Skip to main content
SpringerLink
Log in

Nitric Oxide in Viral Myocarditis

  • Chapter
Nitric Oxide and Infection

  • 207 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Akaike, T., Noguchi, Y., Ijiri, S., Setoguchi, K., Suga, M, Zheng, Y.M., Dietzschold, B., and Maeda, H., 1996, Pathogenesis of influenza virus-induced pneumonia: Involvement of both nitric oxide and oxygen radicals, Proc. Natl. Acad Sci. USA 93:2448–2453.

    Article  PubMed  CAS  Google Scholar 

  • Akarid, K., Sinet, M., Desforges, B., and Gougerot-Pocidalo, M. A., 1995, Inhibitory effect of nitric oxide on the replication of a murine retrovirus in vitro and in vivo, J Virol. 69:7001–7005.

    PubMed  CAS  Google Scholar 

  • Alvarez, F. L., Neu, N., Rose, N. R., Craig, S. W., and Beisel, K. W., 1987, Heart-specific autoantibodies induced by coxsackic virus B3: Identification of heart autoantigens, Clin. Immunol. Immunopathol. 43:129–135.

    Article  PubMed  CAS  Google Scholar 

  • Aretz, H. T., Billingham, M. E., Edwards, W. D., Factor, S. M., Fallon, J. T., Fenoglio, J. J., and Olsen, E. G. J., 1987, Myocarditis. A pathologic definition and classification, Am. J. Cardiovasc. Pathol. 1:3–11.

    PubMed  CAS  Google Scholar 

  • Bendinelli, M., Matteucci, D., Toniolo, A., Patane, A. M., and Pistillo, M. P., 1982, Impairment of immunocompetent mouse spleen cell functions by infection with coxsackievirus B3, J. Infect. Dis. 146:797–805.

    PubMed  CAS  Google Scholar 

  • Bi, Z., and Reiss, C. S., 1995, Inhibition of vesicular stomatitis virus infection by nitric oxide, J. Virol. 69:2208–2213.

    PubMed  CAS  Google Scholar 

  • Bukrinsky, M. I., Nottet, H. S., Schmidtmayerova, H., Dubrovsky, L., Flanagan, C. R., Mullins, M. E., Lipton, S. A., and Gendelman, H. E., 1995, Regulation of nitric oxide synthase activity in human immunodeficiency virus type 1 (HIV-l)-infected monocytes: Implications for HIV-associated neurological disease, J. Exp. Med. 181:735–745.

    Article  PubMed  CAS  Google Scholar 

  • Butz, E. A., Hostager, B. S., and Southern, P. J., 1994, Macrophages in mice acutely infected with lymphocytic choriomeningitis virus are primed for nitric oxide synthesis, Microb. Pathog. 16:283–295.

    Article  PubMed  CAS  Google Scholar 

  • Campbell, A. E., Loria, R. M., Madge, G. E., and Kaplan, A. M., 1982, Dietary hepatic cholesterol elevation: Effects on coxsackievirus B infection and inflammation, Inject. Immun. 37:307–317.

    CAS  Google Scholar 

  • Chow, L. H., Beisel, K. W., and McManus, B. M., 1992, Enteroviral infection of mice with severe combined immunodeficiency. Evidence for direct viral pathogenesis of myocardial injury, Lab. Invest. 66:24–31.

    PubMed  CAS  Google Scholar 

  • Cook, D. N., 1996, The role of M1P-1 alpha in inflammation and hematopoiesis, J. Leukoc. Biol. 59:61–66.

    PubMed  CAS  Google Scholar 

  • Cook, D. N., Beck, M. A., Coffman, T. M., Kirby, S. L., Sheridan, J. F., Pragnell, I. B., and Smithies, O., 1995, Requirement of MIP-1 alpha for an inflammatory response to viral infection. Science 269:1583–1585.

    PubMed  CAS  Google Scholar 

  • Croen, K. D., 1993, Evidence for antiviral effect of nitric oxide. Inhibition of herpes simplex virus type 1 replication, J Clin. Invest. 91:2446–2452.

    PubMed  CAS  Google Scholar 

  • Finkel, M. S., Oddis, C. V, Jacob, T. D., Watkins, S. C., Hattler, B. G., and Simmons, R. L., 1992, Negative inotropic effects of cytokines on the heart mediated by nitric oxide, Science 257:387–389.

    PubMed  CAS  Google Scholar 

  • Godeny, E. K., and Gauntt, C. J., 1986, Involvement of natural killer cells in coxsackievirus B3 induced murine myocarditis, J. Immunol. 137:1695–1702.

    PubMed  CAS  Google Scholar 

  • Godeny, E. K.. and Gauntt, C. J., 1987a, In situ immune autoradiographic identification of cells in heart tissues of mice with coxsackievirus B3-induced myocarditis. Am. J. Pathol 129:267–276.

    PubMed  CAS  Google Scholar 

  • Godeny, E. K., and Gauntt, C. J., 1987b, Murine natural killer cells limit coxsackievirus B3 replication, J. Immunol. 139:913–918.

    PubMed  CAS  Google Scholar 

  • Groeneveld, P. H., Colson, P., Kwappenberg, K. M., and Clement, J., 1995, Increased production of nitric oxide in patients infected with the European variant of hantavirus, Scand. J. Inject. Dis. 27:453–456.

    CAS  Google Scholar 

  • Harris, N., Buller, R. M., and Karupiah, G., 1995, Gamma interferon-induced, nitric oxide-mediated inhibition of vaccinia virus replication, J. Virol. 69:910–915.

    PubMed  CAS  Google Scholar 

  • Hashimoto, I., Tatsumi, M., and Nakagawa, M., 1983, The role of T lymphocytes in the pathogenesis of coxsackie virus B3 heart disease, Br. J. Exp. Pathol. 64:497–504.

    PubMed  CAS  Google Scholar 

  • Heim, A., Canu, A., Kirschner, P., Simon, T, Mall, G., Hofschneider, P. H., and Kandolf, R., 1992, Synergistic interaction of interferon-beta and interferon-gamma in coxsackievirus B3-infected carrier cultures of human myocardial fibroblasts, J. Infect. Dis. 166:958–965.

    PubMed  CAS  Google Scholar 

  • Hiraoka, Y., Kishimoto, C., Takada, H., Suzaki, N., and Shiraki, K., 1995, Colony-stimulating factors and coxsackievirus B3 myocarditis in mice: Macrophage colony-stimulating factor suppresses acute myocarditis with increasing interferon-alpha. Am. Heart J. 130:1259–1264.

    Article  PubMed  CAS  Google Scholar 

  • Hiraoka, Y., Kishimoto, C., Takada, H., Nakamura, M., Kurokawa, M., Ochiai, H., and Shiraki, K., 1996, Nitric oxide and murine coxsackievirus B3 myocarditis: Aggravation of myocarditis by inhibition of nitric oxide synthase, J. Am. Coll. Cardiol. 28:1610–1615.

    Article  PubMed  CAS  Google Scholar 

  • Huber, S. A., and Cunningham, M. W., 1996, Streptococcal M protein peptide with similarity to myosin induces CD4 + T cell-dependent myocarditis in MRL/++ mice and induces partial tolerance against coxsackieviral myocarditis, J. Immunol. 156:3528–3534.

    PubMed  CAS  Google Scholar 

  • Huber, S. A., and Lodge, P. A., 1984, Coxsackievirus B-3 myocarditis in BALB/c mice. Evidence for autoimmunity to myocyte antigens, Am. J. Pathol. 116:21–29.

    PubMed  CAS  Google Scholar 

  • Huber, S. A., and Pfaeffle, B., 1994, Differential Th1 and Th2 cell responses in male and female BALB/c mice infected with coxsackievirus group B type 3, J. Virol 68:5126–5132.

    PubMed  CAS  Google Scholar 

  • Huber, S. A., Job, L. P., and Woodruff, J. F., 1980, Lysis of infected myofibers by coxsackievirus B-3-immune T lymphocytes, Am. J. Pathol. 98:681–694.

    PubMed  CAS  Google Scholar 

  • Huber, S. A., Mortensen, A., and Moulton, G., 1996, Modulation of cytokine expression by CD4+ T cells during coxsackievirus B3 infections of BALB/c mice initiated by cells expressing the gamma delta+T-cell receptor, J. Virol. 70:3039–3044.

    PubMed  CAS  Google Scholar 

  • Ignarro, L. J., 1990, Biosynthesis and metabolism of endothelium-derived nitric oxide, Annu. Rev. Pharmacol. Toxicol. 30:535–560.

    Article  PubMed  CAS  Google Scholar 

  • Kamijo, R., Harada, H., Matsuyama, T., Bosland, M., Gerecitano, J., Shapiro, D., Lc, J., Koh, S. I., Kimura, T., and Green, S. J., 1994, Requirement for transcription factor IRF-1 in NO synthase induction in macrophages, Science 263:1612–1615.

    PubMed  CAS  Google Scholar 

  • Kandolf, R., Canu, A., and Hofschneider, P. H., 1985, Coxsackie B3 virus can replicate in cultured human foetal heart cells and is inhibited by interferon, J. Mol. Cell Cardiol. 17:167–181.

    PubMed  CAS  Google Scholar 

  • Kandolf, R., Kirschner, P., Ameis, D., Canu, A., and Hofschneider, P. H., 1987, In situ detection of enteroviral genomes in myocardial cells by nucleic acidhybridization: An approach to the diagnosis of viral heart disease, Proc. Natl. Acad. Sci. USA 84:6272–6276.

    PubMed  CAS  Google Scholar 

  • Karupiah, G., and Harris, N., 1995, Inhibition of viral replication by nitric oxide and its reversal by ferrous sulfate and tricarboxylic acid cycle metabolites, J. Exp. Med. 181:2171–2179.

    Article  PubMed  CAS  Google Scholar 

  • Karupiah, G., Xie, Q. W., Buller, R. M., Nathan, C., Duarte, C., and MacMicking, J. D., 1993, Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase. Science 261:1445–1448.

    PubMed  CAS  Google Scholar 

  • Kreil, T. R., and Eibl, M. M., 1996, Nitric oxide and viral infection: NO antiviral activity against a flavivirus in vitro, and evidence for contribution to pathogenesis in experimental infection in vivo, Virology 219:304–306.

    Article  PubMed  CAS  Google Scholar 

  • Lewis, N. P., Tsao, P. S., Rickenbacher, P. R., Xue, C., Johns, R. A., Haywood, H., von der Leyen, G. A., Trindade, P. T., Cooke, J. P., Hunt, S. A., Billingham, M. E., Valantine, H. A., and Fowler, M. B., 1996, Induction of nitric oxide synthase in the human cardiac allograft is associated with contractile dysfunction of the left ventricle, Circulation 93:720–729.

    PubMed  CAS  Google Scholar 

  • Lowenstein, C. J., and Snyder, S. H., 1992, Nitric oxide, a novel biologic messenger, Cell 70:705–707.

    PubMed  CAS  Google Scholar 

  • Lowenstein, C. J., Alley, E. W., Raval, P., Snowman, A. M., Snyder, S. H., Russell, S. W., and Murphy, W. J., 1993, Macrophage nitric oxide synthase gene: Two upstream regions mediate induction by interferon gamma and lipopolysaccharide, Proc. Natl. Acad. Sci. USA 90:9730–9734.

    PubMed  CAS  Google Scholar 

  • Lowenstein, C. J., Hill, S. L., Lafond-Walker, A., Wu, J., Allen, G., Landavere, M., Rose, N. R., and Herskowitz, A., 1996, Nitric oxide inhibits viral replication in murine myocarditis, J. Clin. Invest 97:1837–1843.

    PubMed  CAS  Google Scholar 

  • Mannick, J. B., Asano, K., Izumi, K., Kieff, E., and Stamler, J. S., 1994, Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstem-Barr virus reactivation, Cell 79:1137–1146.

    Article  PubMed  CAS  Google Scholar 

  • Marletta, M. A., 1989, Nitric oxide: Biosynthesis and biological significance, Trends Biochem. Sci. 14:488–492.

    Article  PubMed  CAS  Google Scholar 

  • Martin, E., Nathan, C., and Xie, Q. W, 1994, Role of interferon regulatory factor 1 in induction of nitric oxide synthase, J. Exp. Med. 180:977–984.

    Article  PubMed  CAS  Google Scholar 

  • Mason, J. W, O’Connell, J. B., Herskowitz, A., Rose, N. R., McManus, B. M., Billingham, M. E., and Moon, T. E., 1995, A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators, N. Engl. J. Med. 333:269–275.

    Article  PubMed  CAS  Google Scholar 

  • Melkova, Z., and Esteban, M., 1994, Interferon-gamma severely inhibits DNA synthesis of vaccinia virus in a macrophage cell line, Virology 198:731–735.

    PubMed  CAS  Google Scholar 

  • Melkova, Z., and Esteban, M., 1995, Inhibition of vaccinia virus DNA replication by inducible expression of nitric oxide synthase, J. Immunol. 155:5711–5718.

    PubMed  CAS  Google Scholar 

  • Melnick, J. L., 1985, Enteroviruses: Polioviruses, coxsackieviruses, echoviruses, and newer entero-viruses, in: Virology (B. N. Fields, ed.), Raven Press, New York, pp. 739–794.

    Google Scholar 

  • Mikami, S., Kawashima, S., Kanazawa, K., Hirata, K., Katayama, Y, Hotta, H., Hayashi, Y, Ito, H., and Yokoyama, M., 1996, Expression of nitric oxide synthase in a murine model of viral myocarditis induced by coxsackievirus B3, Biochem. Biophys. Res, Commun. 220:983–989.

    Article  CAS  Google Scholar 

  • Moncada, S., Palmer, R. M., and Higgs, E. A., 1991, Nitric oxide: Physiology, pathophysiology, and pharmacology, Pharmacol. Rev. 43:109–142.

    PubMed  CAS  Google Scholar 

  • Nathan, C., 1995, Natural resistance and nitric oxide, Cell 82:873–876.

    Article  PubMed  CAS  Google Scholar 

  • Nathan, C., and Xie, Q. W., 1994, Nitric oxide synthases: Roles, tolls, and controls, Cell 78:915–918.

    Article  PubMed  CAS  Google Scholar 

  • Neu, N., Craig, S. W., Rose, N. R., Alvarez, F., and Beisel, K. W, 1987, Coxsackievirus induced myocarditis in mice: Cardiac myosin autoantibodies do not cross-react with the virus, Clin. Exp Immunol 69:566–574.

    PubMed  CAS  Google Scholar 

  • Neumann, D. A., Rose, N. R., Ansari, A. A., and Herskowitz, A., 1994, Induction of multiple heart autoantibodies in mice with coxsackievirus B3-and cardiac myosin-induced autoimmune myocarditis, J. Immunol. 152:343–350.

    PubMed  CAS  Google Scholar 

  • O’Connell, J. B., and Mason, J. W., 1989, Diagnosing and treating active myocarditis, West. J. Med. 150:431–437.

    Google Scholar 

  • Quigley, P. J., Richardson, P. J., and Meaney, B. T, 1987, Long-term follow-up of acute myocarditis. Correlation of left ventricular function and outcome, Eur. Heart J. Suppl.: J39.

    Google Scholar 

  • Ray, C. G., 1994, Enteroviruses and reoviruses, in: Harrison’s Principles of Internal Medicine (K. J. Isselbacher, E. Braunwald, J. D. Wilson, J. B. Martin, A. S. Fauci, and D. L. Kasper, eds.), McGraw-Hill, New York, pp. 821–825.

    Google Scholar 

  • Rolph, M. S., Ramshaw, I. A., Rockett, K. A., Ruby, J., and Cowden, W. B., 1996, Nitric oxide production is increased during murine vaccinia virus infection, but may not be essential for virus clearance, Virology 217:470–477.

    Article  PubMed  CAS  Google Scholar 

  • Rose, N. R., Wolfgram, L. J., Herskowitz, A., and Beisel, K. W., 19X6, Postinfectious autoimmunity: Two distinct phases of coxsackievirus B3-induced myocarditis, Ann. N. Y. Acad. Sci. 475:146–156.

    Google Scholar 

  • Rose, N. R., Beisel, K. W., Herskowitz, A., Neu, N., Wolfgram, L. J., Alvarez, F. L., Traystman, M. D., and Craig, S. W, 1987, Cardiac myosin and autoimmune myocarditis, in: Autoimmunity and Autoimmune Disease (D. Evered and J. Whelan, eds.), Wiley, New York, pp. 3–24.

    Google Scholar 

  • Rose, N. R., Neumann, D. A., Herskowitz, A., Traystman, M. D., and Beisel, K. W, 1988, Genetics of susceptibility to viral myocarditis in mice, Pathol. Immunopathol. Res. 7:266–278.

    Article  PubMed  CAS  Google Scholar 

  • Rueckert, R. R., 1985, Picornaviruses and their replication, in: Virology (B. N. Fields, ed.), Raven Press, New York, pp. 705–738.

    Google Scholar 

  • Tucker, P. C., Griffin, D. E., Choi, S., Bui, N., and Wesselingh, S., 1996, Inhibition of nitric oxide synthesis increases mortality in Sindbis virus encephalitis, J. Virol 70:3972–3977.

    PubMed  CAS  Google Scholar 

  • Wolfgram, L. J., Beisel, K. W., and Rose, N. R., 1985, Heart-specific autoantibodies following murine coxsackievirus B3 myocarditis, J. Exp. Med. 161:1112–1121.

    Article  PubMed  CAS  Google Scholar 

  • Wolfgram, L. J., Beisel, K. W., Herskowitz, A., and Rose, N. R., 1986, Variations in the susceptibility to coxsackievirus B3-induced myocarditis among different strains of mice, J. Immunol. 136:1846–1852.

    PubMed  CAS  Google Scholar 

  • Woodruff, J. F, 1979, Lack of correlation between neutralizing antibody production and suppression of coxsackievirus B3 replication in target organs: Evidence for the involvement of mononuclear inflammatory cells in defense, J. Immunol. 123:31–35.

    PubMed  CAS  Google Scholar 

  • Woodruff, J. F., 1980, Viral myocarditis: A review, Am. J.Pathol. 101:425–484.

    PubMed  CAS  Google Scholar 

  • Woodruff, J. F., and Woodruff, J. J., 1974, Involvement of T lymphocytes in the pathogeneisis of coxsackie virus B3 heart disease, J. Immunol. 113:1726–1730.

    PubMed  CAS  Google Scholar 

  • Xie, Q.W., Whisnant, R., and Nathan, C., 1993, Promoterof themousegeneencodingcalcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide, J.Exp. Med. 177:1779–1784.

    Article  PubMed  CAS  Google Scholar 

  • Xie, Q. W, Kashiwabara, Y., and Nathan, C., 1994, Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase, J. Biol. Chem. 269:4705–4708.

    PubMed  CAS  Google Scholar 

  • Zaragoza, C., Ocampo, C. J., Saura, M., McMillan, A., and Lowenstein, C. J., 1997, Nitric oxide inhibition of coxsackievirus replication in vitro, J.Clin. Invest. 100:1760–1767.

    Article  PubMed  CAS  Google Scholar 

  • Zaragoza, C., Ocampo, C., Saura, M., Leppo, M., Wei, X. Q., Quick, R., Moncada, S., Liew, F. Y, and Lowenstein, C. J., 1998, The role of inducible nitric oxide synthase in the host response to coxsackie myocarditis, Proc. Natl. Acad. Sci. USA 95:2469–2474.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205

    Charles J. Lowenstein, Marta Saura & Carlos Zaragoza

Authors
  1. Charles J. Lowenstein
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Marta Saura
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Carlos Zaragoza
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Colorado Health Sciences Center, Denver, Colorado

    Ferric C. Fang

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Kluwer Academic Publishers

About this chapter

Cite this chapter

Lowenstein, C.J., Saura, M., Zaragoza, C. (2002). Nitric Oxide in Viral Myocarditis. In: Fang, F.C. (eds) Nitric Oxide and Infection. Springer, Boston, MA. https://doi.org/10.1007/0-306-46816-6_18

Download citation

  • DOI: https://doi.org/10.1007/0-306-46816-6_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46147-7

  • Online ISBN: 978-0-306-46816-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation