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The Biology and Pathology of Innate Immunity Mechanisms pp 185–202Cite as

Distinct Patterns of IL-Lα and IL-Lβ Organ Distribution-A Possible Basis for Organ Mechanisms of Innate Immunity

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 479))

6. Conclusion

The findings presented in this work show that IL-1α and IL-1β display differential and even inverse patterns of organ expression, demonstrated most clearly at old age and beyond the realm of immunology. Based on these IL- 1α /IL- 1β specific patterns of organ expression and considering the distinct physiological function of various organs, IL-1 á may be highlighted more as a potent anti-infectious/toxic agent, which can initiate and potentiate prolonged inflammatory responses, apparently mainly based on activation of cellular immunity. In contrast, it possibly appears that IL-1α may be involved in more restricted inflammatory responses, than conceived before. Other homeostatic functions of both IL-1 molecules can also be envisioned, including for example control of the cell cycle and apoptosis. In this context, diverse and even opposing biological effects of IL-la/IL-lb may be anticipated. The “net” activity of IL-1 in a certain organ may depend on the type of expressed IL-1 and IL-lreceptors, as well as on the locally operant cytokine network. The in vivo interactions between the two IL-1 forms may be of crucial importance to organ homeostasis, especially under the stressful conditions, characterizing old age. Further studies are needed to clarify the full perspective of IL-la and IL-lb roles in organ homeostasis, the understanding and manipulation of which may hopefully lead to development of beneficial therapeutic interventions.

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  1. Departnrent of Microbiology and Immunology, Ben-Gurion University of the Negev, Beer-Sheva, Israel

    Moshe Hacham, Rosalyn M. White, Shraga Segal & Ron N. Apte

  2. Department of Pathology, Soroka Medical Center, Faculty of Health Sciences and The Cancer Research Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel

    Shmuel Argov

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  1. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Yona Keisari  & Itzhak Ofek  & 

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Hacham, M., Argov, S., White, R.M., Segal, S., Apte, R.N. (2002). Distinct Patterns of IL-Lα and IL-Lβ Organ Distribution-A Possible Basis for Organ Mechanisms of Innate Immunity. In: Keisari, Y., Ofek, I. (eds) The Biology and Pathology of Innate Immunity Mechanisms. Advances in Experimental Medicine and Biology, vol 479. Springer, Boston, MA. https://doi.org/10.1007/0-306-46831-X_16

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