Skip to main content
SpringerLink
Log in

Nitric Oxide in AIDS-Associated Neurological Disease

  • Chapter
Nitric Oxide and Infection

  • 208 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adamson, D. C., Wildemann, B., Sasaki, M., Glass, J. D., McArthur, J. C., Christov, V. I., Dawson, T. M., and Dawson, V. L., 1996. Immunologic NO synthase: Elevation in severe AIDS dementia and induction by HIV-1 gp41, Science 274:1917–1921.

    Article  PubMed  CAS  Google Scholar 

  • Ankarcrona, M., Dypbukt, J. M., Bonfoco, E., Zhivotovsky, B., Orrenius, S., Lipton, S. A., and Nicotera, P., 1995, Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15:961–973.

    Article  PubMed  CAS  Google Scholar 

  • Bacellar, H., Muñoz, A., Miller, E. N., Cohen, B. A., Besley, D., Seines, O. A., Becker, J. T, and McArthur, J. C., 1994, Temporal trends in the incidence of HIV-1-related neurologic diseases: Multicenter AIDS cohort study, 1985–1992, Neurology 44:1892–1900.

    PubMed  CAS  Google Scholar 

  • Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., and Freeman, B. A., 1990, Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide, Proc. Natl Acad. Sci. USA 87:1620–1624.

    Article  PubMed  CAS  Google Scholar 

  • Behl, C., Davis, J. B., Klier, F. G., and Schubert, D., 1994a, Amyloid beta peptide induces necrosis rather than apoptosis, Brain Res.665:253–264.

    Article  Google Scholar 

  • Behl, C., Davis, J. B., Lesley, R., and Schubert, D., 1994b, Hydrogen peroxide mediates amyloid β protein toxicity, Cell 77:817–827.

    Article  PubMed  CAS  Google Scholar 

  • Benveniste, H., Drejer, J., Schousboe, A., and Diemer, N. H., 1984, Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis, J. Neurochem. 43:1369–1374.

    Article  PubMed  CAS  Google Scholar 

  • Bonfoco, E., Kraine, D., Ankarcrona, M., Nicotera, P., and Lipton, S. A., 1995, Apoptosis and necrosis: Two distinct events induced respectively by mild and intense insults with NMDA or nitric oxide/superoxide in cortical cell cultures, Proc. Natl. Acad. Sci. USA 92:7162–7166.

    Article  PubMed  CAS  Google Scholar 

  • Bonfoco, E., Ankarcrona, M., Kraine, D., Nicotera, P., and Lipton, S. A., 1997, Techniques for distinguishing apoptosis from necrosis in cerebrocortical and cerebellar neurons, in: Neuromethods: Apoptosis Techniques and Protocols (J. Poirier, ed.), Humana Press, Totowa, N.J., pp. 237–253.

    Chapter  Google Scholar 

  • Brenneman, D. F., Westbrook, G. L., Fitzgerald, S. P., Ennist, D. L., Elkins, K. L., Ruff, M., and Pert, C. B., 1988, Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinalpeptide, Nature 335:639–642.

    Article  PubMed  CAS  Google Scholar 

  • Budka, H., 1991, Neuropathology of human immunodeficiency virus infection, Brain Pathol. 1:163–175.

    Article  PubMed  CAS  Google Scholar 

  • Bukrinsky, M. I., Nottet, H. S. L. M., Schmidtmayerova, H., Dubrovsky, L., Flanagan, C. R., Mullins, M. E., Lipton, S. A., and Gendelman, H. E., 1995, Regulation of nitric oxide synthase activity in human immunodeficiency virus type 1 (HIV-l)-infected monocytes: Implications for HIV-associated neurological disease, J. Exp. Med. 181:735–745.

    Article  PubMed  CAS  Google Scholar 

  • Bustos, G., Abarca, J., Forray, M. I., Gysling, K., Bradberry, C. W., and Roth, R. H., 1992, Regulation of excitatory amino acid release by N-methyl-D-aspartatereceptors in rat striatum: In vivo microdialysis studies, Brain Res. 585:105–115.

    Article  PubMed  CAS  Google Scholar 

  • Chen, H.-S. V, and Lipton, S. A., 1997, Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: Uncompetitive antagonism, J. Physio l. (London) 499:27 46.

    CAS  Google Scholar 

  • Chen, H.-S. V, Pellegrini, J. W., Aggarwal, S. K., Lei, S. Z., Warach, S., Jensen, F. E., and Lipton, S. A., 1992, Open-channel block of NMDA responses by memantine: Therapeutic advantage against NMDA receptor-mediated neurotoxicity, J. Neurosci. 12:4427–4436.

    PubMed  CAS  Google Scholar 

  • Choi, D.W.,1988, Glutamate neurotoxicityand diseases of the nervous system, Neuron 1:623–634.

    Google Scholar 

  • Choi, Y.-B., Chen, H.-S. V, Sucher, N. J., and Lipton, S. A., 1996, Redox modulatory site(s) of recombinant NMDA receptors: Subunit composition and conformation, Soc. Neurosci. Abstr. 22:1761.

    Google Scholar 

  • Dawson, T. M., Dawson, V. L., and Snyder, S. H., 1992, A novel neuronal messenger molecule in brain: The free radical, nitric oxide, Ann. Neural. 32:297–311.

    Article  CAS  Google Scholar 

  • Dawson, V. L., Dawson, T. M., London, E. D., Bredt, D. S., and Snyder, S. H., 1991, Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures, Proc. Natl. Acad. Sci. USA 88:6368–6371.

    Article  PubMed  CAS  Google Scholar 

  • Dawson, V. L., Dawson, T. M., Bartley, D. A., Uhl, G. R., and Snyder, S. H., 1993a, Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures, J. Neurosci. 13:2651–2661.

    PubMed  CAS  Google Scholar 

  • Dawson, V. L., Dawson, T. M., Uhl, G. R., and Snyder, S. H., 1993b, Human immunodeficiency virus-1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures, Proc. Natl. Acad. Sci. USA 90:3256–3259.

    Article  PubMed  CAS  Google Scholar 

  • Dessi, F., Charriaut-Marlangue, C., Khrestchatisky, M., and Ben-Ari, Y., 1993, Glutamate induced neuronal death is not a programmed cell death in cerebellar cultures, J. Neurochem. 60:1953–1955.

    Article  PubMed  CAS  Google Scholar 

  • Dickson, D. W., 1995, Apoptosis in the brain. Physiology and pathology, Am. J. Pathol. 146:1040–1044.

    PubMed  CAS  Google Scholar 

  • Diop, A. G., Lesort, M., Esclaire, F., Sindou, P., Couratier, P., and Hugon, J., 1994, Tetrodotoxin blocks HIV coat protein (gp120) toxicity in primary neuronal cultures, Neurosci. Lett. 165:187–190.

    Article  PubMed  CAS  Google Scholar 

  • Dreyer, E. B., and Lipton, S. A., 1994, Toxic neuronal effects of the HIV coat protein gp120 may be mediated through macrophage arachidonic acid, Soc. Neurosci. Abstr. 20:1049.

    Google Scholar 

  • Dreyer, E. B., Kaiser, P. K., Offermann, J. T., and Lipton, S. A., 1990, HIV-1 coat protein neurotoxicity prevented by calcium channel antagonists, Science 248:364–367.

    Article  PubMed  CAS  Google Scholar 

  • Dreyer, E. B., Zhang, D., and Lipton, S. A., 1995, Transcriptional or translational inhibition blocks low dose NMDA-mediated cell death, NeuroReport 6:942–944.

    PubMed  CAS  Google Scholar 

  • Duval, E., Wyllie, A. H., and Morris, R. G., 1985, Macrophage recognition of cells undergoing programmed cell death (apoptosis), Immunology 56:351–358.

    Google Scholar 

  • Erdö, S. L., and Schäfer, M., 1991, Memantine is highly potent in protecting cortical cultures against excitotoxic cell death evoked by glutamate and N-methyl-D-aspartate, Eur. J. Pharmacol. 198:215–217.

    Article  PubMed  Google Scholar 

  • Everall, I. P., Luthbert, P. J., and Lantos, P. L., 1991, Neuronal loss in the frontal cortex in HIV infection, Lancet 337:1119–1121.

    Article  PubMed  CAS  Google Scholar 

  • Filipkowski, R. K., Hetman, M., Kaminska, B., and Kaczmarek, L., 1994, DNA fragmentation in rat brain after intraperitoneal administration of kainate, NeuroReport 5:1538–1540.

    Article  PubMed  CAS  Google Scholar 

  • Gelbard, H. A., Nottet, H. S. L. M., Swindells, S., Jett, M., Dzenko, K. A., Genis, P., White, R., Wang, L., Choi, Y.-B., Zhang, D., Lipton, S. A., Tourtellotte, W. W, Epstein, L. G., and Gendelman, H. E., 1994, Platelet-activating factor: A candidate human immunodeficiency virus type 1-induced neurotoxin, J. Virol. 68:4628–4635.

    PubMed  CAS  Google Scholar 

  • Genis, P., Jett, M., Beraton, E. W., Boyle, T, Gelbard, H. A., Dzenko, K., Keane, R. W., Resnick, L., Mizrachi, T., Volsky, D. J., Epstein, L. G., and Gendelman, H. E., 1992, Cytokines and arachidonic acid metabolites produced during human immunodeficiency virus (HlV)-infected macrophage-astroglia interactions: Implications for the neuropathogenesis of HIV disease, J. Exp. Med. 176:1703–1718.

    Article  PubMed  CAS  Google Scholar 

  • Giovannoni, G., Miller, R. F, Heales, S. J. R., Land, J. M., Harrison, M. J. G., and Thompson, E. J., 1998, Elevated cerebrospinal fluid and serum nitrate and nitrite levels in patients with central nervous system complications of HIV-1 infection—A correlation with blood-brain-barrier dysfunction, J. Neurol. Sci. 156:53–58.

    Article  PubMed  CAS  Google Scholar 

  • Giuhan, D., Vaca, K., and Noonan, C. A., 1990, Secretion of neurotoxins by mononuclear phagocytes infected with HIV-1, Science 250:1593–1596.

    Article  Google Scholar 

  • Giulian, D., Wendt, E., Vaca, K., and Noonan, C. A., 1993, The envelope glycoprotein of human immunodeficiency virus type 1 stimulates release of neurotoxins from monocytes, Proc. Natl. Acad. Sci. USA 90:2769–2773.

    Article  PubMed  CAS  Google Scholar 

  • Giulian. D., Yu, J., Li, X., Tome, D., Li, J., Wendt, E., Lin, S.-N., Schwarcz, R., and Noonan, C., 1996, Study of receptor-mediated neurotoxins released by HIV-l-infected mononuclear phagocytes found in human brain, J. Neurosci. 16:3139–3153.

    PubMed  CAS  Google Scholar 

  • Globus, M. Y., Busto, R., Dietrich, W. D., Martinez, E., Valdes, I., and Ginsberg, M. D., 1988, Effect of ischemia on the in vivo release of striatal dopamine, glutamate, and gamma-aminobutyric acid studied by intracerebral microdialysis, J. Neurochem. 51:1455–1464.

    Article  PubMed  CAS  Google Scholar 

  • Griffin, D. E., Wesselingh, S. L., and McArthur, J. C., 1994, Elevated central nervous system prostaglandins in human immunodeficiency virus-associated dementia, Ann. Neurol. 35:592–597.

    Article  PubMed  CAS  Google Scholar 

  • Harvey, A. R., Cui, Q., and Robertson, D., 1994, The effect of cycloheximide and ganglioside GM1 on the viability of retinotectally projecting ganglion cells following ablation of the superior colliculus in rats, Eur. J. Neurosci. 5:550–557.

    Article  Google Scholar 

  • Hayman, M., Arbuthnott, G., Harkiss, G., Brace, H., Filippi, P., Philippon, V, Thompson, D., Vigne, R., and Wright, A., 1993, Neurotoxicity of peptide analogies of the transactivating protein tat from Maedi-Visna virus and human immunodeficiency virus, Neuroscience 53:1–6.

    Article  PubMed  CAS  Google Scholar 

  • Heyes, M. P., Brew, B. J., Martin, A., Price, R. W., Salazqr, A. M., Sidtis, J. J., Yergey, J. A., Mouradian, M. M., Sadler, A., Keilp, J., Rubinow, D., and Markey, S. P., 1991, Quinolinic acid in cerebrospinal fluid and serum in HIV-1 infection: Relationship to clinical and neurological status, Ann. Neurol. 29:202–209.

    Article  PubMed  CAS  Google Scholar 

  • Heyes, M. P., Saito, K., and Markey, S. P., 1992, Human macrophages convert L-tryptophan to the neuroloxin quinolinic acid, Biochem. J. 283:633–635.

    PubMed  CAS  Google Scholar 

  • Keilhoff, G., and Wolf, G., 1992, Memantine prevents quinolinic acid-induced hippocampal damage, Eur. J Pharmacol. 219:451–454.

    Article  PubMed  CAS  Google Scholar 

  • Kerr, J. F. R., Wyllie, A. H., and Currie, A. R., 1972, Apoptosis: A basic biological phenomenon with wide ranging implications in tissue kinetics, Br. J. Cancer 26:239–257.

    PubMed  CAS  Google Scholar 

  • Ketzler, S., Weis, S., Haug, H., and Budka, H., 1990, Loss of neurons in frontal cortex in AIDS brains, Acta Neuropathol. 80:90–92.

    Article  Google Scholar 

  • Koenig, S., Gendelman, H. E., Orenstein, J. M., Dal Canto, M. C., Pozeshkpour, G. H., Yungbluth, M., Janotta, F, Kasmit, A., Martin, M. A., and Fauci, A. S., 1986, Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy, Science 233:1089–1093.

    Article  PubMed  CAS  Google Scholar 

  • Kohr, G., Eckardt, S., Luddens, H., Monyer, H., and Seeburg, P. H., 1994, NMDA receptor channels: Subunit-specific potentiation by reducing agents, Neuron 12:1031–1040.

    Article  PubMed  CAS  Google Scholar 

  • Lannuzel, A., Lledo, P.-M., Lamghitnia, H. O., Vincent, J.-D., and Tardieu, M., 1995, HIV-1 envelope proteins gp 120 and gp 160 potentiate NMDA-induced [Ca2+]1, increase, alter [Ca2+]1 homeostasis and induce neurotoxicity in human embryonic neurons, Eur, J. Neurosci. 7:2285–2293.

    Article  CAS  Google Scholar 

  • Lee, S. C., Dickson, D. W., Liu, W., and Brosnan, C. F., 1993, Induction of nitric oxide synthase activity in human astrocytes by IL-1β and IFN-γ, J. Neuroimmunol. 46:19–24.

    Article  PubMed  CAS  Google Scholar 

  • Lei, S. Z., Pan, Z.-H., Aggarwal, S. K., Chen, H.-S. V., Hartman, J., Sucher, N. J., and Lipton, S. A., 1992, Effect of nitric oxide production on the redoxmodulatory site of the NMDA receptor-channel complex, Neuron 8:1087–1099.

    Article  PubMed  CAS  Google Scholar 

  • Linnik, M. D., Zobrist, R. H., and Hatfield, M. D., 1993, Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats, Stroke 24:2002–2008.

    PubMed  CAS  Google Scholar 

  • Lipton, S. A., 1991, Calcium channel antagonists in the prevention of neurotoxicity, Adv. Pharmacol. 22:271–291.

    Article  PubMed  CAS  Google Scholar 

  • Lipton, S. A., 1992a, 7-Chlorokynurenate ameliorates neuronalinjury mediated by HIV envelope protein gp120 in retinal cultures, Eur. J. Neurosci, 4:1411–1415.

    Article  PubMed  Google Scholar 

  • Lipton, S. A., 1992b, Memantine prevents HIV coat protein-induced neuronal injury in vitro, Neurology 42:1403–1405.

    PubMed  CAS  Google Scholar 

  • Lipton, S. A., 1992c, Models of neuronal injury in AIDS: Another role for the NMDA receptor? Trends Neurosci. 15:75–79.

    Article  PubMed  CAS  Google Scholar 

  • Lipton, S. A., 1993a, Human immunodeficiency virus-infected macrophages, gp120, and N-methyl-D-aspartate receptor-mediated neurotoxicity, Ann. Neurol. 33:227–228.

    Article  PubMed  CAS  Google Scholar 

  • Lipton, S. A., 1993b, Prospects for clinically tolerated NMDA antagonists: Open-channel blockers and alternative redoxstates of nitric oxide, Trends Neurosci. 16:527–532.

    Article  PubMed  CAS  Google Scholar 

  • Lipton, S. A., 1994, Neurobiology: HIV displays its coat of arms, Nature 367:113–114.

    Article  PubMed  CAS  Google Scholar 

  • Lipton, S. A., 1997a, Neuropathogenesis of acquired immunodeficiency syndrome dementia, Curr. Opin. Neurol. 10:247–253.

    PubMed  CAS  Google Scholar 

  • Lipton, S. A., 1997b, Treating AIDS dementia, Science 276:1629–1630.

    Article  PubMed  CAS  Google Scholar 

  • Lipton, S. A., and Gendelman, H. E., 1995, The dementia associated with the acquired immuno-deficiency syndrome, N. Engl. J. Med. 332:934–940.

    Article  PubMed  CAS  Google Scholar 

  • Lipton, S. A., and Jensen, F. E., 1992, Memantine, a clinically-tolerated NMDA open-channel blocker, prevents HIV coatprotein-induced neuronal injury in vitro and in vivo, Soc. Neurosci. Abstr. 18:757.

    Google Scholar 

  • Lipton, S. A., and Kieburtz, K., 1998, Development of adjunctive therapies for the neurologic manifestations of AIDS: Dementia and painful neuropathy, in: The Neurology of AIDS (H. E. Gendelman, S. A. Lipton, L. G. Epstein, and S. Swindells, eds.), Chapman & Hall, New York, pp. 377–381.

    Google Scholar 

  • Lipton, S. A., and Rosenberg, P. A., 1994, Excitatory amino acids as a final common pathway for neurologic disorders, N. Engl. J. Med. 330:613–622.

    Article  PubMed  CAS  Google Scholar 

  • Lipton, S. A., and Stamler, J. S., 1994, Actions of redox-related congeners of nitric oxide at the NMDA receptor, Neuropharmacology 33:1229–1233.

    Article  PubMed  CAS  Google Scholar 

  • Lipton, S. A., and Wang, Y. F., 1996, NO-related species can protect from focal cerebral ischemia/ reperfusion, in: Pharmacology of Cerebral Ischemia (J. Krieglstein, ed.), Medpharm Scientific Publishers, Stuttgart, pp. 183–191.

    Google Scholar 

  • Lipton, S. A., Kaiser, P. K., Sucher, N. J., Dreyer, E. B., and Offermann, J. T., 1990, AIDS virus coat protein sensitizes neurons to NMDA receptor-mediated toxicity, Soc. Neurosci. Abstr. 16:289.

    Google Scholar 

  • Lipton, S. A., Sucher, N. J., Kaiser, P. K., and Dreyer, E. B., 1991, Synergistic effects of HIV coat protein and NMDA receptor-mediated neurotoxicity, Neuron 7:111–118.

    Article  PubMed  CAS  Google Scholar 

  • Lipton, S. A., Choi, Y.-B., Pan, Z.-H., Lei, S. Z., Chen, H.-S. V., Sucher, N. J., Loscalzo, J., Singel, D. J., and Stamler, J. S., 1993, A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds, Nature 364:626–632.

    Article  PubMed  CAS  Google Scholar 

  • Lipton, S. A., Choi, Y.-B., Sucher, N. J., Pan, Z.-H., and Stamler, J. S., 1996, Redox state, NMDA receptors, and NO-related species, Trends Pharmacol. Sci. 17:186–187.

    Article  PubMed  CAS  Google Scholar 

  • Lo, T.-M., Fallert, C. J., Piser, T. M., and Thayer, S. A., 1992, HIV-1 envelope protein evokes intracellular calcium oscillations in rat hippocampal neurons. Brain Res. 594:189–196.

    Article  PubMed  CAS  Google Scholar 

  • Lombardi, G., and Moroni, F., 1992, GM1 ganglioside reduces ischemia-induced excitatory amino acid output: A microdialysis study in the gerbil hippocampus, Neurosci. Lett. 134:171–174.

    Article  PubMed  CAS  Google Scholar 

  • Loo, D. T., Agata, C., Pike, C. J., Whittemore, E. R., Wulencewicz., A. J., and Cotman, C. W., 1993, Apoptosis is induced by beta-amyloid in cultured central nervous system neurons, Proc. Natl. Acad. Sci. USA 90:7951–7955.

    Article  PubMed  CAS  Google Scholar 

  • Louzada, J. P., Dias, J. J., Santos, W. F., Lachat, J. J., Bradford, H. F., and Coutinho, N. J., 1992, Glutamate release in experimental ischaemia of the retina: An approach using microdialysis, J. Neurochem. 59:358–363.

    Article  Google Scholar 

  • MacManus, J. P., Buchan, A. M., Hill, I. E., Rasquinha, I., and Preston, E., 1993, Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain, Neurosci. Lett 159:89–92.

    Article  Google Scholar 

  • MacManus, J. P., Hill, I. E., Huang, Z.-G., Rasquinha, I., Xue, D., and Buchan, A. M., 1994, DNA damage consistent with apoptosis in transient focal ischemic neocortex, Neuro Report 5:493–496.

    CAS  Google Scholar 

  • Masliah, E., Achim, C. L., Ge, N., DeTeresa. R., Terry, R. D., and Wiley, C. A., 1992, Spectrum of human immunodeficiency virus-associated neocortical damage, Ann. Neurol. 32:321–329.

    Article  PubMed  CAS  Google Scholar 

  • Meldrum, B., and Garthwaite, J., 1990, Excitatory amino acid neurotoxicity and neurodegencrative disease, Trends Pharmacol. Sci. 11:379–387.

    Article  PubMed  CAS  Google Scholar 

  • Meucci, O., Fatatis, A., Simen, A. A., Bushell, T. J., Gray, P. W., and Miller, R. J., 1998, Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity, Proc. Natl. Acad. Sci. USA 95:14500–14505.

    Article  PubMed  CAS  Google Scholar 

  • Mitchell, J., Lawson, S., Moser, B., Laidlaw, S. M., Cooper, A. J., Walkinshaw, G., and Waters, C. M., 1994, Glutamate-induced apoptosis results in a loss of striatal neurons in the parkinsonian rat, Neuroscience 63:1–5.

    Article  PubMed  CAS  Google Scholar 

  • Müller, W. E. G., Schröder, H. C., Ushijima, H., Dapper, J., and Bormann, J., 1992, gp120 of HIV-1 induces apoptosis in rat cortical cell cultures: Prevention by memantine, Eur. J. Pharmacol. Mol. Pharm. Sect. 226:209–214.

    Article  Google Scholar 

  • Nottet, H. S. L. M., Jett, M., Flanagan, C. R., Zhai, Q.-H., Persidsky, Y., Rizzino, A., Genis, P., Baldwin, T., Schwartz, J., and Gendelman, H. E., 1995, A regulatory role for astrocytes in HIV-encephalitis: An overexpression of eieosanoids, platelet-activating factor and tumor necrosis factor-α by activated HIV-l-infected monocytes is attenuated by primary human astrocytes, J. Immunol. 154:3567–3581.

    PubMed  CAS  Google Scholar 

  • Omerovic, A., Chen, S.-J., Leonard, J. P., and Kelso, S. R., 1995, Subunit-specific redox modulation of NMDA receptors expressed in Xenopus oocytes, J. Recep. Sign. Transduc. Res. 15:811–827.

    CAS  Google Scholar 

  • Osborne, N. N., and Quack, G., 1992, Memantine stimulates inositol phosphates production in neurones and nullifies N-methyl-D-aspartate-induced destruction of retinal neurones, Neurochem. Int. 21:329–336.

    Article  PubMed  CAS  Google Scholar 

  • Pellegrini, J. W., and Lipton, S. A., 1993, Delayed administration of memantine prevents N-methyl-D-aspartate receptor-mediated neurotoxicity, Ann. Neurol. 33:403–407.

    Article  PubMed  CAS  Google Scholar 

  • Perrson, L., and Hillered, L., 1992, Chemical monitoring of neurosurgical intensive care patients using intracerebral microdialysis, J. Neurosurg. 76:72–80.

    Google Scholar 

  • Petito, C. K., and Roberts, B., 1995, Evidence of apoptotic cell death in HIV encephalitis, Am. J. Pathol. 146:1121–1130.

    PubMed  CAS  Google Scholar 

  • Pollard, H., Cantagrel, S., Charriaut-Marlangue, C., Moreau, J., and Ben-Ari, Y., 1994a, Apoptosis associated DNA fragmentation in epileptic brain damage, Neuro Report 5:1053–1055.

    CAS  Google Scholar 

  • Pollard, H., Charriaut-Marlangue, C., Cantagrel, S., Represa, A., Robain, O., Moreau, J., and Ben-Ari, Y., 1994b, Kainate-induced apoptotic cell death in hippocampal neurons, Neuroscience 63:7–18.

    Article  PubMed  CAS  Google Scholar 

  • Price, R. W., Brew, B., Sidtis, J., Rosenblum, M., Scheck, A. C., and Clearly, P., 1988, The brain and AIDS: Central nervous system HIV-1 infection and AIDS dementia complex, Science 239:586–592.

    Article  PubMed  CAS  Google Scholar 

  • Pulliam, L., Herndler, B. G., Tang, N. M., and McGrath, M. S., 1991, Human immunodeficiency virus-infected macrophages produce soluble factors that cause histological and neurochemical alterations in cultured human brains, J. Clin. Invest. 87:503–512.

    Article  PubMed  CAS  Google Scholar 

  • Ratan, R. R., Murphy, T. H., and Baraban, J. M., 1994, Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione, J. Neurosci. 14:4385–4392.

    PubMed  CAS  Google Scholar 

  • Saito, T., Sarer, L. R., Epstein, L. G., Michales, J., Mintz, M., Louder, M., Goldring, K., Cvetkovich, T. A., and Blumberg, B. M., 1994, Overexpression of nef as a marker for restricted HIV-1 infection of astrocytes in postmortem pediatric central nervous tissues, Neurology 44:474–481.

    PubMed  CAS  Google Scholar 

  • Sathi, S., Edgecomb, P., Warach, S., Manchester, K., Donaghey, T., Stieg, P. E., Jensen, F. E., and Lipton, S. A., 1993, Chronic transdermal nitroglycerin (NTG) is neuroprotective in experimental rodent stroke models, Soc. Neurosci. Abstr. 19:849.

    Google Scholar 

  • Savill, J. S., Fadok, V., Henson, P., and Haslett, C., 1993, Phagocyte recognition of cells undergoing apoptosis, Immunol. Today 14:131–136.

    Article  PubMed  CAS  Google Scholar 

  • Savio, T., and Levi, G., 1993, Neurotoxicity of HIV coat protein gp120, NMDA receptors, and protein kinase C: A study with rat cerebellar granule cell cultures, J. Neurosci. Res. 34:265–272.

    Article  PubMed  CAS  Google Scholar 

  • Schwartz, L. M., Smith, S. W., Jones, M. E. E., and Osborne, B. A., 1993, Do all programmed cell deaths occur via apoptosis? Proc. Natl. Acad. Sci. USA 90:980–984.

    Article  PubMed  CAS  Google Scholar 

  • Seif el Nasr, M., Perucher, B., Rossberg, C., Mennel, H.-D., and Krieglstein, J., 1990, Neuroprotective effect of memantine demonstrated in vivo and in vitro, Eur. J. Pharmacol. 185:19–24.

    Article  Google Scholar 

  • Selmaj, K. N., Farooq, M., Norton, T., Raine, C. S., and Brosman, C. F., 1990, Proliferation of astrocytes in vitro in response to cytokines, J. Immunol. 144:129–135.

    PubMed  CAS  Google Scholar 

  • Sidtis, J. J., Gatsonis, C., Price, R. W., Singer, E. J., Collier, A. C., Richman, D. D., Hirsch, M. D., Schaerf, F. W., Fischl, M. A., Kieburtz, K., Simpson, D., Koch, M. A., Feinberg, J., and Dafni, U., 1993, Zidovudine treatment of the AIDS dementia complex: Results of a placebo-controlled trial, Ann. Neurol. 33:343–349.

    Article  PubMed  CAS  Google Scholar 

  • Silverstein, F. S., Naik, B., and Simpson, J., 1991, Hypoxia-ischemia stimulates hippocampal glutamate efflux in perinatal rat brain: An in vivo microdialysis study, Pediatr. Res. 30:587–590.

    Article  PubMed  CAS  Google Scholar 

  • Simmons, M. L., and Murphy, S., 1993, Cytokines regulate l-arginine-dependent cyclic GMP production in rat glial cells, Eur. J. Neurosci. 5:825–831.

    Article  PubMed  CAS  Google Scholar 

  • Soliven, B., and Albert, J., 1992, Tumor necrosis factor modulates Ca2+ currents in cultured sympathetic neurons, J. Neurosci. 12:2665–2671.

    PubMed  CAS  Google Scholar 

  • Stamler, J. S., Toone, E. J., Lipton, S. A., and Sucher, N. J., 1997, (S)NO signals: Translocation, regulation, and a consensus motif, Neuron 18:691–696.

    Article  PubMed  CAS  Google Scholar 

  • Stieg, P. E., Sathi, S., Alvarado, S. P., Jackson, P. S., Pellegrini, J. W., Chen, H.-S. V., Lipton, S. A., and Jensen, F. E., 1993, Post-stroke neuroprotection by memantine minimally affects behavior and does not block LTP, Soc. Neurosci. Abstr. 19:1503.

    Google Scholar 

  • Sucher, N. J., Awobuluyi, M., Choi, Y.-B., and Lipton, S. A., 1996, NMDA receptors: From genes to channels, Trends Pharmacol. Sci. 17:348–355.

    Article  PubMed  CAS  Google Scholar 

  • Sullivan, J. M., Traynelis, S. F., Chen, H.-S. V., Escobar, W., Heinemann, S. F., and Lipton, S. A., 1994, Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor, Neuron 13:929–936.

    Article  PubMed  CAS  Google Scholar 

  • Tenhula, W. N., Xu, S. Z., Madigan, M. C., Heller, K., Freeman, W. R., and Sadun, A. A., 1992, Morphometric comparisons of optic nerve axon loss in acquired immunodeficiency syndrome, Am. J. Ophthalmol. 113:14–20.

    PubMed  CAS  Google Scholar 

  • Tenneti, L., D’Emilia, D. M., and Lipton, S. A., 1997, Suppression of neuronal apoptosis by S-nitrosylation of caspases, Neurosci. Lett. 236:139–142.

    Article  PubMed  CAS  Google Scholar 

  • Toggas, S. M., Masliah, E., Rockenstein, E. M., Rall, G. F., Abraham, C. R., and Mucke, L., 1994, Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice, Nature 367:188–193.

    Article  PubMed  CAS  Google Scholar 

  • Toggas, S. M., Masliah, E., and Mucke, L., 1996, Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine, Brain Res. 706:303–307.

    Article  PubMed  CAS  Google Scholar 

  • Tornatore, C., Chandra, R., Berger, J. R., and Major, E. O., 1994, HIV-1 infection of subcortical astrocytes in the pediatric central nervous system, Neurology 44:481–487.

    PubMed  CAS  Google Scholar 

  • Tyor, W. R., Glass, J. D., Griffin, J. W., Becker, S., McArthur, J. C., Bezman, L., and Griffin, D. E., 1992, Cytokine expression in the brain during the acquired immunodeficiency syndrome, Ann. Neurol. 31:349–360.

    Article  PubMed  CAS  Google Scholar 

  • Valone, F. H., and Epstein, L. B., 1988, Biphasic platelet-activating factor synthesis by human monocytes stimulated with IL-1β, tumor necrosis factor, or IFN-γ, J. Immunol. 141:3945–3950.

    PubMed  CAS  Google Scholar 

  • Wahl, L. M., Corcoran, M. L., Pyle, S. W., Arthur, L. O., Harel-Bellan, A., and Farrar, W. L., 1989, Human immunodeficiency virus glycoprotein (gp120) induction of monocyte arachidonic acid metabolites and interleukin 1, Proc. Natl. Acad. Sci. USA 86:621–625.

    Article  PubMed  CAS  Google Scholar 

  • Wesselingh, S. L., Power, C., Glass, J. D., Tyor, W. R., McArthur, J. C., Farber, J. M., Griffin, J. W., and Griffin, D. E., 1993, Intracerebral cytokine messenger RNA expression in acquired immunodeficiency syndrome dementia, Ann. Neurol. 33:576–582.

    Article  PubMed  CAS  Google Scholar 

  • Whittemore, E. R., Loo, D. T., and Cotman, C. W., 1994, Exposure to hydrogen peroxide induces cell death via apoptosis in cultured rat cortical neurons, Neuro Report 5:1485–1488.

    CAS  Google Scholar 

  • Wiley, C. A., Masliah, E., Morey, M., Lemere, C., DeTeresa, R. M., Grafe, M. R., Hansen, L. A., and Terry, R. D., 1991, Neocortical damage during HIV infection, Ann. Neurol. 29:651–657.

    Article  PubMed  CAS  Google Scholar 

  • Wyllie, A. H., Kerr, J. F. R., and Currie, A. R., 1980, Cell death: The significance of apoptosis, Int. Rev. Cytol. 68:251–306.

    Article  PubMed  CAS  Google Scholar 

  • Yeh, M. W., Nottet, H. L. M., Gendelman, H. E., and Lipton, S. A., 1994, HIV-1 coat protein gp120 stimulates human macrophages to release l-cysteine, an NMDA agonist, Soc. Neurosci. Abstr. 20:451.

    Google Scholar 

  • Yun, H. Y., Gonzalez-Zulueta, M., Dawson, V. L., and Dawson, T. M., 1998, Nitric oxide mediates N-methyl-D-aspartate receptor-induced activation of p21 ras, Proc. Natl. Acad. Sci. USA 95:5773–5778.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. CNS Research Institute, Harvard Medical School, and Brigham and Women’s Hospital, Boston, Massachusetts, 02115

    Stuart A. Lipton

Authors
  1. Stuart A. Lipton
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Colorado Health Sciences Center, Denver, Colorado

    Ferric C. Fang

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Kluwer Academic Publishers

About this chapter

Cite this chapter

Lipton, S.A. (2002). Nitric Oxide in AIDS-Associated Neurological Disease. In: Fang, F.C. (eds) Nitric Oxide and Infection. Springer, Boston, MA. https://doi.org/10.1007/0-306-46816-6_21

Download citation

  • DOI: https://doi.org/10.1007/0-306-46816-6_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46147-7

  • Online ISBN: 978-0-306-46816-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation