320.

    Article  PubMed  CAS  Google Scholar 

  • Benson, R. F., & Fields, B. S. (1998). Classification of the genus Legionella. Semin. Respir. Infect., 13, 90–99.

    PubMed  CAS  Google Scholar 

  • Berbari, E. F, Cockerill, F. R. III, & Steckelberg, J. M. (1997). Infective endocarditis due to unusual or fastidious micro-organisms. Mayo Clinic Proc., 72, 532–542.

    Article  CAS  Google Scholar 

  • Bopp, C. A., Sumner, J. W., Morris, G. K., & Wells, J. C. (1981). Isolation of Legionella spp. from environmental water samples by low-pH treatment and use of a selective medium, J. Clin. Microbiol., 13. 714–719.

    PubMed  CAS  Google Scholar 

  • Brenner, D.J., Feeley, J. C., & Weaver, R. F. (1984). Re: Family VII, Legionellaceae, in: Bergey’s Manual of Systematic Bacteriology, vol. 1 (N. R. Krieg & J. G. Holt, eds.). Baltimore, MD: Williams & Wilkins, pp. 279–288.

    Google Scholar 

  • Brieland, J., McClain, M., Heath, L., Chrisp, C., Huffnagle, G., DeGendre, M., Hurley, M., Fantone, J., & Engleberg, C. (1996). Comoculation with Hartmannella vermiformis enhances replicative Legionella pneumophila lung infection in a murine model of Legionnaires’ disease. Infect. Immun., 64, 2449–2456.

    PubMed  CAS  Google Scholar 

  • Buesching, W.L. Brust, R.A., & Ayers, L.W. (1983). Enhanced primary isolation of Legionella pneumophila from clinical specimens by low-pH treatment. J. Clin. Microbiol., 17, 1153–1155.

    PubMed  CAS  Google Scholar 

  • Butler, J. C., Benson, R. F., Drozanski, W. J., Rowbotham, T. J., Bialkowska, I., Lipman, H. B., Fields, B. S., File, T. M., Plouffe, J. E., & the CBPIS Group. (1995). Pneumonia associated with Legionella like amoebal pathogens: characteristics and clinical manifestations. 35th Annual Meeting of the Interscience Conference on Antimicrobial Agents and Chemotherapy, September 17–20, San Francisco.

    Google Scholar 

  • Centers for Disease Control and Prevention. (1997a). Legionnaires disease associated with a whirlpool spa display— Virginia. MMWR, 46. 83–86.

    Google Scholar 

  • Centers for Disease Control and Prevention. (1997b). Sustained transmission of nosocomial Legionnaires disease—Arizona, 1997. MMWR, 46, 416–421.

    Google Scholar 

  • Chang, F. Y., Jacobs, S. L., Colodny, S. M., Stout, J. E., & Yu, V. L. (1996b). Nosocomial Legionnaires’ disease caused by Legionella pneumophila serogroup 5: laboratory and epidemiologic implications. J. Infect. Dis., 174, 1116–1119.

    PubMed  CAS  Google Scholar 

  • Chang, F. Y., Stout, J. E., & Yu, V. L. (1996a). Assessment of enzyme immunoassay versus radioimmunoassay for detection of Legionella pneumophila serogroup 1 antigen in frozen urine specimens, J. Clin. Microbiol., 34, 2628–2629.

    PubMed  CAS  Google Scholar 

  • Chen, T. T., Schapiro, J. M., & Loutit, J. (1996). Prosthetic valve endocarditis due to Legionella pneumophila, J. Cardiovasc. Surg., 37, 631–633.

    CAS  Google Scholar 

  • Chiba, Y., Okamoto, H., Nagatomo, A., Kunikane, H., & Watanabe, K. (1998). Legionnaires’ disease diagnosed by bronchoalveolar lavage. Intern. Med., 37, 153–156.

    PubMed  CAS  Google Scholar 

  • College of American Pathologists (1989). College of American Pathologists Survey Program: Bacteriology survey, specimen D-12, final critique, 1989. Skokie, IL.

    Google Scholar 

  • Cunha, B. A. (1998). Severe community acquired pneumonia. Crit. Care Clin. North Am., 14, 105–118.

    CAS  Google Scholar 

  • Domingo, P., Rodriguez, P., Lopez-Contreras, J., Rebasa, P., Mota, S., & Matias-Guiu, X. (1996). Spontaneous rupture of the spleen associated with pneumonia. Eur. J. Clin. Microbiol. Infect. Dis., 15, 733–736.

    Article  PubMed  CAS  Google Scholar 

  • Drozanski, W. J. (1991). Sarcobium lyticum gen. nov., sp. nov., an obligate intracellular bacterial parasite of small free-living amoebae. Int. J. Syst. Bacteriol., 41, 82–97.

    Article  Google Scholar 

  • Ebiary, M., Sarmiento, X., Torres, A., Nogue, S., Mesalles, E., Bodi, M., & Almirall, J. (1997). Prognostic factors of severe Legionella pneumonia requiring admission to ICU. Am. J. Respir. Crit. Care Med., 156, 1467–1472.

    PubMed  Google Scholar 

  • Edelstein, P. H., & Cetron, M. S. (1999). Editorial response: sea, wind, and pneumonia. Clin. Infect. Dis., 28, 39–41.

    PubMed  CAS  Google Scholar 

  • Edelstein, P. H., Edelstein, M. A., Lehr, K. H., & Ren, J. (1996a). In-vitro activity of levofloxacin against clinical isolates of Legionella spp, its pharmacokinetics in guinea pigs, and use in experimental Legionella pneumophila pneumonia. J. Antimicrobial. Chemother., 37, 117–126.

    CAS  Google Scholar 

  • Edelstein, P. H., Edelstein, M. A., Ren, J., Polzer, R., & Gladue, R. P. (1996b). Activity of trovafloxacin (CP-99,219) against Legionella isolates: in vitro activity, intracellular accumulation and killing in macrophages, and pharmacokinetics and treatment of guinea pigs with L. pneumophila pneumonia. Antimicrob. Agents Chemother., 40, 314–319.

    PubMed  CAS  Google Scholar 

  • Eisenberg, V. H., Eidelman, L. A., Arbel, R., & Ezra, Y. (1997). Legionnaire’s disease during pregnancy: a case presentation and review of the literature. Eur. J. Obstet. Gyn. Reprod. Biol., 72, 15–18.

    CAS  Google Scholar 

  • Ernst, A., Gordon, F. D., Hayek, J., Silvestri, R. C., & Koziel, H. (1998). Lung abscess complicating Legionella micdadei pneumonia in an adult liver transplant recipient: case report and review. Transplantation, 65, 130–134.

    PubMed  CAS  Google Scholar 

  • Fabbi, M., Pastoris, M. C., Scanziani, E., Magnino, S., & Di Matteo, L. (1998). Epidemiological and environmental investigations of Legionella pneumophila infection in cattle and case report of fatal pneumonia in a calf. J. Clin. Microbiol., 36, 1942–1947.

    PubMed  CAS  Google Scholar 

  • Fiore, A. E., Nuorti, J. P., Levine, O. S., Marx, A., Weltman, A. C., Yeager, S., Benson, R. F., Pruckler, J., Edelstein, P. H., Greer, P., Zaki, S. R., Fields, B. S., & Butler, J. C. (1998). Epidemic Legionnaires’ disease two decades later: old sources, new diagnostic methods. Clin. Infect. Dis., 26, 426–433.

    PubMed  CAS  Google Scholar 

  • Fraser, D. W., Tsai, T. R., Orenstein, W., Parkin, W. E., Beecham, H. J., Sharrar, R. G., Harris, J., Mallison, G. F., Martin, S. M., McDade, J. E., Shepard, C. C., & Brachman, P. S. (1977). Legionnaires’ disease: description of an epidemic of pneumonia. N. Engl. J. Med., 297, 1189–1197.

