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Sensitization of Tumors to Chemotherapy Through Gene Therapy

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References

  • Badie, B., Kramar, M.H., Lau, R., Boothman, D.A., Economou, J.S., and Black, K.L., 1998, Adenovirus-mediated p53 gene delivery potentiates the radiation-induced growth inhibition of experimental brain tumors, J. Neurooncol.37:217–222.

    PubMed  CAS  Google Scholar 

  • Bakalkin, G., Selivanova. G., Yakovleva, T., Kiseleva, E., Kashuba, E., Magnusson, K.P., Szekely, L., Klein, G., Terenus, L., and Wiman, K.G., 1995, p53 binds single stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain, Nucl. Acids Res.23:362–269.

    PubMed  CAS  Google Scholar 

  • Barret, J.M., and Hill, B.T., 1998, DNA repair mechanisms associated with cellular resistance to antitumor drugs: potential novel targets, Anticancer Drugs9:105–123.

    PubMed  CAS  Google Scholar 

  • Binetruy, B., Smeal, T., and Karin, M., 1991, Ha-ras augments c-Jun activity and stimulates phosphorylation of its activation domain, Nature351:122–127.

    PubMed  CAS  Google Scholar 

  • Cavigelli, M., Dolfi, F., Claret, F.X., and Karin, M., 1995, Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation, EMBO J.14:5957–5964.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Chelliah, J., and Jarvis, W.D., 1996, Effect of 1-beta-D-arabinofuranosylcytosine on apoptosis and differentiation in human monocytic leukemia cells (U937) expressing a c-Jun dominant-negative mutant protein (TAM67), Cell Growth Differ.7:603–613.

    PubMed  Google Scholar 

  • Clarke, A.R., Purdie, C.A., and Harrison, D.J., et al., 1993, Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature362:849–852.

    PubMed  CAS  Google Scholar 

  • Crooke, S.T., 1992, Therapeutic applications of oligonucleotides, Annu. Rev. Pharmacol. Toxicol.32:329–376.

    PubMed  CAS  Google Scholar 

  • Crooke, ST., 1998, Molecular mechanisms of antisense drugs: Rnase H, Antisense Nucleic Acid Drug Dev.8:133–134.

    PubMed  CAS  Google Scholar 

  • Crul, M., Schellens, J.H., Beijnen, J.H., and Maliepaard, M., 1997, Cisplatin resistance and DNA repair, Cancer Treat Rev.23:341–366.

    PubMed  CAS  Google Scholar 

  • Dean, N.M., McKay, R., Miraglia, L., Geiger, T., Muller, M., Fabbro, D., and Bennett, C.F., 1996, Antisense oligonucleotides as inhibitors of signal transduction: development from research tools to therapeutic agents, Biochem. Soc. Trans.24:623–629.

    PubMed  CAS  Google Scholar 

  • De Luca, L.G., Johnson, D.R., Whitley, M.Z., Collins, T., and Pober, J.S., 1994, cAMP and tumor necrosis factor competitively regulated transcriptional activation through a nuclear factor binding to the cAMP-responsive element/activating transcription fact element of the endothelial leukocyte adhesion molecule-1 (E-selectin) promoter, J. Biol. Chem.269:19193–19196.

    PubMed  Google Scholar 

  • Derijard, B., Hibi, M., Wu, I.H., Barrett, T., Su, B., Deng, T., Karin, M., and Davis, R.J., 1994, JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain, Cell76:1025–1037.

    PubMed  CAS  Google Scholar 

  • Dorigo, O., Turla, S.T., Lebedeva, S., and Gjerset, R.A., 1998, Sensitization of rat glioblastoma multiforme to cisplatin in vivo following restoration of wild-type p53 function, J. Neurosurg.88:535–540.

    PubMed  CAS  Google Scholar 

  • Fink, D., Aebi, S., Howell, S.B., 1998, The role of DNA mismatch repair in drug resistance, Clin. Cancer Res.4:1–6.

    PubMed  CAS  Google Scholar 

  • Fujiwara, T., Grimm, E.A., Mukhopadhyay, T., Zhang, W.W., Owen-Schaub, L.B., and Roth, J.A., 1994, Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene, Cancer Res.54:2287–2291.

    PubMed  CAS  Google Scholar 

  • Funato, T., Yoshida, E., Jiao, L., Tone, T., Kashani-Sabet, M., and Scanlon, K.J., 1992, The utility of an antifos ribozyme in reversing cisplatin resistance in human carcinomas, Adv. Enzyme Regul.32:195–209.

    PubMed  CAS  Google Scholar 

  • Gjerset, R.A., Turla, S.T., Sobol, R.E., Scalise, J.J., Mercola, D., Collins, H., Hopkins, and P.J., 1995, Use of wild-type p53 to achieve complete treatment sensitization of tumor cells expressing endogenous mutant p53. Molec. Carcinog.14:275–285.

    CAS  Google Scholar 

  • Gjerset, R.A., Dorigo, O., and Maung, V., et al., 1997, Tumor regression in vivo following p53 combination therapy, Cancer Gene Therapy4:0–2.

    Google Scholar 

  • Grant, S., Freemerman, A.J., Birrer, M.J., Martin, H.A., Turner, A.J., Szabo, E., and Reed, E., 1998, Platinum-DNA adduct, nucelotide excision repair and platinum based anti-cancer chemotherapy, Cancer Treat Rev.24:331–344.

    Google Scholar 

  • Gupta, S., Campbell, D., Derijard, B., and Davis, R.J., 1995, Transcription factor ATF2 regulation by the JNK signal transduction pathway, Science267:389–393.

    PubMed  CAS  Google Scholar 

  • Hibi, M., Lin, A., Smeal, T., Minden, A., and Karin, M., 1993, Identification of an oncoprotein-and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain, Genes Dev.7:2135–2148.

    PubMed  CAS  Google Scholar 

  • Jennerwein, M.M., and Eastman, A., 1991, A polymerase chain reaction-based method to detect cisplatin adducts in specific genes, Nucleic Acids Res.19:6209–6214.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Lee, S., Elenbas, B., Levine, A., and Griffith, J., 1995, p53 and its 14kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches, Cell81:1013–1021.

    PubMed  CAS  Google Scholar 

  • Levine, A.J., 1993, The tumor suppressor genes, Annu. Rev. Biochem.62:623–651.

    PubMed  CAS  Google Scholar 

  • Levine, A.J., 1997, p53, the cellular gatekeeper for growth and division, Cell88:323–331.

    PubMed  CAS  Google Scholar 

  • Livingstone, C., Patel, G., and Jones, N., 1995, ATF-2 contains a phosphorylation-dependent transcriptional activation domain, EMBO J.14:1785–1797.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Lotem, J., and Sachs, L., 1993, Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents, Blood82:1092–1096.

    PubMed  CAS  Google Scholar 

  • Lowe, S.W., Ruley, H.E., and Jacks, T., and Housman, D.E., 1993, p53-mediated apoptosis modulates the cytotoxicity of anti-cancer agents, Cell74:957–967.

    PubMed  CAS  Google Scholar 

  • Lowe, S.W., Bodis, S., McClatchy A., Remington, L., Ruley, H.E., Fisher, D.E., Housman, D.E., and Jacks, T., 1994, p53 status and the efficacy of cancer therapy in vivo, Science266:807–810.

    PubMed  CAS  Google Scholar 

  • McKay, R.A., Miraglia, L.J., Cummins, L.L., Owens, S.R., Sasmor, H., and Dean, N.M., Characterization of a potent and specific class of antisense oligonucleotide inhibitor of human protein kinase C-alpha expression, J. Biol. Chem.274:1715–1722.

    Google Scholar 

  • Miyake, H., Hara, I., Gohji, K., Yamanaka, K., Arakawa, S., and Kamidono, S., 1998, Enhancement of chemosensitivity in human bladder cancer cells by adenoviral-mediated p53 gene transfer, Anticancer Res.18:3087–3092.

    PubMed  CAS  Google Scholar 

  • Newell, C.L., Deisseroth, A.B., and Lopez-Berestein, G., 1994, Interaction of nuclear proteins with an AP-1/CRE-like promoter sequence in the human TNF-alpha gene, J. Leukocyte Biol.56:27–35.

    PubMed  CAS  Google Scholar 

  • Nguyen, D.M., Spitz, F.R., Yen, N., Cristiano, R.J., and Roth, J.A., 1996, Gene therapy for lung cancer: enhancement of tumor suppression by a combination of sequential systemic cisplatin and adenovirus-mediated p53 gene transfer, J. Thorac. Cardiovasc. Surg.112:1372–1376, discussion 1376–1377.

    PubMed  CAS  Google Scholar 

  • Nielsen, L.L., Lipari, P., Dell, J., Gurnani, M., and Hajian, G., 1998, Adenovirus-mediated p53 gene therapy and paclitaxel have synergistic efficacy in models of human head and neck, ovarian, prostate, and breast cancer, Clin. Cancer Res.4:835–846.

    PubMed  CAS  Google Scholar 

  • O’Connor, P.M., Jackman, J., Bae, I., Myers, T.G., Fan, S., Mutoh, M., Scuderio, D.A., Monks, A., Sausville, E.A., Weinstein, J.N., Friend, S., Fornace, A.J., Jr., and Kohn, K.W., 1997, Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents, Cancer Res., 57:4285–4300.

    PubMed  Google Scholar 

  • Oshita, F., and Saijo, N., 1994, Rapid polymerase chain reaction assay to detect variation in the extent of genespecific damage between cisplatin-or VP-16-resistant and sensitive lung cancer cell lines, Jpn J. Cancer Res.85:669–673.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Potapova, O., Haghighi, A., Bost, F., Liu, C., Birrer, M.J., Gjerset, R., and Mercola, D., 1997, The JNK/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin, J. Biol. Chem.272:14041–14044.

    PubMed  CAS  Google Scholar 

  • Potapova, O., Bost, F., Dean, N., and Mercola, D., 1998, Inhibition of the JNK pathway blocks cell cycle progression in human tumor cells, Proc. AACR, 89th Annual Meeting, abstract #1720, p. 251.

    Google Scholar 

  • Reed, E., 1998, Platinum-DNA adduct, nucleotide excision repair and platinum based anti-cancer chemotherapy, Cancer Treatment Reviews24: 331–344.

    PubMed  CAS  Google Scholar 

  • Roth, J.A., Swisher, S.G., Merritt, J.A., Lawrence, D.D., Kemp, B.L., Carrasco, C.H., EI-Naggar, A.K., Fossella, F.V., Glisson, B.S., Hong, W.K., Khurl, F.R., Kurie, J.M., Nesbitt, J.C., Pisters, K., Putnam, J.B., Schrump, D.S., Shin, D.M., and Walsh, G.L.,1998, Gene therapy for non-small cell lung cancer: a preliminary report of a phase I trial of adenoviral p53 gene replacement, Semin. Oncol.25:33–37.

    PubMed  CAS  Google Scholar 

  • Saves, I., and Masson, J.M., 1998, Mechanisms of resistance to xenobiotics in human therapy, Cell Mol Life Sci.54:405–426.

    PubMed  CAS  Google Scholar 

  • Scanlon, K.J., Kashani-Sabet, M., 1988, Elevated expression of thymidylate synthase cycle genes in cisplatin-resistant human ovarian carcinoma A2780 cells, Proc. Natl. Acad. Sci. USA.85:650–653.

    PubMed  CAS  Google Scholar 

  • Scanlon, K.J., Kashani-Sabet, M., Miyachi, H., Sowers, L.C., and Rossi, J., 1989, Molecular basis of cisplatin resistance in human carcinomas: model systems and patients, Anticancer Res.9:1301–1312.

    PubMed  CAS  Google Scholar 

  • Scanlon, K.J., Jiao, L., Funato, T., Wang, W., Tone, T., Rossi, J.J., and Kashani-Sabet, M., 1991, Ribozyme-mediated cleavage of c-fos mRNA reduces gene expression of DNA synthesis enzymes and metallothionein, Proc. Natl. Acad. Sci. USA.88:10591–10595.

    PubMed  CAS  Google Scholar 

  • Smeal, T., Binetruy, B., Mercola, D., Birrer, M., and Karin, M., 1991, Oncogenic and transcriptional co-operation with Ha-ras requires phosphorylation of c-Jun on serines 63 and 73, Nature354:494–496.

    PubMed  CAS  Google Scholar 

  • Smeal, T., Binetruy, B., Mercola, D., Grover-Bardwick, A., Heidecker, G., Rapp, U.R., and Karin, M., 1992, Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73, Mol. Cell. Biol.12:3507–3513.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Stark, G.R., 1993, Regulation and mechanisms of mammalian gene amplification. Adv. Cancer Res.61:87–113.

    PubMed  CAS  Google Scholar 

  • Stein, C.A., and Kreig, A.M., 1994, Problems in interpretation of data derived from in vitro and in vivo use of antisence oligodeoxynucleotides, Antisense Res. Dev.4:67–69.

    PubMed  CAS  Google Scholar 

  • Van Dam, H., Wilhelm, D., Herr, I., Steffen, A., Herrlich, P., and Angel, P., 1995, ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents, EMBO J.14:1798–1811.

    PubMed  PubMed Central  Google Scholar 

  • Wilhelm, D., van Dam, H., Herr, I., Baumann, B., Herrlich, P., and Angel, P., 1995, Both ATP-2 and c-Jun are phosphorylated by stress-activated protein kinases in response to UV irradiation, Immunobiology193:143–148.

    PubMed  CAS  Google Scholar 

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Gjerset, R.A., Mercola, D. (2002). Sensitization of Tumors to Chemotherapy Through Gene Therapy. In: Habib, N.A. (eds) Cancer Gene Therapy. Advances in Experimental Medicine and Biology, vol 465. Springer, New York, NY. https://doi.org/10.1007/0-306-46817-4_24

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