Skip to main content
SpringerLink
Log in

Immunomodulatory Actions of Nitric Oxide

  • Chapter
Nitric Oxide and Infection

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Albina, J. E., Cui, S., Mateo, R. B., and Reichner, J. S., 1993, Nitric oxide mediated apoptosis in murine peritoneal macrophages, J. Immunol. 150:5080–5085.

    PubMed  CAS  Google Scholar 

  • Amin, A. R., Di Cesare, P. E., Vyas, P., Attur, M., Tzeng, E., Billiar, T. R., Stuchin, S. A., and Abramson, S. B., 1995, The expression and regulation of nitric oxide synthase in human osteoarthritis affected chondrocytes: Evidence for up-regulated neuronal NOS activity, J. Exp. Med. 182:2097–2102.

    Article  PubMed  CAS  Google Scholar 

  • Barnes, P. J., and Liew, F. Y., 1995, Nitric oxide and asthmatic inflammation, Immunol. Today 16:128–130.

    Article  PubMed  CAS  Google Scholar 

  • Beckerman, K. P., Rogers, J. A., Corbett, R. D., Schreiber, M. L., and Unanue, E. R., 1993, Release of nitric oxide during the T cell independent pathway of macrophage activation. Its role in resistance to Listeria monocytogenes, J. Immunol. 150:888–895.

    PubMed  CAS  Google Scholar 

  • Bredt, D. S., and Snyder, S. H., 1994, Nitric oxide: A physiological messenger molecule, Annu. Rev. Biochem. 63:175–95.

    Article  PubMed  CAS  Google Scholar 

  • Broughton-Evans, N. K., Evans, S. M., Hawkey, C. J., Cole, A. T., Balsitis, M., Whittle, B. J. R., and Moncada, S., 1993, Nitric oxide synthase activity in ulcerative colitis and Crohn’s disease, Lancet 42:338–340.

    Google Scholar 

  • Burkrinsky, M. I., Nottet, H. S. L. M., Schmidtmayerova, N., Dubrovsky, L., Mullins, M. E., Lipton, S. A., and Gendelman, H. E., 1995, Regulation of nitric oxide activity in HIV-infected monocytes: Implications for HIV associated neurological disease, J. Exp. Med. 181:735–745.

    Google Scholar 

  • Chang, R.-H., Lin Feng, M.-H., Liu, W.-H., and Lai, M.-Z., 1997, Nitric oxide increases interleukin-4 expression in T lymphocytes, Immunology 90:364–369.

    Article  PubMed  CAS  Google Scholar 

  • Charles, I. G., Palmer, R. J., Hickery, M. S., Bayliss, M. T, Chubb, A. P., Hall, V. S., Moss, D. W., and Moncada, S., 1993, Cloning, characterization and expression of a cDNA encoding an inducible nitric oxide synthase from human chondrocytes, Proc. Natl. Acad. Sci. USA 90:11419–11423.

    PubMed  CAS  Google Scholar 

  • Cho, H. J., Xie, Q. W., Calalcay, J., Mumford, R. A., Lee, T. D., and Nathan, C., 1992, Calmodulin is a subunit of nitric oxide synthase from macrophages, J. Exp. Med. 176:599–604.

    Article  PubMed  CAS  Google Scholar 

  • Corbett, J. A., Mikhael, A., Shimizu, J., Frederick, K., Misko, T. P., McDaniel, M. L., Kanagawa, O., and Unanue, E. R., 1993, Nitric oxide production in islets from nonobese diabetic mice. Aminoguanidine-sensitive and-resistant stages in the immunological diabetic process, Proc. Natl. Acad. Sci. USA 90:8992–8995.

    PubMed  CAS  Google Scholar 

  • Deakin, A. M., Payne, A. N., Whittle, B. J. R., and Moncada, S., 1995, The modulation of IL-6 and TNFβ release by nitric oxide following stimulation of J774 cells with LPS and IFNγ. Cytokine 7:408–416.

    Article  PubMed  CAS  Google Scholar 

  • De Kimpe, S. J., Kengatharan, M., Thiermann, C., and Vane, J. R., 1995, The cell wall components peptidoglycan and lipoteichoic acid from Staphylococcus aureus act in synergy to cause shock and multiple organ failure, Proc. Natl. Acad. Sci. USA 92:10359–10363.

    PubMed  Google Scholar 

  • Denis, M., 1991, Tumour necrosis factor and granulocyte colony stimulating factor stimulate human macrophages to restrict growth of virulent Mycobacterium avium and to kill avirulent M. avium Killing effector mechanism depends on generation of reactive nitrogen intermediates, J. Leukoc. Biol. 49:380–387.

    PubMed  CAS  Google Scholar 

  • Di Rosa, M., Radomski, M., Carnuccio, R., and Moncada, S., 1990, Glucocorticoids inhibit the induction of nitric oxide synthesis in macrophages, Biochem. Biophys. Res. Commun. 172:1246–1252.

    PubMed  Google Scholar 

  • Dugas, B., Djavad Mossalayi, M., Damais, C., and Kolb, J. P., 1995, Nitric oxide production by human monocytes: Evidence for a role of CD23, Immunol. Today 16:574–580.

    Article  PubMed  CAS  Google Scholar 

  • Duhe, R. J., Evans, G. A., Erwin, R. A., Kirken, R. A., Cox, G. W., and Farrar, W. L., 1998, Nitric oxide and thiol redox regulation of Janus kinase activity, Proc. Natl. Acad. Sci. USA 95:126–131.

    Article  PubMed  CAS  Google Scholar 

  • Fenyk-Melody, J. E., Garrison, A. E., Brunnert, S. R., Weidner, J. R., Shen, F., Shelton, B. A., and Mudgett, J. S., 1998, Experimental autoimmune encephalomyelitis is exacerbated in mice lacking the NOS2 gene, J. Immunol. 160:2940–2946.

    PubMed  CAS  Google Scholar 

  • Florquin, S., and Goldman, M., 1996, Immunoregulatory mechanisms of T cell dependent shock induced by a bacterial superantigen in mice, Infect. Immun. 64:3443–3445.

    PubMed  CAS  Google Scholar 

  • Garside, P., Hutton, A., Severn, A., Liew, F. Y., and Mowat, A. M., 1992, Nitric oxide mediates intestinal pathology in graft versus host disease, Eur. J. Immunol. 22:2141–2145.

    PubMed  CAS  Google Scholar 

  • Geller, D. A., Nussler, A. K., Di Silvio, M., Lowenstein, C. J., Shapiro, R. A., Wang, S. C., Simmons, R. I., and Billiar, T. R., 1993, Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes, Proc. Natl. Acad. Sci. USA 90:522–526.

    PubMed  CAS  Google Scholar 

  • Gilbert, R. S., and Herschman, H. R., 1993, TGF beta differentially modulates the iNOS gene in distinct cell types. Biochem. Biophys. Res. Commun. 195:380–384

    Article  PubMed  CAS  Google Scholar 

  • Habib, A., Bernard, C., Lebret, M., Creminon, C., Esposito, B., Tedgui, A., and Maclouf, J., 1997, Regulation of the expression of cyclooxygenase-2 by nitric oxide in rat peritoneal macrophages, J. Immunol. 158:3845–3851.

    PubMed  CAS  Google Scholar 

  • Hogaboam, C. M., Chensue, S. W., Steinhauser, M. L., Huffnagle, G. B., Lukacs, N. W., Strieter, R. M., and Kunkel, S. L., 1997, Alteration of the cytokine phenotype in an experimental lung granuloma model by inhibiting nitric oxide, J. Immunol. 159:5585–5593.

    PubMed  CAS  Google Scholar 

  • Huang, F.-P., Feng, G.-J., Lindop, G., Stott, D., and Liew, F. Y., 1996, The role of IL-12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice, J. Exp. Med. 183:1447–1459.

    PubMed  CAS  Google Scholar 

  • Huang, P. L., Huang, Z., Mashimo, H., Bloch, K. D., Moskowitz, M. A., Bevan, J. A., and Fishman, M. C., 1995, Hypertension in mice lacking the gene for endothelial nitric oxide synthase, Nature 377:239–242.

    Article  PubMed  CAS  Google Scholar 

  • Ialenti, A., Moncada, S., and Di Rosa, M., 1993, Modulation of adjuvant arthritis by endogenous nitric oxide, Br. J. Pharmacol. 110:701–706.

    PubMed  CAS  Google Scholar 

  • Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., and Chaudhuri, G., 1987, Endothelium derived relaxation factor produced and released from arteries and veins in nitric oxide, Proc. Natl. Acad. Sci. USA 84:9265–9269

    PubMed  CAS  Google Scholar 

  • Isobe, K., and Nakashima, J., 1992, Feedback suppression of staphylococcal enterotoxin-stimulated T-lymphocyte proliferation by macrophages through inductive nitric oxide synthesis, Infect. Immun. 60:4832–4837.

    PubMed  CAS  Google Scholar 

  • Kaplan, S. S., Lancaster, J. R., Basford, R. E., and Simmons, R. L., 1996, Effect of nitric oxide on staphylococcal killing and interactive effect with superoxide, Infect. Immun. 64:69–76.

    PubMed  CAS  Google Scholar 

  • Kleinert, H., Euchenhofer, C., Ihrigbiedert, I., and Forstermann, U., 1996, Glucocorticoids inhibit the induction of iNOS by downregulating cytokine induced activity of transcription factor nuclear factor-κB, Mol. Pharmacol. 49:15–21

    PubMed  CAS  Google Scholar 

  • Kolb, H., and Kolb-Bachofen, V., 1992, Nitric oxide: A pathogenetic factor in autoimmunity, Immunol Today 13:157–160.

    Article  PubMed  CAS  Google Scholar 

  • Kubes, P., Kanwar, S., Niu, X., and Gaboury, J. P., 1993, Nitric oxide synthesis inhibition induces leukocyte adhesion via superoxide and mast cells, FASEB J. 7:1293–1299.

    PubMed  CAS  Google Scholar 

  • Kunz, D., Walker, G., Eberhardt, W., and Pfeilschifter, J., 1996, Molecular mechanisms of dexamethasone inhibition of nitric oxide synthase expression in IL-1 stimulated mesangial cells: Evidence for the involvement of transcriptional and posttranscriptional regulation, Proc. Natl. Acad. Sci. USA 93:255–259.

    Article  PubMed  CAS  Google Scholar 

  • Lander, H. M., Sehajpal, P., Levine, D. M., and Novogrodsky, A., 1993, Activation of human peripheral blood cells by nitric oxide generating compounds, J. Immunol. 150:1509–1516.

    PubMed  CAS  Google Scholar 

  • Lefer, D. J., Scalia, R., Campbell, B., Nossuli, T., Hayward, R., Salamon, M., Grayson, J., and Lefer, A. M., 1997, Peroxynitrite inhibits leukocyte endothelial cell interactions and protects against ischaemia perfusion injury in rats, J. Clin. Invest. 99:684–691.

    Article  PubMed  CAS  Google Scholar 

  • Liew, F. Y., 1994, Regulation of nitric oxide synthesis in infectious and autoimmune diseases, Immunol. Lett. 43:95–98.

    Article  PubMed  CAS  Google Scholar 

  • Liew, F. Y., and Cox, F. E. G., 1991, Non specific defence mechanism: The role of nitric oxide, Immunol. Today 12:A17–A21.

    Article  PubMed  CAS  Google Scholar 

  • Liew, F. Y, Millot, S., Parkinson, C., Palmer, R. M. J., and Moncada, S., 1990, Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from l-arginine, J. Immunol. 144:4794–4797.

    PubMed  CAS  Google Scholar 

  • Liew, F. Y., Li, Y., Severn, A., Millot, S., Schmidt, J., Salter, M., and Moncada, S., 1991, A possible novel pathway of regulation by murine T helper type-2 cells of a Thl cell activity via the modulation of the induction of nitric oxide synthase in macrophages, Eur. J. Immunol. 21:2489–2494.

    PubMed  CAS  Google Scholar 

  • Lukic, M. L., Stosic-Grujicic, S., Ostojic, N., Chan, W. L., and Liew, F. Y., 1991, Inhibition of nitric oxide generation affects the induction of diabetes by streptozocin in mice, Biochem. Biophys. Res. Commun. 178:913–920.

    Article  PubMed  CAS  Google Scholar 

  • Lyons, C. R., 1995, The role of nitric oxide in inflammation, Adv. Immunol. 60:323–360.

    PubMed  CAS  Google Scholar 

  • MacMicking, J. D., Nathan, C., Hom, G., Chartrain, N., Fletcher, D. S., Trumbauer, M., Stevens, K., Xie, Q. W., Sokol, K., Hutchinson, N., Chen, H., and Mudgett, J. S., 1995, Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase, Cell 81:641–650.

    Article  PubMed  CAS  Google Scholar 

  • Malewista, S. E., Montgomery, R. R., and Van Blaricom, G., 1996, Evidence for nitrogen intermediates in killing of staphylococci in human neutrophil cytoplasts, J. Clin. Invest. 90:631–636.

    Google Scholar 

  • Manfield, L., Jang, D., and Murrell, G. A. C., 1996, Nitric oxide enhances cyclooxygenase activity in articular cartilage, Inflamm. Res. 45:254–258.

    Article  PubMed  CAS  Google Scholar 

  • Marcinkiewicz, J., Grabowska, A., and Chain, B. M., 1996, Is there a role for nitric oxide in regulation of T cell secretion of IL-2? J. Immunol. 156:4617–4621.

    PubMed  CAS  Google Scholar 

  • McCartney-Francis, N., Alien, J. B., Mizel, D. E., Albina, J. E., Xie, Q., Nathan, C. F., and Wahl, S., 1993, Suppression of arthritis by an inhibitor of nitric oxide synthase, J. Exp. Med. 178:749–754.

    Article  PubMed  CAS  Google Scholar 

  • McInnes, I. B., Leung, B. P., Field, M., Huang, F.-P., Wei, X. Q., Sturrock, R. D., Kinninmonth, A., Mumford, R. A., and Liew, F. Y., 1996, Nitric oxide production in the synovial membranes of rheumatoid and osteoarthritis patients, J. Exp. Med. 184:1519–1524.

    Article  PubMed  CAS  Google Scholar 

  • McInnes, I. B., Leung, B. P., Wei, X. Q., Gemmell, C. G., and Liew, F. Y., 1998, Septic arthritis following Staphylococcus aureus infection in mice lacking inducible nitric oxide synthase, J. Immunol. 160:308–315.

    PubMed  CAS  Google Scholar 

  • Merryman, P. F., Clancy, R. M., He, X. Y., and Abramson, S. B., 1993, Modulation of human T cell responses by nitric oxide and its derivative S-nitrosoglutathione, Arthritis Rheum. 36:1414–1422.

    PubMed  CAS  Google Scholar 

  • Mulligan, M. S., Heirel, J. M., Marietta, M. A., and Ward, P. A., 1991, Tissue injury caused by deposition of immune complexes is L-arginine dependent, Proc. Natl. Acad. Sci. USA 88:6338–6342.

    PubMed  CAS  Google Scholar 

  • Nathan, C., and Xie, Q.-W, 1994, Regulation of biosynthesis of nitric oxide, J. Biol. Chem. 269:13725–13728.

    PubMed  CAS  Google Scholar 

  • Nelson, R. J., Demas, G. E., Huang, P. L., Fishman, M. C., Dawson, V L., Dawson, T. M., and Snyder, S. H., 1995, Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase, Nature 378:383–386.

    PubMed  CAS  Google Scholar 

  • Nukaya, I., Takagi, K., Kawabe, T., and Suketa, Y., 1995, Suppression of cytokine production by Th2 cells by nitric oxide in comparison with Thl cells, Microbiol. Immunol. 39:709–714.

    PubMed  CAS  Google Scholar 

  • Okuda, Y., Nakatsuji, Y., Fujimura, H., Esumi, H., Ogura, T., and Yanagihara, T., 1995, Expression of the inducible isoform of nitric oxide synthase in the CNS of mice correlates with severity of actively induced EAE, J. Neuroimmunol. 62:103–112.

    Article  PubMed  CAS  Google Scholar 

  • Palmer, R. M. J., Ferrige, A. G., and Moncada, S., 1987, Nitric oxide release accounts for the biologic activity of endothelium derived relaxing factor, Nature 327:524–526.

    Article  PubMed  CAS  Google Scholar 

  • Park, K. G. M., Hayes, P. D., Garlick, P. J., Sewell, H., and Eremin, O., 1991, Stimulation of lymphocyte natural cytotoxicity by L-arginine, Lancet 337:645–646.

    PubMed  CAS  Google Scholar 

  • Ruuls, S. R., Van Der Linden, S., Sontrop, K., Huitinga, I., and Dijkstra, C. D., 1996, Aggravation of experimental allergic encephalomyelitis (EAE) by administration of nitric oxide (NO) synthase inhibitors, Clin. Exp. Immunol. 103:467–474.

    PubMed  CAS  Google Scholar 

  • Schmidt, H. H. H., and Walter, U., 1994, NO at work, Cell 78:919–925.

    Article  PubMed  CAS  Google Scholar 

  • Schneemann, M., Schoedon, G., Hoefer, S., Blau, N., Guerrero, L., and Schaffner, A., 1993, Nitric oxide synthase is not a constituent of the antimicrobial armature of human mononuclear phagocytes, J. Infect. Dis. 167:1358–1363.

    PubMed  CAS  Google Scholar 

  • Stefanovic-Racic, M., Meyers, K., Meschter, C., Coffey, J. W., Hoffman, R. A., and Evans, C. H., 1994, N-Monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in rats, Arthritis Rheum. 37:1062–1069.

    PubMed  CAS  Google Scholar 

  • Stout, R., Suttles, J., Xu, J., Grewal, I. S., and Flavell, R. A., 1996, Impaired T cell mediated macrophage activation in CD40 ligand-deficient mice, J. Immunol. 156:8–11.

    PubMed  CAS  Google Scholar 

  • Sunyer, T., Rothe, L., Jiang, X., Osdoby, P., and Collin-Osdoby, P., 1996, Proinflammatory agents, IL-8 and IL-10, upregulate inducible nitric oxide synthase expression and nitric oxide production in avian osteoclast like cells, J. Cell. Biochem. 60:469–483.

    Article  PubMed  CAS  Google Scholar 

  • Tao, X., and Stout, R., 1993, T cell mediated cognate signalling of nitric oxide production by macrophages. Requirements for macrophage activation by plasma membranes isolated from T cells, Eur. J. Immunol. 23:2916–2921.

    PubMed  CAS  Google Scholar 

  • Taylor-Robinson, A. W., Liew, F. Y., Severn, A., Xu, D., McSorley, S., Garside, P., Padron, J., and Phillips, R. S., 1994, Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells, Eur. J. Immunol. 24:980–984.

    PubMed  CAS  Google Scholar 

  • Wei, X. Q., Charles, I., Smith, A., Ure, J., Feng, G. J., Huang, F. P., Xu, D., Muller, W., Moncada, S., and Liew, F. Y., 1995, Altered immune responses in mice lacking inducible nitric oxide synthase, Nature 375:408–411.

    Article  PubMed  CAS  Google Scholar 

  • Weinberg, J. B., Granger, D. L., Pisetsky, D. S., Seldin, M. J., Misukonis, M. A., Mason, S. N., Pippen, A. M., Ruiz, P., Wood, E. R., and Gilkeson, G. S., 1994, The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered Ng-monomethyl-l-arginine, J. Exp. Med. 179:651–660.

    Article  PubMed  CAS  Google Scholar 

  • Xiong, H., Kawamura, I., Nishibori, T., and Mitsuyama, M., 1996, Suppression of IFNy production from Listeria monocytogenes specific T cells by endogenously produced nitric oxide, Cell. Immunol. 172:118–125.

    Article  PubMed  CAS  Google Scholar 

  • Zembala, M., Siedlar, M., Marcinkiewicz, J., and Pryjma, J., 1994, Human macrophages are stimulated for nitric oxide release in vitro by some tumour cell lines but not by cytokines and lipopolysaccharide, Eur. J. Immunol. 24:435–439.

    PubMed  CAS  Google Scholar 

  • Zhao, W., Tilton, R. G., Corbett, J. A., McDaniel, M. L., Misko, T. P., and Williamson, J. R., 1996, Experimental allergic encephalomyelitis in the rat is inhibited by aminoguanidine, an inhibitor of nitric oxide synthase, J. Neuroimmunol. 64:123–133.

    Article  PubMed  CAS  Google Scholar 

  • Zhao, Y.-X., Abdelnour, A., Kalland, T., and Tarkowski, A., 1995, Overexpression of the T cell receptor VB3 in transgenic mice increases mortality during infection by enterotoxin A producing Staphylococcus aureus, Infect. Immun. 63:4463–4469.

    PubMed  CAS  Google Scholar 

  • Zielasek, J., Jung, S., Gold, R., Liew, F. Y., Toyka, K. V., and Hartung, H. P., 1995, Administration of nitric oxide synthase inhibitors in experimental autoimmune neuritis and experimental autoimmune encephalomyelitis, J. Neuroimmunol. 59:81–88.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Immunology and Centre for Rheumatic Diseases, University of Glasgow, Glasgow, G11 6NT, UK

    Iain B. McInnes & Foo Y. Liew

Authors
  1. Iain B. McInnes
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Foo Y. Liew
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Colorado Health Sciences Center, Denver, Colorado

    Ferric C. Fang

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Kluwer Academic Publishers

About this chapter

Cite this chapter

McInnes, I.B., Liew, F.Y. (2002). Immunomodulatory Actions of Nitric Oxide. In: Fang, F.C. (eds) Nitric Oxide and Infection. Springer, Boston, MA. https://doi.org/10.1007/0-306-46816-6_10

Download citation

  • DOI: https://doi.org/10.1007/0-306-46816-6_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46147-7

  • Online ISBN: 978-0-306-46816-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation