This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Abbas, A.K., A.H. Lichtman, and J.S. Pober, 1994, Functional anatomy of local and systemic immune responses. 2nd ed. In Cellular and molecular immunology. W. B. Saunders Company, Philadelphia, PA., pp. 222–236.
Albert, M.L., B. Sauter, and N. Bhardwaj, 1998, Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 392:86–89.
Casares, S., K. Inaba, T.D. Brumeanu, R.M. Steinman, and C.A. Bona, 1997, Antigen presentation by dendritic cells after immunization with DNA encoding a major histocompatibility complex class I1-restricted viral epitope. J Exp Med 186: 1481–6.
Ciernik, I.F., J.A. Berzofsky, and D.P. Carbone, 1996, Induction of cytotoxic T lymphocytes and antitumor immunity with DNA vaccines expressing single T cell epitopes. J Immunol. 1.56:2369–75.
Condon, C., S.C. Watkins, C.M. Celluzzi, K. Thompson, and L.D. Falo, Jr., 1996, DNA-based immunization by in vivo transfection of dendritic cells. Nat Med 2.1:122–8.
Corr, M., D.J. Lee, D.A. Carson, and H. Tighe, 1996, Gene vaccination with naked plasmid DNA: Mechanism of CTL priming. J. Exp. Med. 184:1555–1560.
Danko, I., P. Williams, H. Herweijer, G. Zhang, J.S. Latendresse, I. Bock, and J.A. Wolff, 1997, High expression of naked plasmid DNA in muscles of young rodents. Hum Mol Genet 6:1435–43.
Doe, B., M. Selby, S. Barnett, Baenziger, and C.M. Walker, 1996, Induction of cytotoxic T lymphocytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow-derived cells. Proc. Natl. Acad. Sci. USA 93:8578–8583.
Fu, T., J. Ulmer, M. Caulfield, R. Deck, A. Friedman, S. Wang, X. Liu, J. Donnelly, and M. Liu, 1997, Priming of cytotoxic T lymphocytes by DNA vaccines: requirement for professional antigen presenting cells and evidence for antigen transfer from myocytes. Mol. Med. 3:362–371.
Irvine, K.R., J.B. Rao, S.A. Rosenberg, and N.P. Restifo, 1996, Cytokine enhancement of DNA immunization leads to effective treatment of established pulmonary metastases. J Immunol 1.56:238–245.
Iwasaki, A., C.A. Torres, P.S. Ohashi, H.L. Robinson, and B.H. Barber, 1997a, The dominant role of bone marrow-derived cells in CTL induction following plasmid DNA immunization at different sites. J Immunol 1.59:11–4.
Iwasaki, A., B.J. Stiernholm, A.K. Chan, N.L. Berinstein, and B.H. Barber, 1997b, Enhanced CTL responses mediated by plasmid DNA immunogens encoding costimulatory molecules and cytokines. J Immunol 158:4591–601.
Klinman, D.M., J.M.G. Sechler, J. Conover, M. Gu, and A.S. Rosenberg, 1998, Contribution of cell at the site of DNA vaccination to the generation of antigen-specific immunity and memory. J. Immunol. 160:2388–92.
Lu, B., G. Scott, and L.A. Goldsmith. 1996. A model for keratinocyte gene therapy: preclinical and therapeutic considerations. Proc Assoc Am Physicians 108: 165–72.
Porgador, A., K.R. Irvine, A. Iwasaki, B.H. Barber, N.P. Restifo, and R.N. Germain, 1998, Predominant role for directly transfected dendritic cells in antigen presentation to CD8′ T cells after gene gun immunization. J. Exp. Med. 188:1075–1082.
Sato, Y., M. Roman, H. Tighe, D. Lee, M. Corr, M.D. Nguyen, G.J. Silverman, M. Lotz, D.A. Carson, and E. Raz, 1996, Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 273:352–4.
Steinman, R.M., 1991, The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9:271–279.
Tighe, H., M. Corr, M. Roman, and E. Raz, 1998, Gene vaccination: plasmid DNA is more than just a blueprint Immunol Today 19(2):89–97.
Torres, C.A.T., A. Iwasaki, B.H. Barber, and H.L. Robinson, 1997, Differential dependence on target site tissue for gene gun and i.m. DNA immunizations. J. Immunol. 158:4529–4532.
Williams, R.S., S.A. Johnston, M. Reidy, M.J. DeVit, S.G. Mcelligott, and J.C. Sanford, 1991, Introduction of foreign genes into tissues of living mice by DNA-coated microprojectiles. Proc. Natl. Acad, Sci. USA. 88:2726–2730.
Wolff, J.A., R.W. Malone, P. Williams, W. Chong, G. Acsadi, A. Jani, and P.L. Felgner, 1990, Direct gene transfer into mouse muscle in vivo. Science 247:1465–1468.
Xiang, Z., and H.C. Ertl, 1995, Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines. Immunity 2: 129–135.
Ulmer, J.B., J.J. Donnelly, S.E. Parker, G.H. Rhodes, P.L. Felgner, V.J. Dwarki, S.H. Gromkowski, R.R. Deck, C.M. DeWitt, A. Friedman, L.A. Hawe, K.R. Leander, D. Martinez, H.C. Perry, J.W. Shiver, D.L. Montgomery, and M.A. Liu, 1993, Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259:1745–1749.
Ulmer, J.B., J.C. Sadoff, and M.A. Liu, 1996, DNA vaccines. Curr Opin Immunol 8:531–6.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Kluwer Academic Publishers
About this chapter
Cite this chapter
Paul, L., Porgador, A. (2002). DNA-Based Vaccines: Role of Dendritic Cells in Antigen Presentation. In: Keisari, Y., Ofek, I. (eds) The Biology and Pathology of Innate Immunity Mechanisms. Advances in Experimental Medicine and Biology, vol 479. Springer, Boston, MA. https://doi.org/10.1007/0-306-46831-X_15
Download citation
DOI: https://doi.org/10.1007/0-306-46831-X_15
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-306-46409-6
Online ISBN: 978-0-306-46831-5
eBook Packages: Springer Book Archive