Conclusion
Since the original idea of vector-based gene therapy, a great deal of progress in adenoviral vector development has been made. Judging from the published work using the adenoviral vectors, it is apparent that the existing adenoviral vectors have provided excellent tools to learn the basic science of cancer gene therapy; and will most likely find some applications in the clinical setting. It has become clear that a high level transient gene expression through adenoviral vectors even in a limited number of the target cells could also be potentially beneficial. The most impressive progress in the vector development is in the area of generating the adenoviral vectors with complete deletion of viral sequences. These vectors if can be grown to high titers and have level transgene expression are likely to have minimum immunological responses the most common problem associated with adenoviruses. It is encouraging to note that in Phase I clinical trials, first generation adenoviral vectors have been found to be fairly safe.
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Seth, P. (2002). Adenoviral Vectors. In: Habib, N.A. (eds) Cancer Gene Therapy. Advances in Experimental Medicine and Biology, vol 465. Springer, New York, NY. https://doi.org/10.1007/0-306-46817-4_2
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