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MLT and the Immune-hematopoietic System

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Melatonin After Four Decades

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References

  1. Ader, R., Cohen, N., and Felten, D.: Psychoneuroimmunology: interactions between the nervous system and the immune system. Lancet 345(8942):99–103, 1995.

    Article  PubMed  CAS  Google Scholar 

  2. Ader, R., Felten, D.L., and Cohen, N.: Psychoneuroimmunology II. San Diego, Academic Press, 1991.

    Google Scholar 

  3. Angeli, A., Gatti, G., Sartori, M.L., Del Ponte, D., and Cerignola, R.: Effect of exogenous melatonin on human natural killer (NK) cell activity. An approach to the immunomodulatory role of the pineal gland, in Gupta, D., Attanasio, A., and Reiter, R.J. (eds): The Pineal Gland and Cancer. Tübingen, Müller and Bass, 1988, pp. 145–157.

    Google Scholar 

  4. Anwar, M.M., Mahfouz, H.A., and Sayed, AS.: Potential protective effects of melatonin on bone marrow of rats exposed to cytotoxic drugs. Comp.Biochem. Physiol. 119:493–591,1998.

    CAS  Google Scholar 

  5. Banks, R.E., Patel, P.M., and Selby, P.J.: Interleukin-12: a new player in cytokine therapy. Br. J. Cancer 71:655–659, 1995.

    PubMed  CAS  Google Scholar 

  6. Barath, P. and Csaba, G.: Histological changes in the lung, thymus and adrenal one and half year after pinealectomy. Acta Biol. Acad. Sci. Hung. 25:123–125, 1974.

    PubMed  CAS  Google Scholar 

  7. Becker, J., Veit, G., Handgretinger, R., Attanasio, G., Bruchett, G., Trenner, I., Niethammer, D., and Gupta, D.: Circadian variations in the immunomodulatory role of the pineal gland. Neuroendocrinology Letters 10:65–80, 1988.

    Google Scholar 

  8. Ben-Nathan, D., Maestroni, G.J., Lustig, S., and Conti, A.: Protective effects of melatonin in mice infected with encephalitis viruses. Arch. Virol. 140:223–230, 1995.

    Article  PubMed  CAS  Google Scholar 

  9. Ben-Nathan, D., Maestroni, G.J.M., and Conti, A.: Protective effect of melatonin in viral and bacterial infections, in Maestroni, G.J.M., Conti, A., and Reiter, J.R. (eds): Frontiers in Hormone Research, vol. 23. Basel, Karger, 1997, pp. 72–81.

    Google Scholar 

  10. Bernstein, Z.P., Porter, M.M., Gould, M., Lipman, B., Bluman, E.M., Stewart, C.C., Hewitt, R.G., Fyfe, G., Poiesz, B., and Caligiuri, M.A.: Prolonged administration of low-dose interleukin-2 in human immunodeficiency virus-associated malignancy results in selective expansion on innate immune effectors without significant clinical toxicity. Blood 86:3287–3294, 1995.

    PubMed  CAS  Google Scholar 

  11. Bindoni, M. and Cambria, A.: Effects of pinealectomy on the in vivo and in vitro biosynthesis of nucleic acids on the mitotic rate in some organs of the rat. Arch. Sci. Biol. 52:271–283, 1968.

    CAS  Google Scholar 

  12. Blask, D.E.: Melatonin in oncology, in Yu, H.-S. and Reiter, R.J. (eds): Melatonin. Biosynthesis, Physiological Effects, and Clinical Applications. Boca Raton, CRC Press, 1993, pp. 447–477.

    Google Scholar 

  13. Bonilla, E., Valerofuenmajor, N., Pons, H., and Chacin-Bonilla, L.: Melatonin protects mice infected with Venezuelan equine encephalomyelitis virus. Cell Mol. Life Sci. 53:430–434, 1997.

    Article  PubMed  CAS  Google Scholar 

  14. Carlberg, C. and Wiesenberg, I.: The orphan receptor family RZR/ROR, melatonin and 5-lipoxygenase: an unexpected relationship. J. Pineal Res. 18:171–178, 1995.

    PubMed  CAS  Google Scholar 

  15. Caroleo, M.C., Frasca, D., Nistico, G., and Doria, G.: Melatonin as immunomodulator in immunodeficient mice. Immunopharmacology 23:81–89, 1992.

    Article  PubMed  CAS  Google Scholar 

  16. Champney, T.H. and McMurray, D.N.: Spleen morphology and lymphoproliferative activity in short photoperiod exposed hamsters, in Fraschini, F. and Reiter, R.J. (eds): Role of melatonin and pineal peptides in neuroimmunomodulation. London, Plenum Publ Co, 1991, pp. 219–225.

    Google Scholar 

  17. Colombo, L.L., Chen, G.4, Lopez, M.C., and Watson, R.R.: Melatonin induced increase in gamma-interferon production by murine splenocytes. Immunol. Lett. 33:123–126, 1992.

    Article  PubMed  CAS  Google Scholar 

  18. Conti, A., Haran-Ghera, N., and Maestroni, G.J.M.: Role of pineal melatonin and melatonin-induced-immuno-opioids in murine leukemogenesis. Med. Oncol. Tumor Pharmacoth. 987–92, 1992.

    CAS  Google Scholar 

  19. Conti, A. and Maestroni, G.J.M.: The clinical neuroimmunotherapeutic role of melatonin in oncology. J. Pineal Res. 19:103–110, 1995.

    PubMed  CAS  Google Scholar 

  20. Csaba, G. and Barath, P.: Morphological changes of thymus and the thyroid gland after postnatal extirpation of pineal body. Endocrinol. exp. 959–67, 1975.

    PubMed  CAS  Google Scholar 

  21. Csaba, G., Bodocky, M., Fischer, J., and Acs, T.: The effect of pinealectomy and thymectomy on the immune capacity of the rat. Experientia 22:168–175,1965.

    Google Scholar 

  22. Del Gobbo, V., Libri, V., Villani, N., Caliò, R., and Nstico, G.: Pinealectomy inhibits interleukin-2 production and natural killer activity in mice. Int. J. Immunopharmacol. 11:567–577, 1989.

    PubMed  Google Scholar 

  23. Del Prete, G., Maggi, E., and Romagnani, S.: Human Th1 and Th2 cells: Functional properties, mechanisms of regulation and role in disease. Lab. Invest. 70:299–307, 1994.

    PubMed  Google Scholar 

  24. Garcia-Mauriño, S., Gonzales-Haba, M.G., Calvo, J.R., Rafii-El-Idrissi, M., Sanchez-Margalet, V., Goberna, R., and Guerrero, J.M.: Melatonin enhances IL-2,II-6, and IFN-g production by human circulating CD4+ cells. J. Immunol. 159:574–581, 1997.

    PubMed  Google Scholar 

  25. Garcia-Perganeda, A., Pozo, D., Guerrero, J.M., and Calvo, J.R.: Signal transduction for melatonin in human lymphocytes. Involvement of a pertussis toxin-sensitive G protein. J.Immunol. 159:3774–3781, 1997.

    PubMed  CAS  Google Scholar 

  26. Giordano, M. and Palermo, M.S.: Melatonin-induced enhancement of antibody dependent cellular cytotoxicity. J. Pineal Res. 10117–121, 1991.

    PubMed  CAS  Google Scholar 

  27. Guerrero, J.-M., Garcia-Maurino, S., Gil-Haba, M., Rafii-El-Idrissi, M., Pozo, D., Garcia-Perganeda, A., and Calvo, J.R.: Mechanisms of action on the human immune system: Membrane receptors versus nuclear receptors., in Maestroni, G.J.M., Conti, A., and Reiter, R.J. (eds): Therapeutic potential of the Pineal Hormone Melatonin, vol. 23, Frontiers of Hormone Research. Basel, Karger, 1996, pp. 43–52.

    Google Scholar 

  28. Haldar, C., Haussler, D., and Gupta, D.: Response of CFU-GM (colony forming units for granulocytes and macrophages) from intact and pinealectomized rat bone marrow to macrophage colony stimulating factor (rGM-CSF) and human recombinant erythropoietin (rEPO). Prog. Brain Res. 91:323–325, 1992.

    PubMed  CAS  Google Scholar 

  29. Hansson, I., Holmdahl, R., and Mattsson, R.: The pineal hormone melatonin exaggerates development of collagen-induced arthritis in mice. Journal of Neuroimmunology 39:23–31, 1992.

    Article  PubMed  CAS  Google Scholar 

  30. Hiddinga, H.J., Isaak, D.D., and Lewis, R.V.: Enkephalin-containing peptides processed from proenkephalin significantly enhance the antibody-forming cell responses to antigens. J. Immunol. 152:3748–3758, 1994.

    PubMed  CAS  Google Scholar 

  31. Hofbauer, L.C. and Heufelder, A.E.: Endocrinology meets immunology: T lymphocytes as novel targets for melatonin. Eur. J. Endocrinol. 134:424–425, 1996.

    PubMed  CAS  Google Scholar 

  32. Jankovic, B.D., Isakovic, S., and Petrovic, S.: Effect of pinealectomy on immune reactions in the rat. Immunology 8:1–6,1970.

    Google Scholar 

  33. Kinter, A.L., Bende, S.M., Hardy, E.C., Jackson, R., and Fauci, AS.: Interleukin 2 induces CD8+ T cell-mediated suppression of human immunodeficiency virus replication in CD4+ T cells and this effect overrides its ability to stimulate virus expression. Proc. Natl. Acad. Sci. USA 92:19985–10989, 1995.

    Google Scholar 

  34. Konakchieva, R., Kyurkchiev, S., Kehayov, I., Taushanova, P., and Kanchev, L.: Selective effect of methoxyndoles on the lymphocyte proliferation and melatonin binding to activated human lymphoid cells. J. Neuroimmunol. 63:125–132, 1995.

    Article  PubMed  CAS  Google Scholar 

  35. Lewinsky, A., Zelazowsky, P., Sewerynek, E., Zerek-Melen, G., and Szudlinsky, M.: Melatonin-induced immunosuppression of humal lymphocyte natural killer activity in vitro. J. Pineal Res. 7:153–164, 1989.

    Google Scholar 

  36. Lissoni, P., Ardizzoia, A., Barni, S., Brivio, F., Tisi, E., Rovelli, F., Tancini, G., and Maestroni, G.J.M.: Efficacy and tolerability of cancer neuroimmunotherapy with subcutaneous low-dose interleukin-2 and the pineal hormone melatonin: A progress report of 200 patients with advanced solid neoplasms. Oncology Reports 2:1063–1068, 1995.

    CAS  Google Scholar 

  37. Lissoni, P., Ardizzoia, A., Tisi, E., Rossini, F., Barni, S., Tancini, G., Conti, A., and Maestroni, G.J.M.: Amplification of eosinophilia by melatonin during the immunotherapy of cancer with interleukin-2. J. Biol. Reg. Homeos. Agents 7:34–36, 1993.

    CAS  Google Scholar 

  38. Lissoni, P., Ardizzoia, A., Tisi, E., Rossini, F., Barni, S., Tancini, G., Conti, A., and Maestroni, G.J.M.: Amplification of eosinophilia by melatonin during the immunotherapy of cancer with interleukin-2. J. Biol. Reg. Homeos. Agents 7:34–36, 1993.

    CAS  Google Scholar 

  39. Lissoni, P., Barni, S., Ardizzoia, A., Brivio, F., Tancini, G., Conti, A., and G.J.M., M.: Immunological effects of a single evening subcutaneous injection of low-dose interleukin-2 in association with the pineal hormone melatonin in advanced cancer patients. J. Biol. Reg. Homeos. Agents 6:132–136, 1992.

    CAS  Google Scholar 

  40. Lissoni, P., Barni, S., Rovelli, F., Brivio, F., Ardizzoia, A., Tancini, G., Conti, A., and Maestroni, G.J.M.: Neuroimmunotherapy of advanced solid neoplasms with single evening subcutaneous injection of low-dose interleukin-2 and melatonin: preliminary results. Eur. J. Cancer 29A:185–189, 1993.

    PubMed  CAS  Google Scholar 

  41. Lissoni, P., Barni, S., Tancini, G., Ardizzoia, A., Ricci, G., Aldeghi, R., Brivio, F., Tisi, E., Rescaldani, R., Quadro, G., and Maestroni, G.J.M.: A randomised study with subcutaneous low-dose interleukin 2 alone vs interleukin 2 plus the pineal neurohormone melatonin in advanced solid neoplasms other than renal cancer and melanoma. Br. J. Cancer 69:196–199, 1994.

    PubMed  CAS  Google Scholar 

  42. Lissoni, P., Barni, S., Tancini, G., Ardizzoia, A., Rovelli, F., Cazzaniga, M., Brivio, F., Piperno, A., Aldeghi, R., Fossati, D., Characjeius, D., Kothari, L., Conti, A., and Maestroni, G.J.M.: Immunotherapy with subcutaneous low-dose interleukin-2 and the pineal indole melatonin as a new effective therapy in advanced cancers of the digestive tract. Br. J. Cancer 67:1404–1407, 1993.

    PubMed  CAS  Google Scholar 

  43. Lissoni, P, Barni, S., Tancini, G., Ardizzoia, A., Rovelli, F., Cazzaniga, M., Brivio, F., Piperno, A., Aldeghi, R., Fossati, D., Characjeius, D., Kothari, L., Conti, A., and Maestroni, G.J.M.: Immunotherapy with subcutaneous low-dose interleukin-2 and the pineal indole melatonin as a new effective therapy in advanced cancers of the digestive tract. Br. J. Cancer 67:1404–1407, 1993.

    PubMed  CAS  Google Scholar 

  44. Lissoni, P., Barni, S., Tancini, G., Rovelli, F., Ardizzoia, A., Conti, A., and Maestroni, G.J.M.: A study of the mechanisms involved in the immunostimulatory action of the pineal hormone in cancer patients. Oncology50:399–402, 1993.

    PubMed  CAS  Google Scholar 

  45. Lissoni, P., Barni, S., Tancini, G., Rovelli, F., Ardizzoia, A., Conti, A., and Maestroni, G.J.M.: A study of the mechanisms involved in the immunostimulatory action of the pineal hormone in cancer patients. Oncology 50399–402, 1993

    Article  PubMed  CAS  Google Scholar 

  46. Lissoni, P., Brivio, F., Brivio, O., Fumagalli, L., Gramazio, F., Rossi, M., Emanuelli, G., Alderi, G., and Lavorato, F.: Immune effects of preoperative immunotherapy with high-dose subcutaneous interleukin-2 versus neuroimmunotherapy with low-dose interleukin-2 plus the neurohormone melatonin in gastrointestinal tract tumor patients. J. Biol. Regul. Homeost. Agents 9:31–33, 1995.

    PubMed  CAS  Google Scholar 

  47. Lissoni, P., Pittalis, S., Barni, S., Rovelli, F., Fumagalli, L., and Maestroni, G.J.-M.: Regulation of interleukin-2/interleukin-12 interactions by the pineal gland. Int. J. Thymology 5:443–447, 1997.

    CAS  Google Scholar 

  48. Lissoni, P., Rovelli, F., Brivio, F., Pittalis, S., Maestroni, G.J.M., and Fumagalli, L.: In vivo study of the modulatory effect of the pineal hormone melatonin on interleukin-12 secretion in response to interleukin-2. Int. J.Thymology 5:482–486, 1997.

    CAS  Google Scholar 

  49. Lissoni, P., Tisi, E., Barni, S., Ardizzoia, A., Rovelli, F., Rescaldani, R., Ballabio, D., Benenti, C., Angeli, M., Tancini, G., Conti, A., and Maestroni, G.J.M.: Biological and clinical results of a neuroimmunotherapy with interleukin-2 and the pineal hormone melatonin as a first line treatment in advanced non-small cell lung cancer. Br. J. Cancer 66:155–158, 1992.

    PubMed  CAS  Google Scholar 

  50. Maestroni, G., Hertens, E., Galli, P., Conti, A., and Pedrinis, E.: Melatonin-induced T-helper cell hematopoietic cytokines resembling both interleukin-4 and dynorphin. J. Pineal Res. 21:131–139, 1996.

    PubMed  CAS  Google Scholar 

  51. Maestroni, G.J.M.: The immunoneuroendocrine role of melatonin. J. Pineal Res. 14:1–10, 1993.

    PubMed  CAS  Google Scholar 

  52. Maestroni, G.J.M.: Kappa-opioid receptors in marrow stroma mediate the hematopoietic effects of melatonin-induced opioid cytokines. Neuroimmunomodulation: Molecular Aspects, Integrative Systems, and Clinical Advances, 1998,pp. 411–420.

    Google Scholar 

  53. Maestroni, G.J.M. and Conti, A.: Beta-endorphin and dynorphin mimic the circadian immunoenhancing and anti-stress effects of melatonin. Int. J. Immunopharmacol. 11:333–340, 1989

    Article  PubMed  CAS  Google Scholar 

  54. Maestroni, G.J.M. and Conti, A.: The pineal neurohormone melatonin stimulates activated CD4+,Thy-1+ cells to release opioid agonist(s) with immunoenhancing and anti-stress properties. J. Neuroimmunol.28:167–176, 1990.

    Article  PubMed  CAS  Google Scholar 

  55. Maestroni, G.J.M. and Conti, A.: Anti-stress role of the melatonin-immuno-opioid network. Evidence for a physiological mechanism involving T cell-derived, immunoreactive b-endorphin and met.enkephalin binding to thymic opioid receptors. Int. J. Neurosci. 61:289–298, 1991.

    Article  PubMed  CAS  Google Scholar 

  56. Maestroni, G.J.M. and Conti, A.: Melatonin in relation to the immune system, in Yu, H.-S. and Reiter, R.J. (eds): Melatonin. Biosynthesis, Physiological effects and Clinical Applications. Boca Raton, CRC Press, 1993, pp. 290–306.

    Google Scholar 

  57. Maestroni, G.J.M. and Conti, A.: Melatonin and the immune-hematopoietic system. Therapeutic and adverse pharmacological correlates. Neuroimmunomodulation 3:325–332, 1996.

    Article  PubMed  CAS  Google Scholar 

  58. Maestroni, G.J.M., Conti, A., and Lissoni, P.: Colony-stimulating activity and hematopoietic rescue from cancer chemothereapy compounds are induced by melatonin via endogenous interleukin 4. Cancer Res.54:4740–4743, 1994.

    PubMed  CAS  Google Scholar 

  59. Maestroni, G.J.M., Conti, A., and Pierpaoli, W.: Role of the pineal gland in immunity. Circadian synthesis and release of melatonin modulates the antibody response and antagonize the imunosuppressive effect of corticosterone. J. Neuroimmunol. 13:19–30, 1986.

    Article  PubMed  CAS  Google Scholar 

  60. Maestroni, G.J.M., Conti, A., and Pierpaoli, W.: Role of the pineal gland in immunity: II. Melatonin enhances the antibody response via an opiatergic mechanism. Clin. Exp. Immunol. 68:384–391, 1987.

    PubMed  CAS  Google Scholar 

  61. Maestroni, G.J.M., Covacci, V., and Conti, A.: Hematopoietic rescue via T-cell-dependent, endogenous GM-CSF by the pineal neurohormone melatonin in tumor bearing mice. Cancer Res. 54:2429–2432, 1994.

    PubMed  CAS  Google Scholar 

  62. Maestroni, G.J.M., Flamigni, L., Hertens, E., and Conti, A.,: Biochemical and functional characterization of melatonin-induced opioids in spleen and bone marrow T-helper cells. Neuroendocrinol. Lett. 17:145–153, 1995.

    CAS  Google Scholar 

  63. Maestroni, G.J.M. and Pierpaoli, W.: Pharmacological control of the hormonally modulated immune response, in Ader, R. (ed): Psychoneuroimmunology, vol. I. New York, Academic Press, 1981, pp. 405–425.

    Google Scholar 

  64. Morrey, M.K., McLachlan, J.A., Serkin, C.D., and Bakouche, 0.: Activation of human monocytes by the pineal neurohormone melatonin. J. Immunol. 153:2671–2680, 1994.

    PubMed  CAS  Google Scholar 

  65. Neri, B., DeLeonardis, V., Gemelli, M.T., DiLoro, M., Mottola, A., Ponchietti, R., Raugei, A., and Cini, G.: Melatonin as biological response modifier in cancer patients. Anticancer Res. 18:1329–1332, 1998.

    PubMed  CAS  Google Scholar 

  66. Neri, B., Fiorelli, C., Moroni, F., Nicita, G., Paoletti, M.C., Ponchietti, R., Raugei, A., Santoni, G., Trippitelli, A., and Grechi, G.: Modulation of human lymphoblastoid interferon activity by melatonin in metastatic renal cell carcinoma. A phase II study. Cancer 73:3015–3019, 1994.

    PubMed  CAS  Google Scholar 

  67. Palermo, M.S., Vermeulen, M., and Giordano, M.: Modulation of antibody-dependent cellular cytotoxicity by pineal gland, in Maestroni, G.J.M., Conti, A., and Reiter, R.J. (eds): Advances in Pineal Research, vol. 7. London, John Libbey, 1994, pp. 143–147.

    Google Scholar 

  68. Pioli, C., Caroleo, M.C., Nistico, G., and Doria, G.: Melatonin increases antigen presentation and amplifies specific and non specific signals for T-cell proliferation. Int. J. Immunopharmacol. 15:463–469,1993.

    Article  PubMed  CAS  Google Scholar 

  69. Poon, A.M., Liu, Z.M., Pang, C.S., Brown, G.M., and Pang, S.F.: Evidence for a direct action of melatonin on the immune system. Biol. Signals 3:107–117, 1994.

    PubMed  CAS  Google Scholar 

  70. Rella, W. and Lapin, V.: Immunocompetence of pinealectomized and simultaneously pinealectomized and thymectomized rats. Oncology 33:3–6, 1978.

    Google Scholar 

  71. Sei, S., Akiyoshi, H., Bernard, J., Venzon, D.J., Fox, C.H., Schwartzentruber, D.J., Anderson, B.D., Kopp, J.B., Mueller, B.U., and Pizzo, P.A.: Dynamics of virus versus host intercation in children with human immunodeficiency virus type 1 infection. J. Infect. Dis. 173:1485–1490, 1996

    PubMed  CAS  Google Scholar 

  72. Spector, N.H., Dolina, S., Cornelissen, G., Halberg, F., Markovic, B.M., and Jankovic, B.D.: Neuroimmunomodulation: neuroimmune interactions with the environment, in Blatteis, C.M. (ed): Handbook of Physiology: The Environment. Bethesda, Amer. Physiol. Society, 1996, pp. 1437–1549.

    Google Scholar 

  73. Vaughan, M.K. and Reiter, R.J.: Transient hypertrophy of the ventral prostate and coagulating glands and accelerated thymic involution following pinealectomy in the mouse. Texas Rep. Biol. Med. 29:579–586, 1971.

    CAS  Google Scholar 

  74. Wichmann, M., Zellweger, R., DeMaso, A., Ayala, A., and Chaudry, I.: Melatonin administration attenuates depressed immune functions trauma-hemorrhage. J. Surg. Res. 63:256–262, 1996.

    Article  PubMed  CAS  Google Scholar 

  75. Wichmann, M.W., haisken, J.M., Ayala, A., and Chaudry, I.H.: Melatonin administration following hemorrhagic shock decreases mortality from subsequent septic challenge. J. Surg. Res. 65:109–114,1996.

    Article  PubMed  CAS  Google Scholar 

  76. Withyachumnarnkul, B., Nonaka, K.O., Santana, C., Attia, A.M., and Reiter, R.J.: Interferon-gamma modulates melatonin production in rat pineal gland in organ culture. J. Interferon Res. 10403–411, 1990.

    Google Scholar 

  77. Young, M.R.I., Young, M.E., and Kim, K.: Regulation of tumor-induced myelopoiesis and the associated immune suppressor cells in mice bearing metastatic Lewis lung carcinoma by prostaglandin E2. Cancer Res.48:6826–6831, 1988.

    PubMed  CAS  Google Scholar 

  78. Yu, H.-S and Reiter, R.J.: Melatonin. Biosynthesis, Physiological Effects, and Clinical Applications. Boca Raton, CRC Press, 1993.

    Google Scholar 

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Maestroni, G.J.M. (2002). MLT and the Immune-hematopoietic System. In: Olcese, J. (eds) Melatonin After Four Decades. Advances in Experimental Medicine and Biology, vol 460. Springer, Boston, MA. https://doi.org/10.1007/0-306-46814-X_47

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  • DOI: https://doi.org/10.1007/0-306-46814-X_47

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