Skip to main content

The Use Of Skeletal Muscle To Express Genes For The Treatment Of Cancer

  • Chapter
  • First Online:
Book cover Cancer Gene Therapy

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 465))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ayling, C., Moreland, B.H., Zanelli, J.M., and Schulster, D., (1989), Human growth hormone treatment of hypophysectomized rats increases the proportion of type-1 fibres in skeletal muscle. J. Endocrinol. 123:429–435.

    PubMed  CAS  Google Scholar 

  • Baker, J., Liu, J.P., Robertson, E.J., and Efstratiadis, A., (1993), Role of Insulin-like growth factors in embryonic and postnatal growth. Cell 75:73–82.

    PubMed  CAS  Google Scholar 

  • Baserga, R., Hongo, A., Rubini, M., Prisco, M., and Valentis, B., (1997), The IGF-1 receptors in cell growth, transformation and apoptosis. Biochim. Biophy. Acta. 1332:105–126.

    Google Scholar 

  • Bergsma, D.J., Grichnikm, J.M., Gossett, I.M., and Schwartz, R.J., (1986), Delimitation and characterization of cis-acting of DNA sequences required for the regulated expression and transcriptional control of the chicken skeletal a-actin gene. Mol. Cell Biol. 6:2452–2475.

    Google Scholar 

  • Bouvet, M., Ellis, L.M., Nishizaki, M., Fujiwara, T., Liu, W., Bucana, C.D., Fang, B., Lee, J.J., and Roth, J.A., (1998), Adenovirus-mediated wild type p53 gene transfer down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human colon cancer. Cancer Res. 58:2288–2292.

    PubMed  CAS  Google Scholar 

  • Brahm, H., Piehl-Aulin, K., Saltin, B., and Ljunghall, S., (1997), Net fluxes over working thigh of hormones, growth factors and biomarkers of bone metabolism during lasting dynamic exercise. Calcified Tissue 60:175–189.

    CAS  Google Scholar 

  • Bittner, R.E., Shony, S., Streubel, B., Hubner, C., Volt, T., and Kress, W., (1995), Serum antibodies to the deleted dystrophin sequence after cardiac transplantation in a patient with Becker’s muscular dystrophy. New Eng. J. Med. 333:732–733.

    PubMed  CAS  Google Scholar 

  • Bucbinder, L., Talbott, R., Velasco-Miguel, S., Takenaka, I., Faha, B., Seizinger, B.R., and Kley, N., (1995), Induction of the growth inhibitor IGF-binding protein 3 by p53. Nature 377:646–649.

    Google Scholar 

  • Chen, H.H., Mack, L.M., Kelly, R., Ontell, M., Kochanek, S., and Clemens, P.R., (1997), Persistence in muscle of an adenoviral vector that lacks all viral genes. Proc. Natl. Acad. Sci. USA 94:1645–1650.

    PubMed  CAS  Google Scholar 

  • Clemens, P.R., Kochanek, S., Sunada, Y., Chan, S., Chen, H.H., Campbell, K.P., and Caskey, C.T., (1996), In vivo muscle gene transfer of full-length dystrophin with an adenoviral vector that lacks all viral genes. Gene Therapy 3:965–972.

    PubMed  CAS  Google Scholar 

  • Coleman, M.E., DeMayo, F., Yin, K.C., Lee, H.M., Geske, R., Montgomery, C, and Schwartz, R.J., (1995), Myofenic vector expression of insulin-like growth factor I stimulates muscle cell differentiation and myofiber hypertrophy in transgenic mice. J. Biol. Chem. 270:12109–12116.

    PubMed  CAS  Google Scholar 

  • Conry, R.M., LoBuglio, A.F., Loechel, F., Moore, S.E., Sumerel, L.A., Barlow, D.L., and Curiel, D.T., (1995), A carcinoembryonic antigen polynucleotide vaccine has in vivo antitumor activity. Gene Therapy 2:59–65.

    PubMed  CAS  Google Scholar 

  • Conry, R.M., White, S.A., Fultz, P.N., Khazaeli, M.B., Strong, T.V., Allen, K.O., Barlow, D.L., Moore, S.E., Coan, P.N., Davis, I., Curiel, D.T., and LoBuglio, A.F., (1998), Clinical Cancer Research 4:2903–2912.

    PubMed  CAS  Google Scholar 

  • Corrado, K., Wills, P.L., and Chamberlain, J.S., (1994), Deletion analysis of the dystrophin-actin binding domain. FEBS Lett. 344:255–260.

    PubMed  CAS  Google Scholar 

  • Cox, G.A., Cole, N.M., Matsumura, K., Phelps, S.F., Hauschka, S.D., Campbell, K.P., Faulkner, J.A., and Chamberlain, J.S., (1993), Overexpression of dystrophin in transgenic mdx mice eliminates dystrophic symptoms without toxicity. Nature 364:725–729.

    PubMed  CAS  Google Scholar 

  • Dai, Y., Roman, M., Naviaux, R.K., and Verma, I.M., (1992), Gene therapy via primary myoblasts, long-term expression of factor IX protein following transplantation in vivo. Proc. Natl. Acad. Sci. USA 89:10892–10895.

    PubMed  CAS  Google Scholar 

  • Dai, Y., Schwarz, E.M., Gu, D., Zhang, W.W., and Verma, I., (1995), Cellular and humoural immune responses to adenoviral vectors containing factor IX gene. Tolerization of Factor IX and vector antigens allows for long-term expression. Proc. Natl. Acad. Sci. USA 92:1401–1405.

    PubMed  CAS  Google Scholar 

  • D’Ambrosio, C., Ferber, A., Resnicoff, M., and Baserga, R., (1996), A soluble insulin-like growth factor 1 receptor that induces apoptosis of tumor cells in vivo and inhibits tumorigenesis. Cancer Res. 56:4013–4020.

    PubMed  Google Scholar 

  • Daughaday, W.H., and Rotwein, P., (1989), Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations. Endocrine Rev. 10:68–91.

    CAS  Google Scholar 

  • Davis, H.L., Demeneix, B.A., Quantin, B., Coulombe, J., and Whalen, R.G., (1993), Plasmid DNA is superior to viral vectors for direct gene transfer into adult mouse skeletal muscle. Hum. Gene. Ther. 4:733–740.

    PubMed  CAS  Google Scholar 

  • D’Ercole, J.A., Stiles, A.D., and Underwood, L.E., (1984), Tissue concentrations of somatemedin C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action. Proc. Natl. Acad. Sci. USA 81:935–939.

    PubMed  Google Scholar 

  • Dhawan, J., Pan, L.C., Pavlath, G.K., Travis, M.A., Lanctot, A.M., and Blau, H.M., (1991), Systemic delivery of human growth hormone by injection of genetically engineered myoblasts. Science 254:1509–1512.

    PubMed  CAS  Google Scholar 

  • Draghia-Akli, R., Li, X., and Schwartz, R.J., (1997), Enhanced growth by ectopic expression of growth hormone releasing hormone using an injectable myogenic vector. Nature Biotechnol. 15:1285–1289.

    CAS  Google Scholar 

  • Eisenbraun, M.D., Fuller, D.H., and Haynes, J.R., (1993), Examination of parameters affecting the elicitation of humoral immune responses by particle bombardment-mediated genetic immunisation. DNA Cell Biol. 12:791–797.

    PubMed  CAS  Google Scholar 

  • England, S., Nicholson, L.V.B., Johnson, M.A., Forrest, S.M., Bundy, S., Zubrzycka-Gaarn, E., Love, D.R., and Davies, K.E., (1990), Very mild muscular dystrophy associated with the deletion of 46% of dystrophin. Nature 343:180–182.

    PubMed  CAS  Google Scholar 

  • Fabbrizio, E., Pons, F., Robert, A., Hugon, G., Bonet-Kerrache, A., and Momet, D., (1994), The dystrophin superfamily, variability and complexity. J. Mucle Res. Cell Motil. 15:595–606.

    CAS  Google Scholar 

  • Fassati, A., Wells, D.J., Sgro Serpente, P.A., Walsh, F.S., Brown, S.C., Strong, P.N., and Dickson, G., (1997), Genetic correction of dystrophin deficiency and skeletal muscle remodeling in adult MDX mouse via transplantation of retroviral producer cells. J. Clin. Invest. 100:620–628.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Fields, P., Herzog, R., Arruda, V., Hagstrom, N., Pasi, K.J., and High, K., (1998b), Immune response to a secretable protein following gene transfer into muscle by plasmid based, adenoviral or adeno-associated viral vectors. Blood 92:147a.

    Google Scholar 

  • Fields, P., Murdoch, P., Bayele, H., Perry, D., Wells, D., Watt, D., Goldspink, G., and Pasi, J., (1998a), Immune responses to direct plasmid injection in muscle, implications for transgene expression. Keystone Symposia, Molecular and cellular biology of gene therapy. SUPPLEMENT 25A:P435.

    Google Scholar 

  • Fisher, K., Jooss, K., Alston, J., Yang, Y., Haecker, S., High, K., Pathak, R., Raper, S., and Wilson, J.M., (1997), Recombinant Adeno-associated virus for muscle directed gene therapy. Nature Med. 3:3227–3234.

    Google Scholar 

  • Fisher, K.J., Choi, H., Burda, J., Chen, S., and Wilson, J.M., (1996), Recombinant adenoviruses deleted of all viral genes for gene therapy of cystic flbrosis. Virology 217:11–22.

    PubMed  CAS  Google Scholar 

  • Floyd, S.S. Jr., Clemens, P.R., Ontell, M.R., Kochanek, S., Day, C.S., Yang, J., Hauschka, S.D., Balkir, L., Morgan, J., Moreland, M.S., Feero, G.W., Epperly, M., and Huard, J., (1998), Ex vivo gene transfer using adenovirus-mediated full-length dystrophin delivery to dystrophic muscles. Gene Therapy 5:19–30.

    PubMed  CAS  Google Scholar 

  • Folkman, J., (1995), Angiogenesis in cancer, vascular, rheumatoid and other diseases. Nature Medicine 1:27–31.

    PubMed  CAS  Google Scholar 

  • Goldspink, G., and Booth, F., (1992), General Remarks for Editorial Issue—Mechanical signals and gene expression in muscle. Am. J. Physiol. 262:R327–R328.

    Google Scholar 

  • Goldspink, G., Yang, S.Y., Skarli, M., and Vrbova, G., (1996), Local growth regulation is associated with an isoform of IGF-1 that is expressed in normal muscles but not in dystrophic muscles when subjected to stretch. J. Physiol. 496:P10.

    Google Scholar 

  • Gorecki, D.C., and Simons, J.P., (1999), The dangers of DNA vaccination (Letter). Nature Medicine 5:126.

    PubMed  CAS  Google Scholar 

  • Hardy, S., Kitamura, Harris, T., Dai, Y., and Phipps, L., (1997), Construction of adenovirus through Cre Lox Recombination. J. Virol. 71:1842–1849.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Griscelli, F., Li, H., Bennaceur-Griscelli, A., Soria, J., Opolon, P., Soria, C., Perricaudet, M., Yeh, P., and Lu, H., (1998), Angiostatin gene transfer: Inhibition of tumor growth in vivo by blockage of endothelial cell proliferation associated with mitosis arrest. Proc. Natl. Acad. Sci. USA 95:6367–6372.

    PubMed  CAS  Google Scholar 

  • Hansen, E., Goldspink, G., Butterworth, P.W., and Chang, K-C., (1991), Strong expression of some mammalian gene constructs in fish muscle following direct gene transfer. FEBS Letts. 290:73–76.

    CAS  Google Scholar 

  • Herzog, R., Hagstrom, J., Kung, Z., Tai, S.J., Wilson, J.M., Fisher, K., and High, K.A., (1997a), Stable gene transfer and expression of human blood coagulation factor IX after intramuscular injection of recombinant adeno-associated virus. Proc. Natl. Acad. Sci. USA 94:5804–5809.

    PubMed  CAS  Google Scholar 

  • Herzog, R., Hagstrom, J.N., Kung, S.Z., Yang, E.Y., Couto, L.B., Kurtzmann, G.J., and High, K.A., (1997b), Absence of antibodies against factor IX following IM injection of an AAV vector encoding a species specific transgene. Blood 90:1957.

    Google Scholar 

  • Hollstein, M., Sidransky, D., Vogelstein, B., and Harris, C.C., (1991), p53 mutations in human cancers. Science 253:49–53.

    PubMed  CAS  Google Scholar 

  • Huard, J., Krisky, D., Oligino, T., Marconi, P., Day, C.S., Watkins, S.C., and Glorioso, J.C., (1997), Gene transfer to muscle using herpes simplex-based vectors. Neuromusc. Disord. 7:299–313.

    PubMed  CAS  Google Scholar 

  • Kay, M.A., Holterman, A.X., Meuse, L., Gown, A., Linsley, P., and Wilson, C.B., (1995), Long term hepatic adenovirus mediated gene expression in mice following CTLAIg administration. Nat. Genet. 11:191–197.

    PubMed  CAS  Google Scholar 

  • Keir, S.D., Mitchell, W.J., Feldman, L., and Martin, J.R., (1995), Targeting and gene expression in spinal cord motorneurones following intramuscular inoculation of an HSV-1 vector. J. Neurovirol. 1:259267.

    Google Scholar 

  • Kessler, P.D., Podsakoff, G.M., Chen, X., McQiuston, S.A., Colosi, PC., Kurtzmann, G., and Byrne, B., (1996), Gene delivery to skeletal muscle results in sustained expression and systemic delivery of a therapeutic protein. Proc. Natl. Acad. Sci. USA 93:14082–14087.

    PubMed  CAS  Google Scholar 

  • Klauber, N., Rohan, R., Flynn, E., and D’Amato, R.J., (1997), Critical components of the female reproductive pathway are suppressed by the angiogenesis inhibitor AGM-1470. Nature Medicine 3:443–446.

    PubMed  CAS  Google Scholar 

  • Kochanek, S., Clemens, P.R., Mitani, K., Chen, H.H., Chan, S., and Caskey, C.T., (1996), A new adenoviral vector, Replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and Beta-galactosidase. Proc. Natl. Acad. Sci. USA 93:5731–5736.

    PubMed  CAS  Google Scholar 

  • Kong, H., and Crystal, R.G., (1998), Gene therapy strategies for tumor antiangiogenesis. Journal of the National Cancer Institute 90:273–286.

    PubMed  CAS  Google Scholar 

  • Li, Q., Kay, M.A., Finegold, M., Stratford-Perricaudet, L.D., and Woo, S.L., (1993), Assessment of recombinant adenoviral vectors for hepatic gene therapy. Hum. Gene Ther. 4:403–409.

    PubMed  CAS  Google Scholar 

  • Kong, H., Hechet, D., Song, W., Kovesdi, I., Hackett, N.R., Yayon, A., and Crystal, R.G., (1998), Regional suppression of tumor growth in vivo transfer of a cDNA encoding a secreted form of the extracellular domain of the flt-1 vascular endothelial growth factor receptor. Human Gene Therapy 9:823–833.

    PubMed  CAS  Google Scholar 

  • Lin, P., Buxton, J.A., Acheson, A., Radziejewski, C., Maisonpierre, P.C., Yancopoulos, G.D., Channon, K.M., Hale, L.P., Dewhirst, M.W., George, S.E., and Peters, K.G., (1998), Antiangiogenic therapy targeting the endothelium tyrosine kinase TIE2. Proc. Natl. Acad. Sci. USA 95:8829–8834.

    PubMed  CAS  Google Scholar 

  • Lochmuller, H., Petrof, B.J., Pari, G., Larochelle, N., Dodelet, V., Wang, Q., Allen, C., Prescott, S., Massie, B., Nalbantoglu, J., and Karpati, G., (1996), Transient immunosuuression by FK506 permits a sustained high-level dystrophin expression after adenovirus-mediated dystrophin minigene transfer to skeletal muscles of adult dystrophic (mdx) mice. Gene Therapy 3:706–716.

    PubMed  CAS  Google Scholar 

  • Lund, P.K., (1994), Insulin-like growth factor I: molecular biology and relevance to tissue-specific expression and action. Recent. Prog. Horm. Res. 49:125–148.

    PubMed  CAS  Google Scholar 

  • Michou, A., Santoro, L., Christ, M., Jiullard, V., Pavirani, A., and Mehtali, M., (1997), Adenovirus-mediated gene transfer influence of transgene, mouse strain and type of immune response on persistence of trans-gene expression. Gene Therapy 4:473–482.

    PubMed  CAS  Google Scholar 

  • Miller, G., Steinbrecher, R.A., Murdock, P.J., Tuddenham, E.G.D., Lee, C.A., Pasi, K.J., and Goldspink, G., (1995), Expression of factor VII by muscle cells in vitro and in vivo following direct gene transfer, modelling gene therapy for haemophilia, Gene Therapy 2:736–742.

    PubMed  CAS  Google Scholar 

  • Miller, R.G., Sharma, K.R., Pavlath, G.K., Gussoni, E., Mynhier, M., Lanctot, A.M., Greco, C.M., Steinman, L., and Blau, H.M., (1997), Myoblast implantation in Duchenne muscular dystrophy, the San Francisco study. Muscle and Nerve. 20:469–478.

    PubMed  CAS  Google Scholar 

  • Milner, R.E., Busaan, J.L., Wang, J.H., and Michalak, M., (1993), Phosphorylation of dystrophin. The carboxy-terminal region of dystrophin is a substrate for in vitro phosphorylation by p34cdc2 protein kinase. J. Biol. Chem. 268:21901–21905.

    PubMed  CAS  Google Scholar 

  • Monahan, P.E., Samulski, R.J., Tazelaar, J., Xiao, X., Nichols, T.C., Bellinger, D.A., and Read, M.S., (1998), Direct intramuscular injection with recombinant AAV vectors results in sustained expression in a dog model of haemophilia. Gene Therapy 5:40–49.

    PubMed  CAS  Google Scholar 

  • Murphy, L.J., Bell, G.I., and Friesen, H.G., (1987), Tissue distribution of insulin-like growth factor I and II messenger nucleic acid in the adult rat. Endocrinology 120:1279–1282.

    PubMed  CAS  Google Scholar 

  • Nov, F.J., Kruszewski, A., MacDermot, K.D., Goldspink, G., and Gorecki, D.C., (1995), Editing of human alpha-galactosidase RNA resulting in a pyrimidine to purine conversion. Nucleic. Acids. Res. 2636–2640.

    Google Scholar 

  • Ohlsson, C., Kley, N., Werner, H., and LeRoith, D., (1998), p53 regulates insulin-like growth factor I receptor expression and IGF-1-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Spl. Endocrinology 139:1101–1107.

    PubMed  CAS  Google Scholar 

  • O’Reilly, M.S., Holmgren, L., Shing, Y., Chan, C., Rosenthal, R.A., Moses, M., Lane, W.S., Cao, Y., Sage, E.H., and Folkman, J., (1994), Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 79:315–328.

    PubMed  Google Scholar 

  • O’Reilly, M.S., Boeham, T., Shing, Y., Fukai, N., Vasios, G., Lane, W.S., Flynne, E., Birkhead, J.R., Olsen, B.R., and Folkman, J., (1997), Endostatin: An endogenous inhibitor of angiogenesis and tumor growth. Cell 88:277–285.

    PubMed  Google Scholar 

  • Paillard, F., (1998), Suppression of angiogenesis: a means to fight cancer, Human Gene Therapy 9:768–770.

    PubMed  CAS  Google Scholar 

  • Palmer, T.D., Thompson, A.R., and Miller, A.D., (1989), Production of human factor IX in animals by genetically modified skin fibroblasts, Potential therapy for Haemophilia B. Blood 73:438–445.

    PubMed  CAS  Google Scholar 

  • Parrizas, M., Saltiel, A.R., and LeRoith, D., (1997), Insulin-like growth factor 1 inhibits apoptosis using the phosphaditylinositol 3′-kinase and the mitogen-activated protein kinase pathways. J. Biol. Chem. 272:154–161.

    PubMed  CAS  Google Scholar 

  • Powell-Braxton, L., Hollingshead, P., Warburton, C., Dowd, M., Pitts-Meek, S., Dalton, D., Gillet, N., and Stewart, T.A., (1993), IGF-1 is required for normal embryonic growth in mice. Genes Dev. 7:2609–2617.

    PubMed  CAS  Google Scholar 

  • Rando, T.A., and Blau, H.M., (1994), Primary mouse myoblast purification, characterization, and transplantation for cell-mediated gene therapy. J. Cell Biol. 125:1275–1287.

    PubMed  CAS  Google Scholar 

  • Rando, T.A., Pavlath, G.K., and Blau, H.M., (1995), The fate of myoblasts following transplantation into mature muscle. Exp. Cell Res. 220:383–389.

    PubMed  CAS  Google Scholar 

  • Reiss, K., D’Ambrosio, C., Tu, X., Tu, C., and Baserga, R., (1998), Inhibition of tumor growth by a dominant negative mutant of the insulin-like growth factor 1 receptor with a bystander effect (1998). Clinical Cancer Res. 4:2647–2655.

    CAS  Google Scholar 

  • Resnicoff, M., Abraham, D., Yutanawiboonchai, W., Rotman, H.L., Kajstura, J., Rubin, R., Zoltick, P., and Baserga, R., (1995), The insulin-like growth factor 1 receptor protects tumor cells from apoptosis in vivo. Cancer Res. 55:2463–2469.

    PubMed  CAS  Google Scholar 

  • Ribotta, M.G.Y., Revah, F., Pradier, L., Loquet, I., Mallet, J., and Privat, A., (1997), Prevention of motoneuron death by adenovirus-mediated neurotrophic factors. J. Neurosc Res. 48:281–285.

    Google Scholar 

  • Rudman, D.M., Kutner, M.H., Rogers, C.M., Lubin, M.F., Fleming, G.A., and Brain, R.P., (1981), Impaired growth hormone secretin in the adult population. J. Clin. Inv. 67:1361–1369.

    CAS  Google Scholar 

  • Sato, Y., Roman, M., Tighe, H., Lee, D., Corr, M., Nguyen, M., Silverman, G., Lotz, M., Carson, D., and Raz, E., (1996), Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 273:352–354.

    CAS  Google Scholar 

  • Schelechter, N.L., Russell, S.M., Spencer, E.M., and Nicoll, C.S., (1986), Evidence suggesting that the direct growth promoting effect of growth hormone on cartilage in vivo is mediated by local production of somatomedin. Proc. Natl. Acad. Sci. USA 83:7932–7934.

    Google Scholar 

  • Shemanko, C.S., Sanghera, J.S., Milner, R.E., Pelech, S., and Michalak, M., (1995), Phosphorylation of the carboxyl terminal region of dystrophin by mitogen-activated protein (MAP) kinase. Mol. Cell. Biochem. 152:63–70.

    PubMed  CAS  Google Scholar 

  • Shively, J., and Beatty, J., (1985), Molecular biological and clinical significance. CRC Crit. Rev. Oncol. Hematol. 2:355–399.

    CAS  Google Scholar 

  • Skarli, M., Kiri, A., Vrbova, G., Lee, C.A., and Goldspink, G., (1998), Myosin regulatory elements as vectors for gene transfer by intramuscular injection. Gene Therapy 5:514–520.

    PubMed  CAS  Google Scholar 

  • Snyder, R., Spratt, S., Lgarde, C., Bohl, D., Kasper, B., Sloan, B., Cohen, L.K., and Danos, O., (1997), Efficient and stable adeno-associated virus mediated transduction in the skeletal muscle of adult immuno-competent mice. Human Gene Therapy 8:1891–1900.

    PubMed  CAS  Google Scholar 

  • Stratford-Perricaudet, L.D., Levrero, M., Chasse, J.F., Perricaudet, M., and Briand, P., (1990), Evaluation of the transfer and expression in mice of an enzyme-encoding gene using a human adenovirus vector. Hum. Gene Ther. 1:241–256.

    PubMed  CAS  Google Scholar 

  • Sunada, Y., Bernier, S.M., Kozak, C.A., Yamada, Y., and Campbell, K.P., (1994), Deficiency of merosin in dystrophic mice and genetic linkage of laminin M chain gene to dy locus. J. Biol. Chem. 269:13729–13732.

    PubMed  CAS  Google Scholar 

  • Svenson, E., Black, H., Dugger, D., Tripathy, S., Goldwasser, E., Hao, Z., Chu, L., and Leiden, J., (1997), Long term erythropoietin expression in rodents and non human primates following intramuscular injection of a replication defective adenoviral vector. Hum. Gene Ther. 8:797–1806.

    Google Scholar 

  • Tanaka, T., Manome, Y., Wen, P., Kuffe, D.W., and Fine, H.A., (1997), Viral vector-mediated transduction of a modified platelet factor 4. Cancer Research 58:3362–3369.

    Google Scholar 

  • Thompson, J., Grunert, F., and Zimmerman, W., (1991), CEA gene family: molecular biology and clinical perspectives. J. Clin. Lab. Anal. 5:344–366.

    PubMed  CAS  Google Scholar 

  • Tighe, H., Corr, M., Roman, M., and Raz, E., (1997), Gene vaccination, plasmid DNA is more than just a blueprint. Immunol. Today 19:89–97.

    Google Scholar 

  • Tinsley, J.M., Potter, A.C., Phelps, S.R., Fisher, R., Tricket, J.I., and Davies, K.E., (1996), Amelioration of the dystrophic phenotype of mdx mice using a truncated utrophin transgene. Nature 384:349–353.

    PubMed  CAS  Google Scholar 

  • Ullrich, A., Bell, J.R., Chen, E.Y., Herrera, R., Petruzzelli, L.M., Dull, T.J., Gray, A., Coussens, L., Liao, Y.C., Tsubokawa, M., Mason, A., Seeburg, P., Grunfield, C., Rosen, O.M., and Ramachandran, J., (1985), Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes. Nature 313:756–761.

    PubMed  CAS  Google Scholar 

  • Ullrich, A., Gray, A., Tam, A.W., Yang-Feng, T., Tsubokawa, M., Collins, C., Henzel, W., Le Bon, T., Kathuria, S., Chen, E., Jacobs, S., Francke, U., Ramachandran, J., and Fujita-Yamaguchi, Y., (1986), insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests determinants that define functional specificity. EMBO J. 5:2503–2512.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Verma, I.M., and Dai, Y., (1994), Progress in gene therapy. Proc XXI Int Congr world federation of haemophilia, 15.

    Google Scholar 

  • Wang, J.M., Zheng, H., Blaivas, M., and Kurachi, K., (1997), Persistent systemic production of human Factor IX in mice by skeletal myoblast-mediated gene transfer, feasibility of repeat application to obtain therapeutic levels. Blood 90:1075–1082.

    PubMed  CAS  Google Scholar 

  • Wang, Y., and Becker, D., (1997), Antisense targeting of basic fibroblast growth factor receptor-1 in human melanomas blocks intratumoral angiogenesis and tumor growth. Nature Medicine 3:887–893.

    PubMed  CAS  Google Scholar 

  • Wells, D.J., Maule, J., McMahon, J., Mitchell, R., Damien, E., Poole, A., and Wells, K.E., (1998), Evaluation of plasmid DNA for in vivo gene therapy, factors affecting the number of transfected fibers. J. Pharm. Sci. 87:763–768.

    PubMed  CAS  Google Scholar 

  • Wells, D.J., and Goldspink, G., (1992), Age and sex influence expression of plasmid DNA directly injected into mouse skeletal muscle. FEBS Letts 306:203–205.

    CAS  Google Scholar 

  • Wells, K.E., Walsh, F.S., Goldspink, G., Love, D.R., Chan-Thomas, P., Dunckley, M., Piper, T., and Dickson, G., (1992), Human dystrophin expression corrects the myopathic phenotype in transgenic mdx mice. Hum. Mol. Genet. 1:5–40.

    Google Scholar 

  • Werner, H., Karnieli, E., Rauscher, III F.J., and LeRoith, D., (1996), Wild type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene. Proc. Natl. Acad. Sci. USA 93:8318–8323.

    PubMed  CAS  Google Scholar 

  • Wolff, J.A., Ludtke, J.L., Acsadi, G., Williams, P., and Jani, A., (1992), Long-term persistence of plasmid DNA and foreign gene expression in mouse muscle. Hum. Mol. Genet. 1:363–369.

    PubMed  CAS  Google Scholar 

  • Wolff, J.A., Malone, R.W., Williams, P., Chong, W., Acasadi, G., Jani, A., and Felgner, P.L., (1990), Direct gene transfer into mouse muscle in vivo. Science 247:1465–1468.

    PubMed  CAS  Google Scholar 

  • Wright, M.J., Rosenthal, E., Stewart, L., Withtman, L.M., Miller, A.D., Latchman, D.S., and Marber, M.S., (1998), beta-galactosidase staining following intracoronary infusion of cationic liposomes in the in vivo rabbit heart is produced by microinfarcion rather than effective gene transfer, a cautionary tale. Gene Therapy 5:301–308.

    PubMed  CAS  Google Scholar 

  • Xiao, X., Li, J., and Samulski, R.J., (1996), Efficient long-term gene transfer into muscle tissue of immunecom-petent mice by adeno-associated virus vector. J. Virol. 70:8098–8108.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Xu, H., Christmas, P., Wu, X.P., Wewer, U.M., and Engvall, E., (1994), Defective muscle basement membrane and lack of M-laminin in the dystrophic dy/dy mouse. Proc. Natl. Acad. Sci. 91:572–5576.

    Google Scholar 

  • Yang, S.Y., Alnaqeeb, M., Simpson, H., and Goldspink, G., (1996), Cloning and characterisation of an IGF-1 isoform expressed in skeletal muscle subjected to stretch. J. Muscle Res. Cell Motil. 17:487–495.

    PubMed  CAS  Google Scholar 

  • Yang, Y., Ertl, H.C., and Wilson, J.M., (1994), MHC class I restricted cytotoxic T lymphocytes to viral antigens create barriers to lung directed gene therapy with recombinant adenoviruses. Immunity 1:433–442.

    PubMed  CAS  Google Scholar 

  • Yang, Y., Nunes, F.A., Berensci, K., Furth, E.E., Gonzzol, E., and Wilson, J.M., (1994), Cellular immunity to viral antigens limits El deleted adenovirus for gene therapy. Proc. Natl. Acad. Sci. USA 91:4407–4411.

    PubMed  CAS  Google Scholar 

  • Yao, S.N., and Kuracchi, K., (1992), Expression of human factor IX in mice after injection of genetically modified myoblasts. Proc. Natl. Acad. Sci. USA 89:3357–3361.

    PubMed  CAS  Google Scholar 

  • Yao, S.N., Wilson, J.M., Nabel, E.G., Kurachi, K., Hachiya, H.L., and Kurachi, K., (1991), Expression of human factor IX in rat capillary endothelial cells. Toward somatic gene therapy for Haemophilia B. Proc. Natl. Acad. Sci. USA 88:8101–8105.

    PubMed  CAS  Google Scholar 

  • Zdanowitz, M.M., Moyse, J., Wingert Zahn, M.A., O’Connor, M., Teichberg, S., and Slonim, A.E., (1995), Effect of insulin-like growth factor I in murine muscular dystrophy. Endocrinology 136:4880–4886.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Kluwer Academic Publishers

About this chapter

Cite this chapter

Coe, S., Harron, M., Winslet, M., Goldspink, G. (2002). The Use Of Skeletal Muscle To Express Genes For The Treatment Of Cancer. In: Habib, N.A. (eds) Cancer Gene Therapy. Advances in Experimental Medicine and Biology, vol 465. Springer, New York, NY. https://doi.org/10.1007/0-306-46817-4_10

Download citation

  • DOI: https://doi.org/10.1007/0-306-46817-4_10

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-306-46191-0

  • Online ISBN: 978-0-306-46817-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics