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Biology of the Mammary Gland pp 77–84Cite as

Translocation and Action of Polypeptide Hormones within the Nucleus

Relevance to Lactogenic Transduction

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 480))

Abstract

The action of polypeptide hormones at the cell surface as mediated by transmembrane receptors is well recognised. However, a growing body of evidence also indicates that such hormones are also translocated and act directly within the cell nucleus. This chapter will overview what is known of the action of one such example, namely prolactin (PRL), from its classic action at the cell surface, to its novel function within the nucleus.

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Authors and Affiliations

  1. Department of Pathology & Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, USA

    Charles V. Clevenger & Michael A. Rycyzyn

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  1. Charles V. Clevenger
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  2. Michael A. Rycyzyn
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Editors and Affiliations

  1. Utrecht University, Utrecht, The Netherlands

    Jan A. Mol

  2. Hannah Research Institute, Ayr, Scotland, UK

    Roger A. Clegg

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© 2002 Kluwer Academic Publishers

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Clevenger, C.V., Rycyzyn, M.A. (2002). Translocation and Action of Polypeptide Hormones within the Nucleus. In: Mol, J.A., Clegg, R.A. (eds) Biology of the Mammary Gland. Advances in Experimental Medicine and Biology, vol 480. Springer, Boston, MA. https://doi.org/10.1007/0-306-46832-8_9

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  • DOI: https://doi.org/10.1007/0-306-46832-8_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46414-0

  • Online ISBN: 978-0-306-46832-2

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