    Article  PubMed  CAS  Google Scholar 

  • Garcia-de-Lomas, J., Millas, E., Lazaro, M. A., Bermejo, M., Gimeno, C., Navarro, D., & Sanchez, S. (1998). A comparative study on the efficacy of the new quinolone alatrofloxacin in the treatment of experimental legionellosis in guinea pigs. Eur. J. Clin. Microbiol. Infect. Dis., 17, 420–423.

    Article  PubMed  CAS  Google Scholar 

  • Gardumo, R. A., Quinn, F. D., & Hoffman, P. S. (1998). HeLa cells as a model to study the invasiveness and biology of Legionella pneumophila. Can. J. Microbiol., 44, 430–440.

    Google Scholar 

  • Girod, J. C., Reichman, R. C., Winn, W. C. Jr., Klaucke, D. N., Vogt, R. L., & Dolin, R. (1982). Pneumonic and non-pneumonic forms of legionellosis. The result of a common-source exposure to L. pneumophila. Arch. Intern. Med., 142, 545–547.

    Article  PubMed  CAS  Google Scholar 

  • Goetz, A. M., Stout, J. E., Jacobs, S. L., Fisher, M. A., Ponzer, R. E., Drenning, S., & Yu, V. L. (1998). Nosocomial Legionnaires’ disease discovered in community hospitals following cultures of the water system: seek and ye shall find. Am. J. Infect. Control, 26, 8–11.

    PubMed  CAS  Google Scholar 

  • Green, M., Wald, E. R., Dashefsky, B., Barbadora, K., & Wadowsky, R. M. (1996). Field inversion gel electrophoretic analysis of Legionella pneumophila strains associated with nosocomial legionellosis in children. J. Clin. Microbiol., 34, 175–176.

    PubMed  CAS  Google Scholar 

  • Hackman, B. A., Plouffe, J. F., Benson, R. F., Fields, B. S., & Breiman, R. F. (1996). Comparison of Binax Legionella Urinary Antigen EIA kit with Binax RIA Urinary Antigen kit for detection of Legionella pneumophila serogroup 1 antigen. J. Clin. Microbiol., 34, 1579–1580.

    PubMed  CAS  Google Scholar 

  • Harrington, R. D., Woolfrey, A. E., Bowden, R., McDowell, M. G., & Hackman, R. C. (1996). Legionellosis in a bone marrow transplant center. Bone Marrow Transplant., 18, 361–368.

    PubMed  CAS  Google Scholar 

  • Harris, A., Lally, M., & Albrecht, M. (1998). Legionella bozemanii pneumonia in three patients with AIDS. Clin. Infect. Dis., 27, 97–99.

    PubMed  CAS  Google Scholar 

  • Heath, C. H., Grove, D. L, & Looke, D. F. (1996). Delay in appropriate therapy of Legionella pneumonia associated with increased mortality. Eur. J. Clin. Microbiol. Infect. Dis., 15, 286–290.

    Article  PubMed  CAS  Google Scholar 

  • Heller, R., Holler, C., Sussmuth, R., & Gundermann, K. O. (1998). Effect of salt concentration and temperature on survival of Legionella pneumophila. Lett. Appl. Microbiol., 26, 64–68.

    Article  PubMed  CAS  Google Scholar 

  • Ingram, J. G., & Plouffe, J. F. (1994). Community acquired pneumonia: new pathogens, new therapy. Intern. Med., 15, 41–59.

    Google Scholar 

  • Ivanyi, B., Hamilton-Dutoit, S. J., Hansen, H. E., & Olsen, S. (1996). Acute tubulointerstitial nephritis: phenotype of infiltrating cells and prognostic impact of tubulitis. Virchows Archiv., 428, 5–12.

    PubMed  CAS  Google Scholar 

  • Jack, C. I., Smith, T., Jones, R., Ibreck, R., Malster, M. G., & Lye, M. (1996). Legionnaires’ disease—a potential hazard of rationalisation. Br. J. Clin. Pract., 50, 106–107.

    PubMed  CAS  Google Scholar 

  • Jernigan, D. B., Hofmann, J., Cetron, M. S., Genese, C. A., Nuorti, J. P., Fields, B. S., Benson, R. F., Carter, R. J., Edelstein, P. H., Guerrero, I. C., Paul, S. M., Lipman, H. B., & Breiman, R. (1996). Outbreak of Legionnaires’ disease among cruise ship passengers exposed to a contaminated whirlpool spa. Lancet, 347, 494–499.

    Article  PubMed  CAS  Google Scholar 

  • Johnson, K. M., & Huseby, J. S. (1997). Lung abscess caused by Legionella micdadei. Chest, 111, 252–253.

    PubMed  CAS  Google Scholar 

  • Joseph, C., Morgan, D., Birtles, R., Pelaz, C., Martin-Bourgon, C., Black, M., Garcia-Sanchez, I., Griffin, M., Bornstein, N., & Bartlett, C. (1996). An international investigation of an outbreak of Legionnaires’ disease among UK and French tourists. Eur. J. Epidemiol, 12, 215–219.

    Article  PubMed  CAS  Google Scholar 

  • Joseph, C. A., Harrison, T. G., Ilijic-Car, D., & Bartlett, C. L. (1997). Legionnaires’ disease in residents of England and Wales: 1996. Commun. Dis. Rep. CDR Rev., 7, R153–R159.

    PubMed  CAS  Google Scholar 

  • Kazandjian, D., Chiew, R., & Gilbert, G. L. (1997). Rapid diagnosis of Legionella pneumophilla serogroup 1 infection with the binax enzyme immunoassay urinary antigen test. J. Clin. Microbiol, 35, 954–956.

    PubMed  CAS  Google Scholar 

  • Keller, D. W., Lipman, H. B., Marston, B. J., Plouffe, J. F., File, T. M., & Breiman, R. F. (1995). Clinical diagnosis of Legionnaires’ disease (LD) using a multivariate model. 35th Annual Meeting of the Interscience Conference on Antimicrobial Agents and Chemotherapy, September 17–20, San Francisco, CA.

    Google Scholar 

  • Keller, D. W., Hajjeh, R., DeMaria, A., Fields, B. S., Pruckler, J. M., Benson, R. S., Kludt, P. E., Lett, S. M., Mermel, L. A., Giorgio, C., & Breiman, R. F. (1996). Community outbreak of Legionnaires’ disease: an investigation confirming the potential for cooling towers to transmit Legionella species. Clin. Infect. Dis., 22, 257–261.

    PubMed  CAS  Google Scholar 

  • Kirby, B. D., Snyder, R. M., Meyer, R. D., & Finegold, S. M. (1980). Legionnaires’ disease: report of 65 nosocomially acquired cases and a review of the literature. Medicine, 59, 188–205.

    PubMed  CAS  Google Scholar 

  • Konecny, P., & Bell, A. J. (1996). Positive serology to Legionella longbeachae in patients with adult respiratory distress syndrome. Anaesth. Intens. Care, 24, 678–681.

    CAS  Google Scholar 

  • Kool, J. L., Carpenter, J. C., & Fields, B. S. (1999). Effect of monochloramine disinfection of municipal drinking water on risk of nosocomial Legionnaires’ disease. Lancet, 353, 272–277.

    Article  PubMed  CAS  Google Scholar 

  • Korman, T. M., Fuller, A., Ibrahim, J., Kaye, D., & Bergin, P. (1998). Fatal Legionella longeachae infection following heart transplantation. Eur. J. Clin. Microbiol. Infect. Dis., 17, 53–55.

    Article  PubMed  CAS  Google Scholar 

  • Levy, I., & Rubin, L. G. (1998). Legionella pneumonia in neonates: a literature review. J. Perinatol., 18, 287–290.

    PubMed  CAS  Google Scholar 

  • Lieberman, D., Porath, A., Schlaeffer, F., Lieberman, D., & Boldur, I. (1996). Legionella species community-acquired pneumonia. A review of 56 hospitalized adult patients. Chest, 109, 1243–1249.

    PubMed  CAS  Google Scholar 

  • Liu, Z., Stout, J. E., Boldin, M., Rugh, J., Diven, W. F., & Yu, V. L. (1998). Intermittent use of copper-silver ionization for Legionella control in water distribution systems: a potential option in buildings housing individuals at low risk of infection. Clin. Infect. Dis., 26, 138–140.

    PubMed  CAS  Google Scholar 

  • LoPresti, F., Riffard, S., Neyret, C., Celard, M., Vandenesch, F., & Etienne, J. (1998). First isolation in Europe of Legionella feeleii from two cases of pneumonia. Eur. J. Clin. Microbiol. Infect. Dis., 17, 64–66.

    CAS  Google Scholar 

  • Lüttichau, H. R., Vinther, C., Uldum, S. A., Moller, J., Faber, M., & Jensen, J. S. (1998). An outbreak of Pontiac fever among children following use of a whirlpool. Clin. Infect. Dis., 26, 1374–1378.

    PubMed  Google Scholar 

  • Marco, F., Biedenbach, D. J., & Jones, R. N. (1997). Anti-Legionella activity of trovafloxacin compared with seven other antimicrobial agents including an intermethod evaluation. Diagn. Microbiol. Infect. Dis., 29, 55–57.

    Article  PubMed  CAS  Google Scholar 

  • McDade, J. E., Shepard, C. C., Fraser, D. W., Tsai, T. R., Redus, M. A., & Dowdle, W. R. (1977). Legionnaires’ disease: isolation of a bacterium and demonstration of its role in other respiratory disease. N. Engl. J. Med., 297, 1197–1203.

    Article  PubMed  CAS  Google Scholar 

  • McNally, C., Hackman, B., Fields, B., & Plouffe, J. (1998). Importance of Legionella species as etiologies in community acquired pneumonia (CAP). 98th General Meeting of the American Society for Microbiology, May 17–21, Atlanta, Georgia.

    Google Scholar 

  • Muder, R. R., Yu, V. L., & Woo, A. H. (1986). Mode of transmission of Legionella pneumophila. A critical review. Arch. Intern. Med., 146, 1607–1612.

    Article  PubMed  CAS  Google Scholar 

  • Murdoch, D. R., Walford, E. J., Jennings, L. C., Light, G. J., Schousboe, M. I., Chereshsky, A. Y., Chambers, S. T., & Town, G. I. (1996). Use of the polymerase chain reaction to detect Legionella DNA in urine and serum samples from patients with pneumonia. Clin. Infect. Dis., 23, 475–480.

    PubMed  CAS  Google Scholar 

  • Musso, D., & Raoult, D. (1997). Serological cross-reactions between Coxiella burnetii and Legionella micdadei. Clin. Diagn. Lab. Immun., 4, 208–212.

    CAS  Google Scholar 

  • Ostergaard, L., Huniche, B., & Andersen, P. L. (1996). Relative bradycardia in infectious diseases. J. Infect., 33, 185–191.

    Article  PubMed  CAS  Google Scholar 

  • Pai, P., Kumar, S., Bell, G. M., & Ahmad, R. (1996). Rapidly progressive crescentic glomerulonephritis and Legionnaires’ disease. Clin. Nephrol., 45, 209–210.

    PubMed  CAS  Google Scholar 

  • Pankhurst, C. L., Johnson, N. W., & Woods, R. G. (1998). Microbial contamination of dental unit waterlines: the scientific argument. Int. Dent. J., 48, 359–368.

    PubMed  CAS  Google Scholar 

  • Pastoris, M. C., Monaco, R. L., Goldoni, P., Mentore, B., Balestra, G., Ciceroni, L., & Visca, P. (1999). Legionnaires’ disease on a cruise ship lined to the water supply system, clinical and public health implications. Clin. Infect. Dis., 28, 33–39.

    Google Scholar 

  • Pechere, J. C., & Gootz, T. D. (1998). Bacteriological activity of trovafloxacin, a new quinolone, against respiratory tract pathogens. Eur. J. Clin. Microbiol. Infect. Dis., 17, 405–412.

    PubMed  CAS  Google Scholar 

  • Pedro-Botet, M. L., Sabria-Leal, M., Sopena, N., Manterola, J. M., Morera, J., Blavia, R., Padilla, E., Matas, L., & Gimeno, J. M. (1998). Role of immunosuppression in the evolution of Legionnaires’ disease. Clin. Infect. Dis., 26. 14–19.

    PubMed  CAS  Google Scholar 

  • Plouffe, J. F., File, T. M., Breiman, K. F., Hackman, B. A., Salstrom, S. J., Marston, B. J., Fields, B. S., & CBPIS Study Group. (1995). Reevalualion of the definition of Legionnaires’ disease: use of the urinary antigen assay. Clin. Infect. Dis., 20, 1286–1291.

    PubMed  CAS  Google Scholar 

  • Porath, A., Schlaeffer, F., & Lieberman, D. (1997). The epidemiology of community-acquired pneumonia among hospi-Uihed adults. J. Infect., 34, 41–48

    Article  PubMed  CAS  Google Scholar 

  • Ramirez., J. A., Ahkee, S., Tolentino, A., Miller, R. D., & Summersgill, J. T. (1996). Diagnosis of Legionella pneumophila, Mycoplasma pneumoniae, or Chlamydia pneumoniae lower respiratory infection using the polymerase chain reaction on a single throat swab specimen. Diagn. Microbiol. Infect. Dis., 24, 7–14.

    Article  PubMed  CAS  Google Scholar 

  • Ramon, D. F., Ruiz de Porras, L., Elizalde, G., & Abella, M. (1997). Description and study of the etiology of a community outbreak of atypical pneumonia in L’Espluga de Francoli, Tarragona. Medicina Clinca, 108, 490–494.

    Google Scholar 

  • Rowbotham, T. J. (1993). Legionella-like amoebal pathogens, in: Legionella: Current State and Emerging Perspectives (J. M. Barbaree, R. F. Breiman, & A. P. Dufour, eds.). Washington, DC: American Society for Microbiology, pp. 137–140.

    Google Scholar 

  • Schrock, J., Hackman, B. A., & Plouffe, J. F. (1997). Susceptibility of ninety-eight clinical isolates of Legionella to macrolides and quinolones using the E test. Diagn. Microbiol. Infect. Dis., 28, 221–223.

    Article  PubMed  CAS  Google Scholar 

  • Schulin, T., Wennersten, C. B., Ferraro, M. J., Moellering, R. C. Jr., & Eliopoulos, G. M. (1998). Susceptibilities of Legionella spp. to newer antimicrobials in vitro. Antimicrob. Agents Chemother., 42, 1520–1523.

    PubMed  CAS  Google Scholar 

  • Sommese, L., Scarfogliero, P., Vitiello, M., Catalanotti, P., & Galdiero, E. (1996). Presence of Legionella spp. in thermal springs of the Campania region of south Italy. New Microbiologica, 19, 315–320.

    PubMed  CAS  Google Scholar 

  • Sopena, N., Sabria-Leal, M., Pedro-Botet, M. L., Padilla, E., Dominguez, J., Morera, J., & Tudela, P. (1998). Comparative study of the clinical presentation of Legionella pneumonia and other community-acquired pneumonias. Chest. 113, 1195–1200.

    PubMed  CAS  Google Scholar 

  • Stout, J. E., Arnold, B., & Yu, V. L. (1998a). Activity of azithromycin, clarithromycin, roxithromycin, dirithromyein. quinupristin/dalfopristin and erythromycin against Legionella species by intracellular susceptibility testing in HL-60 cells. J. Antimicrob. Chemother., 41, 289–291.

    Article  PubMed  CAS  Google Scholar 

  • Stout, J. E., Yu-sen, E. L., Goetz, A. M., & Muder, R. R. (1998b). Controlling Legionella in hospital water systems: experience with the superheat-and-flush method and copper-silver ionization. Infect. Control Hosp. Epidemiol., 19, 911–914.

    PubMed  CAS  Google Scholar 

  • Straus, W. L., Plouffe, J. F., File, T. M. Jr., Lipman, H. B., Hackman, B. H., Salstrom, S. J., Benson, R. F., & Breiman, R. F. (1996). Risk factors for domestic acquisition of legionnaires disease. Ohio Legionnaires Disease Group. Arch. Intern. Med., 156, 1685–1692.

    Article  PubMed  CAS  Google Scholar 

  • Tang, P. W., & Toma, S. (1986). Broad-spectrum enzyme-linked immunosorbent assay for detection of Legionella soluble antigens. J. Clin. Microbiol, 24, 556–558.

    PubMed  CAS  Google Scholar 

  • Tewari, K., Wold, S. M., & Asrat, T. (1977). Septic shock in pregnancy associated with Legionella pneumonia: case report. Am. J. Obstet. Gynecol., 176, 706–707.

    Google Scholar 

  • Tolentino, A., Ahkee, S., & Ramirez, J. (1996). Hot tub legionellosis. J. Kentucky Med. Assoc., 94, 393–394.

    CAS  Google Scholar 

  • Torres, A., Dorca, J., Zalacain, R., Bello, S., El-Ebiary, M., Molinos, L., Arevalo, M., Blanquer, J., Celis, R., Iriberri, M., Prats, E., Fernandez, R., Irigaray, R., & Serra, J. (1996). Community-acquired pneumonia in chronic obstructive pulmonary disease: a Spanish multicenter study. Am. J. Respir. Crit. Care Med., 154, 1456–1461.

    PubMed  CAS  Google Scholar 

  • Verhaeverbeke, I., Van der Niepen, P., Sennesael, J., Van den Houte, K., Lauwers, S., & Verbeelen, D. (1995). Legionnaires’ disease and acute renal insufficiency: report of a case and review of the literature. Acta Clinica Belgica, 50, 363–367.

    PubMed  CAS  Google Scholar 

  • Walz, A., Nichterlein, T., & Hof., H. (1997). Excellent activity of newer quinolones on Legionella pneumophila in J774 macrophages. Zentralblatt Bakteriol., 285, 431–439.

    CAS  Google Scholar 

  • Weir, S. C., Fischer, S. H., Stock, F, & Gill, V. J. (199X). Detection of Legionella by PCR in respiratory specimens using a commercially available kit. Am. J. Clin. Pathol., 110, 295–300.

    Google Scholar 

  • Whitney, C. G., Hofmann, J., Pruckler, J. M., Benson, R. F, Fields, B. S., Bandyopadhyay, U., Donnally, E. F., Giorgio-Almonte, C., Mermel, L. A., Boland, S., Matyas, B. T., & Breiman, R. F. (1997). The role of arbitrarily primed PCR in identifying the source of an outbreak of Legionnaires’ disease. J. Clin. Microbiol., 35, 1800–1804.

    PubMed  CAS  Google Scholar 

  • Yu, V. L. (1998). Resolving the controversy on environmental cultures for Legionella: a modest proposal. Infect. Control Hosp. Epidemiol., 19, 893–897.

    PubMed  CAS  Google Scholar 

  • Yu-sen, E. L., Stout, J. E., Yu, V. L., & Vidic, R. D. (1998). Disinfection of water distribution systems for Legionella. Semin. Respir. Infect., 13, 147–159.

    Google Scholar 

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Plouffe, J.F. (2002). Legionnaires’ Disease. In: Marrie, T.J. (eds) Community-Acquired Pneumonia. Springer, Boston, MA. https://doi.org/10.1007/0-306-46834-4_32

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