Skip to main content
SpringerLink
Log in

Nitric Oxide in Bacterial Meningitis

  • Chapter
Nitric Oxide and Infection

  • 207 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Amaee, F. R., Comis, S. D., and Osborne, M. P., 1995, N G-Methyl-l-arginine protects the guinea pig cochlea from the cytotoxic effects of pneumolysin, Acta Oto-Laryngol. 115:386–391.

    Article  CAS  Google Scholar 

  • Amaee, F. R., Comis, S. D., Osborne, M. P., Drew, S., and Tarlow, M. J., 1997, Possible involvement of nitric oxide in the sensorineural hearing loss of bacterial meningitis, Acta Oto-Laryngol. 117:329–336.

    Article  CAS  Google Scholar 

  • Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., and Freeman, B. A., 1990, Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide, Proc. Natl. Acad. Sci. USA 87:1620–1624.

    Article  PubMed  CAS  Google Scholar 

  • Bernatowicz, A., Kodel, U., Frei, K., Fontana, A., and Pfister, H. W., 1995, Production of nitrite by primary rat astrocytes in response to pneumococci, J. Neuroimmunol. 60:53–61.

    Article  PubMed  CAS  Google Scholar 

  • Blough, N., and Zafiriou, O., 1985, Reaction of superoxide with nitric oxide to form peroxynitrite in alkaline aqueous solution, Inorg. Chem. 24:3502–3504.

    Article  CAS  Google Scholar 

  • Boje, K. M., 1995, Inhibition of nitric oxide synthase partially attenuates alterations in the blood-cerebrospinal fluid barrier during experimental meningitis in the rat, Eur. J. Pharmacol. 272:297–300.

    Article  PubMed  CAS  Google Scholar 

  • Boje, K. M., 1996, Inhibition of nitric oxide synthase attenuates blood-brain barrier disruption during experimental meningitis, Brain Res. 720:75–83.

    Article  PubMed  CAS  Google Scholar 

  • Boje, K., and Arora, P., 1992, Microglial-produced nitric oxide and reactive oxides mediate neuronal cell death, Brain Res. 587:250–256.

    Article  PubMed  CAS  Google Scholar 

  • Bonfoco, E., Krainc, D., Ankarcrona, M., Nicotera, P., and Lipton, S. A., 1995, Apoptosis and necrosis: Two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures, Proc. Natl. Acad. Sci. USA 92:7162–7166.

    Article  PubMed  CAS  Google Scholar 

  • Bredt, D. S., and Snyder, S. H., 1989, Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum, Proc. Natl. Acad. Sci. USA 86:9030–9033.

    Article  PubMed  CAS  Google Scholar 

  • Brian, Y. E., Jr., Heistad, D. D., and Faraci, F. M., 1995, Dilatation of cerebral arterioles in response to lipopolysaccharide in vivo, Stroke 26:277–280.

    PubMed  CAS  Google Scholar 

  • Buster, B. L., Weintrob, A. C., Townsend, O. C., and Scheld W. M., 1995, Potential role of nitric oxide in the pathophysiology of experimental bacterial meningitis in rats, Infect. Immun. 63:3835–3839.

    PubMed  CAS  Google Scholar 

  • Cleeter, M., Cooper, J., Darley-Usmar, V., Moncada, S., and Schapira, A., 1994, Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide: Implications for neurodegenerative diseases, FEBS Lett. 345:50–54.

    Article  PubMed  CAS  Google Scholar 

  • Dawson, T., Dawson, V., and Snyder, S., 1992, A novel neuronal messenger molecule in brain: The free radical, nitric oxide, Ann. Newol. 32:297–311.

    Article  CAS  Google Scholar 

  • Dawson, V., Dawson, T., London, E., Brent, D., and Snyder, S., 1991, Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures, Proc. Natl. Acad. Sci. USA 88:6368–6371.

    Article  PubMed  CAS  Google Scholar 

  • Drapier, J. C., Wietzerbin, J., and Hibbs, J. B., Jr., 1988, Interferon-gamma and tumor necrosis factor induce the L-arginine cytotoxic effector mechanism in murine macrophages, Eur. J. Immunol. 18:1587–1592.

    Article  PubMed  CAS  Google Scholar 

  • Estevez, A. G., Radi, R., Barbeito, L., Shin, J. T., Thompson, J. A., and Beckman, J. S., 1995. Peroxynitrite-induced cytotoxicity in PC12 cells: Evidence for an apoptotic mechanism differentially modulated by neurotrophic factors, J. Neurochem. 65:1543–1550.

    PubMed  CAS  Google Scholar 

  • Faraci, F., 1992, Regulation of the cerebral circulation by endothelium, Pharmacol. Ther. 56:1–22.

    Article  PubMed  CAS  Google Scholar 

  • Freyer, D., Weih, M., Weber, J. R., Burger, W., Scholz, P., Manz, R., Ziegenhorn, A., Angestwurm, K., and Dirnagl, U., 1996, Pneumococcal cell wall components induce nitric oxide synthase and TNF-alpha in astroglial-enriched cultures, Glia 16:1–6.

    Article  PubMed  CAS  Google Scholar 

  • Garthwaite, J., Garthwaite, G., Palmer, R., and Moncada, S., 1989, NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices, Eur. J. Pharmacol. 172:413–416.

    Article  PubMed  CAS  Google Scholar 

  • Geng, Y., Petersson, A., Wennmalm, A., and Hanson, G., 1994, Cytokine-induced expression of nitric oxide synthase results in nitrosylation of heme and nonheme iron proteins in vascular smooth muscle cells, Exp. Cell Res. 214:418–428.

    Article  PubMed  CAS  Google Scholar 

  • Goodrum, K. S., McCormick, L. L., and Schneider, B., 1994, Group B streptococcus-induced nitric oxide production in murine macrophages is CR3 (CD11b/CD18) dependent, Infect. Immun. 62:3102–3107.

    PubMed  CAS  Google Scholar 

  • Greenfield, S., 1992, Cell death in Parkinson’s disease, Essays Biochem. 27:103–118.

    PubMed  CAS  Google Scholar 

  • Haberl, R. L., Anneser, F., Kodel, U., and Pfister, H. W., 1994, Is nitric oxide involved as a mediator of cerebrovascular changes in the early phase of experimental pneumococcal meningitis? Neurol. Res 16:108–112.

    PubMed  CAS  Google Scholar 

  • Hibbs, J. B., Jr., Taintor, R. R., Vavrin, Z., and Rachlin, E. M., 1988, Nitric oxide: A cytotoxic activated macrophage effector moleule, Biochem. Biophys. Res. Commun. 157:87–94.

    Article  PubMed  CAS  Google Scholar 

  • Hogg, N., Darley-Usmar, V. M., Wilson, M. T., and Moncada, S., 1992, Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide, Biochem. J. 281:419–424.

    PubMed  CAS  Google Scholar 

  • Ischiropoulos, H., Zhu, L., and Beckman, J. S., 1992, Peroxynitrite formation from macrophage-derived nitric oxide, Arch. Biochem. Biophys. 298:445–451.

    Google Scholar 

  • Kanno, K., Hirata, Y., Imai, T., and Marumo, F., 1993, Induction of nitric oxide synthase gene by interleukin in vascular smooth muscle cells, Hypertension 22:34–39.

    PubMed  CAS  Google Scholar 

  • Kim, Y. S., and Tauber, M. G., 1996, Neurotoxicity of glia activated by gram-positive bacterial products depends on nitric oxide production, Infect. Immun. 64:3148–3153.

    PubMed  CAS  Google Scholar 

  • Knowles, R. G., Palacios, M., Palmer, R. M. J., and Moncada, S., 1990, Kinetic characteristics of nitric oxide synthase from rat brain, Biochem. J. 269:207–210.

    PubMed  CAS  Google Scholar 

  • Koedel, U., and Pfister, H. W., 1997, Protective effect of the antioxidant N-acetyl-L-cysteine in pneumococcal meningitis in the rat, Neurosci. Lett. 225:33–36.

    Article  PubMed  CAS  Google Scholar 

  • Koedel, U., Bernatowicz, A., Paul, R., Frei, K., Fontana, A., and Pfister, H. W., 1995, Experimental pneumococcal meningitis: Cerebrovascular alterations, brain edema, and meningeal inflammation are linked to the production of nitric oxide, Ann. Neurol. 37:313–323.

    Article  PubMed  CAS  Google Scholar 

  • Koedel, U., Bernatowicz, A., Frei, K., Fontana, A., and Pfister, H. W., 1996, Systemically (but not intrathecally) administered IL-10 attenuates pathophysiologic alterations in experimental pneumococcal meningitis, J. Immunol. 157:5185–5191.

    PubMed  CAS  Google Scholar 

  • Koenig, H., Trout, J., Goldstone, A., and Lu, C., 1992, Capillary NMDA receptors regulate blood-brain barrier function and breakdown, Brain Res. 588:297–303.

    Article  PubMed  CAS  Google Scholar 

  • Kooy, N., and Royall, J., 1994, Agonist-induced peroxynitrite production from endothelial cells, Arch. Biochem. Biophys. 310:352–359.

    Article  PubMed  CAS  Google Scholar 

  • Kornelisse, R. F., Hoekman, K., Visser, J. J., Hop, W. C., Huijmans, J. G., van der Straaten, P. J., van der Heijden, A. J., Sukhai, R. N., Neijens, H. J., and de Groot, R., 1996, The role of nitric oxide in bacterial meningitis in children, J. Infect. Dis. 174:120–126.

    PubMed  CAS  Google Scholar 

  • Korytko, P. J., and Boje, K. M., 1996, Pharmacological characterization of nitric oxide production in a rat model of meningitis, Neuropharmacology 35:231–237.

    Article  PubMed  CAS  Google Scholar 

  • Kovach. A., Szabo, C., Benyo, Z., Csaki, C., Greenberg, J., and Reivich, M., 1992, Effects of N G-nitro-L-arginine l-arginine on regional blood flowinthecat, J. I’hysiol. (London) 449:183–196.

    CAS  Google Scholar 

  • Lee, S., Dickson, D., Liu, W., and Brosnan, C., 1993, Induction of nitric oxide synthase activity in human astrocytes by interleukin-1 α and interferon-γ. J. Neuroimmunol. 46:19–24.

    Article  PubMed  CAS  Google Scholar 

  • Leib, S. L., Kim, Y. S., Black, S. M., Ferriero, D. M., and Tauber, M. G., 1996, Detrimental effect of nitric oxide inhibition in experimental bacterial meningitis, Ann. Neurol. 39:555–556.

    Article  PubMed  CAS  Google Scholar 

  • Leib, S. L., Kim, Y. S., Black, S. M., Tureen, J. H., and Tauber, M. G., 1998, Inducible nitric oxide synthase and the effect of aminoguanidine in experimental neonatal meningitis, J. Infect. Dis. 177:692–700.

    Article  PubMed  CAS  Google Scholar 

  • Leist, M., Fava, E., Montecucco, C., and Nicotera, P., 1997, Peroxynitrite and nitric oxide donors induce neuronal apoptosis by eliciting autocrine excitotoxicity, Eur. J. Neurosci. 9:1488–1498.

    Article  PubMed  CAS  Google Scholar 

  • Milstien, S., Sakai, N., Brew, B. J., Krieger, C., Vickers, J. H., Saito, K., and Heyes, M. P., 1994, Cerebrospinal fluid nitrite/nitrate levels in neurologic diseases, J. Neurochem. 63:178–180.

    Google Scholar 

  • Murphy, S., Minor, R. L., Jr., Welk, G., and Harrison, D. G., 1990, Evidence for an astrocyte-derived vasorelaxing factor with properties similar to nitric oxide, J. Neurochem. 55:349–351.

    Article  PubMed  CAS  Google Scholar 

  • Nowicki, J., Duval, D., Poignet, H., and Scatton, B., 1991, Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse, Eur. J. Pharmacol. 204:339–340.

    Article  PubMed  CAS  Google Scholar 

  • Palluy, O., and Rigaud, M., 1996, Nitric oxide induces cultured conical neuron apoptosis, Neurosci. Lett. 208:1–4.

    Article  PubMed  CAS  Google Scholar 

  • Paul, K., Koedel, U., and Pfister, H. W., 1997, 7-Nitroimidazole inhibits pial arteriolar vasodilation in a rat model of pneumococcal meningitis, J. Cereb. Blood Flow Metab. 17:985–991

    Article  PubMed  CAS  Google Scholar 

  • Peterson, P., Hu, S., Anderson, R., and Chao, C., 1994, Nitric oxide production and neurotoxicity mediated by activated microglia from human versus mouse brain, J. Infect. Dis. 170:457–460.

    PubMed  CAS  Google Scholar 

  • Pfeilschifter, J., and Schwarzenbach, H., 1990, Interleukin 1 and tumor necrosis factor stimulate cGMP formation in rat mesangial cells, FEBS Lett., 273:185–187.

    Article  PubMed  CAS  Google Scholar 

  • Radi, R., Beckman, J. S., Bush, K. M., and Freeman, B. A., 1991a, Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide, Arch. Biochem. Biophys. 288:481–487.

    Article  PubMed  CAS  Google Scholar 

  • Radi, R., Beckman, J. S., Bush, K. M., and Freeman, B. A., 1991b, Peroxynitrite oxidation of sulfhydrylsa, J. Biol. Chem. 266:4244–4250.

    PubMed  CAS  Google Scholar 

  • Radi, R., Rodriguez, M., Castro, L., and Telleri, R., 1994, Inhibition of mitochondrial electron transport by peroxynitrite, Arch. Biochem. Biophys. 308:89–95.

    Article  PubMed  CAS  Google Scholar 

  • Rutgers, M. I. L., Yo, M. S. S., Buster, B. L., and Scheld, W. M., 1997, Increase of the lipidperoxidation byproducts malonaldehyde and 4-hydoxyalkenal in cerebrospinal fluid during experimental bacterial meningitis in the rat, in: Proceedings and Abstracts of the 37th Interscience Conference on Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Washington, D.C., Abstr. B-71.

    Google Scholar 

  • Szabo, C., 1996, Physiological and pathophysiological roles of nitric oxide in the central nervous system, Brain Rex. Bull 41:131–141.

    CAS  Google Scholar 

  • Tsukahara, H., Hara, Y., Tsuchida, S., Shigematsu, Y., Konishi, Y., Kikuchi, K., and Sudo, M., 1996, Nitrite concentration in cerebrospinal fluid of infants: Evidence for enhanced nitric oxide production in Haemophilus influenzae meningitis, Acta Paediatr. Jpn. 38:420–422.

    PubMed  CAS  Google Scholar 

  • Tureen, J., 1995, Effect of recombinant human tumor necrosis factor-alpha on cerebral oxygen uptake, cerebrospinal fluid lactate, and cerebral blood flow in the rabbit: Role of nitric oxide, J. Clin. Invest. 95:1086–1091.

    Article  PubMed  CAS  Google Scholar 

  • Uemura, Y, Kowall, N., and Beal, M., 1990, Selective sparing of NADPH-diaphorase-somatostatin-neuropeptide Yneurons in ischemic gerbilstriatum, Ann.Neurol. 27:620–625.

    Article  PubMed  CAS  Google Scholar 

  • van Furth, A. M., Seijmonsbergen, E. M., Groeneveld, P. H., van Furth, R., and Langermans, J. A., 1996. Levels of nitric oxide correlate with high levels of tumor necrosis factor alpha in cerebrospinal fluid samples from children with bacterial meningitis, Clin. Inject. Dis. 22:876–878.

    Google Scholar 

  • Visser, J. J., Scholten, R. J., and Hoekman, K., 1994, Nitric oxide synthesis in meningococcal meningitis, Ann. Intern. Med. 120:345–346.

    PubMed  CAS  Google Scholar 

  • Xie, Q., Whisnant, R., and Nathan, C., 1993, Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibihty by interferon-gamma and bacterial lipopolysaccharidea, J. Exp. Med. 177:1779–1784.

    Article  PubMed  CAS  Google Scholar 

  • Youdim, M., Ben-Shachar, D., Eshel, G., Finberg, J., and Riederer, P., 1993, The neurotoxicity of iron and nitric oxide:Relevance to the etiology of Parkinson’ s disease, Adv. Neurol. 60:259–266.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, University of Virginia, Charlottesville, Virginia, 22908

    Gregory Townsend & W. Michael Scheld

Authors
  1. Gregory Townsend
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. Michael Scheld
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Colorado Health Sciences Center, Denver, Colorado

    Ferric C. Fang

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Kluwer Academic Publishers

About this chapter

Cite this chapter

Townsend, G., Scheld, W.M. (2002). Nitric Oxide in Bacterial Meningitis. In: Fang, F.C. (eds) Nitric Oxide and Infection. Springer, Boston, MA. https://doi.org/10.1007/0-306-46816-6_20

Download citation

  • DOI: https://doi.org/10.1007/0-306-46816-6_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46147-7

  • Online ISBN: 978-0-306-46816-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation