Skip to main content

Effect of Valproic Acid on the Expression of Acyl-CoA Dehydrogenases in Various Tissues

  • Chapter
  • 303 Accesses

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 466))

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Koch-Weser, J. & Browne, T.R. (1980) New Engl. J. Med. 302, 661–666. Valproic acid.

    CAS  PubMed  Google Scholar 

  2. Gerber, N., Dickinson, R.G., Harland R.C., Lynn, R.K., Houghton, D., Antonias, J.I. & Schimschock, J.C. (1979) J. Pediatr. 95, 142–144. Reye-like syndrome associated with valproic acid therapy.

    CAS  PubMed  Google Scholar 

  3. Dreifess, F.E., Laner, D.H., Moline, K.A. & Maxwell, J.E. (1989) Neurology 39, 201–207. Valproic acid hepatic fatalities. II. US experience since 1984.

    Google Scholar 

  4. Kesterson, J.W., Graneman, G.R. & Machinist, J.M. (1984) Hepatology 4, 1143–1152. The hepatotoxicity of valproic acid and its metabolites in rats. I. Toxicologic, biochemical and histopathologic studies.

    CAS  PubMed  Google Scholar 

  5. Graneman, G.R., Wang, S., Kesterson, J.W. & Machinist, J.M. (1984) Hepatology 4, 1153–1158. The hepatotoxicity of valproic acid and its metabolites in rats. II. Intermediary and valproic acid metabolism.

    Google Scholar 

  6. Mortensen, P.B., Gregersen, N., Kolvraa, S. & Christensen, E. (1980) Biochem. Med. 24, 1531–1561. The occurrence of C6-C10-dicarboxylic acids in urine from patients and rats treated with dipropylacetate.

    Article  Google Scholar 

  7. Ikeda, Y, Dabrowsly, C. & Tanaka, K. (1983) J. Biol. Chem. 258, 1066–1076. Separation and properties of five distinct acyl-CoA dehydrogenases from rat liver mitochondria. Identification of a new 2-methyl branched chain acyl-CoA dehydrogenase.

    CAS  PubMed  Google Scholar 

  8. Ikeda, Y, Okamura-Ikeda, K. & Tanaka, K. (1985) J. Biol. Chem. 260, 1311–1325. Purification and characterization of short-chain, mediumchain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo-and apoenzymes and conversion of the apoenzyme to the holoenzyme.

    CAS  PubMed  Google Scholar 

  9. Ikeda, Y. & Tanaka, K. (1983) J. Biol. Chem. 258, 1077–1085. Purification and characterization of isovareryl coenzyme A dehydrogenase from rat liver mitochondria.

    CAS  PubMed  Google Scholar 

  10. Ikeda, Y. & Tanaka, K. (1983) J. Biol. Chem. 258, 9477–9487. Purification and characterization of 2-methyl-branched chain acylcoenzyme A dehydrogenase, an enzyme involved in the isoleucine and valine metabolism, from rat liver mitochondria.

    CAS  PubMed  Google Scholar 

  11. Matsubara, Y, Indo, Y, Naito, E., Ozasa, H., Glassberg, R., Vockley, J., Ikeda, Y, Kraus, J. & Tanaka, K. (1989) J. Biol. Chem. 264, 16321–16331. Molecular cloning and nucleotide sequence of cDNAs encoding the precursors of rat long chain acyl-coenzymeA, short chain acyl-coenzyme A, and isovaleryl-coenzyme A dehydrogenases. Sequence homology of four enzymes of the acyl-CoA dehydrogenase family.

    CAS  PubMed  Google Scholar 

  12. Ito, M., Ikeda, Y, Arnez, J.G., Finocchiaro, G. & Tanaka, K. (1990) Biochim. Biophys. Acta 1034, 213–218. The enzymatic basis for the metabolism and inhibitory effects of valproic acid: dehydrogenation of valproyl-CoA by 2-methyl-branched-chain acyl-CoA dehydrogenase.

    CAS  PubMed  Google Scholar 

  13. Feinberg, A.P. & Vogelstein, B. (1983) Anal. Biochem. 132, 6–13. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

    Article  CAS  PubMed  Google Scholar 

  14. McGarry, J.D. & Foster, D.W. (1976) J. Lipid Res. 17, 277–281. An improved and simplified radioisotopic assay for the determination of free and esterified carnitine.

    CAS  PubMed  Google Scholar 

  15. Chirgwin, J.M., Przybyla, A.E., MacDonald, R.J. & Rutter, W.J. (1979) Biochemistry 18, 5294–5299. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

    Article  CAS  PubMed  Google Scholar 

  16. Schnaitman, C. & Greenwalt, J.W. (1968) J. Cell Biol. 38, 158–175. Enzymatic properties of the inner and outer membranes of rat liver mitochondria.

    Article  CAS  PubMed  Google Scholar 

  17. Towbin, H., Staehelin, T. & Gordon, J. (1979) Proc. Natl. Acad. Sci. U.S.A. 76, 4530–4534. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications.

    Google Scholar 

  18. Nagao, M. & Tanaka, K. (1992) J. Biol. Chem. 267, 17925–17932. FAD-dependent regulation of transcription.translation, post-translational processing, and post-processing stability of various mitochondrial acyl-CoA dehydrogenases and of electron transfer flavoprotien and the site of holoenzyme formation.

    CAS  PubMed  Google Scholar 

  19. Nishida, N., Sugimoto, T., Araki, A., Woo, M., Sakane, Y. & Kobayashi, Y. (1981) Pediatr. Res. 22, 500–503. Carnitine metabolism in valproate-treated rats: The effect of L-Carnitine supplementation.

    Google Scholar 

  20. Nagao, M., Parimoo, B. & Tanaka, K. (1993) J. Biol. Chem. 268, 24114–24124. Developmental, nutritional, and hormonal regulation of tissue-specific expression of the genes encoding various acyl-CoA dehydrogenases and α-subunit of electron transfer flavoprotein in rat.

    CAS  PubMed  Google Scholar 

  21. Bjorge, S.M. & Baillie, T.A. (1985) Biochem. Biophys. Res. Comm. 132, 245–252. Inhibition of mediumchain fatty acid β-oxidation in vitro by valproic acid and its unsaturated metabolite, 2-n-propyl-4-pentanoic acid.

    Article  CAS  PubMed  Google Scholar 

  22. Parimoo, B. & Tanaka, K. (1993) Genomics 15, 582–590. Structual organization of the human isovaleryl-CoA dehydrogenase gene.

    Article  CAS  PubMed  Google Scholar 

  23. Stumpf, D.A., Parker, W.D. Jr. & Angelini, C. (1982) Neurology 35, 1041–1045. Carnitine deficiency, organic acidemias and Reye’s syndrome.

    Google Scholar 

  24. Thurston, J.H., Caroll, J.E., Hauhart, R.E. & Schiro, J.A. (1985) Life Sci 36, 1643–1651. A single therapeutic dose of valproate affects liver carbohydrate, fat, adenylate, amino acid, coenzyme A, and carnitine metabolism in infant mice: possible clinical signficance.

    Article  CAS  PubMed  Google Scholar 

  25. Papadimitriou, A. & Servidei, S. (1991) Neuromuscul. Disord. 1, 247–252. Late onset lipid storage myopathy due to multiple acyl CoA dehydrogenase deficiency triggered by valproate.

    CAS  PubMed  Google Scholar 

  26. Van Hove, J.L., Zhang, W., Kahler, S.G., Roe, C.R., Chen, Y.T., Terada, N., Chace, D.H., Iafolla, A.K., Ding, J.H. & Millington, D.S. (1993) Am. J. Hum. Genet. 52, 958–966. Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency: diagnosis by acylcarnitine analysis in blood.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Kluwer Academic Publishers

About this chapter

Cite this chapter

Nagao, M., Kibayashi, M., Chiba, S. (2002). Effect of Valproic Acid on the Expression of Acyl-CoA Dehydrogenases in Various Tissues. In: Quant, P.A., Eaton, S. (eds) Current Views of Fatty Acid Oxidation and Ketogenesis. Advances in Experimental Medicine and Biology, vol 466. Springer, Boston, MA. https://doi.org/10.1007/0-306-46818-2_20

Download citation

  • DOI: https://doi.org/10.1007/0-306-46818-2_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46200-9

  • Online ISBN: 978-0-306-46818-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics