Skip to main content
SpringerLink
Log in

Carnitine Acyltransferases and Associated Transport Processes in the Endoplasmic Reticulum

Missing Links in the VLDL Story?

  • Chapter
Current Views of Fatty Acid Oxidation and Ketogenesis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 466))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Markwell, M.A.K., Tolbert, N.E. & Bieber, L.L. (1976) tArch. Biochem. Biophys., 176, 479–488. Comparison of the carnitine acyltransferase activities from rat liver peroxisomes and microsomes.

    CAS  Google Scholar 

  2. Lilly, K., Bugaisky, G.E., Umeda, P.K. & Bieber, L.L. (1990) tArch. Biochem. Biophys., 280, 167–174. The medium-chain carnitine acyltransferase activity associated with rat liver microsomes is malonyl-CoA sensitive.

    CAS  Google Scholar 

  3. Murthy, M.S.R. & Bieber, L.L. (1992) tProtein Expression Purif., 3, 75–79. Purification of the medium-chain/long-chain (COT/CPT) carnitine acyltransferase of rat liver microsomes.

    CAS  Google Scholar 

  4. Chung, C.-D. & Bieber, L.L. (1993) tJ. Biol. Chem., 268, 4519–4524. Properties of the medium/long chain carnitine acyltransferase purified from rat liver microsomes.

    CAS  Google Scholar 

  5. Broadway, N.M. & Saggerson, E.D. (1995) tBiochem. J., 310, 989–995. Solubilization and separation of two distinct carnitine acyltransferases from hepatic microsomes: characterization of the malonyl-CoA-sensitive enzyme.

    CAS  Google Scholar 

  6. Murthy, M.S.R. & Pande, S.V (1994) tJ. Biol Chem., 269, 18283–18286. Malonyl-CoA-sensitive and-insensitive carnitine palmitoyltransferase activities of microsomes are due to different proteins.

    CAS  Google Scholar 

  7. Murthy, M.S.R. & Pande, S.V. (1993) tMol. Cell. Biochem., 122, 133–138. Carnitine medium/long chain acyltransferase of microsomes seems to be the previously cloned approximately 54kDa protein of unknown function.

    CAS  Google Scholar 

  8. Murthy, M.S.R. & Pande, S.V. (1994) tBiochem. J., 304, 31–34. A stress-regulated protein, GRP58, a member of thioredoxin superfamily, is a carnitine palmitoyltransferase isoenzyme.

    CAS  Google Scholar 

  9. Bourdi, M., Demady, D., Martin, J.L., Jabbour, S.K., Martin, B.M., George, J.W. & Pohl, L.R. (1995) Arch. Biochem. Biophys., 323, 397–403. cDNA cloning and baculovirus expression of the human liver endoplasmic reticulum p58: characterization as a protein disulfide isomerase isoform, but not as a protease or a carnitine acyltransferase.

    Article  CAS  PubMed  Google Scholar 

  10. Broadway, N.M. & Saggerson, E.D. (1997) tBiochem. J., 322, 435–440. Effect of membrane environment on the activity and inhibitability by malonyl-CoA of the carnitine acyltransferase of hepatic microsomal membranes.

    CAS  Google Scholar 

  11. Broadway, N.M., Pease, R.J. & Saggerson, E.D. (1998) Biochem. J. —submitted for publication. The liver isoform of carnitine palmitoyltransferase 1 inserts into endoplasmic reticulum membranes in a cell-free system.

    Google Scholar 

  12. McGarry, J.D. & Brown, N.F. (1997) tEm J. Biochem., 244, 1–14. The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis.

    CAS  Google Scholar 

  13. Fraser, F, Corstorphine, C.G. & Zammit, V.A. (1997) tBiochem. J., 323, 711–718. Topology of carnitine palmitoyltransferase 1 in the mitochondrial outer membrane.

    CAS  Google Scholar 

  14. Indiveri, C., Tonazzi, A. & Palmieri, F. (1990) tBiochim. Biophys. Acta, 1020, 81–86. Identification and purification of the carnitine carrier from rat liver mitochondria.

    CAS  Google Scholar 

  15. Indiveri, C., Tonazzi, A., Prezioso, G. & Palmieri, F. (1991) tBiochim. Biophys. Acta, 1065, 231–238. Kinetic characterization of the reconstituted carnitine carrier from rat liver mitochondria.

    CAS  Google Scholar 

  16. Indiveri, C., Tonazzi, A. & Palmieri, F. (1994) tBiochim. Biophys. Acta, 1189, 65–73. The reconstituted carnitine carrier from rat liver mitochondria: evidence for a transport mechanism different from that of the other mitochondrial translocators.

    CAS  Google Scholar 

  17. Indiveri, C., Tonazzi, A., Giangregorio, N. & Palmieri, F. (1995) tEur. J. Biochem., 228, 271–278. Probing the active site of the reconstituted carnitine carrier from rat liver mitochondria with sulfhydryl reagents. A cysteine residue is localized in or near the substrate inding site.

    CAS  Google Scholar 

  18. Indiveri, C., Iacobazzi, V., Giangregorio, N. & Palmieri, F. (1997) tBiochem. J., 321, 713–719. The mitochondrial carnitine carrier protein: cDNA cloning, primary structure and comparison with other mitochondrial transport proteins.

    CAS  Google Scholar 

  19. Polokoff, M.A. & Bell, R.M. (1978) tJ. Biol. Chem., 235, 7173–7178. Limited palmitoyl-CoA penetration into microsomal vesicles as evidenced by a highly latent ethanol acyltransferase activity.

    Google Scholar 

  20. Treloar, T., Madden, L.J., Winter, J.S., Smith, J.L. & de Jersey, J. (1996) tBiochim. Biophys. Acta, 1299, 160–166. Fatty acid ethyl ester synthesis by human liver microsomes.

    Google Scholar 

  21. Gooding, J.M. & Saggerson, E.D. (1998) tBiochem. J.—submitted for publication. Uptake of carnitine and palmitoylcarnitine by rat liver microsomes.

    Google Scholar 

  22. Pfanner, N., Glick, B.S. & Rothman, J.E. (1987) tJ. Cell Biol., 110, 955–961. Fatty acylation promotes fusion of transport vesicles with Golgi cisternae.

    Google Scholar 

  23. Pfanner, N., Orci, L., Glick, B.S., Amherdt, M., Arden, S.R., Malhotra, V. & Rothman, J.E. (1989) tCell, 59, 95–102. Fatty acyl-coenzyme A is required for budding of transport vesicles from Golgi cisternae.

    CAS  Google Scholar 

  24. Lawrence, J.B., Moreau, P., Cassagne, C. & Morre, D.J. (1994) tBiochim. Biophys. Acta, 1210, 146–150. Acyl transfer reactions associated with cis Golgi apparatus of rat liver.

    CAS  Google Scholar 

  25. Hoeg, J.M., Meng, M.S., Ronan, R., Demosky, S.J., Fairwell, T. & Brewer, H.B. (1988) tJ. LipidRes., 29, 1215–1220. Apolipoprotein B synthesized by Hep G2 cells undergoes fatty acid acylation.

    CAS  Google Scholar 

  26. Huang, G., Lee, D.M. & Singh, S. (1988) tBiochemistry, 27, 1395–1400. Identification of the thiol ester lipids in apolipoprotein B.

    CAS  Google Scholar 

  27. Kaufman, J.F., Krangel, M.S. & Strominger, J.L. (1984) tJ Biol. Chem., 259, 7230–7238. Cysteines in the transmembrane region of major histocompatibility complex antigens are fatty acylated via thioester bonds.

    CAS  Google Scholar 

  28. Magee, A.I. & Schlesinger, M.J. (1982) tBiochim. Biophys. Acta, 649, 279–289. Fatty acid acylation of eukaryotic cell membrane proteins.

    Google Scholar 

  29. Borén, J., Wettesten, M., Sjőberg, A., Thorlin, T., Bondjers, G., Wiklund, O. & Olofsson, S-O. (1990) tJ. Biol. Chem., 265, 10556–10564. The assembly and secretion of ApoB 100 containing lipoproteins in Hep G2 cells.

    Google Scholar 

  30. Spring, D.J., Chen-Liu, L.W., Chatterton, J.E., Elovson, J. and Schumaker, V.N. (1992) tJ. Biol. Chem. 267, 14839–14845. Lipoprotein assembly. Apolipoprotein B size determines lipoprotein core circumference.

    CAS  Google Scholar 

  31. Borén, J., Rustaeus, S. & Olofsson, S-O. (1994) tJ. Biol. Chem., 269, 25879–25888. Studies on the assembly of apoliporotein B-100-and B-48-containing very low density lipoproteins in McA-RH7777 cells.

    Google Scholar 

  32. Swift, L.L. (1995) tJ. Lipid Res., 26, 395–406. Assembly of very low density lipoproteins in rat liver: a study of nascent particles recovered from the rough endoplasmic reticulum.

    Google Scholar 

  33. Rustaeus, S., Lindberg, K., Borén, J. & Olofsson, S-O. (1995) tJ. Biol. Chem., 270, 28879–28886. Brefeldin A reversibly inhibits the assembly of ApoB containing lipoproteins in McA-RH7777 cells.

    CAS  Google Scholar 

  34. Cartwright, I.J. & Higgins, J.A. (1995) tBiochem. J., 310, 897–907. Intracellular events in the assembly of very-low-density-lipoprotein lipids with apoliporotein B in isolated rabbit hepatocytes.

    CAS  Google Scholar 

  35. Gordon, D.A., Jamil, H., Gregg, R.E., Olofsson, S-O. & Borén, J. (1996) tJ. Biol. Chem., 271, 33047–33053. Inhibition of the microsomal triglyceride transfer protein blocks the first step of apolipoprotein B lipoprotein assembly but not the addition of bulk core lipids in the second step.

    CAS  Google Scholar 

  36. Cartwright, I.J., Higgins, J.A., Wilkinson, J., Bellavia, S., Kendrick, J.S. & Graham, J.M. (1997) tJ. Lipid. Res., 38, 531–545. Investigation of the role of lipids in the assembly of very low density lipoproteins in rabbit hepatocytes.

    CAS  Google Scholar 

  37. Gregg, R.E. & Wetterau, J.R. (1994) tCurr. Opin. Lipidol., 5, 81–86. The molecularbasis of abetalipoproteinaemia.

    CAS  Google Scholar 

  38. Leiper, J.M., Bayliss, J.D., Pease, R.J., Brett, D.J., Scott, J. & Shoulders, C.C. (1994) tJ. Biol. Chem., 269, 21951–21954. Microsomal triglyceride transfer protein, the abetolipoproteinemia gene product, mediates the secretion of apoliporotein B-containing lipoproteins from heterologous cells.

    CAS  Google Scholar 

  39. Gibbons, G.F., Bartlett, S.M., Sparks, C.E. & Sparks, J.D. (1992) tBiochem. J., 287, 749–753. Extracellular fatty acids are not utilized directly for the synthesis of very-low-density lipoprotein in primary cultures of rat hepatocytes.

    CAS  Google Scholar 

  40. Gibbons, G.F. & Wiggins, D. (1994) tAdv. Enzyme Regul., 35, 179–198. Intracellular triacylglycerol lipase: its role in the assembly of hepatic very-low-density lipoprotein (VLDL).

    Google Scholar 

  41. Gibbons, G.F. & Wiggins, D. (1992) tBiochem. J., 284, 457–462. The lipolysis/esterification cycle of hepatic triacylglycerol. Its role in the secretion of ver-low-density lipoprotein and its response to hormones and sulphonylureas.

    Google Scholar 

  42. Yang, L-Y, Kuksis, A., Myher, J.J. & Steiner, G. (1995) tJ. Lipid Res., 36, 125–136. Origin of triacylglycerol moiety of plasma very low density lipoproteins in the rat: structural studies.

    CAS  Google Scholar 

  43. Owen, M.R., Corstorphine, C.C. & Zammit, V.A. (1997) tBiochem. J., 323, 17–21. Overt and latent activities of diacylglycerol acyltransferase in rat liver microsomes: possible roles in very-low-density lipoprotein triacylglycerol secretion.

    CAS  Google Scholar 

  44. Allan, D., Thomas, P. & Michell, R.H. (1978) tNature, 276, 289–290. Rapid transbilayer diffusion of 1,2-diacylglycerol and its relevance to control of membrane curvature.

    CAS  Google Scholar 

  45. Gibbons, G.F. (1990) tBiochem. J., 268, 1–13. Assembly and secretion of hepatic very-low-density lipoprotein.

    CAS  Google Scholar 

  46. Duerden, J.M. & Gibbons, G.F. (1990) tBiochem. J., 272, 583–587. Storage, mobilization and secretion of cytosolic triacylglycerol in hepatocyte cultures.

    CAS  Google Scholar 

  47. Bartlett, S.M. & Gibbons, G.F. (1988) tBiochem. J., 249, 37–43. Short-and longer-term regulation of very-low-density lipoprotein secretion by insulin, dexamethasone and lipogenic substrates in cultured hepatocytes.

    CAS  Google Scholar 

  48. Sparks, J.D. & Sparks, C.E. (1994) tBiochim. Biophys. Acta, 1215, 9–32. Insulin regulation of triacyl-glycerol-rich lipoprotein synthesis and secretion.

    CAS  Google Scholar 

  49. Zammit, V.A. (1996) tBiochem. J., 314, 1–14. Role of insulin in hepatic fatty acid partitioning: emerging concepts.

    CAS  Google Scholar 

  50. Broadway, N.M. & Saggerson, E.D. (1995) tFEBS Lett., 371, 137–139. Inhibition of liver microsomal carnitine acyltransferases by sulphonylurea drugs.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, University College London, Gower Street, London, WC1E 6BT, UK

    Neil M. Broadway, Jason M. Gooding & E. David Saggerson

Authors
  1. Neil M. Broadway
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jason M. Gooding
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. David Saggerson
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Unit of Paediatric Surgery Institute of Child Health & Great Ormond Street Hospital for Children NHS Trust, University College London Medical School, London, UK

    Patti A. Quant  & Simon Eaton  & 

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Kluwer Academic Publishers

About this chapter

Cite this chapter

Broadway, N.M., Gooding, J.M., Saggerson, E.D. (2002). Carnitine Acyltransferases and Associated Transport Processes in the Endoplasmic Reticulum. In: Quant, P.A., Eaton, S. (eds) Current Views of Fatty Acid Oxidation and Ketogenesis. Advances in Experimental Medicine and Biology, vol 466. Springer, Boston, MA. https://doi.org/10.1007/0-306-46818-2_6

Download citation

  • DOI: https://doi.org/10.1007/0-306-46818-2_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46200-9

  • Online ISBN: 978-0-306-46818-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation