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Analysis of Chromosome Territory Architecture in the Human Cell Nucleus

Overview of Data from a Collaborative Study

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Genomics and Proteomics

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References

  • Bornfleth H., Sätzler K., Eils R., and Cremer C. (1998) High-precision distance measurements and volume-conserving segmentation of objects near and below the resolution limit in three-dimensional confocal fluorescence microscopy. J Microsc 189, 118–136.

    Article  Google Scholar 

  • Bornfleth H., Edelmann P., Zink D., and Cremer C. (1999a) Three-dimensional analysis of genome topology, in: Handbook of Computer Vision and Applications, Vol. Ill. B. Jähne, H. Haußecker, P. Geißler editors, Academic Press, San Diego/New York, 859–878.

    Google Scholar 

  • Bornfleth H., Edelmann P., Zink D., Cremer T., and Cremer C. (1999b) Quantitative motion analysis of subchromosomal foci in living cells using four-dimensional microscopy. Biophysical J 77, 2871–2886.

    Article  CAS  Google Scholar 

  • Bridger J.M., Herrmann H., Miinkel C., and Lichter P. (1998) Identification of an interchromosomal compartment by polymerization of nuclear-targeted vimentin. J Cell Sci III, 1241–1253.

    Google Scholar 

  • Cremer T., Kurz A., Zirbel R., Dietzel S., Rinke R., Schrock E., Speicher M.R., Mathieu U., Jauch A., Emmerich P., Scherthan H., Ried T., Cremer C., and Lichter P. (1993) The role of chromosome territories in the functional compartmentalization of the cell nucleus. Cold Spring Harbor Symp Quant Biol 58, 777–792.

    PubMed  CAS  Google Scholar 

  • Cremer T., Dietzel S., Eils R., Lichter P., and Cremer C. (1995) Chromosome territories, nuclear matrix filaments and interchromatin channels: a topological view on nuclear architecture and function. Kew Chromosome Conference IV (Eds P.E. Brandham and M.D. Bennett), pp. 63–81, Royal Botanic Gardens, Kew.

    Google Scholar 

  • Cremer C., Münkel C., Granzow M., Jauch A., Dietzel S., Eils, R., Guan X.Y., Meltzer P.S., Trent J.M., Langowski J., and Cremer T. (1996) Nuclear architecture and the induction of chromosomal aberrations. Mutat Res Rev Genet Toxicol 366/2, 97–116.

    Google Scholar 

  • Dietzel S., Jauch A., Kienle D., Qu G., Holtgreve-Grez H., Eils R., Miinkel C., Bittner M., Meltzer P.S., Trent J.M., and Cremer T. (1998a) Separate and variably shaped chromosome arm domains are disclosed by chromosome arm painting in human cell nuclei. Chromosome Res 6, 25–33.

    Article  PubMed  CAS  Google Scholar 

  • Dietzel S., Eils R., Sätzler K., Bornfleth H., Jauch A., Cremer C., and Cremer T. (1998b) Evidence against a looped structure of the inactive human X-chromosome territory. Exp Cell Res 240, 187–196.

    Article  PubMed  CAS  Google Scholar 

  • Dietzel S., Schiebel K., Little G., Edelmann P., Rappold G.A., Eils R., Cremer C., and Cremer T. (1999) The 3D-positioning of ANT2 and ANT3 genes within female X-chromosome territories correlates with gene activity. Exp Cell Res 552, 363–375.

    Google Scholar 

  • Eils R., Dietzel S., Bertin E., Granzow M., Schrock E., Speicher M.R., Ried T., Robert-Nicoud M., Cremer C., and Cremer T. (1996) Three-dimensional reconstruction of painted human interphase chromosomes: active and inactive X-chromosome territories have similar volumes but differ in surface and shape. J Cell Biol 135, 1427–1440.

    Article  PubMed  CAS  Google Scholar 

  • Kreth G., Münkel C., Langowski J., Cremer T., and Cremer C. (1999) Chromatinstructureandchromosome aberrations: modeling of damage induced by isotropic and localized irradiation. Mutat Res 404, 77–88.

    Google Scholar 

  • Kurz A., Lampel S., Nickolenko J.E., Bradl J., Benner A., Zirbel R.M., Cremer T., and Lichter P. (1996) Active and inactive genes localize preferentially in the periphery of chromosome territories. J Cell Biol 135, 1195–1205.

    Article  PubMed  CAS  Google Scholar 

  • Lampel S., Bridger J.M., Zirbel R.M., Mathieu U.R., and Lichter P. (1997) Nuclear RNA accumulations contain released transcripts and exhibit specific distributions with respect to Sm antigen foci. DNA Cell Biol 16, 1133–1142.

    Article  PubMed  CAS  Google Scholar 

  • Münkel C.and Langowski J. (1998) Chromosome structure predicted by a polymer model. Phys Rev E 57, 5888–5896.

    Google Scholar 

  • Münkel C., Eils R., Dietzel S., Zink D., Mehring C., Wedemann G., Cremer T., and Langowski J. (1998) Compartmentalization of interphase chromosomes observed in simulation and experiment. J Mol Biol 285, 1053–1065.

    Google Scholar 

  • Solovei I., Kienle D., Little G., Eils R., Schwab M., Cremer C., and Cremer T. (1999) Topology of tumor specific chromatin structures in Neuroblastoma cell nuclei. Manuscript submitted.

    Google Scholar 

  • Tajbakhsh J., Luz H., Bornfleth H., Lampel S., Cremer C., and Lichter P. (2000) Spatial distribution of GC-and AT-rich DNA sequences within human chromosome territories Exp Cell Res 255, 299–237.

    Article  CAS  Google Scholar 

  • Visser A.E., Eils R., Jauch A., Little G., Bakker P.J.M., Cremer T., and Aten J.A. (1998) Spatial Distributions of Early and Late Replicating Chromatin in Interphase Chromosome Territories. Exp Cell Res 243, 398–407.

    Article  PubMed  CAS  Google Scholar 

  • Zink D., Cremer T., Saffrich R., Fischer R., Trendelenburg M.F., Ansorge W., and Stelzer E.H.K. (1998a) Structure and dynamics of human interphase chromosome territories in vivo. Hum Genet 102, 241–251.

    Article  PubMed  CAS  Google Scholar 

  • Zink D. and Cremer T. (1998b) Chromosome dynamics in nuclei of living cells. Current Biology 8, 321–324.

    Article  Google Scholar 

  • Zink D., Bornfleth H., Visser A., Cremer C., and Cremer T. (1999) Organization of early and late replicating DNA in human chromosome territories. Exp Cell Res 247, 176–188.

    Article  PubMed  CAS  Google Scholar 

  • Zirbel R.M., Mathieu U.R., Kurz A., Cremer T., and Lichter P. (1993) Evidence for a nuclear compartment of transcription and splicing located at chromosome domain boundaries. Chromosome Res 1, 93–106.

    Article  PubMed  CAS  Google Scholar 

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© 2002 Kluwer Academic Publishers

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Bornfleth, H. et al. (2002). Analysis of Chromosome Territory Architecture in the Human Cell Nucleus. In: Suhai, S. (eds) Genomics and Proteomics. Springer, Boston, MA. https://doi.org/10.1007/0-306-46823-9_11

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  • DOI: https://doi.org/10.1007/0-306-46823-9_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46312-9

  • Online ISBN: 978-0-306-46823-0

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