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Nitric Oxide in Leishmaniasis

From Antimicrobial Activity to Immunoregulation

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Nitric Oxide and Infection

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References

  • Aebischer, T., Moody, S. F., and Handman, E., 1993, Persistence of virulent Leishmania major in murine cutaneous leishmaniasis: A possible hazard for the host. Infect. Immun. 61:220–226.

    PubMed  CAS  Google Scholar 

  • Albina, J. E., 1995, On the expression of nitric oxide synthase by human macrophages. Why no NO? J. Leukoc. Biol. 58:643–649.

    PubMed  CAS  Google Scholar 

  • Albina, J. E., Abate, J. A., and Henry, W. L., Jr., 1991, Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogen-stimulated T cell proliferation. Role ofIFNγ in the induction of the nitric oxide-synthesizing pathway, J. Immunol. 147:144–148.

    PubMed  CAS  Google Scholar 

  • Assreuy, J., Cunha, F. Q., Epperlein, M., Noronha-Dutra, A., O’Donnell, C. A., Liew, F. Y., and Moncada, S., 1994, Production of nitric oxide and superoxide by activated macrophages and killing of Leishmania major, Eur. J. Immunol. 24:672–676.

    PubMed  CAS  Google Scholar 

  • Augusto, O., Linares, E., and Giorgio, S., 1996, Possible roles of nitric oxide and peroxynitrite in murine leishmaniasis, Braz. J. Med. Biol. Res. 29:853–862.

    PubMed  CAS  Google Scholar 

  • Blank, C., Bogdan, C., Bauer, C., Erb, K., and Moll, H., 1996, Murine epidermal Langerhans cells do not express inducible nitric oxide synthase, Eur. J. Immunol. 26:792–796.

    PubMed  CAS  Google Scholar 

  • Bogdan, C., 1997, Of microbes, macrophages and NO, Behring Inst. Res. Commun. 99:58–72.

    CAS  Google Scholar 

  • Bogdan, C., Moll, H., Solbach, W., and Röllinghoff, M., 1990, Tumor necrosis factor-α in combination with interferon-γ but not with interleukin 4 activates murine macrophages for elimination of Leishmania major amastigotes, Eur. J. Immunol. 20:1131–1135.

    PubMed  CAS  Google Scholar 

  • Bogdan, C., Stenger, S., Röllinghoff, M., and Solbach, W., 1991, Cytokine interactions in experimental cutaneous leishmaniasis. Interleukin 4 synergizes with interon-γ to activate murine macrophages for killing of Leishmania major amastigotes, Eur. J. Immunol. 21:327–333.

    PubMed  CAS  Google Scholar 

  • Bogdan, C., Gessner, A., and Röllinghoff, M., 1993, Cytokines in leishmaniasis: A complex network of stimulatory and inhibitory interactions, Immunobiology 189:356–396.

    PubMed  CAS  Google Scholar 

  • Bogdan, C., Gessner, A., Solbach, W., and Röllinghoff, M., 1996, Invasion, control, and persistence of Leishmania parasites, Curr. Opin. Immunol. 8:517–525.

    Article  PubMed  CAS  Google Scholar 

  • Bogdan, C., Donhauser. N., Lorenz, E., Stenger, S., Röllinghoff, M., and Diefenbach, A., 1999b, Fibroblasts as safe targets for Leishmania in vivo, submitted for publication.

    Google Scholar 

  • Bourguignon, S. C., Alves, C. R., and Giovanni-de-Simone, S., 1997, Detrimental effect of nitric oxide on Trypanosoma cruzi and Leishmania major like cells, Acta Trop. 66:109–118.

    PubMed  CAS  Google Scholar 

  • DeGroote, M. A., Ochsner, U. A., Shiloh, M. U., Nathan, C., McCord, J. M., Dinauer, M. C., Libby, S. J., Vazquez-Torres, A., and Fang, F. C., 1997, Periplasmic superoxide dismutase protects Salmonella from products of phagocyte NADPH-oxidase and nitric oxide synthase, Proc. Natl Acad. Sci USA 94:13997–14001

    CAS  Google Scholar 

  • Diefenbach, A., Schindler, H., Donhauser, N., Lorenz, E., Laskay, T., MacMicking, J., Röllinghoff, M., Gresser, I., and Bogdan, C., 1998, Type 1 interferon IFN-α/β and type 2 nitric oxide synthase regulate the innate immune response to a protozoan parasite, Immunity 8:77–87.

    Article  PubMed  CAS  Google Scholar 

  • Diefenbach, A., Döring, R., Röllinghoff, M., and Bogdan, C., 1999a, An in vitro model for the nitric oxide-dependent control of Leishmania major in the chronically infected host, submitted for publication.

    Google Scholar 

  • Diefenbach, A., Schindler, H., Röllinghoff, M., Yokoyama, W. M., and Bogdan, C., 1999b, Requirement for type 2 NO synthase for IL-12 responsiveness in innate immunity, Science (in press)

    Google Scholar 

  • Ding, A. H., Nathan, C. F., and Stuehr, D. J., 1988, Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production, J. Immunol. 141:2407–2412.

    PubMed  CAS  Google Scholar 

  • Endres, R., Luz, A., Schulze, H., Neubauer, H., Fûutterer, A., Holland S. M., Wagner, H., and Pfeffer, K., 1997, Listeriosis in p47phox-/- and TRp55-/- mice: Protection despite absence of ROI and susceptibility despite presence of RNI, Immunity 7:419–432.

    Article  PubMed  CAS  Google Scholar 

  • Evans, T. G., Thai, L., Granger, D. L., and Hibbs, J. B., Jr., 1993, Effect of in vivo inhibition of nitric oxide production in murine leishmaniasis, J. Immunol. 151:907–915.

    PubMed  CAS  Google Scholar 

  • Evans, T. G., Reed, S. S., and Hibbs, J. B., 1996, Nitric oxide production in murine leishmaniasis: Correlation of progressive infection with increasing systemic synthesis of nitric oxide, Am. J. Trop. Med. Hyg. 54:486–489.

    PubMed  CAS  Google Scholar 

  • Flynn, J. L., Scanga, C. A., Tanaka, K. E., and Chan, J., 1998, Effects of aminoguanidine on latent murine tuberculosis, J. Immunol. 160:1796–1803.

    PubMed  CAS  Google Scholar 

  • Giorgio, S., Linares, E., Capurro, M. d. L., de Bianchi, A. G., and Augusto, O., 1996, Formation of nitrosyl hemoglobin and nitrotyrosine during murine leishmaniasis, Photochem. Photobiol. 63:750–754.

    PubMed  CAS  Google Scholar 

  • Green, S. J., Crawford, R. M., Hockmeyer, J. T., Meltzer, M. S., and Nacy, C. A., 1990a, Leishmania major amastigotes initiate the L-arginine-dependent killing mechanism in IFN-γ stimulated macrophages by induction of tumor necrosis factor-α J. Immunol. 145:4290–4297.

    PubMed  CAS  Google Scholar 

  • Green, S. J., Meltzer, M. S., Hibbs, J. B., Jr., and Nacy, C. A., 1990b, Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism, J. Immunol. 144:278–283

    PubMed  CAS  Google Scholar 

  • Haidaris, C. G., and Bonventre, P. F., 1982, A role for oxygen-dependent mechanisms in killing of Leishmania donovani tissue forms by activated macrophages, J. Immunol. 129:850–855.

    PubMed  CAS  Google Scholar 

  • Hall, L. R., and Titus, R. G., 1995, Sand fly vector saliva selectively modulates macrophage functions that inhibit killing of Leishmania major and nitric oxide production. J. Immunol. 155:3501–3506.

    PubMed  CAS  Google Scholar 

  • Huang, F.-P., Niedbala, W., Wei, X.-O., Xu, D., Feng, G.-J., Robinson, J. H., Lam, C., and Liew, F. Y., 1998a, Nitric oxide regulates Thl cell development through inhibition of IL-12 synthesis by macrophages Eur. J. Immunol. 28:4062–4070.

    Article  PubMed  CAS  Google Scholar 

  • Huang, F.-P, Xu, D., Esfandiari, E.-O., Sands, W., Wei, X.-Q., and Liew, F. Y., 1998b, Mice defective in Fas are highly susceptible to Leishmania major infection despite elevated IL-12 synthesis, strong Th1 responses, and enhanced nitric oxide production, J. Immunol. 160:4143–4147.

    PubMed  CAS  Google Scholar 

  • Kuschel, F., 1902, Ãœber die Wirkung des Einlegens von Fleisch in verschiedene Salze, Arch Hyg. 43:134–150.

    Google Scholar 

  • Lander, H. M., Sehajpal, P. K., and Novogrodsky, A., 1993, Nitric oxide signaling: A possible role for G proteins, J. Immunol. 151:7182–7187.

    PubMed  CAS  Google Scholar 

  • Lehn, M., Weiser, W. Y., Engelhorn, S., Gillis, S., and Remold H. G., 1989, IL-4 inhibits H2O2 production and antileishmanial capacity of human cultured monocytes mediated by IFN-γ J. Immunol. 143:3020–3024.

    PubMed  CAS  Google Scholar 

  • Lemesre, J.-L., Sereno, D., Daulouède, S., Veyret, B., Brajon, N., and Vincendeau, P., 1997, Leishmania spp.: Nitric oxide-mediated inhibition of promastigote and axemcally grown amastigote forms, Exp. Parasitol. 86:58–68.

    Article  PubMed  CAS  Google Scholar 

  • Li, Y., Severn, A., Rogers, M. V, Palmer, R. M. J., Moncada, S., and Liew, F. Y., 1992, Calalase inhibits nitric oxide synthesis and the killing of intracellular Leishmania major in murine macrophages, Eur. J. Immunol. 22:441–446.

    PubMed  CAS  Google Scholar 

  • Liew, F. Y, Li, Y., and Millott, S., I990a, Tumor necrosisfactor-α synergizes with IFN-γ in mediating killing of Leishmania major through the induction of nitric oxide, J Immunol. 145:4306–4310.

    Google Scholar 

  • Liew, F. Y, Millott, S., Parkinson, C., Palmer, R., M. J., and Moncada, S., 1990b, Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine, J. Immunol. 144:4794–4797.

    PubMed  CAS  Google Scholar 

  • Liew, F. Y., Li, Y., Severn, A., Millott, S., Schmidt, J., Sailer, M., and Moncada, S., 1991, A possible-novel pathway of regulation by murine T helper typc-2 (Th2) cells of a Thl cell activity via the modulation of the induction of nitric oxide synthase in macrophages, Eur. J. Immunol. 21:2489–2494.

    PubMed  CAS  Google Scholar 

  • Lopez-Jaramillo, P., Ruano, C., Rivera, J., Teran, E., Salazar-Irigoycn, R., Esplugues, J. V., and Moncada, S., 1998, Treatment of cutaneous leishmaniosis with nitric-oxide donor, Lancet 351:1176–1177.

    PubMed  CAS  Google Scholar 

  • MacMicking, J., Xie, Q.-W., and Nathan, C., 1997a, Nitric oxide and macrophage function, Annu Rev. Immunol. 15:323–350.

    Article  PubMed  CAS  Google Scholar 

  • MacMicking, J. D., North, R. J., LaCourse, R., Mudgett, J. S., Shah, S. K., and Nathan, C. F., I997b, Identification of nitric oxide synthase as a protective locus against tuberculosis, Proc. Natl. Acad. Sci. USA 94:5243–5248.

    Google Scholar 

  • Magrinat, G., Mason, S. N., Shami, P. J., and Weinberg, J. B., 1992, Nitric oxide modulation of human leukemia cell differentiation and gene expression, Blood 80:1880–1884.

    PubMed  CAS  Google Scholar 

  • Marcmkiewicz, J., Grabowska, A., and Chain, B., 1995, Nitric oxide up-regulatcs the release of inflammatory mediators by mouse macrophages, Eur. J. Immunol. 25:947–951.

    Google Scholar 

  • Mauel, J., and BuchmuTler-Rouiller, Y., 1987, Effect of lipopolysaccharide on intracellular killing of Leishmania enriettii and correlation with macrophage oxidative metabolism, Eur.J. Immunol. 17:203–208.

    PubMed  CAS  Google Scholar 

  • MauÄ›l, J., Ransijn, A., and BuchmuTler-Rouiller, Y., 1991, Killing of Leishmania parasites in activated murine macrophages is based on an L-argmine-dependent process that produces nitrogen derivatives, J. Leukoc. Biol. 49:73–82.

    PubMed  Google Scholar 

  • Mirkovich, A. M., Galelli, A., Allison, A. C., and Modabbcr, F. Z., 1986, Increased myelopoiesis during Leishmania major infection in mice: Generation of "safe targets#, a possible way to evade the effector immune mechanism, Clin. Exp. Immunol. 64:1–7.

    PubMed  CAS  Google Scholar 

  • Murray, H. W., 1981a, Interaction of Leishmania with a macrophage cell-line. Correlation between intracellular killing and the generation of oxygen intermediates, J. Exp. Med. 153:1690–1695.

    PubMed  CAS  Google Scholar 

  • Murray, H. W., 1981b, Susceptibility of Leishmania to oxygen intermediates and killing by normal macrophages, J. Exp. Med. 153:1302–1315.

    PubMed  CAS  Google Scholar 

  • Murray, H. W., 1982, Cell-mediated immune response in experimental visceral leishmaniosis. II. Oxygen-dependent killing of intracellular Leishmania donovani amastigotes, J. Immunol. 129:351–357.

    PubMed  CAS  Google Scholar 

  • Murray, H. W., 1990, Gamma interferon, cytokine-induced macrophage activation, and antimicrobial host defense in vitro, in animal models, and in humans, Diagn Microbiol. Infect. Dis. 13:411–421.

    PubMed  CAS  Google Scholar 

  • Murray, H. W., 1994, Blood monocytes: Differing effector role in experimental visceral versus cutaneous leishmaniasis, Parasitol. Today 10:220–223.

    Article  PubMed  CAS  Google Scholar 

  • Nashleanas, M., Kanaly, S., and Scott, P., 1998, Control of Leishmania major infection in mice lacking TNF receptors, J. Immunol. 160:5506–5513.

    PubMed  CAS  Google Scholar 

  • Nelson, B. J., Ralph, P., Green, S. J., and Nacy, C. A., 1991, Differential susceptibility of activated macrophage cytotoxic reactions to the suppressivc effects of transforming growth factor-β1 J. Immunol. 146:1849–1857.

    PubMed  CAS  Google Scholar 

  • Pacelli, R., Wink, D. A., Cook, J. A., Krishna, M. C. W. D., Friedman, N., Tsokos, M., Samuni, A., and Mitchell, J. B., 1995, Nitric oxide potentiates hydrogen peroxide-induced killing of Escherichia coli, J. Exp. Med. 182:1469–1479.

    Article  PubMed  CAS  Google Scholar 

  • Passwell, J. H., Shor, R., and Shoham, J., 1986, The enhancing effect of interferon-β and-γ on the killing of Leishmania tropica major in human mononuclear phagocytes in vitro, J. Immunol. 136:3062–3066.

    PubMed  CAS  Google Scholar 

  • Pearson, R. D., and de Queiroz Sousa, A., 1996, Clinical spectrum of leishmaniasis, Clin. Infect. Dis. 22:1–13.

    PubMed  CAS  Google Scholar 

  • Pearson, R. D., Harcus, J. L., Roberts, D., and Donowitz, G. R., 1983, Differential survival of I.eishmania donovani amastigotes in human monocytes, J. Immunol. 131:1994–1999.

    PubMed  CAS  Google Scholar 

  • Peng, H.-P, Rajavashisth, T. B., Libby, P., and Liao, J. K., 1995, Nitric oxide inhibits macrophagecolony stimulating factor gene transcription in vascular endothelial cells, J. Biol. Chem. 270:17050–17055.

    PubMed  CAS  Google Scholar 

  • Proudfoot, L., O’Donnell, C. A., and Liew, F. Y., 1995, Glycoinositolphospholipids of Leishmania major inhibit nitric oxide synthesis and reduce leishmanicidal activity in murine macrophages, Eur. J. Immunol. 25:745–750.

    PubMed  CAS  Google Scholar 

  • Proudfoot, L., Nikolaev, A. V, Feng, G.-J., Wei, X.-Q., Ferguson, M. A. J., Brimacombe, J. S., and Liew, F. Y., 1996, Regulation of the expression of nitric oxide synthase and leishmanicidal activity by glycoconjugates of Leishmania lipophosphoglycan in murine macrophages, Proc. Natl. Acad. Sci. USA 93:10984–10989.

    Article  PubMed  CAS  Google Scholar 

  • Reiner, S. L., and Locksley, R. M., 1995, The regulation of immunity to Leishmania major, Annu. Rev. Immunol. 13:151–177

    Article  PubMed  CAS  Google Scholar 

  • Remick, D. G., and Villarete, L., 1996, Regulation of cytokine gene expression by reactive oxygen and reactive nitrogen intermediates, J. Leukoc. Biol. 59:471–475.

    PubMed  CAS  Google Scholar 

  • Roach, T. I. A., Kiderlen, A. F, and Blackwell, J. M., 1991. Role of inorganic nitrogen oxides and tumor necrosis factor alpha in killing Leishmania donovani amastigotes in gamma interfer-on/lipopolysaccharide-activated macrophages from Lshs and Lshr congenic mouse strains, Infect. Immun. 59:3935–3944.

    PubMed  CAS  Google Scholar 

  • Schindler, H., Diefenbach, A., R00F6;llinghoff, M., and Bogdan, C., 1998, IFN-γ inhibits the production of latent transforming growth factor-β1 by mouse inflammatory macrophages, Eur. J. Immunol. 28:1181–1188.

    Article  PubMed  CAS  Google Scholar 

  • Schmidt, H. H. H. W., and Walter, U, 1994, NO at work. Cell 78:919–925.

    Article  PubMed  CAS  Google Scholar 

  • Scott, P., James, S., and Sher, A., 1985, The respiratory burst is not required for killing of intracellular and extracellular parasites by a lymphokine-activated macrophage cell-line, Eur. J. Immunol. 15:553–558.

    PubMed  CAS  Google Scholar 

  • Soong, L., Xu, J.-C., Grewal, I. S., Kima, P., Sun, I, Longley, B. J., Ruddle, N. H., McMahon-Pratt, D., and Flavell, R. A., 1996, Disruption of CD40-CD40-ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection, Immunity 4:263–273.

    Article  PubMed  CAS  Google Scholar 

  • Stenger, S., Th016D;ring, H., R00F6;llinghoff, M., and Bogdan, C., 1994, Tissue expression of inducible nitric oxide synthase is closely associated with resistance to Leishmania major, J. Exp. Med. 180:783–793

    Article  PubMed  CAS  Google Scholar 

  • Stenger, S., Th016D;ring, H., R00F6;llinghoff, M., Manning, P., and Bogdan, C., 1995, l-NG-(1-iminoethyl)-lysine potently inhibits inducible nitric oxide synthase and is superior to in vitro and in vivo, Eur. J. Pharmacol. 294:703–712.

    Article  PubMed  CAS  Google Scholar 

  • Stenger, S., Donhauser, N., Th016D;ring, H., R00F6;llinghoff, M., and Bogdan, C., 1996, Reactivation of latent leishmaniasis by inhibition of inducible nitric oxide synthase, J. Exp. Med. 183:1501–1514.

    Article  PubMed  CAS  Google Scholar 

  • Stout, R. D., Suttles, J., Xu, J., Grewal, I., and Flavell, R. A., 1996, Impaired T cell-mediated macrophage activation in CD40 ligand-deficient mice, J. Immunol. 156:8–11.

    PubMed  CAS  Google Scholar 

  • Sypek, J. P., and Wyler, D. J., 1991, Antileishmanial defense in macrophages triggered by tumor necrosis factor expressed on CD4 T lymphocyte plasma membrane, J. Exp. Med. 174:755–759.

    Article  PubMed  CAS  Google Scholar 

  • Tanner, F. W., and Evans, F. L., 1934, Effect of meat curing solutions on anaerobic bacteria. III. Sodium nitrite, Zbl. Bakteriol. II 91:1–14.

    Google Scholar 

  • Tarr, H. L. A., 1941, Bacteriostatic action of nitrates. Nature 147:417–418.

    CAS  Google Scholar 

  • Taylor, A. P., and Murray, H. W., 1997, Intracellular antimicrobial activity in the absence of interferon-γ Effect of interleukin-12 in experimental visceral leishmaniasis in interferon-γ gene-disrupted mice, J. Exp. Med. 185:1231–1239.

    Article  PubMed  CAS  Google Scholar 

  • Th016D;ring, H., Stenger, S., Gmehling, D., R00F6;llinghoff, M., and Bogdan, C., 1995, Lack of inducible nitric oxide synthase in T cell clones and T lymphocytes from naive and Leishmania major-infected mice, Eur. J. Immunol. 25:3229–3234.

    PubMed  Google Scholar 

  • Tian, L., Noelle, R. J., and Lawrence, D. A., 1995, Activated T cells enhance nitric oxide production by murine splenic macrophages through gp39 and LFA-1, Eur. J. Immunol. 25:306–309.

    PubMed  CAS  Google Scholar 

  • Titus, R. G., Theodos, C. M., Shankar, A., and Hall, L. R., 1993, Interactions between Leishmania major and macrophages, in: Macrophage Pathogen Interactions (B. Zwilling and T. Eisenstein, eds.), Dekker, New York, pp. 437–459.

    Google Scholar 

  • Vieira, L. Q., Goldschmidt, M., Nashleanas, M., Pfeffer, K., Mak, T, and Scott, P., 1996, Mice lacking the TNF receptor p55 fail to resolve lesions caused by infection with Leishmania major, but control parasite replication, J. Immunol. 157:827–835.

    PubMed  CAS  Google Scholar 

  • Vieth, M., Will, A., Schr00F6;ppel, K., R00F6;llinghoff, M., and Gessner, A., 1994, Interleukin 10 inhibits antimicrobial activity against Leishmania major in murine macrophages, Scand. J. Immunol. 40:403–409.

    PubMed  CAS  Google Scholar 

  • Vouldoukis, I., Riveros-Moreno, V, Dugas, B., Quaaz, F., Bécherel, P., Debré, P., Moncada, S., and Mossalayi, M. D., 1995, The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the FccRII/CD23 surface antigen, Proc. Natl. Acad. Sci. USA 92:7804–7808.

    PubMed  CAS  Google Scholar 

  • Vouldoukis, I., Bécherel, P.-A., Riveros-Moreno, V., Arock, M., da Silva, O., Debré, P., Mazier, D., and Mossalayi, M. D., 1997, Interleukin-10 and interleukin-4 inhibit intracellular killing of Leishmania infantum and Leishmania major by human macrophages by decreasing nitric oxide generation, Eur. J. Immunol. 27:860–865.

    PubMed  CAS  Google Scholar 

  • Waitumbi, J., and Warburg, A., 1998, Phlebotomus papatasi saliva inhibits protein phosphatase activity and nitric oxide production by murine macrophages, Infect. Immun. 66:1534–1537.

    PubMed  CAS  Google Scholar 

  • Wei, X.-Q., Charles, I. G., Smith, A., Ure, J., Feng, G.-J., Huang, F.-P, Xu, D., Müller, W., Moncada, S., and Liew, F. Y, 1995, Altered immune responses in mice lacking inducible nitric oxide synthase, Nature 375:408–411.

    Article  PubMed  CAS  Google Scholar 

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  1. Institute of Clinical Microbiology, Immunology, and Hygiene, Friedrich-Alexander-University of Erlangen-Nuremberg, D-91054, Erlangen, Germany

    Christian Bogdan, Martin Röllinghoff & Andreas Diefenbach

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  1. Christian Bogdan
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  1. University of Colorado Health Sciences Center, Denver, Colorado

    Ferric C. Fang

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Bogdan, C., Röllinghoff, M., Diefenbach, A. (2002). Nitric Oxide in Leishmaniasis. In: Fang, F.C. (eds) Nitric Oxide and Infection. Springer, Boston, MA. https://doi.org/10.1007/0-306-46816-6_17

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