Conclusions
The studies carried out to date using polyoma and papillomavirus based carriers demonstrate their considerable promise, although numerous aspects of the systems require further attention. Present vectors vary widely in efficacy of DNA transfer, and parameters important in regulating this process need to be more clearly defined. Following establishment of a generalised prototype, modifications could then be made to target specifically to tumours, for instance by encoding tumour specific epitopes within the capsids, or crosslinking them to their surfaces. Further, delivery of prodrug activating enzyme genes to kill tumour cells, once targetted, could be explored. If it proves possible reliably to generate efficient and targetted pseudocapsid/VLP carriers, further approaches to anticancer therapy could be considered. For instance, delivery of wild type anti-oncogenes, such as p53, could be attempted, or where viruses (for example, papillo-maviruses, Epstein Barr virus, or herpesvirus-8) have been implicated in tumour formation, an approach aimed at inhibiting expression of identified oncogenic functions could be explored. These methods, coupled with stimulation of T cell killing by eliciting an immune response against tumour antigens expressed on the VLP/pseudocapsid surface, could produce a very efficient therapy vector.
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Krauzewicz, N., Griffin, B.E. (2002). Polyoma and Papilloma Virus Vectors For Cancer Gene Therapy. In: Habib, N.A. (eds) Cancer Gene Therapy. Advances in Experimental Medicine and Biology, vol 465. Springer, New York, NY. https://doi.org/10.1007/0-306-46817-4_8
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