Skip to main content
SpringerLink
Log in

Opposing Effects of IL-1α and IL-1β on Malignancy Patterns

Tumor cell-associated IL-Iα potentiates anti-tumor immune responses and tumor regression, whereas IL-1β potentiates invasiveness

  • Chapter
The Biology and Pathology of Innate Immunity Mechanisms

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 479))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Anasagasti, M.J., Olaso. E., Calvo, F., Mendoza, L., Martin, J.J., Bidaurrazaga, J. and Vidal-vanaclocha, F. Interleukin 1-dependent and — independent mouse melanoma metastases. J. Natl. Cancer Inst., 89:645–651, 1997.

    Article  PubMed  CAS  Google Scholar 

  • Apte, R.N. Mechanisms of cytokine production by fibroblasts-implications for normal connective tissue homeostasis and pathological conditions. Folia Microbiologica, 40:392–404, 1995.

    PubMed  CAS  Google Scholar 

  • Apte, R.N., Douvdevani, A., Huleihel, M., Fima, E., Hacham, M., Shimoni, N and Segal, S. IL-1 and pro-inflammatory cytokines produced by primary and transformed fibroblasts abrogate the tumorigenic potential of fibrosarcomas. Folia Biologica (Praha), 38:240–257, 1992.

    CAS  Google Scholar 

  • Apte, R.N., Douvdevani, A., Zoller, M., White, R.M., Dvorkin, T., Shimoni, N., Fima, E., Hacham, M., Huleihel, M., Benharroch, D., Voronov, E. and Segal., S. Cytokine-induced tumor immunogenicity: Interleukin-1 alpha expressed by fibrosarcoma cells confers reduced tumorigenicity. Immunol. Lett., 39:45–52, 1994a.

    Article  Google Scholar 

  • Apte, R.N., Douvdevani, A., Zoller, M., White, R.M., Dvorkin, T., Shimoni, N., Huleihel, M., Fima, E., Hacham, M., Voronov, E., Benharroch, D., and Segal., S. Involvement of immune responses in the eradication of IL-1 alpha gene-transduced tumour cells: mechanisms of tumour rejection and immunotherapeutical implications. Folia Biologica (Praha), 40: I–18, 1994b.

    Google Scholar 

  • Colombo, M.P. and Forni, G. Immunotherapy 1: Cytokine gene transfer strategies. Cancer Metastasis Rev., 15: 317–328, 1996.

    Article  PubMed  CAS  Google Scholar 

  • Dinarello, C.A. Biologic basis for interleukin-1 in disease. Blood, 87:2095–2147, 1996.

    PubMed  CAS  Google Scholar 

  • Douvdevani. A., Huleihel, M., Segal, S. and Apte, R.N. Regulation of interleukin-I generation in immune-activated fibroblasts. Eur. Cytokine Net., 2:257–264, 1991.

    CAS  Google Scholar 

  • Douvdevani, A., Huleihel, M., Zoller, M., Segal, S. and Apte, R.N. Reduced tumorigenicity of fibrosarcomas which constitutively generate IL-1 alpha either spontaneously or following IL-1 alpha gene transfer. Int. J. Cancer, 52:822–830, 1992.

    Google Scholar 

  • Dranoff, G. and Mulligan, R.C. Gene transfer as cancer therapy. Adv. Immunol., 58:417–454, 1998.

    Article  Google Scholar 

  • Forni, G., Cavallo, F., Consalvo, M., Allione, A., Dellabona, P., Casorati, G. and Giovarelli, M. Molecular approaches to cancer immunotherapy. Cytok. Molec. Ther., 1: 225–248, 1995.

    CAS  Google Scholar 

  • Pardoll, D.M. Cancer vaccines: a road map for the next decade. Curr. Opin. Immunol., 8:619–621, 1996.

    Article  PubMed  CAS  Google Scholar 

  • QIN, Z. and Blankenstein, T. Influence of local cytokines on tumor metastases: using cytokine gene-transfected tumor cells as experimental models. Curr. Top. Microbiol. Immunol., 213: 55–64, 1996.

    PubMed  CAS  Google Scholar 

  • Wingren, A.G., Bjorkdahl, O., Labuda, T., Bjork, L., Andersson, U., Gullberg, U., Hedlund, G., Sjogfen, H.O., Kalland, T., Widegren, B. and Dohlsten, M. Fusion of a signal sequence to the interleukin-I beta gene directs the protein from cytoplasmic accumulation to extracellular release. Cell-Immunol. 169:226–37, 1996.

    Article  PubMed  CAS  Google Scholar 

  • Zoller, M., Douvdevani, A., Segal, S. and Apte, R.N. Interleukin-I produced by tumorigenic fibroblasts influences tumor rejection. Int. J. Cancer, 50:443–449, 1992a.

    PubMed  CAS  Google Scholar 

  • Zoller, M., Douvdevani, A., Segal, S. and Apte, R.N. Interleukin-I production by transformed fibroblasts. II Influence on antigen presentation and T-cell-mediated anti-tumor response. Int. J. Cancer, 50:-457. 1992b.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Microbiology and Immunology, Faculty of Health Sciences and The Cancer Research Center, Ben-Gurion University of the Negev, Israel

    Ron N. Apte, Tatyana Dvorkin, Xiaoping Song, Eyal Fima, Yakov Krelin, Alon Yulevitch, Reuven Gurfinkel, Ariel Werman, Rosalyn M. White, Shraga Segal & Elena Voronov

  2. Department of Microbiology and Immunology, Department of Pathology, Soroka Medical Center, Beer-Sheva, Israel

    Shmuel Argov & Yacob Shendler

  3. Department of Microbiology and Immunology, University of Lund Luind, Sweden

    Olle Bjorkdahl & Mikael Dohlsten

  4. Department of Microbiology and Immunology, the German Cancer Center, Heidelberg, Germany

    Margot Zoller

Authors
  1. Ron N. Apte
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tatyana Dvorkin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xiaoping Song
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Eyal Fima
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yakov Krelin
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Alon Yulevitch
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Reuven Gurfinkel
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Ariel Werman
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Rosalyn M. White
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Shmuel Argov
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Yacob Shendler
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Olle Bjorkdahl
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Mikael Dohlsten
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Margot Zoller
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Shraga Segal
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. Elena Voronov
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Yona Keisari  & Itzhak Ofek  & 

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Kluwer Academic Publishers

About this chapter

Cite this chapter

Apte, R.N. et al. (2002). Opposing Effects of IL-1α and IL-1β on Malignancy Patterns. In: Keisari, Y., Ofek, I. (eds) The Biology and Pathology of Innate Immunity Mechanisms. Advances in Experimental Medicine and Biology, vol 479. Springer, Boston, MA. https://doi.org/10.1007/0-306-46831-X_24

Download citation

  • DOI: https://doi.org/10.1007/0-306-46831-X_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46409-6

  • Online ISBN: 978-0-306-46831-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation