Skip to main content

Reactive Oxygen Species as Regulators of Oxygen Dependent Gene Expression

  • Chapter
Oxygen Sensing

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 475))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Reference

  • Acker, H., Dufau, E., Huber, J. and Sylvester D., 1989, Indications to an NAD(P)H oxidase as a possible PO2 sensor in the rat carotid body. FEBS Lett. 256: 75–78.

    Google Scholar 

  • Arany, Z., Huang, L.E., Eckner, R., Bhattacharya, S., Jiang, C., Goldberg, M.A., Bunn, H.F., and Livingston, D.M., 1996, An essential role for p300/CBP in the cellular response to hypoxia. Proc. Natl. Acad. Sci. 93: 12969–12973.

    Google Scholar 

  • Babior, B.M., 1999, NADPH Oxidase: An Update. Blood 93, 1464–1476.

    Google Scholar 

  • Bhattacharya, S., Michels, C.L., Leung, M.K., Arany, Z.P., Kung, A.L., Livingston, D.M., 1999, Functionla role of p35srj, a novel p300/CBP binding protein, during transctivation by HIF-1. Genes & Dev. 13: 64–75.

    Google Scholar 

  • Bunn, H.F. and Poyton, R.O., 1996, Oxygen sensing and molecular adaptation to hypoxia. Physiol. Rev. 76: 839–885.

    Google Scholar 

  • Fandrey, J., Frede, S., Ehleben, W., Porwol, T., Acker, H. and Jelkmann, W., 1997, Cobalt chloride and desferrioxamine antagonize the inhibition of erythropoietin production by reactive oxygen species. Kidney Int. 51: 492–496.

    Google Scholar 

  • Fandrey, J., Frede, S. and Jelkmann, W., 1994, Role of hydrogen peroxide in hypoxia-induced erythropoietin production. Biochem J. 303: 507–510.

    Google Scholar 

  • Fandrey, J. and Bunn, H.F., 1993, In vivo and in vitro regulation of erythropoietin mRNA: Measurement by competitive polymerase chain reaction. Blood 81: 617–623.

    Google Scholar 

  • Huang, L.E., Arany, Z., Livingston, D.M. and Bunn, H.F., 1996, Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitivc stabilization of its_-subunit. J. Biol. Chem. 271: 32253–32259.

    Google Scholar 

  • Huang, L.E., Gu, J., Schau, M., and Bunn, H.F., 1998, Regulation of hypoxia-inducible factor 1 alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc. Natl. Acad. Sci. 95: 7987–7992.

    Google Scholar 

  • Imagawa, S., Yamamoto, M., Ueda, M. and Miura, Y., 1996, Erythropoietin gene expression by hydrogen peroxide. Int. J. Hematol. 64: 189–195.

    Google Scholar 

  • Jelkmann, W., 1992, Erythropoietin: Structure, control of production and function. Physiol. Rev. 72: 449–489.

    Google Scholar 

  • Lee, P.J., Jiang, B.-H., Chin, B.Y., Iyer, N.V., Alam, J., Semenza, G.L. and Choi, A.M.K., 1997, Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-l gene in response to hypoxia. J. Biol. Chem. 272: 5375–5381.

    Google Scholar 

  • Levy, A.P., Levy, N.S., Wegner, S., and Goldberg, M.A., 1995, Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J. Biol. Chem. 270, 13333–13340.

    Google Scholar 

  • Melillo, G., Musso, T., Sica, A. and Taylor L.S., 1995, A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter. J. Exp. Med. 182: 1683–1693.

    Google Scholar 

  • Mohazzab-H., K.M., Fuyngersh, R.P., Kaminski, P.M. and Wolin, M.S., 1995, Potential role of NADH oxidoreductase-derived reactive O2 species in calf pulmonary arterial PO2-elicited responses. Am. J. Physiol. 269: L637–644.

    Google Scholar 

  • Pugh, C.W., O’Rourke, J.F., Nagao, M., Gleadle, J.M. Ratcliffe, P.J., 1997, Activation of hypoxia-inducible factor-1; definition of regulatory domains within the α-subunit. J. Biol. Chem. 272: 11205–11214.

    Google Scholar 

  • Wang, G.L., Jiang, B.-H., Rue, E.A. and Semenza, E.A., 1995, Hypoxia-inducible factor 1 is a basic-helix-loop-heclix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl. Acad. Sci. USA 92: 5510–5514.

    Google Scholar 

  • Wang, G.L., and Semenza, G.L., 1993, Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. J. Biol. Chem. 268, 21513–21518.

    Google Scholar 

  • Wenger, R.H., Marti, H.H., Schueler-Maly, C.C., Kvietikova, I., Bauer, C., Gassmann, M. and Maly, F.E., 1996, Hypoxic induction of gene expression in chronic granulomatous disease-derived B-cell lines: oxygen sensing is independent of the cytochrome b558 containing nicotinamide adenine dinucleotide phosphate oxidase. Blood 87: 756–761.

    Google Scholar 

  • Wenger, R.H. and Gassmann, M., 1997, Oxygen(es) and the hypoxia-inducible factor-1. Biol. Chem. 378: 609–616.

    Google Scholar 

  • Youngson, C., Nurse, C., Yeger, H. and Cutz, E., 1993, Oxygen sensing in airways chemoreceptors. Nature 365: 153–155.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Kluwer Academic Publishers

About this chapter

Cite this chapter

Fandrey, J., Genius, J. (2002). Reactive Oxygen Species as Regulators of Oxygen Dependent Gene Expression. In: Lahiri, S., Prabhakar, N.R., Forster, R.E. (eds) Oxygen Sensing. Advances in Experimental Medicine and Biology, vol 475. Springer, Boston, MA. https://doi.org/10.1007/0-306-46825-5_15

Download citation

  • DOI: https://doi.org/10.1007/0-306-46825-5_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46367-9

  • Online ISBN: 978-0-306-46825-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics