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Cardiovascular Actions of Nitric Oxide

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Nitric Oxide and Infection

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References

  • Assreuy, J., Cunha, F. Q., Liew, F. Y., and Moncada, S., 1993, Feedback inhibition of nitric oxide synthase activity by nitric oxide, Br. J. Pharmacol. 108:833–837.

    PubMed  CAS  Google Scholar 

  • Baigrie, R. J., Lamont, P. M., Whiting, S., and Morris, P. J., 1993, Portal endotoxin and cytokine responses during abdominal aortic surgery, Am. J. Surg. 166:248–251.

    PubMed  CAS  Google Scholar 

  • Balligand, J. L., Kelly, R. A., Marsden, P. A., Smith, T. W., and Michel, T., 1993a, Control of cardiac muscle cell function by an endogenous nitric oxide signaling system, Proc. Natl. Acad. Sci. USA 90:347–351.

    PubMed  CAS  Google Scholar 

  • Balligand, J. L., Ungureanu, D., Kelly, R. A., Kobzik, L., Pimental, D., Michel, T., and Smith, T. W., 1993b, Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium, J. Clin. Invest. 91:2314–2319.

    PubMed  CAS  Google Scholar 

  • Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., and Freeman, B. A., 1990, Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide, Proc. Natl. Acad. Sci. USA 87:1620–1624.

    PubMed  CAS  Google Scholar 

  • Benedict, C. R., and Grahame-Smith, D. G., 1978, Plasma noradrenaline and adrenaline concentrations and dopamine-β-hydroxylase activity in patients with shock due to septicaemia, trauma and haemorrhage, Q. J. Med. 185:1–20.

    Google Scholar 

  • Bhagat, K., Moss, R., Collier, J., and Vallance, P., 1996, Endothelial “stunning” following a brief exposure to endotoxin: A mechanism to link infection and infarction? Cardiovasc. Res. 32:822–829.

    Article  PubMed  CAS  Google Scholar 

  • Billiar, T. R., Curran, R. D., Harbrecht, B. G., Stadler, J., Williams, D. L., Ochoa, J. B., Di Silvio, M., Simmons, R. L., and Murray, S. A., 1992, Association between synthesis and release of cGMP and nitric oxide biosynthesis by hepatocytes, Am. J. Physiol. 262:C1077–C1082.

    PubMed  CAS  Google Scholar 

  • Bogle, R. G., Whitley, G. S., Soo, S. C., Johnstone, A. P., and Vallance, P., 1994, Effect of antifungal imidazoles on mRNA levels and enzyme activity of inducible nitric oxide synthase, Br. J. Pharmacol. 111:1257–1261.

    PubMed  CAS  Google Scholar 

  • Bogle, R. G., MacAllister, R. J., Whitley, G. S., and Vallance, P., 1995, Induction of NG-monomethyl-l-arginine uptake: A mechanism for differential inhibition of NO synthases? Am. J. Physiol. 269:C750–C756.

    PubMed  CAS  Google Scholar 

  • Braun, C., and Zumft, W. G., 1991, Marker exchange of the structural genes for nitric oxide reductase blocks the denitrification pathway of Pseudomonas stutzeri at nitric oxide, J. Biol. Chem. 266:22785–22788.

    PubMed  CAS  Google Scholar 

  • Bredt, D. S., Hwang, P. M., Glatt, C. E., Lowenstein, C., Reed, R. R., and Snyder, S. H., 1991, Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase, Nature 351:714–718.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Brown, G. C., Bolanos, J. P., Heales, S. J., and Clark, J. B., 1995, Nitric oxide produced by activated astrocytes rapidly and reversibly inhibits cellular respiration, Neurosci. Lett. 193:201–204.

    Article  PubMed  CAS  Google Scholar 

  • Calver, A., Collier, J., and Vallance, P., 1993, Nitric oxide and cardiovascular control, Exp. Physiol. 78:303–326.

    PubMed  CAS  Google Scholar 

  • Cobb, J. P., Natanson, C., Quezado, Z. M., Hoffman, W. D., Koev, C. A., Banks, S., Correa, R., Levi, R., Elin, R.J., Hosseini, J.M., and Danner, R.L., 1995, Differential hemodynamic effects of L-NMMA in endotoxemic and normal dogs, Am. J. Physiol. 268:H1634–H1642.

    PubMed  CAS  Google Scholar 

  • Cocks, T.M., and Angus, J.A., 1983, Endothelium-dependent relaxation of coronary arteriesby noradrenaline and serotonin, Nature 305:627–630.

    PubMed  CAS  ISI  Google Scholar 

  • Cunha, F. Q., Moss, D. W., Leal, L. M., Moncada, S., and Liew, F. Y, 1993, Induction of macrophage parasiticidal activity by Staphylococcus aureus and exotoxins through the nitric oxide synthesis pathway, Immunology 78:563–567.

    PubMed  CAS  ISI  Google Scholar 

  • Cunha, F. Q., Assreuy, J., Moss, D. W., Rees, D. D., Leal, L. M., Moncada, S., Carrier, M., O’Donnell, C. A., and Liew, F. Y., 1994, Differential induction of nitric oxide synthase in various organs of the mouse during endotoxaemia: Role of TNF-alpha and IL-1-beta, Immunology 81:211–215.

    PubMed  CAS  ISI  Google Scholar 

  • Damas, P., Ledoux, D., Nys, M., Vrindts, Y., De Groote, D., Franchimont, P., and Lamy, M., 1992, Cytokine serum level during severe sepsis in human IL-6 as a marker of severity, Ann. Surg. 215:356–362.

    PubMed  CAS  Google Scholar 

  • de Belder, A. J., Radomski, M. W., Martin, J. F., and Moncada, S., 1995, Nitric oxide and the pathogenesis of heart muscle disease. Ear. J. Clin. Invest. 25:1–8.

    Google Scholar 

  • Evans, T., Carpenter, A., Kinderman, H., and Cohen, J., 1993, Evidence of increased nitric oxide production in patients with the sepsis syndrome, Circ. Shock 41:77–81.

    PubMed  CAS  Google Scholar 

  • Feelisch, M., 1993, Biotransformation to nitric oxide of organic nitrates in comparison to other nitrovasodilators, Eur. Heart J. 14:123–132.

    PubMed  CAS  Google Scholar 

  • Finkel, M. S., Oddis, C. V, Jacob, T. D., Watkins, S. C., Harder, B. G., and Simmons, R. L., 1992, Negative inotropic effects of cytokines on the heart mediated by nitric oxide, Science 257:387–389.

    PubMed  CAS  ISI  Google Scholar 

  • Frostell, C. G., Blomqvist, H., Hedenstierna, G., Lundberg, J., and Zapol, W. M., 1993, Inhaled nitric oxide selectively reverses human hypoxic pulmonary vasoconstriction without causing systemic vasodilation, Anesthesiology 78:427–135.

    PubMed  CAS  ISI  Google Scholar 

  • Furchgott, R. F., 1983, Role of endothelium in responses of vascular smooth muscle, Circ. Res. 53:557 573.

    PubMed  Google Scholar 

  • Furchgott, R. F., and Vanhoutte, P. M., 1989, Endothelium-derived relaxing and contracting factors, FASEB J. 3:2007–2018.

    PubMed  CAS  Google Scholar 

  • Furchgott, R. F., and Zawadzki, J. V, 1980, The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine, Nature 288:373–376.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Garvey. E. P., Oplinger, J. A., Furfine, E. S., Kiff, R. J., Laszlo, F., Whittle, B. J., and Knowles, R. G., 1997, 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo, J. Biol. Chem. 272:4959–963.

    PubMed  CAS  Google Scholar 

  • Geller, D. A., Nussler, A. K., Di Silvio, M., Lowenstein, C. J., Shapiro, R. A., Wang, S. C., Simmons, R. L., and Billiar, T. R., 1993, Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes, Proc. Natl. Acad. Sci. USA 90:522–526.

    PubMed  CAS  Google Scholar 

  • Gerlach, H., Pappert, D., Lewandowski, K., Rossaint, R., and Falke, K. J., 1993, Long-term inhalation with evaluated low doses of nitric oxide for selective improvement of oxygenation in patients with adult respiratory distress syndrome, Intensive Care Med. 19:443–449.

    Article  PubMed  CAS  Google Scholar 

  • Griffith, T. M., Edwards, D. H., Davies, R. L., Harrison, T. J., and Evans, K. T., 1987, EDRF coordinates the behaviour of vascular resistance vessels, Nature 329:442–445.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Grover, R., Zaccardelli, D., Colice, G., Guntupalli, K., Watson, D., and Vincent, J.-L., 1995, The cardiovascular effects of 546C88 in human septicshock, Intensive Care Med. 21:S21.

    Google Scholar 

  • Gustafsson, L. E., Wiklund, C. U., Wiklund, N. P., Persson, M. G., and Moncada, S., 1990, Modulation of autonomic neuroeffector transmission by nitric oxide in guinea pig ileum, Biochem. Biophys. Res. Commun. 173:106–110.

    Article  PubMed  CAS  Google Scholar 

  • Haynes, W. G., Noon, J. P., Walker, B. R., and Webb, D. J., 1993, Inhibition of nitric oxide synthesis increases blood pressure in healthy humans, J. Hypertens. 11:1375–1380.

    PubMed  CAS  Google Scholar 

  • Hibbs, J. B., Jr., 1992, Overview of cytotoxic mechanisms and defence of the intracellular environment against microbes, in: The Biology of Nitric Oxide:Enzymology, Biochemistry and Immunology (S. Moncada, M. A. Marletta, J. B. Hibbs, Jr., and E. A. Higgs, eds.), Portl and Press, London, pp. 201–206.

    Google Scholar 

  • Hibbs, J. B., Jr., Vavrin, Z., and Taintor, R. R., 1987, l-Arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells, J. Immunol. 138:550–565.

    PubMed  CAS  Google Scholar 

  • Hibbs, J. B., Jr., Taintor, R. R., Vavrin, Z., Granger, D. L., Drapier, J.-C., Amber, I. J., and Lancaster, J. R., Jr., 1990, Synthesis of nitric oxide from a terminal guanidino nitrogen atom of l-arginine: A molecular mechanism regulating cellular proliferation that targets intracellular iron, in: Nitric Oxide from l-Arginine, a Bioregulatory System (S. Moncada and E. A. Higgs, eds.), Elsevier, Amsterdam, pp. 189–223.

    Google Scholar 

  • Hibbs, J. B., Jr., Westenfelder, C., Taintor, R., Vavrin, Z., Kablitz, C., Baranowski, R. L., Ward, J. H., Menlove, R. L., McMurry, M. P., Kushner, J. P., and Samlowski, W. E., 1992, Evidence for cytokine-inducible nitric oxide synthesis from l-arginine in patients receiving interleukin-2 therapy, J. Clin. Invest. 89:867–877.

    PubMed  Google Scholar 

  • Huang, P. L., Huang, Z., Mashimo, H., Bloch, K. D., Moskowitz, M. A., Bevan, J. A., and Fishman, M. C., 1995, Hypertension in mice lacking the gene for endothelial nitric oxide synthase, Nature 377:239–242.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Ignarro, L. J., 1990, Haem-dependent activation of guanylate cyclase and cyclic GMP formation by endogenous nitric oxide: A unique transduction mechanism for transcellular signaling, Pharmacol. Toxicol. 67:1–7.

    Article  PubMed  CAS  Google Scholar 

  • Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., and Chaudhuri, G., 1987, Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide, Proc. Natl. Acad. Sci. USA 84:9265–9269.

    PubMed  CAS  Google Scholar 

  • Jones, S. B., and Romano, F. D., 1989, Dose-and time-dependent changes in plasma catecholamines in response to endotoxin in conscious rats, Circ. Shock 28:59–68.

    PubMed  CAS  Google Scholar 

  • Kanwar, S., and Kubes, P., 1995, Nitric oxide is an antiadhesive molecule for leukocytes, New Horiz. 3:93–104.

    PubMed  CAS  Google Scholar 

  • Kilbourn, R. G., Fonseca, G. A., Griffith, O. W., Ewer, M., Price, K., Striegel, A., Jones, E., and Logothetis, C. J., 1995, NG-methyl-L-arginine, an inhibitor of nitric oxide synthase, reverses interleukin-2-induced hypotension, Crit. Care Med. 23:1018–1024.

    PubMed  CAS  Google Scholar 

  • Knowles, R. G., Merrett, M., Salter, M., and Moncada, S., 1990, Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat, Biochem. J. 270:833–836.

    PubMed  CAS  Google Scholar 

  • Lansman, J. B., Hallam, T. J., and Rink, T. J., 1987, Single stretch-activated ion channels in vascular endothelial cells as mechanotransducers? Nature 325:811–813.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Lingnau, W., McGuire, R., Dehring, D. J., Traber, L. D., Linares, H. A., Nelson, S. H., Kilbourn, R. G., and Traber, D. L., 1996, Changes in regional hemodynamics after nitric oxide inhibition during ovine bacteremia, Am. J. Physiol. 270:R207–R216.

    PubMed  CAS  Google Scholar 

  • Lizasoain, I., Moro, M. A., Knowles, R. G., Darley Usmar, V., and Moncada, S., 1996, Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose, Biochem. J. 314:877–880.

    PubMed  CAS  Google Scholar 

  • Lundberg, J. O., Weitzberg, E., Nordvall, S. L., Kuylenstierna, R., Lundberg, J. M., and Alving, K., 1994, Primarily nasal origin of exhaled nitric oxide and absence in Kartagener’s syndrome, Eur. Respir. J. 7:1501–1504.

    Article  PubMed  CAS  Google Scholar 

  • MacAllister, R. J., Fickling, S. A., Whitley, G. S., and Vallance, P., 1994, Metabolism of methylarginines by human vasculature; implications for the regulation of nitric oxide synthesis, Br. J. Pharmacol. 112:43–48.

    PubMed  CAS  Google Scholar 

  • MacMicking, J. D., Nathan, C., Hom, G., Chartrain, N., Fletcher, D. S., Trumbauer, M., Stevens, K., Xie, Q.-W, Sokol, K., Hutchinson, N., Chen, H., and Mudgett, J. S., 1995, Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase, Cell 81:641–650.

    Article  PubMed  CAS  ISI  Google Scholar 

  • McCall, T. B., Palmer, R. M., and Moncada, S., 1991, Induction of nitric oxide synthase in rat peritoneal neutrophils and its inhibition by dexamethasone, Eur. J. Immunol. 21:2523–2527.

    PubMed  CAS  Google Scholar 

  • Meyer, J., Traber, L. D., Nelson, S., Lentz, C. W., Nakazawa, H., Herndon, D. N., Noda, H., and Traber, D. L., 1992, Reversal of hyperdynamic response to continuous endotoxin administration by inhibition of NO synthesis, J. Appl. Physiol. 73:324–328.

    PubMed  CAS  Google Scholar 

  • Michel, T., and Feron, O., 1997, Nitric oxide synthases: Which, where, how, and why? J. Clin. Invest. 100:2146–2152.

    PubMed  CAS  Google Scholar 

  • Mitchell, J. A., Kohlhaas, K. L., Sorrentino, R., Warner, T. D., Murad, F., and Vane, J. R., 1993, Induction by endotoxin of nitric oxide synthase in the rat mesentery: Lack of effect on action of vasoconstrictors, Br. J. Pharmacol. 109:265–270.

    PubMed  CAS  Google Scholar 

  • Moncada, S., Palmer, R. M., and Higgs, E. A., 1991, Nitric oxide: Physiology, pathophysiology, and pharmacology, Pharmacol. Rev. 43:109–142.

    PubMed  CAS  Google Scholar 

  • Mugge, A., Lopez, J. A., Piegors, D. J., Breese, K. R., and Heistad, D. D., 1991, Acetylcholine-induced vasodilatation in rabbit hindlimb in vivo is not inhibited by analogues of L-arginine, Am. J. Physiol. 260:H242–H247.

    PubMed  CAS  Google Scholar 

  • Nagao, T., Illiano, S., and Vanhoutte, P. M., 1992, Heterogeneous distribution of endothelium-dependent relaxations resistant to NG-nitro-l-arginic in rats, Am. J.Physiol. 263:H1090–H1094.

    PubMed  CAS  Google Scholar 

  • Navarro, J., Sanchez, A., Saiz, J., Ruilope, L. M., Garcia Estan, J., Romero, J. C., Moncada, S., and Lahera, V., 1994, Hormonal, renal, and metabolic alterations during hypertension induced by chronic inhibition of NO in rats, Am. J. Physiol 267:R15I6–R1521.

    Google Scholar 

  • Nieminen, M.S., Mattila, K., and Valtonen, V., 1993, Infection and inflammation as risk factors for myocardial infarction, Eur. Heart J. 14:12–16.

    PubMed  Google Scholar 

  • Ochoa, J. B., Udekwu, A. O., Billiar, T. R., Curran, R. D., Cerra, F. B., Simmons, R. L., and Peitzman, A. B., 1991, Nitrogen oxide levels in patients after trauma and during sepsis, Ann. Surg. 214:621–626.

    PubMed  CAS  Google Scholar 

  • Olesen, S. P., Clapham, D. E., and Davies, P. F., 1988, Haemodynamic shear stressactivates a K* current in vascular endothelial cells, Nature 331:168–170.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Palmer, R. M., Ashton, D. S., and Moncada, S., 1988a, Vascular endothelial cells synthesize nitric oxide from L-arginine, Nature 333:664–666.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Palmer, R. M., Rees, D. D., Ashton, D. S., and Moncada, S., 1988b, L-Arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation, Biochem. Biophys. Res. Commun. 153:1251–1256.

    Article  PubMed  CAS  Google Scholar 

  • Parnavelas, J.G., Kelly, W., and Burnstock, G., 1985, Ultrastructural localization of choline acetyltransferase in vascular endothelial cells in rat brain, Nature 316:724–725.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Parsons, S. J., Hill, A., Waldron, G. J., Plane, F., and Garland, C. J., 1994, The relative importance of nitric oxide and nitric oxide-independent mechanisms in acetylcholine-evoked dilatation of the rat mesenteric bed, Br. J. Pharmacol. 113:1275–1280.

    PubMed  CAS  Google Scholar 

  • Paul-Eugene, N., Kolb, J. P., Sarfati, M., Arock, M., Ouaaz, F., Debre, P., Mossalayi, D. M., and Dugas, B., 1995, Ligation of CD23 activates soluble guanylate cyclase in human monocytes via an L-arginine-dependent mechanism, J. Leukoc. Biol. 57:160–167.

    PubMed  CAS  Google Scholar 

  • Pepke-Zaba, J., Higenbottam, T. W., Dinh Xuan, A. T., Stone, D., and Wallwork, J., 1991, Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension, Lancet 338:1173–1174.

    PubMed  CAS  Google Scholar 

  • Petros, A., Lamb, G., Leone, A., Moncada, S., Bennett, D., and Vallance, P., 1994, Effects of a nitric oxide synthase inhibitor in humans with septic shock, Cardiovasc. Res. 28:34–39.

    PubMed  CAS  Google Scholar 

  • Radomski, M. W., 1996, Nitric oxide: Biological mediator, modulator and effector, Ann. Med. 27:321–329.

    Google Scholar 

  • Radomski, M. W., Palmer, R. M., and Moncada, S., 1990a, An L-arginine/nitric oxide pathway present in human platelets regulates aggregation, Proc. Natl. Acad. Sci. USA 87:5193–5197.

    PubMed  CAS  Google Scholar 

  • Radomski, M. W., Palmer, R. M., and Moncada, S., 1990b, Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells, Proc. Natl. Acad. Sci. USA 87:10043–10047.

    PubMed  CAS  Google Scholar 

  • Radomski, M. W., Rees, D. D., Dutra, A., and Moncada, S., 1992, S-nitroso-glutathione inhibits platelet activation in vitro and in vivo, Br. J. Pharmacol. 107:745–749.

    PubMed  CAS  Google Scholar 

  • Rajfer, J., Aronson, W. J., Bush, P. A., Dorey, F. J., and Ignarro, L. J., 1992, Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission, N. Engl. J. Med. 326:90–94.

    Article  PubMed  CAS  Google Scholar 

  • Redl, H., Schlag, G., Gasser, H., Davies, J., Rees, D. D., and Grover, R., 1997, Treatment with NO synthase inhibitor, 546C88 twelve hours after start of E. coli bacteraemia is beneficial in a baboon model of septic shock, Shock 8:51.

    Google Scholar 

  • Rees, D. D., 1995, Role of nitric oxide in the vascular dysfunction of septic shock, Biochem. Soc. Trans. 23:1025–1029.

    PubMed  CAS  Google Scholar 

  • Rees, D. D., Palmer, R. M., Hodson, H. F., and Moncada, S., 1989a, A specific inhibitor of nitric oxide formation from L-arginine attenuates endothelium-dependent relaxation, Br. J. Pharmacol. 96:418–424.

    PubMed  CAS  Google Scholar 

  • Rees, D. D., Palmer, R. M., and Moncada, S., 1989b, Role of endothelium-derived nitric oxide in the regulation of blood pressure, Proc. Natl. Acad. Sci. USA 86:3375–3378.

    PubMed  CAS  Google Scholar 

  • Rees, D. D., Cellek, S., Palmer, R. M., and Moncada, S., 1990a, Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: An insight into endotoxin shock, Biochem. Biophys. Res. Commun. 173:541–547.

    Article  PubMed  CAS  Google Scholar 

  • Rees, D. D., Palmer, R. M., Schulz, R., Hodson, H. F., and Moncada, S., 1990b, Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo, Br. J. Pharmacol. 101:746–752.

    PubMed  CAS  Google Scholar 

  • Rees, D. D., Monkhouse, J. E., Morren, D., Davies, N., and Moncada, S., 1997, Nitric oxide induction and inhibition in the conscious mouse, Shock 8:72.

    Google Scholar 

  • Rees, D. D., Monkhouse, J. E., Cambridge, D., and Moncada, S., 1998, Nitric oxide and the haemodynamic profile of endotoxin shock in the conscious mouse, Br. J. Pharmacol. 124:540–546.

    Article  PubMed  CAS  Google Scholar 

  • Rossaint, R., Falke, K. J., Lopez, F., Slama, K., Pison, U., and Zapol, W. M., 1993, Inhaled nitric oxide for the adult respiratory distress syndrome, N. Engl. J. Med. 328:399–405.

    Article  PubMed  CAS  Google Scholar 

  • Salter, M., Knowles, R. G., and Moncada, S., 1991, Widespread tissue distribution, species distribution and changes in activity of Ca 2+-dependent and Ca 2+-independent nitric oxide synthases, FEBS Lett. 291:145–149.

    Article  PubMed  CAS  Google Scholar 

  • Salzman, A. L., Menconi, M. J., Unno, N., Ezzell, R. M., Casey, D. M., Gonzalez, P. K., and Fink, M. P., 1995, Nitric oxide dilates tight junctions and depletes ATP in cultured Caco-2BBe intestinal epithelial monolayers. Am. J. Physiol. 268:G361–G373.

    PubMed  CAS  Google Scholar 

  • Schini, V. B., Durante, W., Elizondo, E., Scott Burden, T., Junquero, D. C., Schafer, A. I., and Vanhoutte, P. M., 1992, The induction of nitric oxide synthase activity is inhibited by TGF-beta 1, PDGFAB and PDGFBB in vascular smooth muscle cells, Eur. J. Pharmacol. 216:379–383.

    Article  PubMed  CAS  Google Scholar 

  • Sheehan, K. C. F., Ruddle, N. H., and Schreiber, R. D., 1989, Generation and characterization of hamster monoclonal antibodies that neutralize murine tumour necrosis factors, J. Immunol. 142:3884–3893.

    PubMed  CAS  Google Scholar 

  • Shultz, P. J., and Raij, L., 1992, Endogenously synthesized nitric oxide prevents endotoxin-induced glomerular thrombosis, J. Clin. Invest. 90:1718–1725.

    Article  PubMed  CAS  Google Scholar 

  • Silva, A. T., Bayston, K. F., and Cohen, J., 1990, Prophylactic and therapeutic effects of a monoclonal antibody to tumour necrosis factor-αin experimental gram-negative shock, J. Infect. Dis. 162:421–427.

    PubMed  CAS  Google Scholar 

  • Singh, S., and Evans, T. W., 1997, Nitric oxide, the biological mediator of the decade: Fact or fiction? Eur. Respir. J. 10:699–707.

    PubMed  CAS  Google Scholar 

  • Stamler, J. S., Simon, D. I., Osborne, J. A., Mullins, M. E., Jaraki, O., Michel, T., Singel, D. J., and Loscalzo, J., 1992, S-nitrosylation of proteins with nitric oxide: Synthesis and characterization of biologically active compounds, Proc. Natl. Acad. Sci. USA 89:444–48.

    PubMed  CAS  Google Scholar 

  • Stoclet, J. C., Schott, C. A., Schneider, F., Berton, C., and Paya, D., 1995, Induction by endotoxin of nitric oxide production in vascular smooth cells, in: Shock, Sepsis and Organ Failure-Nitric Oxide (G. Schlagg and H. Redl, eds.), Springer-Verlag, Berlin, pp. 102–117.

    Google Scholar 

  • Stuehr, D. J., 1997, Structure-function aspects in the nitric oxide synthases, Annu. Rev. Pharmacol. Toxicol 37:339–359.

    Article  PubMed  CAS  Google Scholar 

  • Stuehr, D. J., and Marietta, M. A., 1987, Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma, J. Immunol. 139:518–525.

    PubMed  CAS  Google Scholar 

  • Syrjanen, J., 1993, Infection as a risk factor for cerebral infarction, Eur. Heart J. 14:17–19.

    PubMed  Google Scholar 

  • Syrjanen, J., Valtonen, V V, Iivanainen, M., Kaste, M., and Huttunen, J. K., 1988, Preceding infection as an important risk factor for ischaemic brain infarction in young and middle aged patients, S. Med. J. 296:1156–1160.

    CAS  Google Scholar 

  • Taveira da Silva, A. M., Kaulbach, H. C., Chuidian, F. S., Lambert, D. R., Sufifredini, A. F. and Danner, R. L., 1993, Shock and multiple organ dysfunction after self administration of Salmonella endotoxin, N. Engl. J. Med. 328:1457–1460.

    Google Scholar 

  • Thiemermann, C., 1994, The role of the L-arginine:nitric oxide pathway in circulatory shock, Adv. Pharmacol. 28:45–79.

    PubMed  CAS  Google Scholar 

  • Thiemermann, C., and Vane, J., 1990, Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo, Eur. J. Pharmacol. 182:591–595.

    Article  PubMed  CAS  Google Scholar 

  • Toda, N., 1995, Nitric oxide and the regulation of cerebral arterial tone, in: Nitric Oxide in the Nervous System (S. Vincent, ed.), Academic Press, Orlando, pp. 207–225.

    Google Scholar 

  • Toda, N., and Okamura, T, 1990, Mechanism underlying the response to vasodilator nerve stimulation in isolated dog and monkey cerebral arteries, Am. J. Physiot. 259:H1511–H1517.

    CAS  Google Scholar 

  • Vallance, P., 1996, Control of the human cardiovascular system by nitric oxide, J. Hum. Hypertens. 10:377–381.

    PubMed  CAS  Google Scholar 

  • Vallance, P., and Moncada, S., 1993, Role of endogenous nitric oxide in septic shock, New Horiz. 1:77–86.

    PubMed  CAS  Google Scholar 

  • Vallance, P., Collier, J., and Moncada, S., 1989a, Nitric oxide synthesised from L-arginine mediates endothelium dependent dilatation in human veins in vivo, Cardiovasc. Res. 23:1053–1057.

    Article  PubMed  CAS  Google Scholar 

  • Vallance, P., Collier, J., and Moncada, S., 1989b, Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man, Lancet 2:997–1000.

    PubMed  CAS  ISI  Google Scholar 

  • Wei, X. Q., Charles, I. G., Smith, A., Ure, J., Feng, G. J., Huang, F. P., Xu, D., Muller, W., Moncada, S., and Liew, F. Y., 1995, Altered immune responses in mice lacking inducible nitric oxide synthase, Nature 375:408–411.

    Article  PubMed  CAS  ISI  Google Scholar 

  • Wennmalm, A., Benthin, G., and Petersson, A. S., 1992, Dependence of the metabolism of nitric oxide (NO) in healthy human whole blood on the oxygenation of its red cell haemoglobin, Br. J. Pharmacol. 106:507–508.

    PubMed  CAS  Google Scholar 

  • White, K. A., and Marietta, M. A., 1992, Nitric oxide synthase is a cytochrome P-450 type hemoprotein, Biochemistry 31:6627–6631.

    PubMed  CAS  ISI  Google Scholar 

  • Whittle, B. J., 1995, Nitric oxide in physiology and pathology, Histochem. J. 27:727–737.

    Article  PubMed  CAS  Google Scholar 

  • Williams, D. J., Vallance, P. J. T., Neild, G. H., Spencer, J. A. D., and Imms, F. J., 1997, Nitric oxide-mediated vasodilation in human pregnancy, Am. J. Physiol. 272:H748–H752.

    PubMed  CAS  Google Scholar 

  • Wray, G. M., Millar, C. G., Hinds, C. J., and Thiemermann, C., 1998, Selective inhibition of the activity of inducible nitric oxide synthase prevents the circulatory failure, but not the organ injury/dysfunction, caused by endotoxin. Shock 9:329–335.

    PubMed  CAS  ISI  Google Scholar 

  • Wright, C. E., Rees, D. D., and Moncada, S., 1992, Protective and pathological roles of nitric oxide in endotoxin shock, Cardiovasc. Res. 26:48–57.

    PubMed  CAS  Google Scholar 

  • Yoshizumi, M., Perrella, M. A., Burnett, J. C., Jr., and Lee, M. E., 1993, Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life, Circ. Res. 73:205–209.

    PubMed  CAS  Google Scholar 

  • Zembowicz, A., and Vane, J. R., 1992, Induction of nitric oxide synthase activity by toxic shock syndrome toxin 1 in a macrophage-monocyte cell line, Proc. Nail. Acad. Sci. USA 89:2051–2055.

    CAS  Google Scholar 

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  1. Centre for Clinical Pharmacology, University College London, London, WC1E 6JJ, UK

    Daryl D. Rees

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  1. University of Colorado Health Sciences Center, Denver, Colorado

    Ferric C. Fang

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© 2002 Kluwer Academic Publishers

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Rees, D.D. (2002). Cardiovascular Actions of Nitric Oxide. In: Fang, F.C. (eds) Nitric Oxide and Infection. Springer, Boston, MA. https://doi.org/10.1007/0-306-46816-6_7

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  • DOI: https://doi.org/10.1007/0-306-46816-6_7

  • Publisher Name: Springer, Boston, MA

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  • Online ISBN: 978-0-306-46816-2

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