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References
Rosendaal FR. Thrombosis in the young: epidemiology and risk factors. A focus on venous thrombosis. Thromb Haemostas 1997;78: 1–6.
Ruggeri ZM. Mechanisms initiating platelet thrombus formation. Thromb Haemostas 1997;78:611–616.
Negrescu EV, Grunberg B, Kratzer MA et al. Interaction of antiplatelet drugs in vitro: aspirin, iloprost, and the nitric oxide donors SIN-1 and sodium nitroprusside. Cardiovasc Drugs Ther 1995;9:619–629.
Maclntyre DE. “Platelet prostaglandin receptors.” In Platelets in Biology and Pathology-2, Gordon JL, ed. Elsevier, 1981;211–247.
Seiss W. Molecular mechanisms of platelet activation. Physiol Rev 1989;69:58–178.
Hawiger J. Mechanisms involved in platelet vessel wall interaction. Thromb Haemostas 1995;74:369–372.
Body SC. Platelet activation and interactions with the microvasculature. J Cardiovasc Pharmacol 1996;27(Suppl 1):S13–25.
Coller BS. The role of platelets in arterial thrombosis and the rationale for blockade of platelet GPIIb/IIIa receptors as antithrombotic therapy. Eur Heart J 1995; 16(Suppl L):11–15.
Badimon L. Models to study thrombotic disorders. Thromb Haemostas 1997;78:667–671.
Moncada S, Gryglewski R, Bunting S et al. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 1976;263:663–665.
Gryglewski RJ, Bunting S, Moncada S et al. Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides. Prostaglandins 1976; 12:685–713.
Moncada S, Herman AG, Higgs EA et al. Differential formation of prostacyclin (PGX or PGI2) by layers of the arterial wall. An explanation for the anti-thrombotic properties of vascular endothelium. Thromb Res 1977;11:323–344.
Higgs EA, Higgs GA, Moncada S et al. Prostacyclin (PGI2) inhibits the formation of platelet thrombi in arterioles and venules of the hamster cheek pouch. Br J Pharmacol 1978;63:535–539.
Hornstra G, Haddeman E, Don JA. Blood platelets do not provide endoperoxides for vascular prostacyclin production. Nature 1979;279:66–68.
Needleman P. Prostacyclin in blood vessel-platelet interactions: perspectives and questions. Nature 1979;279: 14–15.
Trial co-ordinators. Randomized trial of ridogrel, a combined thromboxane A2 synthase inhibitor and thromboxane A2 / prostaglandin endoperoxide receptor antagonist, versus aspirin as adjunct to thrombolysis in patients with acute myocardial infarction. Circulation 1994;89:588–595.
Wu KK, Papp AC, Manner CE et al. Interaction between lymphocytes and platelets in the synthesis of prostacyclin. J Clin Invest 1987;79: 1601–1606.
Gryglewski RJ, Korbut R, Ocetkiewicz A. Generation of prostacyclin by lungs in vivo and its release into the arterial circulation. Nature 1978;273:765–767.
Moncada S, Korbut R, Bunting S et al. Prostacyclin is a circulating hormone. Nature 1978;273:767–768.
Christ-Hazelhof E, Nugteren DH. Prostacyclin is not a circulating hormone. Prostaglandins 1981;22:739–746.
Lanham JG, Levin MBZ, Gharavi AE et al. Prostacyclin deficiency in a young woman with recurrent thrombosis. Br Med J 1986;292:435–436.
Nishio S, Matsuura H, Kanai N et al. The in vitro and ex vivo antiplatelet effect of TRK-100, a stable prostacyclin analog, in several species. Jpn J Pharmacol 1988;47:1–10.
Stürzebecher C-S, Losert W. “Effects of iloprost on platelet activation in vitro.” In Prostacyclin and its Stable Analogue Iloprost, Gryglewski RJ, Stock G, eds. Berlin: Springer-Verlag, 1987;39–45.
Moncada S. Biology and therapeutic potential of prostacyclin. Stroke 1983;14: 157–168.
Bavage B, Shattil SJ, Ruggeri ZM. Modulation of platelet function through adhesion receptors. J Biol Chem 1992;267:11300–11306.
Moncada S. Prostacyclin/thromboxane-mediated mechanisms in platelet-vascular wall interactions. Adv Prostaglandin Thromboxane Leukot Res 1985; 15507–512.
