Abstract
Heparan sulphate (HS) is a linear glycosaminoglycan found ubiquitously on the surface and in the pericellular matrix of metazoan cells that is covalently attached to core proteins to form HS proteoglycans. HS interacts specifically with a large number (>100) of extracellular regulatory proteins, many of which are key players in mammary development and function. HS thus acts a receptor, in which capacity it regulates the bioavailability, localisation and activity of these regulatory proteins.
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© 2002 Kluwer Academic Publishers
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Bateman, K.L., Delehedde, M., Sergeant, N., Wartelle, I., Vidyasagar, R., Fernig, D.G. (2002). Heparan Sulphate. In: Mol, J.A., Clegg, R.A. (eds) Biology of the Mammary Gland. Advances in Experimental Medicine and Biology, vol 480. Springer, Boston, MA. https://doi.org/10.1007/0-306-46832-8_7
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DOI: https://doi.org/10.1007/0-306-46832-8_7
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