Murata T, Ushikubi F, Matsuoka T et al. Altered pain perception and inflammatory response in mice lacking prostacyclin receptor. Nature 1997;388:678–682.
Sinzinger H, Schernthaner G, Kaliman J. Sensitivity of platelets to prostaglandins in coronary heart disease and angina pectoris. Prostaglandins 1981;22:773–781.
Kahn NN, Mueller HS, Sinha AK. Impaired prostaglandin E1/I2receptor activity of human blood platelets in acute ischemic heart disease. Circ Res 1990;66:932–940.
Manrique RV, Manrique R. “Resistance of platelets to prostacyclin.” In Prostacyclin and its Stable Analogue Iloprost, Gryglewski RJ, Stock G, eds. Berlin: Springer-Verlag, 1987;57–63.
Armstrong RA. Platelet prostanoid receptors. Pharmacol Ther 1996;72:171–191.
Brass LF, Manning DR, Cichowski K et al. Signaling through G proteins in platelets: to the integrins and beyond. Thromb Haemostas 1997;78:581–589.
Merritt JE, Hallam TJ, Brown AM et al. Octimibate, a potent non-prostanoid inhibitor of platelet aggregation, acts via the prostacyclin receptor. Br J Pharmacol 1991;102:251–259.
Siegl AM, Smith JB, Silver MJ et al. Selective binding site for [3H] prostacyclin on platelets. J Clin Invest 1979;63:215–220.
Ito S, Hashimoto H, Negishi M et al. Identification of the prostacyclin receptor by use of [15-3H1] 19-(3-azidophenyl)-20-norisocarbacyclin, anirreversiblespecific photoaffinity label. J Biol Chem 1992;267:20326–20330.
Eggerman TL, Andersen NH, Robertson RP. Separate receptors for prostacyclin and prostaglandin E2 on human gel-filtered platelets. J Pharmacol Exp Ther 1986;236:568–573.
Jones RL, Qian Y, Wise H et al. Relaxant actions of nonprostanoid prostacyclin mimetics on human pulmonary artery. J Cardiovasc Pharmacol 1997;29:525–535.
Hall JM, Strange PG. The use of a prostacyclin analogue, [3H] iloprost, for studying prostacyclin-binding sites on human platelets and neuronal hybrid cells. Biosci Reports 1984;4:941–948.
Seiler S, Brassard CL, Arnold AJ et al. Octimibate inhibition of platelet aggregation: stimulation of adenylate cyclase through prostacyclin receptor activation. J Pharmacol Exp Ther 1990;255:1021–1026.
Seiler SM, Brassard CL, Federici ME et al. [3-[ 4-(4,5-Diphenyl-2-oxazolyl)-5-oxazolyl] phenoxy] acetic acid (BMY 45778) is a potent non-prostanoid prostacyclin partial agonist: effects on platelet aggregation, adenylyl cyclase, cAMP levels, protein kinase, and iloprost binding. Prostaglandins 1997;53:21–35.
Seiler SM, Brassard CL, Federici ME et al. 2-[ 3-[ 2-(4,5-Dipheny1-2-oxazolyl) ethyl] phenoxy] acetic acid (BMY 42393): a new, structurally-novel prostacyclin partial agonist: (1) inhibition of platelet aggregation and mechanism of action. Thromb Res 1994;74:115–123.
Armstrong RA, Jones RL, MacDermot J et al. Prostaglandin endoperoxide analogues which are both thromboxane receptor antagonists and prostacyclin mimetics. Br J Pharmacol 1986;87: 543–551.
Schillinger E, Prior G. Prostaglandin I2 receptors in a particulate fraction of platelets of various species. Biochem Pharmacol 1980;29:2297–2299.
Armstrong RA, Lawrence RA, Jones RL et al. Functional and ligand binding studies suggest heterogeneity of platelet prostacyclin receptors. Br J Pharmacol 1989;97:657–668.
Lombroso M, Nicosia S, Paoletti R et al. The use of stable prostaglandins to investigate prostacyclin (PGI2)-binding sites and PGI2-sensitive adenylate cyclase in human platelet membranes. Prostaglandins 1984;27:321–333.
Kahn NN, Bauman WA, Sinha AK. Loss of high-affinity prostacyclin receptors in platelets and the lack of prostaglandin-induced inhibition of platelet-stimulated thrombin generation in subjects with spinal cord injury. Proc Natl Acad Sci USA 1996;93:245–249.
Kahn NN, Bauman WA, Sinha AK. Demonstration of a novel circulating anti-prostacyclin receptor antibody. Proc Natl Acad Sci USA 1997;94:8779–8782
Dutta-Roy AK, Kahn NN, Sinha AK. Interaction of receptors for prostaglandin E1/prostacyclin and insulin in human erythrocytes and platelets. Life Sci 1991;49:1129–1139.
Taussig R, Iniguez-Lluhi JA, Gilman AG. Inhibition of adenylyl cyclase by G1α Science 1993;261:218–221.
Hellevuo K, Yoshimura M, Kao M et al. A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line. Biochem Biophys Res Commun 1993;192:311–318.
Merritt JE, Brown AM, Bund S et al. Primate vascular responses to octimibate, a non-prostanoid agonist at the prostacyclin receptor. Br J Pharmacol 1991;102:260–266.
Hecker G, König E, Ney P et al. Potent inhibition of PAF-stimulated human platelets and polymorphonuclear leukocytes by the PGE1 analog OP-1206. Prog Clin Biol Res 1987;247:317–322.
Eigenthaler M, Nolte C, Halbrügge M et al. Concentration and regulation of cyclic nucleotides, cyclic-nucleotide-dependent protein kinases and one of their major substrates in human platelets. Eur J Biochem 1992;205:471–481.
Katsube N, Sakaguchi K, Fujitani B et al. Anti-platelet and anti-thrombotic effect of OP-41483α-CD, a prostacyclin analogue, in experimental animals. Prostaglandins Leukot Essent Fatty Acids 1993;49:795–804.
Whittle BJR, Moncada S, Vane JR. Comparison of the effects of prostacyclin (PGI2), prostaglandin E1 and D2 on platelet aggregation in different species. Prostaglandins 1978;16:373–387.
Matthews JS, Jones RL. Potentiation of aggregation and inhibition of adenylate cyclase in human platelets by prostaglandin E analogues. Br J Pharmacol 1993;108:363–369.
Ashby B. Interactions among prostaglandin receptors. Receptor 1994;4:31–42.
Mao G-F, Jin J-G, Bastepe M et al. Prostaglandin E2 both stimulates and inhibits adenyl cyclase on platelets: comparison of effects on cloned EP4 and EP3 prostaglandin receptor subtypes. Prostaglandins 1996;52:175–185.
Nishimura T, Yamamoto T, Komuro Y et al. Antiplatelet functions of a stable prostacyclin analog, SM-10906 are exerted by its inhibitory effect on inositol 1,4,5-trisphosphate production and cytosolic Ca++increase in rat platelets stimulated by thrombin. Thromb Res 1995;79:307–317.
Tsai A, Hsu M-J, Vijjeswarapu H et al. Solubilization of prostacyclin membrane receptors from human platelets. J Biol Chem 1989;264:61–67.
Wise H, Kobayashi T, Hong LL et al. Modification of the carboxyl-terminal tail of the prostacyclin (IP)-receptor increases the efficacy of the IP-receptor partial agonist, BMY 45778. Proc 1 st IUPHAR Conference 1998;p28.
Meanwell NA, Rosenfeld MJ, Trehan AK et al. Nonprostanoid prostacyclin mimetics. 2. 4,5-Diphenyloxazole derivatives. J Med Chem 1992;35:3483–3497.
Meanwell NA, Romine JL, Rosenfeld MJ et al. Non-prostanoid prostacyclin mimetics. 5. Structure-activity-relationships associated with[3-[4-(4,5-diphenyl-2-oxazolyl)-5-oxazolyl] phenoxy] acetic acid. J Med Chem 1993;36:3884–3903.
Nony P, Ffrench P, Girard P et al. Platelet-aggregation inhibition and hemodynamic effects of beraprost sodium, a new oral prostacyclin derivative: a study in healthy male subjects. Can J Physiol Pharmacol 1996;74:887–893.
Cavallini L, Coassin M, Borean A et al. Prostacyclin and sodium nitroprusside inhibit the activity of the platelet inositol 1,4,5-trisphosphate receptor and promote its phosphorylation. J Biol Chem 1996;271:5545–5551.
Whittle BJR, Moncada S, Mullane K et al. Platelet and cardiovascular activity of the hydantoin BW245C, a potent prostaglandin analogue. Prostaglandins 1983;25:205–223.
Toda N. Beraprost Sodium. Cardiovasc Drug Rev 1988;6:222–238.
Maurice DH, Haslam RJ. Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP. Mol Pharmacol 1990;37:671–681.
Dickinson NT, Jang EK, Haslam RJ. Activation of cGMP-stimulated phosphodiesterase by nitroprusside limits CAMP accumulation in human platelets: effects on platelet aggregation. Biochem J 1997;323:371–377.
Siess W, Lapetina EG. Prostacyclin inhibits platelet aggregation induced by phorbol ester or Ca2+ionophore at steps distal to activation of protein kinase C and Ca2+-dependent protein kinases. Biochem J 1989;258:57–65.
Jorgensen KA, Dyerberg J, Stoffersen E. Prostacyclin (PGI2) and the effect of phosphodiesterase inhibitors on platelet aggregation. Pharmacol Res Commun 1979;11:605–614.
Darius H, Lefer AM, Leprán I et al. In vivo interaction of prostacyclin with an inhibitor of cyclic nucleotide phosphodiesterase, HL 725. Br J Pharmacol 1985;84:735–741.
Alt U, Leigh PJ, Wilkins AJ et al. Desensitization of iloprost responsiveness in human platelets follows prolonged exposure to iloprost in vitro. Br J Clin Pharmacol 1986;22:118–119.
Jaschonek K, Faul C, Schmidt H et al. Desensitization of platelets with iloprost. Loss of specific binding sites and heterologous desensitization of adenylate cyclase. Eur J Pharmacol 1988;147:187–196.
Edwards RJ, MacDermot J, Wilkins AJ. Prostacyclin analogues reduce ADP-ribosylation of the a-subunit of the regulatory Gs-protein and diminish adenosine (A2) responsiveness of platelets. Br J Pharmacol 1987;90:501–510.
Giovanazzi S, Accomazzo MR, Letari O et al. Internalization and down-regulation of the prostacyclin receptor in human platelets. Biochem J 1997;325:71–77.
Fisch A, Tobusch K, Veit K et al. Prostacyclin receptor desensitization is a reversible phenomenon in human platelets. Circulation 1997;96:756–760.
Murray R, Shipp E, Fitzgerald GA. Prostaglandin endoperoxide/thromboxane A2 receptor desensitization. J Biol Chem 1990;265:21670–21675.
Elalamy I, Sharareh E, Vargaftig BB et al. Signal transduction involved in the platelet adenylate cyclase sensitization associated with PGH2/TxA2 receptor desensitization. Br J Haematol 1997;99:190–196.
Discussion on platelet mechanisms. In Prostacyclin and its Stable Analogue Iloprost. Gryglewski RJ, Stock G, eds. Berlin: Springer-Verlag, 1987;103–112.
Sinzinger H, Silberbauer K, Horsch AK et al. Decreased sensitivity of human platelets to PGI2 during long-term intraarterial prostacyclin infusion in patients with peripheral vascular disease — a rebound phenomenom? Prostaglandins 1981;21:49–51.
Darius H, Michael-Hepp J, Meyer J. Platelet prostacyclin receptor desensitization by iloprost but not by the analog taprostene. Thromb Haemostas 1993;69:p1336.
Whittle BJR, Moncada S, Whiting F et al. Carbacyclin — a potent stable prostacyclin analogue for the inhibition of platelet aggregation. Prostaglandins 1980;19:605–627.
MacDermot J, Alt U, Leigh PJ et al. “Desensitization of iloprost or prostacyclin responsiveness”. In Prostacyclin and its Stable Analogue Iloprost, Gryglewski RJ, Stock G, eds. Berlin: Springer-Verlag, 1987;53–56.
Watanabe T, Sunaga S, Togo M et al. Protein kinase C plays a key role in the cross-talk between intracellular signalings via prostanoid receptors in a megakaryoblastic cell line, MEG-01s. Biochim Biophys Acta 1996;1304:161–169.
Adachi M, Ryo R, Yoshida A et al. Elevation of intracellular calcium ion by prostaglandin E1 and itsinhibition by protein kinase C in a human megakaryocyte leukemia cell line. Cancer Res 1989;49:3805–3808.
Feoktistov I, Breyer RM, Biaggioni I. Prostanoid receptor with a novel pharmacological profile in human erythroleukemia cells. Biochem Pharmacol 1997;54:917–926.
Turner JT, Camden JM, Kansra S et al. Potentiation of cyclic adenosine monophosphate production by thrombin in the human erythroleukemia cell line, HEL. J Pharmacol Exp Ther 1992;263:708–716.
Watanabe T, Yatomi Y, Sunago S et al. Characterization of prostaglandin and thromboxane receptors expressed on a megakaryoblastic leukemia cell line, MEG-01 s. Blood 1991;78:2328–2336.
Schwaner I, Seifert R, Schultz G. Receptor-mediated increases in cytosolic Ca2+ in the human erythroleukaemia cell line involve pertussis toxin-sensitive and-insensitive pathways. Biochem J 1992;281:301–307.
Schwaner I, Seifert R, Schultz G. The prostacyclin analogues, cicaprost and iloprost, increase cytosolic Ca2+ concentration in the human erythroleukemia cell line, HEL, via pertussis toxin-insensitive G-proteins. Eicosanoids 1992;5:S10412.
Namba T, Oida H, Sugimoto Y et al. cDNA cloning of a mouse prostacyclin receptor. J Biol Chem 1994;269:9986–9992.
Katsuyama M, Sugimoto Y, Namba T et al. Cloning and expression of a cDNA for the human prostacyclin receptor. FEBS Lett 1994;344:74–78.
Smyth EM, Nestor PV, Fitzgerald GA. Agonist-dependent phosphorylation of an epitope-tagged human prostacyclin receptor. J Biol Chem 1996;271:33698–33704.
Brass LF, Woolkalis MJ. Dual regulation ofcyclic AMP formation by thrombin in HEL cells, a leukaemic cell line with megakaryocytic properties. Biochem J 1992;281:73–80.
Sasaki Y, Takahashi T, Tanaka I et al. Expression of prostacyclin receptor in human megakaryocytes. Blood 1997;90:1039–1046.
Murray R, Furci L, Fitzgerald GA. Induction of prostacyclin receptor expression in human erythroleukemia cells. FEBS Lett 1989;255:172–174.
Schafer AI. Antiplatelet therapy. Am J Med 1996;101:199–209.
Clinprost. Drugs Future 1997;22:608–625.
Meggiato C, Padoin E, Ragazzi E et al. Inhibition of platelet activation by MM-706, a stable carbacyclin analog, in the conscious rat. Gen Pharmacol 1997;28:251–255.
Data JL, Molony BA, Meinzinger MM et al. Intravenous infusion of prostacyclin sodium in man: clinical effects and influence on platelet adenosine diphosphate sensitivity and adenosine 3’:5’-cyclic monophosphate levels. Circulation 1981;64:4–12.
Whittle BJR, Moncada S. Platelet actions of stable carbocyclic analogues of prostacyclin. Circulation 1985;72:1219–1225.
Grant SM, Goa KL. Iloprost. Drugs 1992;43:889–924.
Schrör K. Antiplatelet drugs. Drugs 1995;50:7–28.
Sagripanti A, Carpi A, Rosaia B et al. Iloprost in the treatment of thrombotic microangiopathy: report of thirteen cases. Biomed Pharmacother 1996;50:350–356.
Konno M, Yoshioka A, Takase T et al. Partial clinical improvement in Up shaw-Schulman syndrome following prostacyclin infusion. Acta Paed Jpn 1995;37:97–100.
Blackwell GJ, Radomski M, Vargas JR et al. Prostacyclin prolongs viability of washed human platelets. Biochim Biophys Acta 1982;718:60–65.
Banning A, Brewer L, Wendt M et al. Local delivery of platelets with encapsulated iloprost to balloon injured pig carotid arteries: effect on platelet deposition and neointim a formation. Thromb Haemostas 1997;77:190–196.
Fareed J. Current trends in antithrombotic drug and device development. Sem Thromb Hemostas 1996;22(Suppl1):3–8.
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(2002). IP-receptors on platelets. In: Prostacyclin and Its Receptors. Springer, Boston, MA. https://doi.org/10.1007/0-306-46822-0_5
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